{"id":32777,"date":"2025-12-16T15:12:18","date_gmt":"2025-12-16T12:12:18","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=32777"},"modified":"2025-12-16T15:54:16","modified_gmt":"2025-12-16T12:54:16","slug":"%d8%af%d8%b1%d8%a7%d8%b3%d8%a9-%d8%b1%d8%a7%d8%a6%d8%af%d8%a9-%d9%85%d8%b3%d8%aa%d9%86%d8%af%d8%a9-%d8%a5%d9%84%d9%89-%d8%b9%d9%84%d9%85-%d8%a7%d9%84%d8%ac%d9%8a%d9%86%d9%88%d9%85-%d9%84%d8%a5%d8%b9","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=32777","title":{"rendered":"\u062f\u0631\u0627\u0633\u0629 \u0631\u0627\u0626\u062f\u0629 \u0645\u0633\u062a\u0646\u062f\u0629 \u0625\u0644\u0649 \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0623\u062f\u0648\u064a\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649\u060c \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646 – \u062a\u0631\u062c\u0645\u0629 \u0639\u062f\u0646\u0627\u0646 \u0623\u062d\u0645\u062f \u0627\u0644\u062d\u0627\u062c\u064a"},"content":{"rendered":"

Genomics-driven drug repurposing and novel targets identification for sickle cell disease in Saudi patients<\/span>
\n(\u062f\u0631\u0627\u0633\u0629 \u0631\u0627\u0626\u062f\u0629 \u0645\u0633\u062a\u0646\u062f\u0629 \u0625\u0644\u0649 \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0623\u062f\u0648\u064a\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649\u060c \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646)<\/span>
\n[\u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646\u061b \u0639\u0644\u0649 \u0627\u0644\u063a\u0628\u064a\u0634\u064a\u060c \u0645\u062d\u0645\u062f \u0627\u0644\u0634\u0628\u064a\u0628\u060c \u0648\u064a\u062c\u064a\u0633\u064a\u0646\u062c\u0647\u0627 \u062f\u064a\u0627\u0646\u062c\u0627\u0646\u060c \u0645\u062d\u0645\u062f \u0627\u0644\u0639\u0648\u0636\u060c \u0633\u0639\u0627\u062f \u0627\u0644\u0634\u0645\u0631\u064a\u060c \u062e\u0644\u064a\u0641\u0629 \u0627\u0644\u0631\u0627\u062c\u062d\u060c \u0645\u0646\u0649 \u0627\u0644\u062e\u064a\u0631\u064a\u060c \u0639\u0645\u0627\u062f \u0627\u0644\u0625\u0633\u0644\u0627\u0645\u060c \u0648\u0623\u062d\u0645\u062f \u0627\u0644\u0639\u0633\u0643\u0631]<\/span>
\n(\u0627\u0644\u0646\u0627\u0634\u0631\u061b \u0645\u062c\u0644\u0629 \u0641\u0631\u0648\u0646\u062a\u064a\u0631\u0632 \u0641\u064a \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629)<\/span>
\n{\u0631\u0627\u062c\u0639 \u0627\u0644\u062a\u0631\u062c\u0645\u0629 \u0648\u0642\u062f\u0645 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0645\u062d\u0645\u062f \u0622\u0644 \u0634\u0628\u064a\u0628\u060c \u0627\u0633\u062a\u0634\u0627\u0631\u064a \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629\u060c \u0639\u0627\u0644\u0645 \u0623\u0628\u062d\u0627\u062b\u060c \u0645\u0631\u0643\u0632 \u0627\u0644\u0645\u0644\u0643 \u0639\u0628\u062f \u0627\u0644\u0644\u0647 \u0627\u0644\u0639\u0627\u0644\u0645\u064a \u0644\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0637\u0628\u064a\u0629\u060c \u0627\u0644\u0631\u064a\u0627\u0636}<\/span><\/h3>\n

\u0645\u0642\u062f\u0645\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0645\u062d\u0645\u062f \u0622\u0644 \u0634\u0628\u064a\u0628 <\/span><\/strong>
\n\u062a\u0645 \u0628\u062d\u0645\u062f \u0627\u0644\u0644\u0647 \u0645\u0624\u062e\u0631\u064b\u0627 \u0625\u0643\u0645\u0627\u0644 \u0648\u0646\u0634\u0631 \u0628\u062d\u062b\u0646\u0627 \u062d\u0648\u0644 \u062a\u062d\u062f\u064a\u062f \u062a\u0637\u0628\u064a\u0642\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u062a\u0648\u0641\u0631\u0629 \u062d\u0627\u0644\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u0623\u0633\u0648\u0627\u0642 \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u062f\u0627\u0621 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 (\u0627\u0644\u0633\u0643\u0644\u0633\u0644)\u060c \u0648\u0630\u0644\u0643 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u0639\u0631\u0641\u0629 \u0645\u062a\u063a\u064a\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0643\u062a\u0634\u0641\u0646\u0627\u0647\u0627 \u0645\u0624\u062e\u0631\u064b\u0627. <\/span>
\n\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u062a\u0631\u062c\u0645\u0629 \u0623\u062f\u0646\u0627\u0647 \u0647\u064a \u062f\u0631\u0627\u0633\u0629 \u0646\u0648\u0639\u064a\u0629 \u062a\u064f\u0638\u0647\u0631 \u0643\u064a\u0641\u064a\u0629 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0628\u0639\u0636 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0648\u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0641\u064a \u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649\u060c \u0644\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646\u0647\u0627 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0645\u0633\u0627\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0645\u062d\u062f\u062f\u0629 \u0648\u0645\u0624\u062b\u0631\u0629 \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629. \u0631\u0643\u0632 \u0627\u0644\u0628\u062d\u062b \u0639\u0644\u0649 \u0639\u062f\u0629 \u0645\u0624\u0634\u0631\u0627\u062a \u062c\u0632\u064a\u0626\u064a\u0629 \u0623\u0633\u0627\u0633\u064a\u0629 \u0627\u0631\u062a\u0628\u0637\u062a \u0628\u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u062c\u064a\u0646\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u062a\u0624\u062b\u0631 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u0627\u0647\u0645\u0629 \u0641\u064a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0643\u0644\u0633\u0644 \u0648\u0627\u0646\u063a\u0644\u0627\u0642 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629.<\/span><\/p>\n

\u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629:<\/em> <\/span>\u064a\u0645\u062b\u0644 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u062a\u0642\u062f\u0645\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0641\u064a \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u064a\u0648\u0641\u0631 \u0625\u0645\u0643\u0627\u0646\u064a\u0627\u062a \u062a\u0634\u0645\u0644:<\/span>
\n– \u0625\u064a\u062c\u0627\u062f \u0628\u062f\u0627\u0626\u0644 \u0639\u0644\u0627\u062c\u064a\u0629 \u0623\u0643\u062b\u0631 \u0633\u0647\u0648\u0644\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0645\u062b\u0644 (Casgevy) \u0648 (Lyfgenia) \u0627\u0644\u0628\u0627\u0647\u0638\u0629 \u0627\u0644\u062b\u0645\u0646<\/span>
\n– \u062a\u0642\u0644\u064a\u0644 \u062a\u0643\u0627\u0644\u064a\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0623\u062f\u0648\u064a\u0629 \u0645\u0639\u062a\u0645\u062f\u0629 \u0631\u062e\u064a\u0635\u0629 \u0648\u0645\u0635\u0627\u062f\u0642 \u0639\u0644\u064a\u0647\u0627 \u0633\u0627\u0628\u0642\u064b\u0627<\/span>
\n– \u0633\u0631\u0639\u0629 \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0639\u0645\u0644\u064a \u0646\u0638\u0631\u064b\u0627 \u0644\u0633\u062c\u0644\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629<\/span>
\n– \u062a\u0648\u0641\u064a\u0631 \u062d\u0644\u0648\u0644 \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u0648\u062c\u0647\u0629 \u0628\u062d\u0633\u0628 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0643\u0644 \u0645\u0631\u064a\u0636. <\/span>
\n\u064a\u0631\u062a\u0643\u0632 \u0647\u0630\u0627 \u0627\u0644\u0628\u062d\u062b \u0639\u0644\u0649 \u062a\u0637\u0648\u0631\u0627\u062a \u062d\u062f\u064a\u062b\u0629 \u0641\u064a \u0641\u0647\u0645 \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u060c \u0628\u0645\u0627 \u064a\u0634\u0645\u0644 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u0627\u0647\u0627 \u0641\u0631\u064a\u0642\u0646\u0627 \u0627\u0644\u0628\u062d\u062b\u064a \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0633\u0627\u0628\u0642\u0629.<\/span>
\n\u0623\u0636\u0627\u0641 \u0627\u0644\u0645\u062a\u0631\u062c\u0645 \u062a\u0639\u0631\u064a\u0641\u0627\u062a \u0648\u0646\u0635\u0648\u0635 \u0648\u0628\u0639\u0636 \u0627\u0644\u0634\u0631\u0648\u062d \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629 \u0628\u064a\u0646 \u0645\u0632\u062f\u0648\u062c\u064a\u0646\u060c \u0644\u0644\u062a\u0639\u0631\u064a\u0641 \u0628\u0628\u0639\u0636 \u0627\u0644\u0645\u0635\u0637\u0644\u062d\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0645\u0639 \u0625\u062f\u0631\u0627\u062c \u0628\u0639\u0636 \u0627\u0644\u0623\u0645\u062b\u0644\u0629 \u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0625\u064a\u0636\u0627\u062d.<\/span><\/p>\n

( \u0627\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0645\u062a\u0631\u062c\u0645\u0629 )<\/span><\/strong><\/p>\n

\u062e\u0644\u0641\u064a\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629: <\/span><\/strong><\/span>
\n\u062f\u0627\u0621 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u0623\u0648 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (\u0633\u0643\u0644\u0633\u0644 SCD)\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0639\u0631\u0641 \u0623\u064a\u0636\u064b\u0627 \u0628\u062f\u0627\u0621 \u0627\u0644\u0623\u0646\u064a\u0645\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629\u060c \u0647\u0648 \u0627\u0636\u0637\u0631\u0627\u0628 \u062f\u0645 \u0648\u0631\u0627\u062b\u064a \u064a\u062a\u0645\u064a\u0632 \u0628\u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0632\u0645\u0646 (\u0627\u0646\u062d\u0644\u0627\u0644 \u0623\u0646\u064a\u0645\u064a \u0628\u0633\u0628\u0628 \u062a\u062d\u0644\u0644 \u0643\u0631\u064a\u0627\u062a \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621)\u060c \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u0646\u0648\u0628\u0627\u062a \u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 (VOC) \u0628\u0633\u0628\u0628 \u0627\u0644\u062a\u0635\u0627\u0642 \u0648\u062a\u0643\u062a\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0645\u0639\u0627\u0646\u0627\u0629 \u0627\u0644\u0645\u0635\u0627\u0628 \u0628\u062d\u0627\u0644\u0627\u062a \u0645\u0631\u0636\u064a\u0629 \u062b\u0627\u0646\u0648\u064a\u0629 \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0645\u062a\u0648\u0633\u0637 \u0639\u0645\u0631\u0647 \u0627\u0644\u0645\u062a\u0648\u0642\u0639. \u062a\u062a\u0648\u0641\u0631 \u062d\u0627\u0644\u064a\u064b\u0627 \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0641\u0639\u0627\u0644\u0629\u060c \u0644\u0643\u0646\u0647\u0627 \u0645\u062d\u062f\u0648\u062f\u0629\u061b \u0628\u064a\u062f \u0623\u0646 \u0646\u062a\u0627\u0626\u062c \u0641\u062d\u0648\u0635 \u062c\u064a\u0646\u064a\u0629 \u062d\u062f\u064a\u062b\u0629 (\u0645\u0635\u0645\u0645\u0629 \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u062d\u0627\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a -\u0627\u0644\u062f\u0646\u0627- \u0644\u0644\u0641\u0631\u062f) \u0645\u0646 \u0639\u064a\u0646\u0629 \u0645\u0646\u062d\u0635\u0631\u0629 \u0641\u064a \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646 (\u063a\u064a\u0631 \u0645\u0645\u062b\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0635\u0639\u064a\u062f \u0627\u0644\u0639\u0627\u0644\u0645\u064a) \u062a\u0628\u0639\u062b \u0628\u0623\u0645\u0644 \u062c\u062f\u064a\u062f \u0644\u0644\u062a\u0646\u0628\u0624 \u0628\u0639\u0644\u0627\u062c\u0627\u062a \u0645\u0648\u062c\u0647\u0629 \u062c\u0632\u064a\u0626\u064a\u064b\u0627 (\u0639\u0644\u0627\u062c\u0627\u062a \u0645\u0635\u0645\u0645\u0629 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0641\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0639\u064a\u0646\u0629) \u0641\u064a \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0647\u062f\u0641\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0623\u062f\u0648\u064a\u0629 \u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649\u060c \u0648\u0627\u0644\u062a\u064a \u064a\u0639\u062a\u0642\u062f \u0623\u0646\u0647\u0627 \u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0639\u0644\u0627\u062c \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u062a\u0641\u0627\u0639\u0644\u0627\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c<\/span> \u0648\u0627\u0643\u062a\u0634\u0627\u0641 \u062c\u064a\u0646\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0647\u0627 \u0645\u0648\u0627\u0636\u0639 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u064a\u063a\u064a\u0631 \u0648\u0638\u064a\u0641\u062a\u0647\u0627 \u0648\u064a\u062c\u0639\u0644\u0647\u0627 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0636\u0645\u0646 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0623\u0648 \u0627\u0644\u0634\u0628\u0643\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062c\u0639\u0644 \u0627\u0644\u0645\u0631\u0636 \u0623\u0643\u062b\u0631 \u062d\u062f\u0629 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0633\u0648\u0621\u064b (\u0645\u0627 \u064a\u0639\u0631\u0641 \u0628\u0640 druggability)\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u064a\u0627\u0646\u0627\u062a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644 (GWAS) \u0627\u0644\u0645\u0639\u0645\u0648\u0644\u0629 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646.<\/span><\/p>\n

\"\"<\/p>\n

\u0645\u0642\u062f\u0645\u0629<\/span><\/strong><\/span>
\n\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (SCD) \u0647\u0648 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u062d\u0627\u062f\u0629\u060c \u064a\u064f\u0633\u0628\u0628\u0647 \u0648\u062c\u0648\u062f \u0645\u062a\u063a\u064a\u0631 (\u0637\u0641\u0631\u0629) \u0642\u064a \u0627\u0644\u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 (rs334 c.20 A>T) \u0641\u064a \u062c\u064a\u0646 (HBB) (\u0623\u064a \u0645\u062a\u063a\u064a\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0631\u0642\u0645 334 \u0641\u064a \u0627\u0644\u0645\u0648\u0636\u0639 \u0631\u0642\u0645 20 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u062c\u064a\u0646\u060c \u0628\u062d\u064a\u062b \u064a\u062a\u063a\u064a\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a \u0627\u0644\u0623\u062f\u064a\u0646\u064a\u0646 \u0625\u0644\u0649 \u0627\u0644\u062b\u0627\u064a\u0645\u064a\u0646)\u060c \u0645\u0645\u0627 \u064a\u064f\u0633\u0628\u0628 \u0646\u0634\u0648\u0621 \u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a \u064a\u0633\u0645\u0649 \u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 S \u0648\u0627\u0644\u0630\u064a \u064a\u0646\u062a\u062c \u062a\u0634\u0648\u0647\u064b\u0627 “\u062a\u0645\u0646\u062c\u0644\u064b\u0627” \u0644\u0643\u0631\u064a\u0627\u062a \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621(1)<\/sup>. <\/span><\/p>\n

\u064a\u0624\u062f\u064a \u0647\u0630\u0627 \u0627\u0644\u062a\u0645\u0646\u062c\u0644 \u0625\u0644\u0649 \u0633\u0644\u0633\u0644\u0629 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0648\u0639\u0627\u0626\u064a\u0629 \u0644\u0627\u062d\u0642\u0629\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0646\u0648\u0628\u0627\u062a \u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u062a\u062e\u062b\u0631 \u0644\u0644\u062f\u0645\u060c \u0648\u0627\u062d\u062a\u0634\u0627\u0621\u0627\u062a (\u0646\u062e\u0631) \u0641\u064a \u0623\u0639\u0636\u0627\u0621 \u0645\u062a\u0639\u062f\u062f\u0629\u060c \u0648\u0630\u0644\u0643 \u0628\u0645\u0648\u062a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0641\u064a\u0647\u0627 \u0628\u0633\u0628\u0628 \u0646\u0642\u0635 \u0627\u0644\u062a\u0631\u0648\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u064f\u0633\u0647\u0645 \u0641\u064a \u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0633\u0631\u064a\u0631\u064a\u064b\u0627 (\u0648\u0627\u0644\u0630\u064a \u064a\u0624\u062b\u0631 \u0633\u0644\u0628\u0627 \u0641\u064a \u062d\u064a\u0627\u0629 \u0627\u0644\u0645\u0635\u0627\u0628) \u0645\u0646 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0641\u0635\u0627\u0639\u062f\u064b\u0627(1\u060c 2)<\/sup>. \u0648\u062a\u062a\u062c\u0644\u0649 \u062e\u0637\u0648\u0631\u0629 \u0647\u0630\u0647 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0628\u0634\u0643\u0644 \u0623\u0643\u062b\u0631 \u0641\u064a \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0644\u062f\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u063a\u064a\u0631 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0641\u064a \u0639\u0645\u0648\u0645 \u0627\u0644\u0633\u0643\u0627\u0646(3)<\/sup>.<\/span><\/p>\n

