{"id":8013,"date":"2020-11-16T07:48:52","date_gmt":"2020-11-16T04:48:52","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=8013"},"modified":"2020-11-16T07:48:52","modified_gmt":"2020-11-16T04:48:52","slug":"%d8%a2%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d8%b1%d8%a8%d8%b7-%d8%a7%d9%84%d8%aa%d9%8a-%d9%8a%d8%aa%d9%85-%d8%a7%d9%86%d8%aa%d9%82%d8%a7%d8%b5%d9%87%d8%a7-%d9%85%d8%b1%d8%a9-%d9%88%d8%a7%d8%ad%d8%af%d8%a9","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=8013","title":{"rendered":"\u0622\u0644\u064a\u0629 \u0627\u0644\u0631\u0628\u0637 \u0627\u0644\u062a\u064a \u064a\u062a\u0645 \u0627\u0646\u062a\u0642\u0627\u0635\u0647\u0627 \u0645\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u0642\u062f \u062a\u0643\u0648\u0646 \u0645\u0641\u062a\u0627\u062d\u064b\u0627 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a – \u062a\u0631\u062c\u0645\u0629* \u0645\u062d\u0645\u062f \u062c\u0648\u0627\u062f \u0622\u0644 \u0627\u0644\u0633\u064a\u062f \u0646\u0627\u0635\u0631 \u0627\u0644\u062e\u0636\u0631\u0627\u0648\u064a"},"content":{"rendered":"

Once-discounted binding mechanism may be key to targeting viruses<\/strong>.
\n( \u0628\u0642\u0644\u0645: \u0645\u0627\u064a\u0643 \u0648\u0644\u064a\u0627\u0645\u0632 – Mike Williams )<\/span><\/h3>\n
\"\"
\u064a\u0648\u0636\u062d \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a \u0628\u0631\u0648\u062a\u064a\u0646\u064b\u0627 \u0631\u0626\u064a\u0633\u064a\u064b\u0627 \u0644\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a (\u0631\u0645\u0627\u062f\u064a) \u064a\u0634\u062a\u0645\u0644 \u0639\u0644\u0649 \u0628\u0628\u062a\u064a\u062f [\u0661] \u0645\u0623\u062e\u0648\u0630 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 SARS-CoV (\u0648\u0631\u062f\u064a). \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0631\u0643\u0628 \u0639\u0644\u0649 \u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u062f \u062c\u0632\u0621\u064b\u0627 \u0645\u0646 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629. \u0627\u0643\u062a\u0634\u0641 \u0628\u0627\u062d\u062b\u0648 \u062c\u0627\u0645\u0639\u0629 \u0631\u0627\u064a\u0633 \u0628\u0645\u062f\u064a\u0646\u0629 \u0647\u064a\u0648\u0633\u062a\u0646 \u2013 \u0648\u0644\u0627\u064a\u0629 \u062a\u0643\u0633\u0627\u0633 \u0628\u0642\u0627\u064a\u0627 \u0631\u0627\u0628\u0637\u0629 \u063a\u064a\u0631 \u0645\u062b\u0628\u062a\u0629 \u0641\u064a \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0647\u0645 \u0641\u064a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u0647\u0632\u064a\u0645\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u0627\u0644\u0635\u0648\u0631\u0629 \u0645\u0623\u062e\u0648\u0630\u0629 \u0641\u064a: \u0645\u062e\u062a\u0628\u0631 \u0643\u0627\u0641\u0631\u0627\u0643\u064a \/ \u062c\u0627\u0645\u0639\u0629 \u0631\u0627\u064a\u0633<\/span><\/figcaption><\/figure>\u0644\u0645 \u064a\u0628\u062f\u0648 “\u0627\u0644\u0645\u0648\u0636\u0639 4” (position 4) \u0645\u0647\u0645\u064b\u0627 \u062d\u062a\u0649 \u0623\u0644\u0642\u0649 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0646\u0638\u0631\u0629 \u0637\u0648\u064a\u0644\u0629 \u0639\u0644\u0649 \u0628\u0628\u062a\u064a\u062f \u0645\u0639\u064a\u0646. \u0648\u062a\u0628\u064a\u0646 \u0623\u0646 \u0630\u0644\u0643 \u0627\u0644\u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0645\u0623\u062e\u0648\u0630 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0633\u0627\u0631\u0633 (SARS-CoV) \u0644\u0647 \u062a\u0623\u062b\u064a\u0631 \u063a\u064a\u0631 \u0645\u062a\u0648\u0642\u0639\u060c \u0648\u0644\u0643\u0646\u0647 \u0645\u0647\u0645\u060c \u0639\u0644\u0649 \u0643\u064a\u0641\u064a\u0629 \u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u062b\u0628\u0627\u062a \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u064d \u0645\u0631\u0643\u0632\u064a\u064d \u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0639\u0644\u0649 \u0645\u0647\u0627\u062c\u0645\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0631\u064a\u0636\u0629.<\/p>\n
\"\"
\u0631\u0627\u0628\u0637 \u0627\u0644\u0628\u0628\u062a\u064a\u062f: \u0635\u0648\u0631\u0629 \u0645\u0646 \u0645\u0648\u0642\u0639 mun.ca\/biology<\/span><\/figcaption><\/figure>\n