\u0645\u0646 \u0645\u0646\u0638\u0648\u0631 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0645\u0629\u060c \u064a\u064f\u0634\u0643\u0644 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (SCD) \u0639\u0628\u0626\u064b\u0627 \u0639\u0627\u0644\u0645\u064a\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627. \u0641\u0628\u064a\u0646\u0645\u0627 \u062a\u0641\u064a\u062f \u0628\u0639\u0636 \u0627\u0644\u062a\u0642\u062f\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0625\u0644\u0649 \u0648\u062c\u0648\u062f \u0623\u0643\u062b\u0631 \u0645\u0646 7 \u0645\u0644\u0627\u064a\u064a\u0646 \u0634\u062e\u0635 \u0645\u064f\u0635\u0627\u0628 \u0628\u0627\u0644\u0645\u0631\u0636 \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645(4\u060c 5)<\/sup>\u060c \u062a\u064f\u0642\u062f\u0651\u0631 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 (WHO) \u0623\u0646 \u062d\u0648\u0627\u0644\u064a 300 \u0623\u0644\u0641 \u0631\u0636\u064a\u0639 \u064a\u064f\u0648\u0644\u062f\u0648\u0646 \u0633\u0646\u0648\u064a\u064b\u0627 \u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0629. \u0648\u064a\u064f\u0642\u062f\u0651\u0631 \u0623\u0646 \u0646\u064a\u062c\u064a\u0631\u064a\u0627 \u0648\u062d\u062f\u0647\u0627 \u062a\u064f\u0633\u062c\u0651\u0644 (\u0646\u0635\u0641 \u0647\u0630\u0627 \u0627\u0644\u0639\u062f\u062f) \u062d\u0648\u0627\u0644\u064a 150 \u0623\u0644\u0641 \u0645\u0648\u0644\u0648\u062f \u0645\u0635\u0627\u0628 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0633\u0646\u0648\u064a\u064b\u0627\u060c \u0645\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u0627\u0644\u062f\u0648\u0644\u0629 \u0627\u0644\u0623\u0639\u0644\u0649 \u0639\u0627\u0644\u0645\u064a\u064b\u0627 \u0641\u064a \u0645\u0639\u062f\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(6)<\/sup>. <\/span><\/p>\n

\u0648\u0644\u0643\u0646\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0641\u064a \u0627\u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u0645\u064f\u0648\u0628\u0648\u0621\u0629 \u0648\u0627\u0644\u0641\u0634\u0644 \u0641\u064a \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0645\u0631\u0636 \u0623\u0648 \u062a\u0634\u062e\u064a\u0635\u0647 \u0628\u0634\u0643\u0644 \u062e\u0627\u0637\u0626\u060c \u0644\u0627 \u0633\u064a\u0645\u0627 \u0641\u064a \u062c\u0646\u0648\u0628 \u0627\u0644\u0635\u062d\u0631\u0627\u0621 \u0627\u0644\u0643\u0628\u0631\u0649 \u0627\u0644\u0623\u0641\u0631\u064a\u0642\u064a\u0629 \u0648\u062c\u0646\u0648\u0628 \u0622\u0633\u064a\u0627\u060c \u0641\u0625\u0646 \u0627\u0644\u0639\u062f\u062f \u0627\u0644\u062d\u0642\u064a\u0642\u064a \u0644\u0644\u0645\u064f\u0635\u0627\u0628\u064a\u0646 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0645\u0627 \u064a\u0632\u0627\u0644 \u063a\u064a\u0631 \u0645\u0624\u0643\u062f \u0648\u0645\u064f\u062b\u0627\u0631\u064b\u0627 \u0644\u0644\u062c\u062f\u0644 \u0628\u064a\u0646 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0641\u064a \u0627\u0644\u0623\u062f\u0628\u064a\u0627\u062a \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629. <\/span><\/p>\n

\u0643\u0645\u0627 \u062a\u0639\u0627\u0646\u064a \u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u062f\u0648\u0644\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u062f\u0648\u0644 \u0634\u0628\u0647 \u0627\u0644\u0642\u0627\u0631\u0629 \u0627\u0644\u0647\u0646\u062f\u064a\u0629 \u0648\u062f\u0648\u0644 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u062a\u064a\u0646 \u0648\u062f\u0648\u0644 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0628\u062d\u0631 \u0627\u0644\u0623\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u062f\u0648\u0644 \u0627\u0644\u0634\u0631\u0642 \u0627\u0644\u0623\u0648\u0633\u0637 \u0645\u0646 \u0627\u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0645\u0637\u0651\u0631\u062f\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636\u060c \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0648\u0628\u0627\u0626\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u062a\u0643\u0648\u0646 \u0645\u062d\u062f\u0648\u062f\u0629 \u0628\u0633\u0628\u0628 \u0639\u062f\u0645 \u0643\u0641\u0627\u064a\u0629 \u0627\u0644\u0631\u0635\u062f \u0648\u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644\u0627\u062a \u0648\u0641\u064a\u0627\u062a \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0645\u0646 \u0627\u0644\u0646\u0627\u062d\u064a\u0629 \u0627\u0644\u062a\u0627\u0631\u064a\u062e\u064a\u0629\u060c \u0628\u0633\u0628\u0628 \u0646\u0642\u0635 \u0627\u0644\u0639\u0646\u0627\u064a\u0629 \u0627\u0644\u0637\u0628\u064a\u0629(7)<\/sup>.<\/span><\/p>\n

\u0627\u0646\u0639\u0643\u0627\u0633\u064b\u0627 \u0644\u0639\u0628\u0621 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0639\u0627\u0644\u0645\u064a\u064b\u0627\u060c \u062a\u0648\u0627\u062c\u0647 \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0629 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u0629 \u0645\u0633\u062a\u0648\u0649 \u0639\u0628\u0621 \u0645\u0631\u062a\u0641\u0639 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0645\u0646 \u062c\u0631\u0627\u0621 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u062d\u064a\u062b \u062a\u0635\u0644 \u0645\u0639\u062f\u0644\u0627\u062a \u062d\u0627\u0645\u0644\u064a \u0646\u0633\u062e\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0644\u0645\u0631\u0636 (HbSA) \u0627\u0644\u0645\u0648\u062b\u0642\u0629 \u0625\u0644\u0649 27% (\u0648\u0625\u0646 \u0644\u0645 \u062a\u0638\u0647\u0631 \u0639\u0644\u064a\u0647\u0645 \u0628\u0627\u0644\u0636\u0631\u0648\u0631\u0629 \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u0636 \u0648\u0642\u062f \u064a\u0639\u064a\u0634\u0648\u0646 \u0637\u0628\u064a\u0639\u064a\u064b\u0627 \u0648\u0628\u0635\u062d\u0629 \u062c\u064a\u062f\u0629)\u060c \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u062f\u0631\u0627\u0633\u0627\u062a \u0642\u062f \u0623\u0634\u0627\u0631\u062a \u0625\u0644\u0649 \u062a\u0642\u062f\u064a\u0631\u0627\u062a \u0639\u0646 \u0646\u0633\u0628\u0629 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0645\u0631\u0636 \u0628\u0644\u063a\u062a \u062d\u0648\u0627\u0644\u064a 2.6% (\u0647\u0624\u0644\u0627\u0621 \u0647\u0645 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0647 \u0648\u0631\u0627\u062b\u064a\u064b\u0627 \u0648\u064a\u062d\u0645\u0644\u0648\u0646 \u0646\u0633\u062e\u062a\u064a\u0646 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0644\u0645\u0631\u0636 (HbSS) \u0648\u062a\u0638\u0647\u0631 \u0639\u0644\u064a\u0647\u0645 \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u0636)(7\u060c 8)<\/sup>. <\/span><\/p>\n

\u0646\u0633\u0628\u0629 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0647\u0630\u0647 \u0644\u0627 \u062a\u064f\u0645\u062b\u0644 \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0641\u064a \u0639\u0645\u0648\u0645 \u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u0629\u060c \u0628\u0644 \u0642\u062f \u062a\u062e\u062a\u0644\u0641 \u0627\u062e\u062a\u0644\u0627\u0641\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0628\u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0645\u0646\u0627\u0637\u0642\u060c \u0645\u0639 \u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0645\u0639\u062f\u0644\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0627\u062a \u0627\u0644\u0634\u0631\u0642\u064a\u0629 \u0648\u0627\u0644\u062c\u0646\u0648\u0628\u064a\u0629 \u0627\u0644\u063a\u0631\u0628\u064a\u0629\u060c \u0628\u062d\u064a\u062b \u064a\u0639\u062f \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0641\u064a\u0647\u0627 \u0623\u0643\u062b\u0631 \u0627\u0646\u062a\u0634\u0627\u0631\u064b\u0627 \u0645\u0646 \u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649. \u0648\u0645\u0646 \u0627\u0644\u0645\u0631\u062c\u062d \u0623\u0646 \u064a\u062a\u0641\u0627\u0642\u0645 \u0647\u0630\u0627 \u0627\u0644\u0639\u0628\u0621 \u0627\u0644\u0643\u0628\u064a\u0631 \u0628\u0633\u0628\u0628 \u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644\u0627\u062a \u0632\u0648\u0627\u062c \u0627\u0644\u0623\u0642\u0627\u0631\u0628 (\u062d\u064a\u062b \u062a\u0635\u0644 \u0625\u0644\u0649 \u0645\u0639\u062f\u0644\u0627\u062a \u062a\u0632\u064a\u062f \u0639\u0644\u0649 50%)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062a\u0631\u0643\u0632 \u0641\u064a\u0647\u0627 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0644\u0644\u0645\u0631\u0636(8\u060c 10)<\/sup>. \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u0628\u0627\u0644\u0645\u0645\u0644\u0643\u0629\u060c \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 90% \u0645\u0646 \u062d\u0627\u0645\u0644\u064a \u0627\u0644\u0645\u0631\u0636 \u0623\u0635\u0631\u0648\u0627 \u0639\u0644\u0649 \u0627\u0644\u0625\u0642\u062f\u0627\u0645 \u0639\u0644\u0649 \u0627\u0644\u0632\u0648\u0627\u062c \u0645\u0646 \u0646\u0638\u0631\u0627\u0626\u0647\u0645\u060c \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0648\u062c\u0648\u062f \u062a\u0648\u0635\u064a\u0627\u062a \u0628\u0631\u0646\u0627\u0645\u062c \u0641\u062d\u0635 \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0632\u0648\u0627\u062c \u0628\u0639\u062f\u0645 \u0627\u0644\u0625\u0642\u062f\u0627\u0645(8)<\/sup>.<\/span><\/p>\n

\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0645\u0627 \u0632\u0627\u0644\u062a \u063a\u064a\u0631 \u0645\u062a\u0648\u0641\u0631\u0629 \u0628\u0634\u0643\u0644 \u0643\u0627\u0641\u064d\u060c \u0648\u0644\u0627 \u062a\u0644\u0628\u064a \u062d\u0627\u062c\u0629 \u0627\u0644\u0639\u062f\u062f \u0627\u0644\u0645\u062a\u0632\u0627\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649. \u0641\u064a \u0627\u0644\u0623\u0635\u0644\u060c \u062f\u0648\u0627\u0621 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u064a\u0648\u0631\u064a\u0627 (hydroxyurea) \u0643\u0627\u0646 \u0647\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u062d\u064a\u062f \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0642\u0650\u0628\u0644 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0644\u0644\u0631\u0627\u0634\u062f\u064a\u0646 (18 \u0633\u0646\u0629 \u0648\u0623\u0643\u0628\u0631) \u0648\u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0645\u0646\u0630 \u0639\u0627\u0645 2017\u060c \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0634\u0647\u062f \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0648\u062a\u063a\u064a\u0631 \u0627\u0644\u0648\u0636\u0639 \u0627\u0644\u0639\u0627\u0645 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0628\u0639\u062f \u0623\u0646 \u0648\u0627\u0641\u0642\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0639\u0644\u0649 \u0627\u0639\u062a\u0645\u0627\u062f \u062b\u0644\u0627\u062b\u0629 \u0623\u062f\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u062a\u0633\u062a\u0647\u062f\u0641 \u062c\u0648\u0627\u0646\u0628 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0641\u0633\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u062f\u0648\u0627\u0621 \u063a\u0644\u0648\u062a\u0627\u0645\u064a\u0646 (L-glutamine)\u060c \u0648\u0643\u0631\u064a\u0632\u0627\u0646\u0644\u064a\u0632\u0648\u0645\u0627\u0628 (crizanlizumab)\u060c \u0648\u0641\u0648\u0643\u0633\u064a\u0644\u0648\u062a\u0648\u0631(11\u060c 12)<\/sup> (voxelotor)\u060c \u0648\u0644\u0643\u0646 \u0627\u0644\u062a\u0637\u0648\u0631\u0627\u062a \u0627\u0644\u0623\u062e\u064a\u0631\u0629 \u0623\u0628\u0631\u0632\u062a \u0628\u0639\u0636 \u0627\u0644\u0635\u0639\u0648\u0628\u0627\u062a \u0641\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629. <\/span><\/p>\n

\u0648\u0627\u0644\u062c\u062f\u064a\u0631 \u0628\u0627\u0644\u0630\u0643\u0631 \u0623\u0646\u0647 \u0627\u0639\u062a\u0628\u0627\u0631\u064b\u0627 \u0645\u0646 \u0633\u0628\u062a\u0645\u0628\u0631\u060c 2024\u060c \u0633\u064f\u062d\u0628 \u0641\u0648\u0643\u0633\u064a\u0644\u0648\u062a\u0648\u0631 \u0637\u0648\u0627\u0639\u064a\u0629\u064b \u0645\u0646 \u0627\u0644\u0623\u0633\u0648\u0627\u0642 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0628\u0633\u0628\u0628 \u0645\u062e\u0627\u0648\u0641 \u062a\u062a\u0639\u0644\u0642 \u0628\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0648\u0641\u064a \u0645\u0627\u064a\u0648 2023\u060c \u062a\u0645 \u0633\u062d\u0628 \u0643\u0631\u064a\u0632\u0627\u0646\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u0645\u0646 \u0627\u0644\u0633\u0648\u0642 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0628\u0633\u0628\u0628 \u0636\u0639\u0641 \u0645\u0641\u0639\u0648\u0644\u064a\u062a\u0647(13\u060c 14)<\/sup>. \u0648\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0633\u062d\u0628 \u0627\u0644\u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 (EMA) \u0645\u0648\u0627\u0641\u0642\u062a\u0647\u0627 \u0644\u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0639\u062f \u0645\u0631\u0627\u062c\u0639\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u062a\u062c\u0631\u0628\u0629 (STAND) \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u0633\u0644\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u064f\u062b\u0628\u062a \u0623\u064a \u0641\u0627\u0626\u062f\u0629 \u0645\u0636\u0627\u0641\u0629\u060c \u0627\u0633\u062a\u0645\u0631\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0641\u064a \u0645\u0648\u0627\u0641\u0642\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0639\u062a\u0645\u0627\u062f \u0643\u0631\u064a\u0632\u0627\u0646\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0644\u0643\u0646\u0647\u0627 \u0645\u0627 \u0632\u0627\u0644\u062a \u062a\u0646\u062a\u0638\u0631 \u0645\u0631\u0627\u062c\u0639\u0629 \u0634\u0627\u0645\u0644\u0629 \u0644\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0648\u0627\u0644\u062a\u064a \u062a\u0628\u064a\u0651\u0653\u0646 \u0623\u0646\u0647\u0627 \u063a\u064a\u0631 \u062d\u0627\u0633\u0645\u0629 \u0628\u0639\u062f.<\/span><\/p>\n

\u062a\u064f\u0628\u0631\u0632 \u0647\u0630\u0647 \u0627\u0644\u0623\u062d\u062f\u0627\u062b \u062a\u0639\u0642\u064a\u062f\u0627\u062a \u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u062a\u064f\u0624\u0643\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u062d\u0627\u0633\u0645\u0629 \u0644\u0645\u0648\u0627\u0635\u0644\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0628\u0647\u0630\u0627 \u0627\u0644\u062e\u0635\u0648\u0635\u060c \u0648\u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0633\u0644\u0627\u0645\u0629 \u0623\u064a \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u062f \u0627\u0644\u0637\u0648\u064a\u0644\u060c \u0648\u0627\u0633\u062a\u0645\u0631\u0627\u0631 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062f\u0648\u0631\u064a \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0628\u0627\u0644\u0641\u0639\u0644.<\/span><\/p>\n