\u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0646\u0634\u0631\u062a\u0647\u0627 \u0627\u0644\u0627\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 (Proceedings of the National Academy of Sciences) \u060c \u0643\u0634\u0641 \u0628\u0627\u062d\u062b\u0648\u0646 \u0641\u064a \u0643\u0644\u064a\u0629 \u0628\u0631\u0627\u0648\u0646 \u0644\u0644\u0647\u0646\u062f\u0633\u0629 \u0628\u062c\u0627\u0645\u0639\u0629 \u0631\u0627\u064a\u0633 (\u0645\u062f\u064a\u0646\u0629 \u0647\u064a\u0648\u0633\u062a\u0646 \u2013 \u0648\u0644\u0627\u064a\u0629 \u062a\u0643\u0633\u0627\u0633) \u0648\u0645\u0631\u0643\u0632 \u0625\u0645 \u062f\u064a \u0623\u0646\u062f\u0631\u0633\u0648\u0646 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0628\u062c\u0627\u0645\u0639\u0629 \u062a\u0643\u0633\u0627\u0633 \u0639\u0646 \u0646\u0645\u0627\u0630\u062c \u0628\u062f\u0642\u0629 \u0630\u0631\u064a\u0629 \u062a\u064f\u0641\u0635\u0650\u0651\u0644 \u0644\u064a\u0633 \u0641\u0642\u0637 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u0644\u0643\u0646 \u0623\u064a\u0636\u064b\u0627 – \u0648\u0644\u0623\u0648\u0644 \u0645\u0631\u0629 – \u0622\u0644\u064a\u0627\u062a \u0641\u0643 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062a\u064a \u062a\u0643\u0645\u0646 \u0648\u0631\u0627\u0621 \u0645\u0643\u0648\u0646 \u0631\u0626\u064a\u0633\u064a \u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629. \u0648\u064a\u0642\u0648\u0644\u0648\u0646 \u0625\u0646 \u0627\u0644\u0641\u0647\u0645 \u0627\u0644\u0623\u0641\u0636\u0644 \u0644\u0644\u0622\u0644\u064a\u0629 \u0628\u0623\u0643\u0645\u0644\u0647\u0627 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0637\u0648\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0630\u064a \u064a\u0639\u0632\u0632 \u0642\u062f\u0631\u0629 \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0623\u0645\u0631\u0627\u0636.<\/p>\n

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\u0648\u0623\u0636\u0627\u0641: “\u0645\u0646 \u062e\u0644\u0627\u0644 \u062f\u0645\u062c \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0647\u064a\u0643\u0644\u064a\u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0643\u062a\u0634\u0627\u0641 \u0645\u0633\u0627\u0647\u0645\u0629 \u0647\u0630\u0647 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0641\u064a \u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u060c \u0648\u0646\u0623\u0645\u0644 \u0623\u0646 \u0646\u062a\u0645\u0643\u0646 \u0645\u0646 \u0625\u064a\u062c\u0627\u062f \u0623\u0647\u062f\u0627\u0641 \u0623\u0641\u0636\u0644 \u0644\u062a\u0637\u0648\u064a\u0631 \u0644\u0642\u0627\u062d \u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0639\u0644\u0649 \u0623\u0633\u0627\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629”.<\/p>\n