\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0645\u064a (BMT) \u0642\u062f \u064a\u0643\u0648\u0646 \u0639\u0644\u0627\u062c\u064b\u0627 \u0645\u0645\u0643\u0646\u064b\u0627 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0625\u0644\u0627 \u0623\u0646 \u0647\u0646\u0627\u0643 \u062a\u062d\u062f\u064a\u0627\u062a \u0645\u0639\u062a\u0628\u0631\u0629 \u062a\u0642\u0641 \u062d\u062c\u0631 \u0639\u062b\u0631\u0629 \u0623\u0645\u0627\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0647 \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0627\u062c\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0631\u062a\u0641\u0627\u0639 \u062a\u0643\u0644\u0641\u062a\u0647\u0627 \u0627\u0644\u0645\u0627\u0644\u064a\u0629\u060c \u0648\u0639\u062f\u0645 \u062a\u0648\u0641\u0631 \u0627\u0644\u0645\u062a\u0628\u0631\u0639\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u064a\u0646 \u0644\u0646\u0642\u0644 \/ \u0632\u0631\u0639 \u0627\u0644\u0646\u062e\u0627\u062e\u060c \u0648\u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0645\u0635\u0627\u062d\u0628\u0629 \u0644\u0647\u0627. \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0623\u062e\u064a\u0631\u0629 \u0639\u0644\u0649 \u0627\u0639\u062a\u0645\u0627\u062f \u0623\u0648\u0644 \u0639\u0644\u0627\u062c\u064a\u0646 \u062e\u0644\u0648\u064a\u064a\u0646 \u0648\u062c\u064a\u0646\u064a\u064a\u0646 (\u064a\u0639\u0645\u0644\u0627\u0646 \u0639\u0644\u0649 \u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0623\u0648 \u0627\u0644\u062c\u064a\u0646\u0627\u062a)\u060c \u0648\u0647\u0645\u0627 (Casgevy) \u0648(Lyfgenia) \u060c \u0641\u064a 8 \u062f\u064a\u0633\u0645\u0628\u0631 2023\u060c \u0623\u062d\u062f\u062b \u062a\u0642\u062f\u0645\u064b\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0641\u064a \u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(15)<\/sup>.<\/span><\/p>\n

\u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0629 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u0629 \u0647\u064a \u0623\u0648\u0644 \u062f\u0648\u0644\u0629 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0639\u0644\u0627\u062c (Casgevy) \u0628\u0639\u062f \u0627\u0639\u062a\u0645\u0627\u062f\u0647 \u0648\u0646\u062c\u062d\u062a \u0641\u064a \u0645\u0639\u0627\u0644\u062c\u0629 \u062e\u0645\u0633\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0645\u0627 \u062a\u0632\u0627\u0644 \u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629 \u063a\u064a\u0631 \u0645\u062a\u0627\u062d\u0629 \u0644\u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u062a\u0643\u0627\u0644\u064a\u0641\u0647\u0627 \u0627\u0644\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0628\u0627\u0647\u0638\u0629 \u062c\u062f\u064b\u0627\u064b \u062d\u064a\u062b \u062a\u0628\u0644\u063a \u062a\u0643\u0644\u0641\u0629 (Casgevy) \u0645\u0644\u064a\u0648\u0646\u064a\u0646 \u0648\u0645\u0627\u0626\u062a\u064a \u0623\u0644\u0641 \u062f\u0648\u0644\u0627\u0631 \u0623\u0645\u0631\u064a\u0643\u064a \u0644\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u0648\u0627\u062d\u062f\u060c \u0628\u064a\u0646\u0645\u0627 \u062a\u0628\u0644\u063a \u062a\u0643\u0644\u0641\u0629 (Lyfgenia) \u062b\u0644\u0627\u062b\u0629 \u0645\u0644\u064a\u0648\u0646 \u0648\u0645\u0627\u0626\u0629 \u0623\u0644\u0641 \u062f\u0648\u0644\u0627\u0631 \u0623\u0645\u0631\u064a\u0643\u064a \u0644\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u0648\u0627\u062d\u062f.\u00a0<\/span> \u062a\u064f\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0645\u0646 \u0623\u063a\u0644\u0649 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u0639\u062a\u0645\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u0625\u0637\u0644\u0627\u0642\u060c \u0648\u062a\u0645\u062b\u0644 \u062a\u062d\u062f\u064a\u064b\u0627 \u0627\u0642\u062a\u0635\u0627\u062f\u064a\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0644\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0623\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0639\u0644\u0649 \u062d\u062f \u0633\u0648\u0627\u0621(16)<\/sup>.<\/span><\/p>\n

\u064a\u064f\u0628\u0631\u0632 \u0647\u0630\u0627 \u0627\u0644\u0648\u0636\u0639 \u0627\u0644\u062d\u0627\u062c\u0629 \u0627\u0644\u0645\u064f\u0644\u062d\u0629 \u0644\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u062a\u062a\u0646\u0627\u0648\u0644 \u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u062f\u0648\u064a\u0629 \u0645\u0628\u062a\u0643\u0631\u0629 \u062a\u064f\u0648\u0641\u0631 \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0623\u0643\u062b\u0631 \u0623\u0645\u0627\u0646\u064b\u0627 \u0648\u0645\u0641\u0639\u0648\u0644\u064a\u0629 \u0648\u0628\u0623\u0633\u0639\u0627\u0631 \u0645\u0639\u0642\u0648\u0644\u0629 \u0644\u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. <\/span>
\n\u0639\u0644\u0627\u0648\u0629\u064b \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u064f\u0645\u062b\u0644 \u0627\u0644\u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u064f\u0639\u0642\u062f\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u064f\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0648\u0627\u0644\u062a\u064a \u062a\u0645 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u064a\u0647\u0627 \u0645\u0624\u062e\u0631\u064b\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644 (GWAS)\u060c \u0641\u0631\u0635\u0629\u064b \u0645\u062b\u0627\u0644\u064a\u0629\u064b \u0644\u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u062c\u0647\u0648\u062f \u062a\u062c\u0627\u0647 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0627\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649 \u0648\u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(18\u060c 19)<\/sup>. <\/span><\/p>\n

\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644 \u0627\u0644\u0623\u062e\u064a\u0631\u0629 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646 – \u0644\u0627 \u0633\u064a\u0645\u0627 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u0627\u0647\u0627 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0627\u0644\u0634\u0628\u064a\u0628 \u0648\u0622\u062e\u0631\u0648\u0646(20)<\/sup> \u0648\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0627\u0644\u063a\u0628\u064a\u0634\u064a \u0648\u0622\u062e\u0631\u0648\u0646(19)<\/sup> \u2013 \u0633\u0627\u0647\u0645\u062a \u0641\u064a \u062a\u0648\u0636\u064a\u062d \u0627\u0644\u0645\u0634\u0647\u062f \u0627\u0644\u062c\u064a\u0646\u064a\u060c \u0645\u064f\u062b\u0628\u062a\u0629\u064b \u0623\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0627\u062d\u0638\u0646\u0627\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646 \u062e\u0627\u0635\u0629\u064b \u0647\u064a \u062c\u0632\u0626\u064a\u064b\u0627 \u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u064b\u0627 \u0628\u064a\u0646 \u0627\u0644\u0633\u0643\u0627\u0646 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646\u060c \u0648\u0630\u0644\u0643 \u0644\u0648\u062c\u0648\u062f \u0639\u0644\u0627\u0645\u0627\u062a \u0641\u0631\u064a\u062f\u0629 \u0648\u0645\u0634\u062a\u0631\u0643\u0629 \u0628\u064a\u0646\u0647\u0645 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0633\u0643\u0627\u0646 \u0645\u0646 \u0623\u0635\u0648\u0644 \u0623\u0641\u0631\u064a\u0642\u064a\u0629. <\/span><\/p>\n

\u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u062a\u0641\u064a\u062f \u0628\u0623\u0646 \u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u062c\u064a\u0646\u0648\u0645\u064a\u0629 \u0645\u0644\u062d\u0648\u0638\u0629 \u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0645\u0645\u064a\u0632 “\u0627\u0644\u0639\u0631\u0628\u064a-\u0627\u0644\u0647\u0646\u062f\u064a” \u0627\u0644\u0633\u0627\u0626\u062f \u0641\u064a \u0634\u0631\u0642 \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0629 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u0629\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u062e\u062a\u0644\u0641 \u0641\u064a \u0627\u0646\u062a\u0634\u0627\u0631\u0647 \u0648\u062a\u0628\u0639\u0627\u062a\u0647 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062e\u0627\u0635\u0629 \u0627\u0644\u0623\u0641\u0631\u064a\u0642\u064a\u0629 (\u0628\u0646\u064a\u0646\u060c \u0627\u0644\u0633\u0646\u063a\u0627\u0644\u060c \u0627\u0644\u0643\u0627\u0645\u064a\u0631\u0648\u0646\u060c \u0648\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0628\u0627\u0646\u062a\u0648 \u0627\u0644\u0639\u0631\u0642\u064a\u0629 \u0641\u064a \u062c\u0646\u0648\u0628 \u0623\u0641\u0631\u064a\u0642\u064a\u0627)\u060c \u062d\u064a\u062b \u0623\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0645\u0645\u064a\u0632 \u064a\u0639\u0646\u064a \u062a\u0648\u0644\u064a\u0641\u0629 \u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u062c\u064a\u0646\u0627\u062a \u0645\u0631\u062a\u0628\u0637\u0629 \u0648\u0631\u0627\u062b\u064a\u064b\u0627 \u0648\u062a\u062d\u062a\u0644 \u0645\u0648\u0627\u0636\u0639 \u0645\u062a\u062c\u0627\u0648\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0645\u0648\u0633\u0648\u0645. <\/span><\/p>\n

\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649 \u062a\u064f\u0645\u062b\u0644 \u0645\u0646\u0647\u062c\u064a\u0629\u064b \u0644\u0627\u0642\u062a\u0631\u0627\u062d \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0648\u0627\u0644\u0645\u062a\u0648\u0641\u0631\u0629 \u0641\u064a \u0627\u0644\u0623\u0633\u0648\u0627\u0642 \u062d\u0627\u0644\u064a\u064b\u0627\u060c \u0627\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u062a\u0641\u0627\u0639\u0644\u0627\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0627\u0644\u062a\u064a \u062a\u064f\u0639\u062f\u0651\u0644 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629 (\u0623\u064a \u0627\u0644\u062a\u064a \u062a\u0624\u062b\u0651\u0631 \u0641\u064a \u0637\u0631\u064a\u0642\u0629 \u062a\u0648\u0627\u0635\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0645\u0639 \u0628\u0639\u0636\u0647\u0627 \u0645\u0645\u0627 \u064a\u062d\u062f\u062b \u0633\u0644\u0633\u0644\u0629 \u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u064a\u0629 \u062a\u062a\u062d\u0643\u0645 \u0641\u064a \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u062e\u0644\u064a\u0629\u060c \u0645\u062b\u0644 \u0646\u0645\u0648\u0647\u0627 \u0648\u062a\u062e\u0635\u0635\u0647\u0627 \u0648\u0645\u0648\u062a\u0647\u0627)\u060c \u0648\u0642\u062f \u062a\u0647\u062f\u0641 \u0625\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0630\u0644\u0643 \u0628\u062e\u0641\u0636 \u062d\u062f\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636\u060c \u0648\u062a\u0623\u062e\u064a\u0631 \u062a\u0642\u062f\u0645 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0627\u0644\u062d\u062f \u0645\u0646 \u0645\u0636\u0627\u0639\u0641\u0627\u062a\u0647\u060c \u0648\u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629(20)<\/sup>. \u0648\u0642\u062f \u0627\u0633\u062a\u064f\u062e\u062f\u0645\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u0642\u0627\u0631\u0628\u0629 \u0627\u0644\u062d\u0648\u0633\u0628\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0633\u062a\u062e\u062f\u0645 \u0623\u0633\u0627\u0644\u064a\u0628 \u062d\u0648\u0633\u0628\u064a\u0629 \u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0627\u0645\u0643\u0627\u0646\u064a\u0629 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0623\u062f\u0648\u064a\u0629 \u0639\u062f\u064a\u062f\u0629 \u062a\u0633\u062a\u062e\u062f\u0645 \u062d\u0627\u0644\u064a\u064b\u0627 \u0644\u0639\u0644\u0627\u062c \u062d\u0627\u0644\u0627\u062a \u0645\u0631\u0636\u064a\u0629 \u0645\u064f\u062e\u062a\u0644\u0641\u0629(21)<\/sup>.<\/span><\/p>\n

\u062f\u0631\u0627\u0633\u062a\u0646\u0627 \u062a\u0631\u062a\u0643\u0632 \u0639\u0644\u0649 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u062d\u0627\u0644\u064a\u0627 \u0648\u0627\u0643\u062a\u0634\u0627\u0641 \u0645\u0631\u0643\u0628\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0627\u0644\u062a\u064a \u0633\u062a\u062e\u0636\u0639 \u0628\u0639\u062f \u0630\u0644\u0643 \u0644\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629. \u064a\u0645\u0643\u0646 \u0644\u0647\u0630\u0647 \u0627\u0644\u062a\u0637\u0648\u0631\u0627\u062a \u0623\u0646 \u062a\u064f\u062d\u062f\u062b \u062b\u0648\u0631\u0629 \u0641\u064a \u0625\u062f\u0627\u0631\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u062a\u064f\u0639\u0632\u0632 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0648\u0627\u0644\u0642\u062f\u0631\u0627\u062a \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0648\u0627\u0644\u0645\u0645\u0627\u0631\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629. \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0623\u0647\u062f\u0627\u0641 \u062c\u064a\u0646\u064a\u0629 \u0645\u0624\u062b\u0631\u0629 \u0641\u064a \u0627\u0644\u0645\u0631\u0636 \u064a\u0645\u0643\u0646 \u062a\u0635\u0645\u064a\u0645 \u0623\u062f\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0644\u062a\u0641\u0627\u0639\u0644 \u0645\u0639\u0647\u0627. \u0645\u0646 \u0634\u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u062c\u0647\u0648\u062f \u0623\u0646 \u062a\u064f\u0641\u0636\u064a \u0625\u0644\u0649 \u0627\u0644\u062a\u0648\u0635\u0644 \u0648\u0627\u0643\u062a\u0634\u0627\u0641 \u0639\u0644\u0627\u062c\u0627\u062a \u0631\u0627\u0626\u062f\u0629\u060c \u0648\u062a\u064f\u0631\u0633\u064a \u0645\u0639\u0627\u064a\u064a\u0631 \u062c\u062f\u064a\u062f\u0629 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u062c\u0627\u0644\u060c \u0648\u062a\u064f\u0639\u0632\u0632 \u0627\u0644\u0627\u0628\u062a\u0643\u0627\u0631 \u0641\u064a \u0627\u0644\u0637\u0628 \u0627\u0644\u0634\u062e\u0635\u064a (\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0648\u062c\u0647 \u0644\u0634\u062e\u0635 \u0628\u0639\u064a\u0646\u0647).<\/span><\/p>\n

\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0645\u0646\u062c\u0644 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0628\u0633\u0628\u0628 \u0645\u062a\u063a\u064a\u0631 (HbS) \u060c \u064a\u064f\u0638\u0647\u0631 \u0637\u064a\u0641 \u0645\u0646 \u0623\u0639\u0631\u0627\u0636 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u062a\u0628\u0627\u064a\u0646\u064b\u0627 \u0633\u0631\u064a\u0631\u064a\u064b\u0627 \u0648\u0627\u0633\u0639\u064b\u0627 \u0645\u0646 \u0646\u0627\u062d\u064a\u0629 \u0634\u062f\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0648\u062a\u0641\u0627\u0642\u0645\u0647\u0627 \u0645\u062a\u0623\u062b\u0631\u0629\u064b \u0628\u0648\u062c\u0648\u062f \u0645\u062a\u063a\u064a\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629(22)<\/sup>. \u0643\u0634\u0641\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0633\u0627\u0628\u0642\u0629 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0646\u064a\u0645\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u0639\u0646 \u062a\u0639\u062f\u062f \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u064f\u0646\u0638\u0645 \u0645\u0633\u0627\u0631\u0627\u062a \u062c\u0632\u064a\u0626\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0644\u0645\u0631\u0636\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u062f\u0645\u060c \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u060c \u0648\u0627\u062e\u062a\u0644\u0627\u0644 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629(22\u060c 23)<\/sup>.<\/span><\/p>\n

\u062a\u0634\u0645\u0644 \u0627\u0644\u0623\u0645\u062b\u0644\u0629 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0638\u0645\u0629 \u0644\u0644\u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 \u0627\u0644\u062c\u0646\u064a\u0646\u064a (HbF) \u0641\u064a (BCL11A) (\u0627\u0644\u062c\u064a\u0646 \u0627\ufedf\u0630\u064a \ufbfe\ufe97\ufea3\ufb90\u0645 \ufed3\ufef2 \u0625\ufee7\ufe97\ufe8e\u062c \u0627\ufedf\ufbad\ufbfe\ufee3\u0648\ufe9f\ufedf\u0648\ufe91\ufbfe\u0646 \u0627\ufedf\ufe9f\ufee7\ufbfe\ufee7\ufef2 \ufed3\ufef2 \u0627\ufedf\ufe9f\ufeb3\u0645) \u0648(HBS1L-MYB) (\u0645\u0646\u0637\u0642\u0629 \u062c\u064a\u0646\u064a\u0629 \u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u062a\u0642\u0639 \u0628\u064a\u0646 \u062c\u064a\u0646 (MYB) \u0648\u0628\u064a\u0646 \u062c\u064a\u0646 (HBS1L) \u062a\u0624\u062b\u0631 \u0641\u064a \u0635\u0641\u0627\u062a \u0627\u0644\u062f\u0645 \u0648\u062a\u0624\u062b\u0631 \u0641\u064a \u062c\u064a\u0646 (MYB)\u060c \u0627\u0644\u0630\u064a \u0644\u0647 \u062f\u0648\u0631 \u0641\u064a \u0627\u0646\u062a\u0627\u062c \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0648\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u062f\u0645. \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062c\u0646\u064a\u0646\u064a\u0629 \u0644\u0647\u0627 \u0639\u0644\u0627\u0642\u0629 \u0628\u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0639\u062f\u062f \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0633\u0627\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0641\u064a \u0645\u062d\u0641\u0632 \u0646\u062e\u0631 \u0627\u0644\u0648\u0631\u0645 (\u0633\u0627\u064a\u062a\u0648\u0643\u0627\u064a\u0646) “TNF-\u03b1” (\u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628) \u0648\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 (VCAM-1)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0631\u062a\u0628\u0637 \u0628\u0632\u064a\u0627\u062f\u0629 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0633\u0643\u062a\u0629 \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629(24)<\/sup>. <\/span><\/p>\n

\u0647\u0630\u0647 \u0627\u0644\u0623\u0641\u0643\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0627 \u062a\u0632\u0648\u062f\u0646\u0627 \u0628\u0623\u0637\u0631 \u0636\u0631\u0648\u0631\u064a\u0629 \u0641\u062d\u0633\u0628 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0622\u0644\u064a\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u0627\u0644\u0646\u0627\u0634\u0626\u0629 (\u0645\u062b\u0644 \u0627\u0644\u062a\u0635\u0627\u0642 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0648\u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0630\u064a \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u0627\u0644\u062a\u062d\u0641\u064a\u0632 \u0627\u0644\u0636\u0627\u0631 \u0644\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a)\u060c \u0628\u0644 \u062a\u0645\u0647\u062f \u0627\u0644\u0637\u0631\u064a\u0642 \u0623\u064a\u0636\u064b\u0627 \u0644\u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u0628\u062a\u0643\u0631\u0629 \u0648\u0645\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u064b\u0627 \u064a\u0645\u0643\u0646\u0647\u0627 \u062a\u062d\u0633\u064a\u0646 \u0645\u062e\u0631\u062c\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u0649 (\u0627\u0644\u0647\u0646\u0627\u0621 \u0627\u0644\u0646\u0641\u0633\u064a \u0648\u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0642\u0644\u064a\u0629 \u0648\u062c\u0648\u062f\u0629 \u0627\u0644\u062d\u064a\u0627\u0629) \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631(25)<\/sup>.<\/span><\/p>\n

\u0646\u0642\u0635 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0634\u062c\u0639 \u0639\u0644\u0649 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0628\u062f\u064a\u0644\u0629\u060c \u0645\u062b\u0644 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0648\u0627\u0644\u0634\u0628\u0643\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 (\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0648\u0627\u0644\u0634\u0628\u0643\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u062f\u0648\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u062c\u062f\u064a\u062f\u0629)\u060c \u0623\u0648 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a (\u0627\u0644\u0645\u0642\u062a\u0635\u0631 \u0639\u0644\u0649 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0638\u0627\u0647\u0631\u064a\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0644\u0645\u0639\u0631\u0641\u0629 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621)\u060c \u0623\u0648 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062d\u0627\u0633\u0648\u0628\u064a (\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u062d\u0627\u0633\u0648\u0628\u064a\u0629 \u0648\u0639\u0644\u0645 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0644\u0644\u062a\u0646\u0628\u0624 \u0628\u0623\u062f\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629)\u060c \u0648\u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0645\u0643\u062a\u0628\u0627\u062a \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0623\u0648 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0622\u0644\u064a\u0627\u062a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0645\u0633\u062a\u062c\u062f\u0629(26\u060c 27\u060c 28)<\/sup>. <\/span><\/p>\n

\u062f\u0645\u062c \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0625\u0646\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u062a\u0646\u0648\u0639\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u064a\u062c\u0639\u0644\u0646\u0627 \u0645\u062a\u0645\u0643\u0646\u064a\u0646 \u0645\u0646 \u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0647\u062f\u0627\u0641 (\u062c\u064a\u0646\u0627\u062a) \u062c\u062f\u064a\u062f\u0629 \u0644\u0647\u0627 \u0645\u0648\u0627\u0636\u0639 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u064a\u063a\u064a\u0631 \u0648\u0638\u064a\u0641\u062a\u0647\u0627 \u0648\u064a\u062c\u0639\u0644\u0647\u0627 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u060c \u0648\u064a\u0639\u0637\u064a \u0623\u0648\u0644\u0648\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0644\u0644\u0641\u062d\u0635 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651(20\u060c 22)<\/sup> (\u0645\u0627 \u064a\u0635\u0637\u0644\u062d \u0639\u0644\u064a\u0647 \u0628\u0640 (druggability) \u0648\u0647\u064a \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0645\u0646 \u062c\u064a\u0646\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0645\u0646 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0648\u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0623\u062f\u0648\u064a\u0629 \u0645\u0639\u064a\u0646\u0629).<\/span><\/p>\n

\u0645\u0639\u0638\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0631\u0643\u0632\u062a \u0628\u0634\u0643\u0644 \u0631\u0626\u064a\u0633 \u0639\u0644\u0649 \u0627\u0644\u0623\u0635\u0648\u0644 \u0627\u0644\u0623\u0641\u0631\u064a\u0642\u064a\u0629 \u0623\u0648 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0627\u0644\u0623\u0641\u0631\u064a\u0642\u064a\u0629\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062f\u0631\u0627\u0633\u0629 \u0645\u062d\u062f\u0648\u062f\u0629 \u0644\u0644\u0641\u0626\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u0645\u0639\u0631\u0636\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629\u060c \u0645\u062b\u0644 \u062a\u0644\u0643 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0645\u0646\u0637\u0642\u062a\u064a \u0627\u0644\u0628\u062d\u0631 \u0627\u0644\u0623\u0628\u064a\u0636 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u0627\u0644\u0634\u0631\u0642 \u0627\u0644\u0623\u0648\u0633\u0637(29)<\/sup>.<\/span><\/p>\n

\u0645\u0624\u062e\u0631\u064b\u0627\u060c \u0643\u0634\u0641\u062a \u0645\u062c\u0645\u0648\u0639\u062a\u0646\u0627 \u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0639\u0646 \u0645\u062a\u063a\u064a\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629<\/span> \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0633\u0639\u0648\u062f\u064a\u064a\u0646 \u062a\u064f\u0633\u0628\u0628 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u062e\u062b\u0627\u0631\u064a (\u0627\u0646\u0641\u0635\u0627\u0644 \u062c\u0644\u0637\u0629 \u0623\u0648 \u062e\u062b\u0631\u0629 \u062f\u0645 \u0645\u0646 \u0645\u0648\u0642\u0639\u0647\u0627 \u0627\u0644\u0623\u0635\u0644\u064a \u0648\u062a\u062d\u0631\u0643\u0647\u0627 \u0641\u064a \u0645\u062c\u0631\u0649 \u0627\u0644\u062f\u0645 \u0648\u0639\u0631\u0642\u0644\u062a\u0647 \u0623\u0648 \u0633\u062f\u0647) \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0639\u0644\u0649 \u0627\u0644\u0646\u0642\u064a\u0636 \u0645\u0646 \u0639\u0644\u0627\u0645\u0627\u062a \u062d\u064a\u0648\u064a\u0629 \u062d\u064f\u062f\u062f\u062a \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0623\u062e\u0631\u0649(20)<\/sup>. \u0625\u0636\u0627\u0641\u0629\u064b \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u062d\u062f\u062f\u062a \u0646\u062a\u0627\u0626\u062c \u0628\u064a\u0627\u0646\u0627\u062a\u0646\u0627 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0639\u062f\u0629 \u0645\u0648\u0627\u0636\u0639 \u0641\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0639\u0631\u0648\u0641\u0629 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0633\u0627\u0631\u0627\u062a \u0645\u0631\u0636\u064a\u0629 \u062c\u0632\u064a\u0626\u064a\u0629 \u0642\u062f \u062a\u0624\u062b\u0631 \u0641\u064a \u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0645\u0645\u0627 \u064a\u064f\u0624\u0643\u062f \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u062a\u062f\u062e\u0644\u0627\u062a \u0645\u064f\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u064b\u0627 \u0644\u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649(19)<\/sup>. <\/span><\/p>\n

\u062a\u0648\u0633\u064a\u0639 \u0646\u0637\u0627\u0642 \u062a\u0648\u0635\u064a\u0641 \u0627\u0644\u0623\u0633\u0633 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0643\u0644 \u0641\u0626\u0629 \u0633\u0643\u0627\u0646\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0634\u0627\u0645\u0644 \u0644\u0647 \u0645\u064a\u0632\u062a\u0627\u0646 \u0631\u0626\u064a\u0633\u064a\u062a\u0627\u0646: \u0641\u0647\u0648 \u064a\u0643\u0634\u0641 \u0639\u0646 \u0623\u0647\u062f\u0627\u0641 \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646\u060c \u0648\u064a\u064f\u0648\u0636\u062d \u0627\u0644\u062a\u0628\u0627\u064a\u0646 \u0641\u064a \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u064f\u0645\u0631\u0636\u0629 (\u0623\u064a \u0627\u0644\u062a\u0646\u0648\u0639 \u0641\u064a \u0643\u064a\u0641\u064a\u0629 \u0646\u0634\u0648\u0621 \u0645\u0633\u0628\u0628\u0627\u062a \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0644\u0645\u0631\u0636) \u0639\u0628\u0631 \u0637\u064a\u0641 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0639\u0627\u0644\u0645\u064a\u064b\u0627 (\u0623\u064a \u0627\u0646\u062a\u0634\u0627\u0631\u0647 \u0639\u0627\u0644\u0645\u064a\u064b\u0627 \u0648\u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a).<\/span><\/p>\n

\u0644\u0630\u0644\u0643\u060c \u0647\u062f\u0641\u0646\u0627 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0646\u062a\u0627\u0626\u062c \u062a\u062d\u0644\u064a\u0644\u0646\u0627 \u0644\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644\u060c \u0628\u0627\u0644\u062a\u0632\u0627\u0645\u0646 \u0645\u0639 \u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0647\u062f\u0627\u0641 (\u062c\u064a\u0646\u0627\u062a) \u062c\u062f\u064a\u062f\u0629 \u0644\u0647\u0627 \u0645\u0648\u0627\u0636\u0639 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u064a\u063a\u064a\u0631 \u0648\u0638\u064a\u0641\u062a\u0647\u0627 \u0648\u064a\u062c\u0639\u0644\u0647\u0627 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a (\u0645\u0627 \u064a\u0635\u0637\u0644\u062d \u0639\u0644\u064a\u0647 \u0628\u0640 druggability)\u060c \u0645\u0639 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u062a\u062d\u062f\u064a\u062f\u064b\u0627 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 (SCD) \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646\u060c \u0644\u0627\u0642\u062a\u0631\u0627\u062d \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629. <\/span><\/p>\n

\u0647\u062f\u0641\u0646\u0627 \u0627\u0644\u0648\u0627\u0633\u0639 \u0648\u0627\u0644\u0628\u0639\u064a\u062f \u0627\u0644\u0623\u0645\u062f \u0647\u0648 \u0648\u0636\u0639 \u062e\u0627\u0631\u0637\u0629 \u0637\u0631\u064a\u0642 \u0645\u062f\u0631\u0648\u0633\u0629 \u0648\u0645\u0648\u062c\u0647\u0629 \u062c\u064a\u0646\u064a\u064b\u0627 \u062a\u064f\u0633\u0631\u0651\u0639 \u0645\u0646 \u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u0628\u062a\u0643\u0631\u0629 \u0648\u0645\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u064b\u0627 \u0644\u0647\u0630\u0647 \u0627\u0644\u0641\u0626\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u0644\u0642\u0652 \u0645\u0646 \u0627\u0644\u0639\u0646\u0627\u064a\u0629 \u0645\u0627 \u062a\u0633\u062a\u062d\u0642 \u0641\u064a \u0627\u0644\u0633\u0627\u0628\u0642. \u0643\u0645\u0627 \u0646\u062d\u0627\u0648\u0644 \u0623\u0646 \u0646\u0633\u062a\u062e\u062f\u0645 \u0647\u0630\u0647 \u0627\u0644\u0645\u0642\u0627\u0631\u0628\u0629 \u0627\u0644\u0634\u0645\u0648\u0644\u064a\u0629 \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0625\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0648\u062a\u0633\u0631\u064a\u0639 \u062c\u0647\u0648\u062f \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629.<\/span><\/p>\n

2 \u0645\u0646\u0647\u062c\u064a\u0629 \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u0628\u062d\u062b\u064a <\/span><\/strong><\/span>
\n2.1 \u062e\u0637 \u0639\u0645\u0644\u064a\u0629 \u062a\u0637\u0648\u064a\u0631 \u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0648\u062a\u0637\u0648\u064a\u0631 \u0623\u062f\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629<\/span>
\n\u0627\u0633\u062a\u062e\u062f\u0645\u0646\u0627 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0633\u062a\u0645\u062f\u0629 \u0645\u0646 \u062a\u062d\u0644\u064a\u0644\u0646\u0627 \u0627\u0644\u0633\u0627\u0628\u0642 \u0644\u0640 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644 \u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0641\u064a \u0639\u064a\u0646\u0627\u062a \u0645\u0646 \u0633\u0643\u0627\u0646 \u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0629 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u0629(19)<\/sup>. \u0631\u0643\u0632 \u062a\u062d\u0644\u064a\u0644\u0646\u0627 \u0639\u0644\u0649 \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0645\u0645\u0643\u0646\u0629 \u0628\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0627\u0642\u062a\u0631\u0627\u062d \u0645\u0631\u0643\u0628\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u0637\u0648\u064a\u0631\u0647\u0627 \u0643\u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629. \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u062c\u0631\u0649 \u0648\u0641\u0642\u064b\u0627 \u0644\u0644\u0645\u0646\u0647\u062c\u064a\u0629 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0646\u0634\u0631\u062a \u0633\u0627\u0628\u0642\u064b\u0627 (\u0627\u0644\u0634\u0643\u0644 1)(30)<\/sup>.<\/span><\/p>\n

\"\"
\u0627\u0644\u0634\u0643\u0644 1- \u062e\u0637 \u0639\u0645\u0644\u064a\u0629 \u0648\u062a\u0637\u0648\u064a\u0631 \u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0648\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0647\u062f\u0627\u0641 \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 (\u062c\u064a\u0646\u0627\u062a \u0644\u0647\u0627 \u0645\u0648\u0627\u0636\u0639 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621)<\/span><\/figcaption><\/figure>\n

2.2 \u0641\u062d\u0635 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a<\/span><\/strong>
\n\u0631\u0643\u0632\u0646\u0627 \u0639\u0644\u0649 31 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u0627\u0644\u062a\u064a \u0646\u0634\u0631\u0647\u0627 \u0627\u0644\u063a\u0628\u064a\u0634\u064a \u0648\u0622\u062e\u0631\u0648\u0646(19)<\/sup>. \u062e\u0636\u0639\u062a \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0644\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u062f\u0648\u0631\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0644\u0645\u0631\u0636 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 (\u0648\u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629 \u0639\u0644\u064a\u0647\u0627 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u0649 \u0645\u0639\u064a\u0646 \u0648\u0625\u064a\u0642\u0627\u0641\u0647\u0627 \u0641\u064a \u0627\u0644\u0646\u0647\u0627\u064a\u0629)\u060c \u0648\u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 (\u0645\u062f\u0649 \u062c\u0648\u062f\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0641\u064a \u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0633\u0627\u0626\u0631 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u062c\u0633\u0645)\u060c \u0648\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0637\u0627\u0646\u064a\u0629 (\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0633\u0646 \u0628\u0647\u0627 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0631\u0642\u064a\u0642\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629)\u060c \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0645\u0631\u0636. <\/span><\/p>\n

\u062a\u0636\u0645\u0646\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u062a\u062d\u0644\u064a\u0644 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062d\u062f\u062f\u0629 (\u0648\u0647\u064a \u0637\u0631\u064a\u0642\u0629 \u062d\u0627\u0633\u0648\u0628\u064a\u0629 \u0644\u0644\u0628\u062d\u062b \u0639\u0646 \u0645\u0633\u0627\u0631\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0644\u0642\u0627\u0626\u0645\u0629 \u062c\u064a\u0646\u0627\u062a \u0644\u0641\u0647\u0645 \u0648\u0638\u0627\u0626\u0641\u0647\u0627 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629) \u0648\u0645\u0631\u0627\u062c\u0639\u0629 \u0634\u0627\u0645\u0644\u0629 \u0644\u0644\u0623\u062f\u0628\u064a\u0627\u062a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u062e\u0635\u0648\u0635\u060c \u0645\u0627 \u0623\u062b\u0628\u062a \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0644\u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0628\u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a.<\/span><\/p>\n

2.3 \u062a\u062d\u0644\u064a\u0644 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627<\/span><\/strong>
\n\u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a (DGIdb) \u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0631\u0642\u0645 5.0\u060c \u0627\u0644\u062a\u064a \u062a\u062c\u0645\u0639 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0646 \u0645\u0635\u0627\u062f\u0631 \u0645\u062a\u0639\u062f\u062f\u0629\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 (DrugBank) \u0648\u0642\u0627\u0639\u062f\u0629 \u0639\u0644\u0645 \u0627\u0644\u0635\u064a\u062f\u0644\u0629 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u0639\u0631\u0641\u064a\u0629 (PharmGKB)\u060c \u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0641\u0631\u0635 \u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0645\u0641\u064a\u062f\u0629 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(31)<\/sup>.<\/span><\/p>\n