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\u064a\u0648\u0636\u062d \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u062a\u0648\u0636\u064a\u062d\u064a \u0627\u0644\u0634\u062d\u0646\u0627\u062a \u0627\u0644\u0643\u0647\u0631\u0648\u0633\u062a\u0627\u062a\u064a\u0643\u064a\u0629 (\u0627\u0644\u0644\u0648\u0646 \u0627\u0644\u0623\u0632\u0631\u0642 \u0645\u0648\u062c\u0628\u060c \u0648\u0627\u0644\u0623\u062d\u0645\u0631 \u0633\u0644\u0628\u064a) \u0641\u064a \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0628\u0628\u062a\u064a\u062f \u0645\u0623\u062e\u0648\u0630 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 SARS-CoV. \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u0645\u0631\u0643\u0628 \u0641\u064a \u062a\u062d\u0641\u064a\u0632 \u0639\u062f\u0648\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u062f \u062c\u0632\u0621\u064b \u0645\u0646 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629. \u0627\u0643\u062a\u0634\u0641 \u0628\u0627\u062d\u062b\u0648 \u062c\u0627\u0645\u0639\u0629 \u0631\u0627\u064a\u0633 \u0628\u0642\u0627\u064a\u0627 \u0631\u0627\u0628\u0637\u0629 \u063a\u064a\u0631 \u0645\u062b\u0628\u062a\u0629 \u0641\u064a \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0647\u0645 \u0641\u064a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u0647\u0632\u064a\u0645\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633. \u0627\u0644\u0635\u0648\u0631\u0629 \u0645\u0646: \u0645\u062e\u062a\u0628\u0631 \u0643\u0627\u0641\u0631\u0627\u0643\u064a \/ \u062c\u0627\u0645\u0639\u0629 \u0631\u0627\u064a\u0633<\/span><\/figcaption><\/figure>\n

\u0648\u0642\u062f \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u062d\u0627\u0643\u0627\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0645 \u0644\u0625\u0644\u0642\u0627\u0621 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u062a\u0641\u0627\u0635\u064a\u0644 \u0643\u064a\u0641\u064a\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0633\u0627\u0631\u0633 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0627\u0630 \u064a\u0631\u062a\u0628\u0637 (QFKDNVILL) [\u0662]\u060c \u0628\u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0631\u0643\u0628 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a (major histocompatibility complex – MHC) \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 [\u0663]\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 (HLA-A * 24:02) \u060c \u0628\u0634\u0643\u0644 \u0623\u0633\u0627\u0633\u064a \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u0633\u064a \u0627\u0644\u0645\u0647\u064a\u0645\u0646\u0629 \u0639\u0644\u0649 \u0637\u0631\u0641\u064a \u0627\u0644\u0628\u0628\u062a\u064a\u062f (\u0641\u064a \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0646 2 \u0648 9) \u0648\u064a\u0642\u062f\u0645\u0647\u0627 \u0627\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0644\u0641\u062d\u0635.<\/p>\n

\u0648\u064a\u0639\u062f \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0645\u0633\u062a\u0642\u0631 \u0644\u0644\u0628\u0628\u062a\u064a\u062f \u0648\u0645\u0631\u0643\u0628 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a (MHC) \u0634\u0631\u0637\u064b\u0627 \u0623\u0633\u0627\u0633\u064a\u064b\u0627 \u0644\u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0628\u062d\u062b \u0639\u0646 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0627 \u062a\u0648\u062c\u062f \u0639\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0644\u064a\u0645\u0629. \u0648\u0625\u0630\u0627 \u0644\u0645 \u064a\u062a\u062d\u062f \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u060c \u0641\u0644\u0646 \u062a\u062a\u0645 \u0645\u0637\u0627\u0644\u0628\u0629 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0628\u0627\u0644\u0647\u062c\u0648\u0645.<\/p>\n

\u0648\u0642\u0627\u0644\u062a \u0627\u0644\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0643\u0627\u0641\u0631\u0627\u0643\u064a: “\u0643\u0627\u0646 \u0647\u0630\u0627 \u0645\u0639\u0631\u0648\u0641\u064b\u0627 \u0643\u062b\u064a\u0631\u064b\u0627 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0644\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0642\u064a\u062f\u0629 \u0648\u063a\u064a\u0631 \u0627\u0644\u0645\u0642\u064a\u062f\u0629 \u0644\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a\u061b \u0648\u0645\u0627 \u0644\u0645 \u064a\u0644\u062a\u0642\u0637\u0648\u0647 \u0647\u0648 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0648\u0633\u064a\u0637\u0629 \u0648\u0627\u0644\u062a\u062d\u0648\u0644\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0642\u0648\u062f \u0645\u0646 \u062d\u0627\u0644\u0629 \u0625\u0644\u0649 \u0623\u062e\u0631\u0649\u060c \u0648\u062e\u0627\u0635\u0629 \u0641\u0643 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637”. \u0648\u062a\u0627\u0628\u0639: “\u0623\u0639\u062a\u0642\u062f \u0623\u0646 \u0647\u0630\u0627 \u0647\u0648 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0648\u062d\u064a\u062f \u0627\u0644\u0630\u064a \u064a\u0638\u0647\u0631 \u0641\u0643 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0645\u0646 \u0645\u0631\u0643\u0628 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a (MHC) \u0628\u0627\u0644\u062f\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0629\u061b \u0641\u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0644\u0647\u0627 \u062e\u0635\u0627\u0626\u0635 \u0645\u062a\u0634\u0627\u0628\u0647\u0629 \u0648\u0646\u0639\u062a\u0642\u062f \u0623\u0646\u0647 \u0633\u064a\u0643\u0648\u0646 \u0644\u0647\u0627 \u0633\u0644\u0648\u0643\u064a\u0627\u062a \u0645\u0645\u0627\u062b\u0644\u0629”.<\/p>\n