\u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u062a\u0646\u0637\u0648\u064a \u0639\u0644\u0649 \u0634\u0631\u062d \u062a\u0641\u0635\u064a\u0644\u064a \u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a\u060c \u0648\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0647\u0627 \u0645\u0648\u0627\u0636\u0639 (\u062c\u064a\u0648\u0628 Pockets) \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u064a\u063a\u064a\u0631 \u0648\u0638\u064a\u0641\u062a\u0647\u0627 \u0648\u064a\u062c\u0639\u0644\u0647\u0627 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u00a0<\/span>(gene druggability)\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0648\u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 [\u0645\u0627\u062f\u0629 \u062e\u0636\u0639\u062a \u0644\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0648\u0648\u0627\u0641\u0642\u062a \u0639\u0644\u064a\u0647\u0627 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0644\u062a\u062c\u0631\u0628\u062a\u0647\u0627 \u0633\u0631\u064a\u0631\u064a\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0628\u0634\u0631]. \u0648\u0646\u0638\u0631\u064b\u0627 \u0644\u0623\u0646 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 (\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a) \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0623\u062f\u0648\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0648\u062e\u0644\u0635\u0646\u0627 \u0644\u0642\u0627\u0626\u0645\u0629 \u0637\u0648\u064a\u0644\u0629 \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629\u060c \u0641\u0642\u062f \u0627\u0633\u062a\u0628\u0639\u062f\u0646\u0627 \u0623\u0648\u0644\u064b\u0627 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0633\u0631\u064a\u0631\u064a\u064b\u0627 (\u0645\u062b\u0644 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645 \u0625\u064a\u0642\u0627\u0641 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0623\u0648 \u0627\u0644\u0645\u0648\u0627\u062f \u0642\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0639\u0631\u0641\u0629 \u0645\u0627 \u0625\u0630\u0627 \u0647\u064a \u0622\u0645\u0646\u0629 \u0648\u0641\u0639\u0627\u0644\u0629 \u0644\u0644\u0639\u0644\u0627\u062c) \u0646\u0638\u0631\u064b\u0627 \u0644\u0639\u062f\u0645 \u0642\u0627\u0628\u0644\u064a\u062a\u0647\u0627 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0627\u0644\u0645\u0628\u0627\u0634\u0631 (\u0623\u064a \u0639\u062f\u0645 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u064a \u0627\u0644\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0645\u0628\u0627\u0634\u0631\u0629 \u062f\u0648\u0646 \u062a\u0623\u062e\u064a\u0631). \u062b\u0645 \u0631\u0628\u0637\u062a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0628\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0648\u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0641\u064a \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u060c \u0645\u0633\u062a\u0628\u0639\u062f\u064a\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u063a\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629.<\/span><\/p>\n

\u062e\u0644\u0627\u0644 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0635\u0641\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629\u060c \u0623\u0639\u0637\u064a\u0646\u0627 \u0627\u0644\u0623\u0648\u0644\u0648\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0634\u0627\u0626\u0639\u0629 (\u0645\u0646 \u0623\u0645\u062b\u0627\u0644 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a\u060c \u0648\u0627\u062e\u062a\u0644\u0627\u0644 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u0627\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629)\u060c \u0644\u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u062a\u0624\u062b\u0631 \u0628\u0634\u0643\u0644 \u0645\u0628\u0627\u0634\u0631 \u0641\u064a \u0634\u062f\u0629 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0643\u0645\u0627 \u0627\u0633\u062a\u064f\u0628\u0639\u062f\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u062a\u0634\u062e\u064a\u0635\u060c \u0648\u0627\u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646\u0627\u062a\u060c \u0648\u0627\u0644\u0645\u0643\u0645\u0644\u0627\u062a \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0627\u0633\u062a\u0628\u062f\u0644\u062a (\u0628\u0628\u062f\u0627\u0626\u0644 \u0623\u0643\u062b\u0631 \u0641\u0639\u0627\u0644\u064a\u0629).<\/span><\/p>\n

\u0645\u0646 \u0628\u064a\u0646 \u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062c\u0631\u062a \u062a\u0635\u0641\u064a\u062a\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0623\u0651\u0639\u0637\u064a\u0646\u0627 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u062b\u0627\u0646\u064a\u0629 \u0648\u0628\u0634\u0643\u0644 \u0623\u0643\u062b\u0631 \u0644\u0628\u0639\u0636 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u062f\u0649 \u0623\u0645\u0627\u0646\u0647\u0627 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 (\u0627\u0644\u0623\u0642\u0644 \u0645\u0646 \u062d\u064a\u062b \u0623\u062b\u0627\u0631\u0647\u0627 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629)\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0631\u0646\u0627\u0645\u062c (VigiBase) \u0648\u0647\u0648 \u0623\u0643\u0628\u0631 \u0633\u062c\u0644 \u0639\u0627\u0644\u0645\u064a \u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0630\u064a \u064a\u0634\u0631\u0641 \u0639\u0644\u064a\u0647 \u0645\u0631\u0643\u0632 \u0623\u0648\u0628\u0633\u0627\u0644\u0627 \u0627\u0644\u0633\u0648\u064a\u062f\u064a \u0644\u0635\u0627\u0644\u062d \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629(32)<\/sup>\u060c \u0648\u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0648\u0627\u0631\u062f \u0622\u062b\u0627\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 (SIDER 4.1). \u0627\u0633\u062a\u0628\u0639\u062f\u0646\u0627 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0647\u0627 \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0634\u062f\u064a\u062f\u0629 \u0645\u062b\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u0645\u064a\u0632 \u0628\u0645\u0633\u062a\u0648\u0649 \u0633\u0645\u064a\u0629 \u062e\u0637\u064a\u0631 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0622\u062b\u0627\u0631\u0647\u0627 \u0627\u0644\u0636\u0627\u0631\u0629 \u062c\u062f\u064b\u0627 \u0628\u0627\u0644\u0633\u0644\u0627\u0645\u0629. <\/span><\/p>\n

\u0643\u0645\u0627 \u0627\u0633\u062a\u064f\u0628\u0639\u062f\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u064f\u0634\u0643\u0644 \u0625\u0635\u0627\u0628\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0627\u0646\u062d\u0644\u0627\u0644\u064a\u060c \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u0627\u062c\u0631\u0627\u0621\u064b \u0648\u0642\u0627\u0626\u064a\u064b\u0627 \u0644\u0645\u0646\u0639 \u062a\u0641\u0627\u0642\u0645 \u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u062f\u0645 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0628\u0634\u0643\u0644 \u0634\u0645\u0648\u0644\u064a\u060c \u0627\u0633\u062a\u062e\u062f\u0645\u0646\u0627 \u0623\u062f\u0627\u0629 \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 (STITCH) \u0648\u0642\u0648\u0627\u0639\u062f \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 (WHO) \u0644\u062a\u0648\u062d\u064a\u062f \u062a\u0633\u0645\u064a\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u062a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0627\u0644\u0623\u0633\u0645\u0627\u0621 \u0627\u0644\u062f\u0648\u0644\u064a\u0629 \u063a\u064a\u0631 \u0645\u0633\u062c\u0644\u0629 \u0627\u0644\u0645\u064f\u0644\u0643\u064a\u0629 (INN) \u0648\u0627\u0644\u0623\u0633\u0645\u0627\u0621 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 (USAN)\u060c \u0648\u0644\u062a\u0639\u064a\u064a\u0646 \u0631\u0645\u0648\u0632 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a\u0629ACT (34\u060c 35)<\/sup> \u0623\u0639\u0637\u064a\u0646\u0627 \u0627\u0644\u0623\u0648\u0644\u0648\u064a\u0629 \u0644\u062a\u062c\u0646\u0628 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0632\u064a\u062f \u0645\u0646 \u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u062e\u0627\u0635\u0629\u064b \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u0646\u0637\u0648\u064a \u0639\u0644\u0649 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0627\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u062f\u0648\u0649\u060c \u0623\u0648 \u0627\u0644\u062a\u062f\u0647\u0648\u0631 \u0627\u0644\u0625\u062f\u0631\u0627\u0643\u064a\u060c \u0623\u0648 \u0639\u062f\u0645 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0636\u063a\u0637 \u0627\u0644\u062f\u0645\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u062a\u0639\u0631\u0636 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a.<\/span><\/p>\n

3. \u0627\u0644\u0646\u062a\u0627\u0626\u062c<\/span><\/strong><\/span>
\n3.1 \u0623\u062f\u0648\u064a\u0629 \u0645\u0631\u0634\u062d\u0629 \u0648\u0627\u0639\u062f\u0629 \u064a\u0645\u0643\u0646 \u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a<\/span><\/strong>
\n\u0645\u0646 \u0628\u064a\u0646 31 \u062c\u064a\u0646\u064b\u0627 \u0645\u0642\u062a\u0631\u062d\u064b\u0627 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647\u0627 \u0645\u064f\u0639\u062f\u0650\u0651\u0644\u0627\u062a \u0623\u0648 \u0639\u0648\u0627\u0645\u0644 \u062a\u0639\u0645\u0644 \u0639\u0644\u0649 \u062a\u063a\u064a\u064a\u0631 \u062d\u062f\u0629 \u0623\u0639\u0631\u0627\u0636 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u062a\u0645 \u062a\u062d\u062f\u064a\u062f \u0623\u062d\u062f \u0639\u0634\u0631 \u062c\u064a\u0646\u0627:\u00a0<\/span>[ACKR1\u060c AGER\u060c FCER1A\u060c HLA-A\u060c HLA-DQB1\u060c HLA-DRB1 HLA-G\u060c NOTCH4\u060c RRM1\u060c STIM1\u060c \u0648TRIM5] \u0642\u0627\u062f\u0631\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0645\u0627 \u0645\u062c\u0645\u0648\u0639\u0647 114 \u0645\u0631\u0643\u0628\u064b\u0627 \u062f\u0648\u0627\u0626\u064a\u064b\u0627 \u0645\u062e\u062a\u0644\u0641\u064b\u0627. \u0628\u0639\u0636 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 (\u0639\u062f\u062f\u0647\u0627 36) \u0644\u0645 \u062a\u064f\u0639\u062a\u0645\u062f \u0628\u0639\u062f \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0627\u0633\u062a\u0628\u0639\u062f\u062a \u0645\u0646 \u0627\u0644\u062a\u062c\u0631\u0628\u0629. \u062c\u064a\u0646 (HBG2) \u0644\u0645 \u064a\u0638\u0647\u0631 \u062a\u0641\u0627\u0639\u0644\u0627 \u0645\u0639 \u0623\u062d\u062f \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629. \u0645\u0646 \u0628\u064a\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0640 78 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629\u060c \u0627\u0633\u062a\u0628\u0639\u062f \u0645\u0627 \u0645\u062c\u0645\u0648\u0639\u0647 21 \u0639\u0644\u0627\u062c\u064b\u0627 \u0643\u064a\u0645\u064a\u0627\u0648\u064a\u064b\u0627\u060c \u0643\u0645\u0627 \u0627\u0633\u062a\u0628\u0639\u062f\u062a \u0645\u0627\u062f\u062a\u0627\u0646 \u0645\u0646 \u0627\u0644\u0641\u064a\u062a\u0627\u0645\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u062a\u0634\u062e\u064a\u0635\u064a\u0629\u060c \u0648\u062b\u0644\u0627\u062b\u0629 \u0644\u0642\u0627\u062d\u0627\u062a\u060c \u064812 \u0645\u0636\u0627\u062f\u064b\u0627 \u0645\u064a\u0643\u0631\u0648\u0628\u064a\u064b\u0627. \u0623\u0645\u0627 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629 (\u0639\u062f\u062f\u0647\u0627 40) \u0641\u0642\u062f \u062a\u0645 \u062a\u0635\u0641\u064a\u0629 \u0628\u0639\u0636\u0647\u0627 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0639\u062f\u0645 \u0633\u0644\u0627\u0645\u062a\u0647\u0627.<\/span><\/p>\n

\u0646\u062a\u064a\u062c\u0629\u064b \u0644\u0630\u0644\u0643\u060c \u0627\u0633\u062a\u0628\u0639\u062f\u0646\u0627 5 \u0645\u0646 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0635\u0631\u0639\u060c \u06485 \u0645\u0646 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0627\u0643\u062a\u0626\u0627\u0628\u060c \u06483 \u0645\u0646 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629\u060c \u0648\u0627\u0644\u062c\u0644\u0648\u0643\u0648\u0643\u0648\u0631\u062a\u064a\u0643\u0648\u064a\u062f\u0627\u062a\u060c \u0648\u0627\u0644\u062a\u064a\u0643\u0644\u0648\u0628\u064a\u062f\u064a\u0646 (\u062f\u0648\u0627\u0621 \u0644\u0645\u0646\u0639 \u0627\u0644\u0633\u0643\u062a\u0627\u062a \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629)\u060c \u0648\u0627\u0644\u0647\u064a\u062f\u0631\u0627\u0644\u0627\u0632\u064a\u0646 (\u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0644\u0639\u0644\u0627\u062c \u0627\u0631\u062a\u0641\u0627\u0639 \u0636\u063a\u0637 \u0627\u0644\u062f\u0645) \u0646\u0638\u0631\u064b\u0627 \u0644\u0622\u062b\u0627\u0631\u0647\u0627 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647\u0627. \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u064a\u0648\u0631\u064a\u0627 (\u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062f\u0645) \u0648\u0645\u0633\u0643\u0646\u0627\u062a \u0627\u0644\u0623\u0644\u0645 (\u0645\u062b\u0644\u060c \u0627\u0644\u0623\u0633\u064a\u062a\u0627\u0645\u064a\u0646\u0648\u0641\u064a\u0646\u060c \u0648\u0627\u0644\u0623\u0633\u0628\u0631\u064a\u0646\u060c \u0648\u0644\u0648\u0645\u064a\u0631\u0627\u0643\u0648\u0643\u0633\u064a\u0628) \u0644\u0645 \u064a\u062a\u0645 \u062a\u0636\u0645\u064a\u0646\u0647\u0627 \u0641\u064a \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629\u060c \u0644\u0623\u0646 \u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u064a\u0635\u0641\u0648\u0646\u0647\u0627 \u0644\u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0641\u064a \u0639\u064a\u0627\u062f\u0627\u062a\u0647\u0645 \u0628\u0634\u0643\u0644 \u0631\u0648\u062a\u064a\u0646\u064a. <\/span><\/p>\n

\u0648\u0646\u062a\u064a\u062c\u0629\u064b \u0644\u0630\u0644\u0643\u060c \u0642\u0644\u0635\u0646\u0627 \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0644\u062a\u0634\u0645\u0644 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0628\u064a\u0646 20 \u062f\u0648\u0627\u0621\u064b \u06486 \u062c\u064a\u0646\u0627\u062a\u060c \u062d\u064a\u062b \u064a\u062a\u0641\u0627\u0639\u0644 18 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u0639 \u0623\u0631\u0628\u0639 \u062c\u064a\u0646\u0627\u062a \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0643\u0631\u064a\u0627\u062a \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 HLA ( HLA-DQB1\u060c \u0648DRB1\u060c \u0648G\u060c \u0648A) \u060c \u064a\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u062f\u0648\u0627\u0621\u0627\u0646 \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0627\u0646 (\u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 “omalizumab” \u0648\u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 “allopurinol”) \u0645\u0639 \u062c\u064a\u0646\u064a\u0646 \u0645\u062e\u062a\u0644\u0641\u064a\u0646 (FCER1A \u0648NOCH4\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a) [\u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u062c\u062f\u0648\u0644 \u0631\u0642\u0645 1\u060c \u0644\u0644\u0627\u0637\u0644\u0627\u0639 \u0639\u0644\u0649 \u0627\u0644\u062c\u062f\u0648\u0644\u060c \u0631\u0627\u062c\u0639 \u062c \u0627\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0623\u0635\u0644\u064a\u0629]. <\/span><\/p>\n

\u0627\u0644\u0635\u0646\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u064b\u0627 \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0634\u0645\u0644\u062a \u0645\u062b\u0628\u0637\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 (\u0639\u062f\u062f\u0647\u0627 12)\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627: [\u0623\u062f\u0627\u0644\u064a\u0645\u0648\u0645\u0627\u0628 adalimumab\u060c \u0648\u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628 canakinumab\u060c \u0648\u0625\u0646\u0641\u0644\u064a\u0643\u0633\u064a\u0645\u0627\u0628 infliximab\u060c \u0648\u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 omalizumab\u060c \u0648\u062a\u0648\u0633\u064a\u0644\u064a\u0632\u0648\u0645\u0627\u0628 tocilizumab\u060c \u0648\u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a etanercept\u060c \u0648\u0631\u064a\u0644\u0648\u0646\u0627\u0633\u064a\u0628\u062a rilonacept\u060c \u0648\u0628\u064a\u063a \u0625\u0646\u062a\u064a\u0631\u0641\u064a\u0631\u0648\u0646 peginterferon \u0623\u0644\u0641\u0627-2\u0623 \u06482\u0628\u060c \u0648\u0622\u0632\u0627\u062b\u064a\u0648\u0628\u0631\u064a\u0646 azathioprine\u060c \u0648\u063a\u0644\u0627\u062a\u064a\u0631\u0627\u0645\u064a\u0631 glatiramer\u060c \u0648\u0623\u0646\u0627\u0643\u064a\u0646\u0631\u0627 anakinra].<\/span><\/p>\n

\u0623\u0645\u0627 \u0627\u0644\u0635\u0646\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0627\u0644\u062b\u0627\u0646\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u064b\u0627 \u0641\u0647\u064a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062e\u0627\u0641\u0636\u0629 \u0644\u0644\u062f\u0647\u0648\u0646 (\u0648\u0639\u062f\u062f\u0647\u0627 7)\u060c \u0648\u0627\u0644\u062a\u064a \u0634\u0645\u0644\u062a \u0641\u064a\u0646\u0648\u0641\u0627\u064a\u0628\u0631\u0627\u062a \u0648\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a (\u0628\u064a\u062a\u0627\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0628\u0631\u0627\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0631\u0648\u0632\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0641\u0644\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646).<\/span><\/p>\n

\u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u0637\u0627\u0641\u060c \u0627\u0642\u062a\u064f\u0631\u062d\u062a \u0645\u062b\u0628\u0637\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 – \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629 – \u0648\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0643\u0623\u0646\u0633\u0628 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641\u0647\u0627 \u0644\u0639\u0644\u0627\u062c \u0634\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0630\u0644\u0643 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u062a\u0641\u0627\u0639\u0644\u0627\u062a\u0647\u0627 \u0645\u0639 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0627\u0644\u062f\u0627\u062e\u0644\u0629 \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0627\u0644\u062d\u0631\u062c\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0628\u062f\u0639\u0645 \u0645\u0646 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629(18\u060c 22)<\/sup>. \u0648\u062a\u062d\u062f\u064a\u062f\u064b\u0627\u060c 3 \u0645\u062b\u0628\u0637\u0627\u062a \u0645\u0646\u0627\u0639\u0629\u060c \u064a\u0639\u0645\u0644 \u0643\u0644 \u0645\u0646\u0647\u0627 \u0639\u0644\u0649 \u0623\u0647\u062f\u0627\u0641 \u062c\u064a\u0646\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 (\u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u064a\u0633\u062a\u0647\u062f\u0641 \u062c\u064a\u0646 (FCER1A)\u060c \u0648\u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628 \u0648\u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a \u064a\u0633\u062a\u0647\u062f\u0641\u0627\u0646 \u0627\u0644\u062c\u064a\u0646 (HLA-DRB1))\u060c \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0633\u062a\u0627\u062a\u064a\u0646 (\u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0627\u0644\u0630\u064a \u064a\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0643\u0644 \u0645\u0646 (HLA-G \u0648HLA-DRB1).<\/span><\/p>\n

\u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u062c\u0629 \u062a\u0641\u0627\u0639\u0644 \u0639\u0627\u0644\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u062c\u064a\u0646. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0627\u0642\u062a\u0631\u062d\u0646\u0627 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644\u060c \u0648\u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u0636\u0627\u062f \u0644\u0641\u0631\u0637 \u0632\u064a\u0627\u062f\u0629 \u062d\u0645\u0636 \u0627\u0644\u064a\u0648\u0631\u064a\u0643 \u0641\u064a \u0627\u0644\u062f\u0645\u060c \u0648\u064a\u0633\u062a\u0647\u062f\u0641 \u062c\u064a\u0646 (NOTCH4)\u060c \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u0645\u0631\u0634\u062d\u064b\u0627 \u0648\u0627\u0639\u062f\u064b\u0627 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u0638\u064a\u0641.<\/span><\/p>\n

4. \u0645\u0646\u0627\u0642\u0634\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c<\/span><\/strong><\/span>
\n\u0628\u0631\u0632 \u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u062c\u0639\u0644 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629\u064b \u0648\u0627\u0639\u062f\u0629 \u0648\u0645\u0628\u062a\u0643\u0631\u0629 \u0641\u064a \u0645\u062c\u0627\u0644 \u0639\u0644\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629. \u0641\u064a \u0639\u0627\u0645 2021\u060c \u0643\u0627\u0646\u062a \u0645\u0648\u0627\u0641\u0642\u0629 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0639\u0644\u0649 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 \u062b\u0644\u062b\u064a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0645\u0628\u0646\u064a\u0629 \u0639\u0644\u0649 \u0623\u0641\u0643\u0627\u0631 \u0648\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0633\u062a\u0645\u062f\u0629 \u0645\u0646 \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0630\u064a \u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u0627\u0643\u062a\u0634\u0627\u0641\u0627\u062a \u062f\u0648\u0627\u0626\u064a\u0629 \u0645\u0647\u0645\u0629(36\u060c 37)<\/sup>. \u062a\u0641\u064a\u062f \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0628\u0623\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0646\u062f\u0629 \u0625\u0644\u0649 \u0623\u062f\u0644\u0629 \u062c\u064a\u0646\u064a\u0629 \u0628\u0634\u0631\u064a\u0629 \u0631\u0635\u064a\u0646\u0629 \u062a\u062a\u0645\u062a\u0639 \u0628\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0623\u0639\u0644\u0649 \u0644\u062a\u062c\u0627\u0648\u0632 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0647\u064a\u0626\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u063a\u0630\u0627\u0621 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u064a\u0633 \u0644\u0647\u0627 \u0647\u0630\u0627 \u0627\u0644\u062f\u0639\u0645 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0628\u0634\u0631\u064a(22)<\/sup>.<\/span><\/p>\n

\u0648\u0644\u0643\u0646 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u062a\u062a\u0637\u0644\u0628 \u0623\u064a\u0636\u0627 \u062a\u0641\u0627\u0639\u0644\u0627 \u0645\u0639\u0642\u062f\u0627 \u0628\u064a\u0646 \u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0648\u062a\u0646\u0648\u0639 \u0627\u0644\u0633\u0643\u0627\u0646 (\u0627\u0644\u0639\u0631\u0642 \u0648\u0627\u0644\u0625\u062b\u0646\u064a\u0629 \u0648\u0627\u0644\u062b\u0642\u0627\u0641\u0629 \u0648\u0627\u0644\u0644\u063a\u0629 \u0648\u0627\u0644\u0648\u0636\u0639 \u0627\u0644\u0633\u064a\u0627\u0633\u064a \u0648\u0627\u0644\u0627\u0642\u062a\u0635\u0627\u062f\u064a)\u060c \u0648\u0627\u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u062f\u0642\u064a\u0642 \u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 (\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0648\u062b\u0648\u0642\u0629 \u0648\u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0642\u064a\u0627\u0633 \u0648\u0627\u0644\u062a\u064a \u062a\u0635\u0628 \u0641\u064a \u0645\u0635\u0644\u062d\u0629 \u0627\u0644\u0645\u0631\u064a\u0636)\u060c \u0648\u0628\u064a\u0627\u0646\u0627\u062a \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u0645\u0641\u0639\u0648\u0644\u064a\u062a\u0647\u0627\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u062e\u0628\u0631\u0629 \u0627\u0644\u0645\u0643\u062a\u0633\u0628\u0629 \u0628\u0639\u062f \u0627\u0644\u062a\u0633\u0648\u064a\u0642. \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062f\u0639\u0645 \u0627\u0644\u062c\u064a\u0646\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0639\u0632\u0632 \u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0635\u062d\u0629 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0643\u0627\u0645\u0646 \u0648\u0631\u0627\u0621 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u0644\u0627 \u064a\u0636\u0645\u0646 \u0627\u0644\u0646\u062c\u0627\u062d \u0648\u062d\u062f\u0647. \u0641\u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u0631 \u0627\u0644\u0645\u062e\u062a\u0635\u0629 \u062a\u0639\u062a\u0645\u062f \u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u0637\u0627\u0641 \u0639\u0644\u0649 \u0627\u0639\u062a\u0628\u0627\u0631 \u062c\u0645\u064a\u0639 \u0647\u0630\u0647 \u0627\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0648\u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0623\u0648\u062c\u0647(38)<\/sup>.<\/span><\/p>\n

\u0644\u0642\u062f \u0623\u062f\u0649 \u062a\u0637\u0648\u064a\u0631 \u0648\u062a\u0637\u0628\u064a\u0642 \u0645\u0646\u0627\u0647\u062c \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629\u060c \u0645\u062b\u0644 \u062f\u0631\u0627\u0633\u0627\u062a \u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0643\u0627\u0645\u0644 (GWAS) \u0648\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u062a\u0627\u0644\u064a (NGS) \u0645\u062b\u0644 \u062a\u0633\u0644\u0633\u0644 \u0643\u0627\u0645\u0644 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 (WGS) \u0648\u062a\u0633\u0644\u0633\u0644 \u0643\u0627\u0645\u0644 \u0627\u0644\u0625\u0643\u0633\u0648\u0645 (WES)\u060c \u0625\u0644\u0649 \u062a\u0639\u0645\u064a\u0642 \u0641\u0647\u0645\u0646\u0627 \u0644\u0644\u0623\u0633\u0633 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u0633\u0645\u0627\u062a \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0627\u0644\u0645\u0639\u0642\u062f\u0629 (\u0637\u0648\u0644 \u0627\u0644\u0642\u0627\u0645\u0629 \u0648\u0644\u0648\u0646 \u0627\u0644\u0634\u0639\u0631 \u0648\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0630\u0643\u0627\u0621\u060c \u0648\u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0627\u0635\u0627\u0628\u0629 \u0628\u0623\u0645\u0631\u0627\u0636 \u0645\u0639\u064a\u0646\u0629\u060c \u0645\u062b\u0644\u064b\u0627) \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631(39\u060c 40, 41)<\/sup>. \u0648\u0642\u062f \u0633\u0647\u0651\u0644 \u0647\u0630\u0627 \u0627\u0644\u062a\u0642\u062f\u0645 \u062a\u062d\u062f\u064a\u062f \u0623\u0647\u062f\u0627\u0641 \u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0639\u062f\u0629\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(42)<\/sup>.<\/span><\/p>\n

\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u062a\u0631\u062c\u0645\u0629 \u0647\u0630\u0647 \u0627\u0644\u0627\u0643\u062a\u0634\u0627\u0641\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0641\u0639\u0627\u0644\u064a\u0629 \u0625\u0644\u0649 \u0645\u0645\u0627\u0631\u0633\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u0627 \u062a\u0632\u0627\u0644 \u062a\u0648\u0627\u062c\u0647 \u0635\u0639\u0648\u0628\u0627\u062a\u060c \u0644\u0627 \u0633\u064a\u0645\u0627 \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0645\u062b\u0644 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0627\u0644\u0630\u064a \u064a\u062a\u0645\u064a\u0632 \u0628\u0633\u0645\u0627\u062a \u0638\u0627\u0647\u0631\u064a\u0629 \u0648\u0623\u0639\u0631\u0627\u0636 \u0645\u062a\u0646\u0648\u0639\u0629 \u062a\u062a\u0623\u062b\u0631 \u0628\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u0639\u0648\u0627\u0645\u0644 \u0628\u064a\u0626\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 (\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0627\u0644\u0633\u0645\u0627\u062a \u0627\u0644\u0634\u0627\u0626\u0639\u0629\u060c \u0645\u062b\u0644\u060c \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0645\u0632\u064a\u062c \u0645\u0639\u0642\u062f \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0639\u0648\u0627\u0645\u0644 \u0628\u064a\u0626\u064a\u0629 \u0648\u0646\u0645\u0637 \u062d\u064a\u0627\u0629 \u0645\u062e\u062a\u0644\u0641\u060c \u0648\u0644\u064a\u0633 \u062c\u064a\u0646\u064b\u0627 \u0648\u0627\u062d\u062f\u064b\u0627 \u0641\u0642\u0637). \u0627\u0639\u062a\u0628\u0627\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u064a\u0639\u062f \u0645\u0646\u0647\u062c\u064a\u0629\u064b \u0642\u064a\u0651\u0645\u0629\u064b \u0622\u062e\u0630\u0629\u064b \u0641\u064a \u0627\u0644\u0627\u0632\u062f\u064a\u0627\u062f \u0648\u0627\u0644\u062a\u0648\u0633\u0639 \u0628\u0627\u0644\u0641\u0639\u0644 \u0641\u064a \u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0633\u0631\u064a\u0631\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 (\u0639\u0644\u0627\u062c\u0627\u062a \u062c\u062f\u064a\u062f\u0629) \u0628\u062a\u0643\u0644\u0641\u0629 \u0645\u0639\u0642\u0648\u0644\u0629(30; 36\u060c 43)<\/sup>. <\/span><\/p>\n

\u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0637\u0631\u064a\u0642\u0629 \u0645\u062d\u0627\u0643\u0627\u0629 \u062d\u0627\u0633\u0648\u0628\u064a\u0629\u064b \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0648\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0644\u0627\u0642\u062a\u0631\u0627\u062d \u0623\u062f\u0648\u064a\u0629\u064d \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0645\u0631\u0634\u062d\u0629 \u0648\u0648\u0627\u0639\u062f\u0629 \u0648\u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0645\u0631\u0643\u0628\u0627\u062a \u0645\u0633\u062a\u0647\u062f\u0641\u0629\u064d \u0644\u0639\u0644\u0627\u062c \u062d\u0627\u0644\u0627\u062a\u064d \u0637\u0628\u064a\u0629\u064d \u0645\u062e\u062a\u0644\u0641\u0629\u064d\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0646\u062a\u0627\u0626\u062c \u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0641\u062a\u0648\u062d\u0629 \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0639\u0627\u0645\u0629(30\u060c 44\u060c 45)<\/sup>. <\/span><\/p>\n

\u062a\u062a\u0648\u0641\u0631 \u0642\u0648\u0627\u0639\u062f \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644\u060c \u0648\u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0623\u0645\u0631\u0627\u0636\u064d \u0628\u0639\u064a\u0646\u0647\u0627. \u0644\u0630\u0644\u0643\u060c \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u062a\u0631\u062c\u0645\u0629 \u0625\u0634\u0627\u0631\u0627\u062a \u0645\u0639\u064a\u0646\u0629 (\u0623\u064a \u062c\u064a\u0646\u0627\u062a \u0623\u0648 \u062a\u063a\u064a\u0631\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629) \u0644\u062a\u0635\u0645\u064a\u0645 \u0623\u062f\u0648\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0645\u0639\u064a\u0646 \u0627\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0648\u062e\u0637\u0629\u064d \u0628\u062d\u062b\u064a\u0629\u064d \u0645\u062b\u0628\u062a\u0629 \u0639\u0644\u0645\u064a\u064b\u0627(30)<\/sup>. \u0641\u064a \u0645\u0634\u0631\u0648\u0639\u0646\u0627\u060c \u0627\u0639\u062a\u0645\u062f\u0646\u0627 \u0645\u0646\u0647\u062c\u064a\u0629\u064b \u0645\u0645\u0627\u062b\u0644\u0629\u064b \u0644\u0627\u0642\u062a\u0631\u0627\u062d \u062e\u064a\u0627\u0631\u0627\u062a\u064d \u0639\u0644\u0627\u062c\u064a\u0629\u064d \u062f\u0648\u0627\u0626\u064a\u0629\u064d \u062c\u062f\u064a\u062f\u0629\u064d \u064a\u064f\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u062a\u0647\u062f\u0641 \u062c\u064a\u0646\u0627\u062a\u064d \u0645\u062d\u062f\u062f\u0629\u064b \u0645\u0639\u0631\u0648\u0641\u0629\u064b \u0628\u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0627\u0644\u0627\u064a\u062c\u0627\u0628\u064a \u0641\u064a \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (\u0623\u064a \u062a\u062e\u0641\u064a\u0641 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0648\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0645\u0631\u0636 \u0648\u062a\u062d\u0633\u064a\u0646 \u062c\u0648\u062f\u0629 \u0627\u0644\u062d\u064a\u0627\u0629 \u0648\u062d\u062a\u0649 \u0627\u0644\u0645\u062d\u0627\u0641\u0638\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629).<\/span><\/p>\n

\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0633\u0627\u0628\u0642\u0629 \u0627\u0633\u062a\u062e\u062f\u0645\u0646\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u062a\u0631\u0627\u0628\u0637 \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a \u0627\u0644\u0643\u0627\u0645\u0644\u060c \u0627\u0643\u062a\u0634\u0641\u0646\u0627 \u062c\u064a\u0646\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u0644\u0647\u0627 \u062f\u0648\u0631 \u0647\u0627\u0645 \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u0645\u0636\u0627\u0639\u0641\u0627\u062a\u0647(18)<\/sup>. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u0647\u062f\u0641 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0625\u0644\u0649 \u062a\u0639\u0638\u064a\u0645 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0644\u062a\u0631\u062c\u0645\u0629 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0625\u0644\u0649 \u0631\u0639\u0627\u064a\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 (\u0639\u0644\u0627\u062c \u062f\u0648\u0627\u0626\u064a) \u0644\u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0648\u0642\u062f \u062a\u0648\u0635\u0644\u062a \u0637\u0631\u064a\u0642\u062a\u0646\u0627 \u0627\u0644\u062a\u064a \u0635\u0645\u0645\u0646\u0627\u0647\u0627 \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062c\u062f\u064a\u062f \u0644\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0639\u0644\u064a\u0647\u0627 \u0628\u0639\u0636 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u0639\u0644\u064a\u0627 \u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0646\u064a\u0645\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u0645\u062b\u0644 \u062c\u064a\u0646 (RRM1) \u0627\u0644\u0645\u0624\u062b\u0631 \u0641\u064a \u0639\u0645\u0644 \u062f\u0648\u0627\u0621 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u064a\u0648\u0631\u064a\u0627\u060c \u0648\u062c\u064a\u0646\u064a (HLA-DQB1) \u0648(HLA-DRB1)\u060c \u0627\u0644\u0644\u0630\u064a\u0646 \u062a\u0639\u0645\u0644 \u0639\u0644\u064a\u0647\u0645\u0627 \u0628\u0639\u0636 \u0627\u0644\u0645\u0633\u0643\u0646\u0627\u062a. \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0634\u0643\u0644\u062a \u0645\u0639\u0627\u064a\u064a\u0631 \u0644\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0635\u062d\u0629 \u0623\u062f\u0627\u0621 \u062e\u0637 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 (\u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0635\u064a\u0644 \u0645\u062a\u0648\u0641\u0631\u0629 \u0641\u064a \u0627\u0644\u0645\u0644\u062d\u0642 \u0627\u0644\u062a\u0643\u0645\u064a\u0644\u064a). \u0627\u0643\u062a\u0634\u0627\u0641 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0648\u0641\u0642 \u064a\u0634\u0647\u062f \u0628\u0631\u0635\u0627\u0646\u0629 \u062e\u0637 \u062a\u0637\u0648\u064a\u0631\u0646\u0627 \u0644\u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a.<\/span><\/p>\n