\u0648\u062a\u0645 \u0627\u0644\u0643\u0634\u0641 \u0639\u0646 \u0643\u0644 \u0647\u0630\u0647 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0628\u062a\u0641\u0635\u064a\u0644 \u0643\u0628\u064a\u0631 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0646\u0645\u0627\u0630\u062c \u062d\u0627\u0644\u0629 \u0645\u0627\u0631\u0643\u0648\u0641 (Markov state models) \u0627\u0644\u062a\u064a \u062a\u062d\u0644\u0644 \u0643\u064a\u0641\u064a\u0629 \u062a\u063a\u064a\u0631 \u0627\u0644\u0623\u0646\u0638\u0645\u0629 \u0628\u0645\u0631\u0648\u0631 \u0627\u0644\u0648\u0642\u062a. \u00a0\u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0629\u060c \u0643\u0634\u0641\u062a \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u0639\u0646 \u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062f\u0639\u0645 \u0627\u0644\u0645\u0631\u0627\u0633\u064a \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u0644\u0628\u0628\u062a\u064a\u062f. \u0647\u0630\u0627 \u0647\u0648 \u0627\u0644\u0645\u0643\u0627\u0646 \u0627\u0644\u0630\u064a \u0628\u0631\u0632 \u0641\u064a\u0647 \u0627\u0644\u0645\u0648\u0636\u0639 4.<\/p>\n

\u0648\u0642\u0627\u0644 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0623\u0646\u062a\u0648\u0646\u064a\u0633: “\u0647\u0646\u0627\u0643 \u0627\u0644\u0645\u0631\u0627\u0633\u064a \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0639\u0631\u0641\u0647\u0627 \u0627\u0644\u0646\u0627\u0633\u060c \u0648\u0644\u0643\u0646 \u0647\u0646\u0627\u0643 \u0647\u0630\u0647 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0627\u0647\u0645 \u0641\u064a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631\u061b \u0648\u064a\u0635\u0639\u0628 \u0627\u0644\u062a\u0642\u0627\u0637 \u0647\u0630\u0647 \u0627\u0644\u0623\u0634\u064a\u0627\u0621\u060c \u0648\u0644\u0643\u0646 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u064a\u0628\u062f\u0648 \u0623\u0646 \u0627\u0644\u0645\u0648\u0636\u0639 4 \u064a\u0644\u0639\u0628 \u062f\u0648\u0631\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0644\u0644\u063a\u0627\u064a\u0629\u060c \u0641\u0639\u0646\u062f\u0645\u0627 \u062a\u0642\u0648\u0645 \u0628\u062a\u063a\u064a\u064a\u0631\u0647\u060c \u0641\u0625\u0646\u0647 \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0633\u0644\u0648\u0643 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0644\u0623\u0646\u0647 \u064a\u0646\u0641\u0635\u0644 \u0639\u0646 \u0627\u0644\u062c\u0632\u064a\u0621”.<\/p>\n

\u0648\u0642\u062f \u0642\u0627\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u0646\u0645\u0630\u062c\u0629 \u0637\u0641\u0631\u0627\u062a \u0645\u0631\u0643\u0628 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0645\u0639\u0631\u0641\u0629 \u0643\u064a\u0641 \u0633\u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u0648\u062c\u062f\u0648\u0627 \u0623\u0646\u0647\u0645 \u064a\u062f\u0639\u0645\u0648\u0646 \u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0645\u0648\u0636\u0639 4 \u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0645\u0631\u0643\u0628.<\/p>\n