\u0627\u0633\u062a\u064f\u0628\u0639\u062f\u062a \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u0646 \u0627\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0625\u0636\u0627\u0641\u064a\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u0643\u0648\u0646\u0647\u0627 \u0645\u0639\u062a\u0645\u062f\u0629 \u0628\u0627\u0644\u0641\u0639\u0644 \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0644\u064a\u0633 \u0628\u0633\u0628\u0628 \u0645\u062e\u0627\u0648\u0641 \u0645\u0646 \u0643\u0648\u0646\u0647\u0627 \u0633\u0645\u064a\u0629. \u0643\u0627\u0646 \u0623\u062d\u062f \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0641\u064a \u062e\u0637\u062a\u0646\u0627 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0647\u0648 \u0627\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0645\u0646\u0647\u062c\u064a \u0644\u0643\u0644 \u0645\u0646 \u0627\u0644\u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0648\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062b\u0645\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0633\u0628\u0639\u064a\u0646 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0637\u064f\u0628\u0642\u062a \u0627\u0639\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0628\u062f\u0642\u0629 \u0641\u064a \u0643\u0644 \u062e\u0637\u0648\u0629 \u0645\u0646 \u062e\u0637\u0648\u0627\u062a \u062a\u0631\u0634\u064a\u062d \u0643\u0644 \u062f\u0648\u0627\u0621 \u0648\u062a\u062d\u062f\u064a\u062f \u0623\u0648\u0644\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 (\u0645\u0646 \u062d\u064a\u062b \u0643\u0648\u0646\u0647\u0627 \u0648\u0627\u0639\u062f\u0629 \u0648\u0641\u0639\u0627\u0644\u0629 \u0648\u0622\u0645\u0646\u0629 \u0644\u0644\u0639\u0644\u0627\u062c). <\/span><\/p>\n

\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0633\u062a\u0628\u0639\u0627\u062f \u062f\u0648\u0627\u0621 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u064a\u0648\u0631\u064a\u0627\u060c \u0627\u0633\u062a\u064f\u0628\u0639\u062f\u062a \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u0627\u0648\u064a \u0627\u0644\u0623\u062e\u0631\u0649 \u0623\u064a\u0636\u064b\u0627 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0639\u0644\u0627\u0642\u062a\u0647\u0627 \u0627\u0644\u0645\u0648\u062b\u0642\u0629 \u0628\u0623\u0639\u0631\u0627\u0636 \u062c\u0627\u0646\u0628\u064a\u0629 \u062e\u0637\u064a\u0631\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0633\u0645\u064a\u0629 \u0627\u0644\u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0645\u064a (\u0623\u0648 \u0643\u0628\u062a \u0627\u0644\u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0645\u064a\u060c \u0648\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062e\u0628\u064a\u062b\u0629 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 (\u0623\u064a \u0627\u0644\u0634\u062e\u0635 \u0627\u0644\u0645\u0635\u0627\u0628 \u0628\u0627\u0644\u0641\u0639\u0644 \u0628\u0633\u0631\u0637\u0627\u0646 \u0642\u062f \u064a\u0635\u0627\u0628 \u0628\u0633\u0631\u0637\u0627\u0646 \u0622\u062e\u0631 \u0645\u062e\u062a\u0644\u0641)\u060c \u0648\u062a\u0633\u0645\u0645 \u0627\u0644\u0643\u0628\u062f\u060c \u0648\u062a\u0633\u0645\u0645 \u0627\u0644\u0642\u0644\u0628\u060c \u0648\u0643\u0628\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0634\u062f\u064a\u062f(33\u060c 34)<\/sup>. \u062a\u064f\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u062d\u0631\u062c\u0629 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0639\u0644\u0649 \u0627\u0644\u0641\u0626\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0629\u060c \u0645\u062b\u0644 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a.<\/span><\/p>\n

\u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0627\u0644\u062a\u064a \u062d\u062f\u062f\u0647\u0627 \u062e\u0637 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u0627\u0633\u062a\u0628\u0639\u062f\u062a \u0645\u0646 \u062e\u0637\u0648\u0629 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0623\u0648\u0644\u064a (\u0645\u062b\u0644 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u0627\u0648\u064a)\u060c \u064a\u0645\u0643\u0646 \u0627\u0644\u0627\u0637\u0644\u0627\u0639 \u0639\u0644\u064a\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0644\u062d\u0642 \u0644\u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0647\u0630\u0627 \u0627\u0644\u0645\u0644\u062d\u0642 \u064a\u064f\u0645\u0643\u0651\u0646 \u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u0648\u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0645\u0646 \u062a\u0642\u064a\u064a\u0645 \u062c\u0645\u064a\u0639 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0642\u0628\u0648\u0644\u0629 \u0645\u0646 \u0627\u0644\u0646\u0627\u062d\u064a\u0629 \u0627\u0644\u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a\u064b\u0629 \u0628\u0634\u0641\u0627\u0641\u064a\u0629\u060c \u0648\u062a\u0635\u0645\u064a\u0645 \u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u064f\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u064b\u0627 \u0644\u062a\u0642\u064a\u064a\u0645 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0648\u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0648\u0641\u0642\u064b\u0627 \u0644\u0627\u062d\u062a\u064a\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u062e\u0627\u0635\u0629\u060c \u0648\u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0645\u0633\u062a\u062c\u062f\u0629\u060c \u0648\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629.<\/span><\/p>\n

\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0628\u0639\u0636 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0627 \u064a\u0645\u0646\u0639 \u0645\u0646 \u0623\u062e\u0630\u0647\u0627 \u0641\u064a \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u0645\u0633\u062a\u0642\u0628\u0644\u064b\u0627. \u064a\u064f\u0630\u0643\u0631 \u0623\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0627\u0644\u062a\u064a \u0623\u064f\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0624\u062b\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0635\u0641\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 (\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0624\u062b\u0631 \u0645\u0646\u062a\u062c\u0627\u062a\u0647\u0627 \u0645\u0628\u0627\u0634\u0631\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u064a\u062b\u0644\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a) \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0623\u0648 \u0645\u0646\u062e\u0641\u0636\u0629 \u0627\u0644\u062c\u0631\u0639\u0629 \u0623\u0648 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u0624\u062e\u0630 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645\u060c \u0645\u062b\u0644 \u062f\u0648\u0627\u0621 \u062f\u064a\u0633\u064a\u062a\u0627\u0628\u064a\u0646 (decitabine)\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0631\u0628\u0627\u0639\u064a \u0647\u064a\u062f\u0631\u0648\u064a\u0648\u0631\u064a\u062f\u064a\u0646 (tetrahydrouridine) \u060c \u0643\u0627\u0646\u062a \u0646\u062a\u0627\u0626\u062c\u0647\u0627 \u0648\u0627\u0639\u062f\u0629\u060c \u062d\u064a\u062b \u0627\u0633\u062a\u064f\u062d\u062b \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 \u0627\u0644\u062c\u0646\u064a\u0646\u064a (HbF) \u0628\u062f\u0648\u0646 \u0645\u0634\u0643\u0644\u0627\u062a\u060c \u0648\u062d\u064f\u0633\u0651\u0646\u062a \u0645\u0642\u0627\u064a\u064a\u0633 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (\u062a\u0644\u0643 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u062a\u062a\u0628\u0639 \u0635\u062d\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u0648\u0634\u062f\u0651\u0629 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u062c\u0648\u062f\u0629 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646\u060c \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a) \u062f\u0648\u0646 \u0623\u0646 \u062a\u0633\u0628\u0628 \u062a\u062b\u0628\u064a\u0637\u064b\u0627 \u0645\u0639\u062a\u0628\u0631\u064b\u0627 \u0644\u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0645 (\u0644\u0625\u0646\u062a\u0627\u062c \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0648\u0627\u0644\u0628\u064a\u0636\u0627\u0621) \u0623\u0648 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0648\u064a \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 (\u0645\u062b\u0644\u064b\u0627\u060c \u0639\u062f\u0645 \u062a\u0645\u064a\u064a\u0632 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0648\u0627\u0644\u0635\u062d\u064a\u062d\u0629)(46).<\/sup> \u062a\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u062a\u0637\u0648\u0631\u0627\u062a \u0625\u0644\u0649 \u0623\u0646\u0647 \u064a\u0646\u0628\u063a\u064a \u0625\u0628\u0642\u0627\u0621 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0648\u064a \u0627\u0644\u0645\u0639\u064a\u0646\u0629\u060c \u0639\u0646\u062f \u062a\u062d\u0633\u064a\u0646 \u0633\u0644\u0627\u0645\u062a\u0647\u0627\u060c \u0641\u064a \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647\u0627 \u062c\u0627\u0646\u0628\u064b\u0627 \u0645\u0646 \u0627\u0644\u0645\u0634\u0647\u062f \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0627\u0644\u0623\u0648\u0633\u0639 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a – \u062e\u0627\u0635\u0629\u064b \u0641\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u064f\u0642\u0627\u0648\u0645\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0623\u0648 \u0627\u0644\u0634\u062f\u064a\u062f\u0629.<\/span><\/p>\n

\u0642\u064f\u0644\u0635\u062a \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0625\u0644\u0649 \u0639\u0634\u0631\u064a\u0646 \u062f\u0648\u0627\u0621\u064b \u0645\u0639\u062a\u0645\u062f\u064b\u0627\u060c \u0648\u0630\u0644\u0643 \u0644\u0642\u062f\u0631\u062a\u0647\u0627 \u0627\u0644\u0642\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0633\u062a \u062c\u064a\u0646\u0627\u062a \u062a\u064f\u0639\u062f\u0651\u0644 \u0623\u0646\u0645\u0627\u0637\u064b\u0627 \u0638\u0627\u0647\u0631\u064a\u0629\u064b \u0645\u064f\u062e\u062a\u0644\u0641\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (\u0648\u0647\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u063a\u064a\u0631 \u0623\u0648 \u062a\u0639\u062f\u0644 \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0645\u0631\u0636\u0649). \u062a\u064f\u0635\u0646\u0651\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u0631\u0634\u0651\u062d\u0629 \u0627\u0644\u0645\u064f\u062e\u062a\u0627\u0631\u0629 \u0625\u0644\u0649 \u0623\u062f\u0648\u064a\u0629 \u0645\u064f\u0639\u062f\u0651\u0644\u0629 \u0644\u0644\u062f\u0647\u0648\u0646 (\u062a\u0646\u0638\u0645 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062f\u0647\u0648\u0646) \u0648\u0623\u062e\u0631\u0649 \u0645\u064f\u0639\u062f\u0651\u0644\u0629 \u0644\u0644\u0645\u0646\u0627\u0639\u0629 (\u0645\u062b\u0628\u0637\u0629 \u0644\u0644\u0645\u0646\u0627\u0639\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0629)\u060c \u0645\u0639 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u0639\u062f\u064a\u0644 \u0645\u0633\u0627\u0631\u0627\u062a \u0645\u064f\u062a\u0639\u062f\u062f\u0629 \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0648\u0638\u064a\u0641\u0629 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u062f\u0645\u060c \u0648\u062a\u0645\u0646\u062c\u0644 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645(47)<\/sup>. \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u0639\u0627\u064a\u064a\u0631 \u0641\u0631\u064a\u062f\u0629.<\/span><\/p>\n

\u0646\u062a\u062c \u0645\u0646 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0635\u0641\u064a\u0629 \u0647\u0630\u0647 \u062e\u0645\u0633\u0629 \u0623\u062f\u0648\u064a\u0629 \u0648\u0627\u0639\u062f\u0629 \u062c\u062f\u064b\u0627 \u0648\u0645\u0631\u0634\u062d\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0647\u064a: [\u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 simvastatin \u0648\u0623\u0644\u0644\u0648\u0628\u0648\u0631\u064a\u0646\u0648\u0644allopurinol \u0648\u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628 canakinumab \u0648\u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a etanercept] – \u0648\u062c\u0645\u064a\u0639\u0647\u0627 \u0633\u0628\u0642 \u0623\u0646 \u062e\u0636\u0639\u062a \u0644\u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0635\u063a\u064a\u0631\u0629 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a – \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 (omalizumab). \u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0646\u062a\u0645\u064a \u0625\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0623\u062f\u0648\u064a\u0629 \u0633\u062a\u0627\u062a\u064a\u0646\u060c \u062a\u0645 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0623\u062f\u0648\u064a\u0629 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0646\u0641\u0633 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0623\u064a\u0636\u064b\u0627\u060c \u0645\u062b\u0644 \u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0628\u0631\u0627\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0641\u0644\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0631\u0648\u0632\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0628\u064a\u062a\u0627\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0648\u0627\u0644\u062a\u064a \u0643\u0627\u0646\u062a \u0646\u062a\u0627\u0626\u062c\u0647\u0627 \u0623\u064a\u0636\u064b\u0627 \u0648\u0627\u0639\u062f\u0629 \u0641\u064a \u0625\u062f\u0627\u0631\u0629 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u062e\u0635\u0627\u0626\u0635\u0647\u0627 \u0627\u0644\u0645\u064f\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a. <\/span><\/p>\n

\u062a\u064f\u062e\u0641\u0650\u0651\u0636 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0633\u062e (NF-KB) (\u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0645\u0639\u0632\u0632 \u0644\u0633\u0644\u0633\u0644\u0629 \u0643\u0627\u0628\u0627 (Kaba) \u0627\u0644\u062e\u0641\u064a\u0641\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u0627\u0626\u064a\u0629 \u0627\u0644\u0646\u0634\u0637\u0629 “NF-\u03baB”) \u0648\u062a\u064f\u062b\u0628\u0650\u0651\u0637 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0633\u0627\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u0629 \u0627\u0644\u0645\u064f\u0633\u0628\u0650\u0651\u0628\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0645\u062b\u0644 (TNF) \u0648(IL1B) \u060c \u0648\u062a\u064f\u062d\u0633\u0650\u0651\u0646 \u0648\u0638\u064a\u0641\u0629 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0644\u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 (NO) \u0648\u062a\u0642\u0644\u0644 \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 (\u0644\u0644\u062d\u062f \u0645\u0646 \u0627\u0644\u062a\u0635\u0627\u0642 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629)\u060c \u0645\u0645\u0627 \u062a\u064f\u0633\u0647\u0645 \u0645\u062c\u062a\u0645\u0639\u0629\u064b \u0641\u064a \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0648\u0642\u0627\u0626\u064a \u0644\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629(48\u060c 49)<\/sup>. \u0648\u0627\u0644\u062c\u062f\u064a\u0631 \u0628\u0627\u0644\u0630\u0643\u0631 \u0623\u0646 \u062a\u062c\u0631\u0628\u0629 \u062c\u0648\u0628\u064a\u062a\u0631 (JUPITER) (\u0627\u0644\u0623\u062d\u0631\u0641 \u0627\u0644\u0622\u0648\u0644\u0649 \u0644\u0627\u0633\u0645 \u0627\u0644\u062a\u062c\u0631\u0628\u0629: \u062a\u0628\u0631\u064a\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629: \u062a\u062c\u0631\u0628\u0629 \u062a\u062f\u062e\u0644\u064a\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u062a\u062c\u0631\u0628\u0629 \u062f\u0648\u0627\u0621 \u0631\u0648\u0632\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646)\u060c \u0623\u062b\u0628\u062a\u062a \u0642\u062f\u0631\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u064f\u0639\u064e\u062f\u0650\u0651\u0644\u0629 \u0644\u0644\u0645\u0646\u0627\u0639\u0629\u060c \u062d\u064a\u062b \u062e\u0641\u064e\u0651\u0636 \u062f\u0648\u0627\u0621 \u0627\u0644\u0631\u0648\u0632\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a (-C) \u0648\u064a\u0631\u0645\u0632 \u0644\u0647 \u0628\u0640 (CRP ) (\u0628\u0631\u0648\u062a\u064a\u0646 \u062a\u0646\u062a\u062c\u0647 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648\u064a\u0631\u062a\u0641\u0639 \u0645\u0633\u062a\u0648\u0627\u0647 \u0641\u064a \u0627\u0644\u062f\u0645 \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0627\u0635\u0627\u0628\u0627\u062a \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a\u060c \u0648\u064a\u0639\u062f \u0639\u0644\u0627\u0645\u0629 \u062d\u064a\u0648\u064a\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643) \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0628\u0646\u0633\u0628\u0629 \u062a\u0642\u0627\u0631\u0628 37%\u060c \u0645\u0645\u0627 \u064a\u064f\u0639\u0632\u0650\u0651\u0632 \u062f\u0648\u0631 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u062a\u062e\u0641\u064a\u0641 \u0645\u0646 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a(50)<\/sup>.<\/span><\/p>\n