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\u0648\u0642\u0627\u0644\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u0629 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0633\u064a\u0633\u064a\u0644\u064a\u0627 \u0643\u0644\u064a\u0645\u0646\u062a\u064a\u060c \u0623\u0633\u062a\u0627\u0630\u0629 \u062c\u0627\u0645\u0639\u0629 \u0631\u0627\u064a\u0633 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0627\u0644\u062a\u064a \u0623\u0635\u0628\u062d\u062a \u0645\u0624\u062e\u0631\u064b\u0627 \u0623\u0633\u062a\u0627\u0630\u0629 \u0641\u064a\u0632\u064a\u0627\u0621 (\u0643\u0644\u064a\u0629 \u0623\u064a\u0646\u0634\u062a\u0627\u064a\u0646 \u0644\u0644\u0641\u064a\u0632\u064a\u0627\u0621) \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u0628\u0631\u0644\u064a\u0646 \u0627\u0644\u062d\u0631\u0629: “\u0625\u0646 \u0646\u0647\u062c\u0646\u0627 \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u0643\u0627\u0646 \u0642\u0627\u062f\u0631\u064b\u0627 \u0639\u0644\u0649 \u0625\u062c\u0631\u0627\u0621 \u062a\u0646\u0628\u0624\u0627\u062a \u062d\u0648\u0644 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645 \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646\u0647\u0627 \u0628\u0639\u062f \u0630\u0644\u0643 \u062a\u062c\u0631\u064a\u0628\u064a\u064b\u0627”.<\/p>\n

\u0648\u0637\u0648\u0631 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0639\u0645\u0644\u064a\u0629 \u0645\u0646 \u0645\u0631\u062d\u0644\u062a\u064a\u0646 \u0644\u062a\u0628\u0633\u064a\u0637 \u0627\u0644\u062a\u0639\u0642\u064a\u062f \u0627\u0644\u062d\u0633\u0627\u0628\u064a \u0644\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0630\u0631\u064a \u0644\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0643\u0628\u064a\u0631\u0629. \u0648\u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u062a\u0642\u0646\u064a\u0629 \u062a\u0633\u0645\u0649 \u0623\u062e\u0630 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0638\u0644\u0629 \u0644\u062a\u0633\u0631\u064a\u0639 \u0627\u0644\u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0627\u0644\u0623\u0648\u0644\u064a \u0644\u0644\u062c\u0632\u064a\u0626\u0627\u062a. \u0643\u0645\u0627 \u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0627\u0633\u062a\u0643\u0634\u0627\u0641\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0623\u062e\u0630 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u0643\u064a\u0641\u064a\u0629\u060c \u062d\u064a\u062b \u064a\u062a\u0645 \u062f\u0641\u0639 \u0627\u0644\u0645\u062d\u0627\u0643\u0627\u0629 \u0644\u062a\u0633\u0631\u064a\u0639 \u0628\u0646\u0627\u0621 \u0646\u0645\u0648\u0630\u062c \u0645\u0627\u0631\u0643\u0648\u0641.<\/p>\n

\u0648\u0642\u0627\u0644 \u0623\u0628\u064a\u0644\u0627\u060c \u0627\u0644\u0630\u064a \u0634\u0643\u0644\u062a \u0623\u0628\u062d\u0627\u062b\u0647 \u062d\u0648\u0644 \u0647\u0630\u0627 \u0627\u0644\u0645\u0648\u0636\u0648\u0639 \u062c\u0632\u0621\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0645\u0646 \u0623\u0637\u0631\u0648\u062d\u062a\u0647 \u0644\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647: “\u0627\u0644\u062a\u062d\u062f\u064a \u0647\u0648 \u0623\u0646 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a (MHCs) \u0647\u064a \u0623\u0646\u0638\u0645\u0629 \u0643\u0628\u064a\u0631\u0629 \u062c\u062f\u064b\u0627 \u0644\u0645\u062d\u0627\u0643\u0627\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u064a\u0646 \u0627\u0644\u062d\u0633\u0627\u0628\u064a\u064a\u0646\u060c \u0648\u0643\u0627\u0646 \u0639\u0644\u064a\u0646\u0627 \u0625\u062c\u0631\u0627\u0621 \u0628\u0639\u0636 \u0627\u0644\u062a\u0642\u0631\u064a\u0628\u0627\u062a \u0648\u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0627\u0644\u062a\u0642\u062f\u0645 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0641\u0626\u0627\u062a \u0645\u0646 \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0644\u0644\u0645\u0636\u064a \u0642\u062f\u0645\u064b\u0627”. \u0648\u062a\u0627\u0628\u0639: “\u0644\u0633\u0646\u0627 \u0623\u0648\u0644 \u0645\u0646 \u062f\u0631\u0633 \u0641\u0643 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u060c \u0648\u0644\u0643\u0646 \u0645\u0627 \u064a\u0645\u064a\u0632 \u0639\u0645\u0644\u0646\u0627 \u0639\u0644\u0649 \u0627\u0644\u0622\u062e\u0631\u064a\u0646 \u0647\u0648 \u0623\u0646\u0646\u0627 \u0646\u062d\u062a\u0641\u0638 \u0628\u0627\u0644\u062f\u0642\u0629 \u0627\u0644\u0630\u0631\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0641\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u062d\u0627\u0643\u0627\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0646\u0627\u061b \u0648\u062a\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0623\u0639\u0645\u0627\u0644 \u0627\u0644\u0623\u062e\u0631\u0649 \u062a\u0642\u0646\u064a\u0629 \u062a\u0639\u0631\u0641 \u0628\u0627\u0633\u0645 \u0633\u0644\u0633\u0644\u0629 \u0645\u0627\u0631\u0643\u0648\u0641 \u0645\u0648\u0646\u062a \u0643\u0627\u0631\u0644\u0648\u060c \u0628\u064a\u0646\u0645\u0627 \u0646\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u062a\u064a\u062d \u0644\u0646\u0627 \u062f\u0645\u062c \u0627\u0644\u0648\u0642\u062a \u0641\u064a \u062d\u0633\u0627\u0628\u0627\u062a\u0646\u0627 \u0644\u0627\u0644\u062a\u0642\u0627\u0637 \u0627\u0644\u062e\u0648\u0627\u0635 \u0627\u0644\u062d\u0631\u0643\u064a\u0629”.<\/p>\n

\u0648\u064a\u0645\u0643\u0646 \u062a\u0637\u0628\u064a\u0642 \u0623\u0633\u0627\u0644\u064a\u0628\u0647\u0645 \u0639\u0644\u0649 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0628\u0628\u062a\u064a\u062f-\u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a (peptide-MHC complexes) \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u0639 \u0627\u0644\u0646\u0645\u0627\u0630\u062c \u062b\u0644\u0627\u062b\u064a\u0629 \u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062d\u0627\u0644\u064a\u0629. \u0648\u0642\u0627\u0644 \u0623\u0628\u064a\u0644\u0627: “\u0643\u0627\u0646\u062a \u0647\u0630\u0647\u060c \u0625\u0644\u0649 \u062d\u062f \u0645\u0627\u060c \u062f\u0631\u0627\u0633\u0629 \u062c\u062f\u0648\u0649 \u0644\u0625\u0638\u0647\u0627\u0631 \u0623\u0646\u0647 \u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0648\u0628\u0646\u0627\u0621 \u0646\u0645\u0648\u0630\u062c \u062d\u0627\u0644\u0629 \u0645\u0627\u0631\u0643\u0648\u0641 \u0644\u0646\u0638\u0627\u0645 \u0628\u0647\u0630\u0627 \u0627\u0644\u062d\u062c\u0645”. \u0648\u0644\u0627\u062d\u0638 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u064a\u0636\u064b\u0627 \u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u0645\u0639\u0631\u0643\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0636\u062f \u0643\u0648\u0641\u064a\u062f-\u0661\u0669 (COVID-19) \u060c \u062d\u064a\u062b \u0623\u0646 \u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0633\u0627\u0631\u0633 (QFKDNVILL) \u0627\u0644\u0630\u064a \u0631\u0627\u062c\u0639\u0648\u0647\u060c \u064a\u0634\u0628\u0647 \u0625\u0644\u0649 \u062d\u062f \u0643\u0628\u064a\u0631 \u0628\u0628\u062a\u064a\u062f-\u0628\u0631\u0648\u062a\u064a\u0646 \u0646\u0648\u0643\u0644\u064a\u0648\u0643\u0627\u0628\u0633\u064a\u062f (NFKDQVILL) \u0641\u064a \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 -\u0662 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0633\u0627\u0631\u0633 (SARS-CoV-2) \u060c \u0645\u0639 \u0648\u062c\u0648\u062f \u062c\u064a\u0648\u0628 \u0627\u0644\u0631\u0628\u0637 \u0646\u0641\u0633\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0648\u0627\u0636\u0639 2 \u0648 4 \u0648 9.<\/p>\n

“\u062a\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646 \u0643\u0644\u0627 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0631\u062a\u0628\u0637 \u0628\u0640 HLA-A * 24:02 \u0648\u062a\u0648\u0641\u0631 \u0623\u0647\u062f\u0627\u0641\u064b\u0627 \u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062d\u0638\u0649 \u0628\u0627\u0647\u062a\u0645\u0627\u0645 \u0643\u0628\u064a\u0631 \u0641\u064a \u0636\u0648\u0621 \u0627\u0644\u062c\u0627\u0626\u062d\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629” \u060c \u0643\u0645\u0627 \u0642\u0627\u0644 \u0627\u0644\u0645\u0624\u0644\u0641 \u0627\u0644\u0645\u0634\u0627\u0631\u0643 \u063a\u0631\u064a\u063a\u0648\u0631\u064a \u0644\u064a\u0632\u064a\u0647\u060c \u0623\u0633\u062a\u0627\u0630 \u0641\u064a \u0642\u0633\u0645 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u064a\u0644\u0627\u0646\u064a\u0646\u064a\u0629 \u0641\u064a \u0625\u0645 \u062f\u064a \u0623\u0646\u062f\u0631\u0633\u0648\u0646. \u0648\u0623\u0636\u0627\u0641: “\u0644\u0643\u0646 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u062a\u0644\u0642\u064a \u0627\u0644\u0636\u0648\u0621 \u0623\u064a\u0636\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0627\u0644\u0623\u062e\u0631\u0649\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0648\u062d\u062a\u0649 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u0628\u0634\u0631\u064a\u0629”.<\/p>\n

\u0648\u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0643\u0627\u0641\u0631\u0627\u0643\u064a \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0627\u0644\u0630\u064a \u0642\u0627\u0645 \u0628\u0647 \u0627\u0644\u0645\u062a\u0639\u0627\u0648\u0646 \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0644\u064a\u0632\u064a \u0648\u0643\u0627\u064a\u0644 \u062c\u0627\u0643\u0633\u0648\u0646\u060c \u0645\u0633\u0627\u0639\u062f \u0628\u0627\u062d\u062b \u0645\u062a\u062e\u0631\u062c \u0641\u064a \u0645\u062e\u062a\u0628\u0631 \u0644\u064a\u0632\u064a\u0647 \u0627\u0644\u0630\u064a \u0623\u0646\u062a\u062c \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u0648\u0644\u0629\u060c \u0643\u0627\u0646 \u062d\u0627\u0633\u0645\u064b\u0627 \u0644\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0635\u062d\u0629 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u062d\u0627\u0643\u0627\u0629. \u0648\u0641\u0627\u0632 \u0645\u062e\u062a\u0628\u0631 \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0643\u0627\u0641\u0631\u0627\u0643\u064a \u0628\u0645\u0646\u062d\u0629 \u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0645\u0646 \u0645\u0624\u0633\u0633\u0629 \u0627\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 (NSF-National Science Foundation) \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0623\u062c\u0632\u0627\u0621 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0633\u0627\u0631\u0633 (SARS-CoV-2) \u0643\u0623\u0647\u062f\u0627\u0641 \u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0644\u0642\u0627\u062d.<\/p>\n

*\u062a\u0645\u062a \u0627\u0644\u062a\u0631\u062c\u0645\u0629 \u0628\u062a\u0635\u0631\u0641<\/span><\/p>\n

\u0627\u0644\u0645\u0635\u062f\u0631<\/strong>:<\/p>\n

https:\/\/phys.org\/news\/2020-11-once-discounted-mechanism-key-viruses.html<\/a><\/p>\n

\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a<\/strong>: Jayvee R. Abella et al, Markov state modeling reveals alternative unbinding pathways for peptide\u2013MHC complexes,\u00a0Proceedings of the National Academy of Sciences\u00a0(2020).\u00a0\u00a0DOI: 10.1073\/pnas.2007246117<\/a><\/p>\n

\u0627\u0644\u0647\u0648\u0627\u0645\u0634<\/strong>:<\/p>\n[\u0661] \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a (peptides) \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0633\u0644\u0627\u0633\u0644 \u0642\u0635\u064a\u0631\u0629 \u0645\u0643\u0648\u0646\u0629 \u0662 \u2013 \u0665\u0660 \u062d\u0645\u0636\u064b\u0627 \u0623\u0645\u064a\u0646\u064a\u064b\u0627\u060c \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0631\u0648\u0627\u0628\u0637 \u0628\u0628\u062a\u064a\u062f\u064a\u0629. \u062a\u0633\u0645\u0649 \u0627\u0644\u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0623\u0642\u0644 \u0645\u0646 \u0639\u0634\u0631\u0629 \u0623\u0648 \u062e\u0645\u0633\u0629 \u0639\u0634\u0631 \u0645\u0646 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0627\u0648\u0644\u064a\u063a\u0648\u0628\u0628\u062a\u064a\u062f\u0627\u062a (oligopeptides) \u060c \u0648\u062a\u0634\u0645\u0644 \u062f\u0627\u064a-\u0628\u0628\u062a\u064a\u062f\u0627\u062a (dipeptides) \u060c \u0648\u062a\u0631\u0627\u064a-\u0628\u0628\u062a\u064a\u062f\u0627\u062a (tripeptides) \u060c \u0648\u062a\u062a\u0631\u0627-\u0628\u0628\u062a\u064a\u062f\u0627\u062a (tetrapeptides). \u0648\u064a\u0643\u064a\u0628\u064a\u062f\u064a\u0627<\/p>\n[\u0662] QFKDNVILL \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062d\u0627\u062a\u0645\u0629 \u062e\u0637\u064a\u0629 \u0628\u0628\u062a\u064a\u062f\u064a\u0629 \u062a\u0645\u062a \u062f\u0631\u0627\u0633\u062a\u0647\u0627 \u0643\u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0646\u0648\u0648\u064a \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u062a\u0646\u0641\u0633\u064a\u0629 \u0627\u0644\u062d\u0627\u062f\u0629 \u0627\u0644\u0648\u062e\u064a\u0645\u0629 (\u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0627\u062c\u064a \u0627\u0644\u0628\u0634\u0631\u064a (\u0633\u0644\u0627\u0644\u0629 \u0627\u0644\u0633\u0627\u0631\u0633)). \u0627\u0644\u0645\u0635\u062f\u0631: http:\/\/www.iedb.org\/epitope\/50779<\/a><\/p>\n[\u0663] \u0645\u0631\u0643\u0628 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a (major histocompatibility complex – MHC)<\/p>\n

\u0647\u0648 \u0645\u0648\u0636\u0639 \u0643\u0628\u064a\u0631 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0644\u0641\u0642\u0627\u0631\u064a\u0627\u062a \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0627\u0631\u062a\u0628\u0627\u0637\u064b\u0627 \u0648\u062b\u064a\u0642\u064b\u0627 \u0648\u0627\u0644\u062a\u064a \u062a\u0631\u0645\u0632 \u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0636\u0631\u0648\u0631\u064a\u0629 \u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u062a\u0643\u064a\u0641\u064a. \u062d\u0635\u0644 \u0647\u0630\u0627 \u0627\u0644\u0645\u0648\u0636\u0639 \u0639\u0644\u0649 \u0627\u0633\u0645\u0647 \u0644\u0623\u0646\u0647 \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641\u0647 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0639\u0646\u062f \u0627\u0644\u0632\u0631\u0639. \u0648\u064a\u0643\u064a\u0628\u064a\u062f\u064a\u0627.<\/p>\n

\"\"
\u0627\u0644\u0645\u0647\u0646\u062f\u0633 \u0645\u062d\u0645\u062f \u062c\u0648\u0627\u062f \u0627\u0644\u062e\u0636\u0631\u0627\u0648\u064a<\/span><\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Once-discounted binding mechanism may be key to targeting viruses. ( \u0628\u0642\u0644\u0645: \u0645\u0627\u064a\u0643 \u0648\u0644\u064a\u0627\u0645\u0632 – Mike Williams ) \u0644\u0645 \u064a\u0628\u062f\u0648 “\u0627\u0644\u0645\u0648\u0636\u0639 4” (position 4) \u0645\u0647\u0645\u064b\u0627 \u062d\u062a\u0649 \u0623\u0644\u0642\u0649 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0646\u0638\u0631\u0629 \u0637\u0648\u064a\u0644\u0629 \u0639\u0644\u0649 \u0628\u0628\u062a\u064a\u062f \u0645\u0639\u064a\u0646. \u0648\u062a\u0628\u064a\u0646 \u0623\u0646 \u0630\u0644\u0643 \u0627\u0644\u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0645\u0623\u062e\u0648\u0630 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0631\u0648\u0646\u0627 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0633\u0627\u0631\u0633 (SARS-CoV) \u0644\u0647 \u062a\u0623\u062b\u064a\u0631 \u063a\u064a\u0631 \u0645\u062a\u0648\u0642\u0639\u060c \u0648\u0644\u0643\u0646\u0647 \u0645\u0647\u0645\u060c \u0639\u0644\u0649 \u0643\u064a\u0641\u064a\u0629 \u0627\u0631\u062a\u0628\u0627\u0637\u0647 \u0628\u062b\u0628\u0627\u062a …<\/p>\n","protected":false},"author":4,"featured_media":8020,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-8013","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-19"],"_links":{"self":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/8013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8013"}],"version-history":[{"count":3,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/8013\/revisions"}],"predecessor-version":[{"id":8022,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/8013\/revisions\/8022"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/media\/8020"}],"wp:attachment":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8013"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}