\u0627\u0642\u062a\u064f\u0631\u062d \u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u0645\u0631\u0634\u062d\u064b\u0627 \u0645\u062b\u0627\u0644\u064a\u064b\u0627 \u0645\u0646 \u0628\u064a\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0644\u062a\u0641\u0648\u0642\u0647 \u0641\u064a \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0648\u0623\u0647\u0645\u064a\u062a\u0647 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629. \u0628\u064a\u0646\u0645\u0627 \u062a\u062a\u0641\u0627\u0639\u0644 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u0639 \u062c\u064a\u0646 (HLA-DRB1) \u0641\u0642\u0637\u060c \u0627\u0644\u0630\u064a \u064a\u064f\u0634\u0641\u0651\u0631 \u0628\u0631\u0648\u062a\u064a\u0646\u064b\u0627 \u0645\u0639\u0642\u062f\u0627\u064b \u0644\u0647 \u062f\u0648\u0631 \u0641\u064a \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0627\u0644\u0631\u0626\u064a\u0633 \u0639\u0646\u062f \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0623\u0639\u0636\u0627\u0621\u060c \u064a\u062a\u0641\u0627\u0639\u0644 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0628\u0634\u0643\u0644 \u0641\u0631\u064a\u062f \u0645\u0639 \u0643\u0644\u064d\u0651 \u0645\u0646 \u062c\u064a\u0646 (HLA-DRB1) \u0648\u062c\u064a\u0646 (HLA-G) \u0648\u064a\u064f\u0639\u062f\u0651 \u0647\u0630\u0627\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u0646 \u0623\u0633\u0627\u0633\u064a\u0627\u0646 \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u064f\u0641\u0627\u0642\u0645 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0645\u062b\u0644 \u0646\u0648\u0628\u0627\u062a \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0648\u0639\u0627\u0626\u064a \u0648\u062a\u0644\u0641 \u0627\u0644\u0623\u0639\u0636\u0627\u0621(51 – 53)<\/sup>. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u062b\u0628\u062a \u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0642\u062f\u0631\u0629 \u0623\u0639\u0644\u0649 \u0639\u0644\u0649 \u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0639\u0627\u0645\u0644 \u06a4\u0648\u0646 \u0648\u064a\u0644\u0628\u0631\u0627\u0646\u062f (vWF) (\u0633\u0644\u0633\u0644\u0629 \u0645\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 \u0633\u0643\u0631\u064a \u0645\u062a\u0639\u062f\u062f\u060c \u0648\u064a\u0639\u062f \u0639\u0627\u0645\u0644 \u062a\u062e\u062b\u0631)\u060c \u0645\u0645\u0627 \u064a\u064f\u0624\u0643\u062f \u062f\u0648\u0631\u0647 \u0627\u0644\u062d\u0627\u0633\u0645 \u0641\u064a \u0625\u062f\u0627\u0631\u0629 \u0641\u0631\u0637 \u0627\u0644\u062a\u062e\u062b\u0631 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629(54\u060c 55)<\/sup>.<\/span><\/p>\n

\u0623\u062b\u0628\u062a\u062a \u062f\u0631\u0627\u0633\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u064f\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0635\u063a\u064a\u0631\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (\u0639\u062f\u062f\u0647\u0645 26) \u0623\u0646 \u062a\u0646\u0627\u0648\u0644 \u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0642\u0635\u064a\u0631 \u062d\u0633\u0651\u0646 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0644\u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 \u0628\u0646\u0633\u0628\u0629 52% \u062a\u0642\u0631\u064a\u0628\u064b\u0627 (\u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 = 0.01\u060c \u0623\u064a \u0623\u0646 \u0647\u0646\u0627\u0643 \u0627\u062d\u062a\u0645\u0627\u0644 \u0645\u0642\u062f\u0627\u0631\u0647 1\u066a \u0628\u0623\u0646 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u062a\u064a \u062d\u0635\u0644 \u0639\u0644\u064a\u0647\u0627 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u062d\u062f\u062b\u062a \u0628\u0627\u0644\u0635\u062f\u0641\u0629 \u0623\u0648 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a\u060c \u0648\u0647\u0630\u0627 \u064a\u0639\u062a\u0628\u0631 \u062f\u0644\u064a\u0644\u064b\u0627 \u0642\u0648\u064a\u064b\u0627 \u063a\u064a\u0631 \u0645\u0628\u0627\u0634\u0631 \u0639\u0644\u0649 \u0635\u062d\u0629 \u0627\u0644\u0646\u062a\u064a\u062c\u0629) \u0648\u0627\u0646\u062e\u0641\u0636\u062a \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a-C (\u0648IL-6 (\u0625\u0646\u062a\u0631\u0644\u0648\u0643\u064a\u0646 – 6)\u060c \u0648\u0643\u0644\u0627\u0647\u0645\u0627 \u064a\u0639\u062a\u0628\u0631\u0627\u0646 \u0639\u0644\u0627\u0645\u062a\u0627\u0646 \u062d\u064a\u0648\u064a\u062a\u0627\u0646 \u0639\u0644\u0649 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0648\u0645\u0631\u062a\u0628\u0637\u0627\u0646 \u0628\u0627\u062d\u062a\u0645\u0627\u0644 \u0632\u064a\u0627\u062f\u0629 \u0636\u0639\u0641 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0641\u064a \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(56)<\/sup>. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0629 \u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0623\u064f\u062c\u0631\u064a\u062a \u0639\u0644\u0649 19 \u0645\u0631\u064a\u0636 \u0641\u0642\u0631 \u062f\u0645 \u0645\u0646\u062c\u0644\u064a \u0623\u0646 \u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0642\u0644\u0644 \u0645\u0646 \u062d\u062f\u0648\u062b \u0623\u0644\u0645 \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0648\u0639\u0627\u0626\u064a \u0628\u0646\u0633\u0628\u0629 85% (\u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 = 0.0003\u060c \u0645\u0645\u0627 \u064a\u062f\u0644 \u0639\u0644\u0649 \u0635\u062d\u0629 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0648\u0641\u0627\u0639\u0644\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621) \u0648\u0642\u0644\u0651\u0644 \u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0633\u0643\u0646\u0627\u062a \u0628\u0646\u0633\u0628\u0629 67% (\u0627\u0644\u0642\u064a\u0645\u0629 \u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 = 0.003).<\/span><\/p>\n

\u0643\u0645\u0627 \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a-C \u0641\u064a \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u0633\u064a\u0644\u064a\u0643\u062a\u064a\u0646 (E) \u0627\u0644\u0630\u0627\u0626\u0628 (s) \u0648\u062c\u0632\u064a\u0621 \u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 1 (sICAM-1) \u0648\u062c\u0632\u064a\u0621 \u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 3 (sICAM-3) \u0648\u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0645\u0639 \u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0623\u0643\u062b\u0631 \u0648\u0636\u0648\u062d\u064b\u0627 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0623\u062e\u0630\u0648\u0646 \u062f\u0648\u0627\u0621 \u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a \u064a\u0648\u0631\u064a\u0627 \u0628\u0627\u0644\u062a\u0632\u0627\u0645\u0646(56)<\/sup>. \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0630\u0643\u0648\u0631\u0629 \u062d\u0648\u0644 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u062a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0648\u0627\u0639\u062f \u0641\u064a \u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u0646\u0648\u0628\u0627\u062a \u0627\u0644\u0623\u0644\u0645 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646 \u0623\u062d\u062c\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0641\u064a \u062a\u0644\u0643 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0643\u0627\u0646\u062a \u0645\u062a\u0648\u0627\u0636\u0639\u0629 (\u062d\u064a\u062b \u0628\u0644\u063a \u0639\u062f\u062f \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0628\u064a\u0646 19 \u064826 \u0645\u0631\u064a\u0636\u0627 \u0641\u0642\u0637)\u060c \u0645\u0645\u0627 \u064a\u0624\u062b\u0631 \u0633\u0644\u0628\u064b\u0627 \u0641\u064a \u0631\u0635\u0627\u0646\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062a\u0639\u0645\u064a\u0645\u0647\u0627. \u0644\u0630\u0644\u0643\u060c \u064a\u0646\u0628\u063a\u064a \u0627\u0639\u062a\u0628\u0627\u0631 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0623\u0648\u0644\u064a\u0629\u060c \u0645\u0627 \u064a\u0628\u0631\u0631 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u062a\u062c\u0627\u0631\u0628 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0646\u0636\u0628\u0637\u0629 \u0628\u062d\u062c\u0645 \u0639\u064a\u0646\u0629 \u0639\u0627\u0644\u064d (\u0639\u062f\u062f \u0623\u0634\u062e\u0627\u0635 \u0643\u0627\u0641\u064a) \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0629 \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0628\u0634\u0643\u0644 \u0623\u0648\u0636\u062d.<\/span><\/p>\n

\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629 (\u062e\u0627\u0631\u062c \u0627\u0644\u062c\u0633\u0645) \u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u060c \u062d\u064a\u062b \u062a\u064f\u0628\u064a\u0646 \u0623\u0646 \u0632\u064a\u0627\u062f\u0629\u064b \u0628\u0645\u0642\u062f\u0627\u0631 1.9 \u0636\u0639\u0641 \u0641\u064a \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 \u0627\u0644\u062c\u0646\u064a\u0646\u064a \u0648\u0627\u0646\u062e\u0641\u0627\u0636\u064b\u0627 \u0628\u0646\u0633\u0628\u0629 30%-35% \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0628\u0642\u0649 \u0645\u062a\u0645\u0646\u062c\u0644\u0629 \u0648\u0644\u0627 \u064a\u0645\u0643\u0646 \u0625\u0635\u0644\u0627\u062d\u0647\u0627 \u0641\u064a \u0638\u0644 \u0646\u0642\u0635 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646(57)<\/sup>. \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0631\u0635\u064a\u0646\u0629 \u0648\u0627\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0645\u062d\u062f\u062f\u0629\u060c \u0646\u0648\u0635\u064a \u0628\u062f\u0631\u0627\u0633\u0629 \u0625\u0643\u0644\u064a\u0646\u064a\u0643\u064a\u0629 \u0644\u062a\u0623\u0643\u064a\u062f \u0641\u0648\u0627\u0626\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u062f\u0648\u0627\u0621\u064b \u0645\u062b\u0627\u0644\u064a\u064b\u0627 \u0645\u0642\u062a\u0631\u062d\u0627 \u0641\u064a \u0639\u0644\u0627\u062c \u062d\u0627\u0644\u0627\u062a \u062f\u0627\u0621 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0645\u0639 \u0623\u0646 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647\u0627 \u0641\u0648\u0627\u0626\u062f \u0623\u064a\u0636\u064b\u0627\u060c \u0648\u0630\u0644\u0643 \u0628\u062d\u0633\u0628 \u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0631\u064a\u0636. \u064a\u062a\u0637\u0644\u0628 \u0627\u0644\u0623\u0645\u0631 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0639\u0634\u0627\u0629 \u0648\u0627\u0633\u0639\u0629 \u0627\u0644\u0646\u0637\u0627\u0642 \u0648\u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649\u060c \u0644\u062a\u0648\u0636\u064a\u062d \u0627\u0644\u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0628\u0634\u0643\u0644 \u0643\u0627\u0645\u0644 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0633\u064a\u0627\u0642.<\/span><\/p>\n

[\u0643\u0644\u0645\u0629 ‘\u0645\u0639\u0634\u0627\u0629’ \u0627\u0644\u0648\u0627\u0631\u062f\u0629 \u0641\u064a \u0627\u0644\u062c\u0645\u0644\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u062a\u0639\u0646\u064a \u0645\u0627 \u064a\u0644\u064a: \u062a\u064f\u0628\u0631\u0632 \u062f\u0631\u0627\u0633\u0629 \u0645\u0635\u0645\u0645\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u0629 \u0623\u0648 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u060c \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0648\u0627\u062d\u062f\u0629 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0623\u064a \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u062a\u062d\u064a\u0632. \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u062a\u0635\u0645\u064a\u0645\u060c \u062a\u062a\u0644\u0642\u0649 \u0625\u062d\u062f\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a (\u062f\u0648\u0627\u0621) \u0642\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0628\u064a\u0646\u0645\u0627 \u062a\u062a\u0644\u0642\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0639\u0644\u0627\u062c\u064b\u0627 \u0628\u062f\u064a\u0644\u064b\u0627\u060c \u0623\u0648 \u062f\u0648\u0627\u0621\u064b \u0648\u0647\u0645\u064a\u064b\u0627].<\/span><\/p>\n

\u062a\u0641\u064a\u062f \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u062a\u0631\u0627\u0643\u0645\u0629 \u0628\u0623\u0646 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a (\u0645\u062b\u0644 \u062f\u0648\u0627\u0626\u064a \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0648\u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646) \u0623\u0646 \u0644\u0647\u0627 \u0641\u0648\u0627\u0626\u062f \u0645\u0639\u062a\u0628\u0631\u0629 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647\u0627 \u0639\u0644\u0627\u062c\u064b\u0627 \u0644\u062f\u0627\u0621 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0639\u0645\u0648\u0645\u064b\u0627\u060c \u0628\u0623\u0639\u0631\u0627\u0636 \u062c\u0627\u0646\u0628\u064a\u0629 \u062e\u0641\u064a\u0641\u0629\u060c \u0648\u0645\u062a\u0648\u0642\u0639\u0629\u060c \u0648\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0625\u062f\u0627\u0631\u0629\u060c \u0648\u0627\u0644\u062a\u062d\u0645\u0644. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u062a\u0648\u0627\u0641\u0631 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639\u060c \u0648\u0628\u0623\u0633\u0639\u0627\u0631 \u0645\u0639\u0642\u0648\u0644\u0629\u060c \u0648\u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0632\u0644\u064a \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f\u060c \u062d\u064a\u062b \u0623\u0646 \u0645\u0646\u0627\u0641\u0639\u0647\u0627 \u062a\u0641\u0648\u0642 \u0643\u062b\u064a\u0631\u064b\u0627 \u0645\u0636\u0627\u0631\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0623\u0645\u062f \u0627\u0644\u0637\u0648\u064a\u0644(56)<\/sup>. \u0645\u0646 \u0627\u0644\u0623\u0645\u0648\u0631 \u0627\u0644\u062a\u064a \u064a\u0646\u0628\u063a\u064a \u0645\u0644\u0627\u062d\u0638\u062a\u0647\u0627 \u0647\u064a \u0623\u0646 \u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a\u060c \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0646\u062f\u0631\u062a\u0647 \u0639\u0645\u0648\u0645\u064b\u0627\u060c \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647 \u0623\u0647\u0645\u064a\u0629 \u0645\u062a\u0632\u0627\u064a\u062f\u0629 \u0641\u064a \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0643\u0644\u0648\u064a\u0629 \u0623\u0648 \u0627\u0644\u0643\u0628\u062f\u064a\u0629 \u0627\u0644\u0645\u0635\u0627\u062d\u0628\u0629 \u0644\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(58)<\/sup>. <\/span><\/p>\n

\u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0647\u064a\u0643\u0644\u064a \u0644\u062f\u0627\u0621 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0642\u062f \u064a\u0639\u064a\u0642 \u0627\u0644\u0643\u0634\u0641 \u0627\u0644\u0645\u0628\u0643\u0631 \u0639\u0646 \u0633\u0645\u064a\u0629 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629. \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0644\u0645 \u062a\u0644\u0627\u062d\u0638 \u0627\u0639\u062a\u0644\u0627\u0644\u064b\u0627 \u0639\u0636\u0644\u064a\u064b\u0627 \u0632\u0627\u0626\u062f\u064b\u0627\u060c \u0625\u0644\u0627 \u0623\u0646 \u0623\u062d\u062c\u0627\u0645 \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0648\u0645\u062f\u0629 \u0627\u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u0643\u0627\u0646\u062a \u0645\u062d\u062f\u0648\u062f\u0629(56)<\/sup>. \u0644\u0630\u0644\u0643\u060c \u0646\u0648\u0635\u064a \u0628\u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0631\u0648\u062a\u064a\u0646\u064a\u0629 \u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0625\u0646\u0632\u064a\u0645 \u0643\u0627\u064a\u0646\u064a\u0632 \u0627\u0644\u0643\u0631\u064a\u0627\u062a\u064a\u0646 (creatine kinase) \u0641\u064a \u0627\u0644\u062f\u0645 (\u0644\u0644\u0643\u0634\u0641 \u0639\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0635\u0627\u0628\u0627\u062a \u0642\u0630 \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u064a \u0623\u0648 \u0625\u0636\u0631\u0627\u0631 \u0628\u0627\u0644\u0642\u0644\u0628) \u0648\u0627\u0644\u0646\u0638\u0631 \u0641\u064a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0651\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 (\u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a (SLCO1B1) \u0648\u0647\u0648 \u062c\u064a\u0646 \u064a\u0639\u0637\u064a \u0627\u0644\u0643\u0628\u062f \u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0644\u062a\u062e\u0644\u064a\u0642 \u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u062a\u0646\u0638\u064a\u0641 \u0627\u0644\u062c\u0633\u0645 \u0645\u0646 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0648\u062e\u0627\u0635\u0629 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a) \u0644\u0644\u062a\u062e\u0641\u064a\u0641 \u0645\u0646 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0648\u062a\u062e\u0635\u064a\u0635 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0644\u0634\u062e\u0635 \u0627\u0644\u0645\u0646\u0627\u0633\u0628(59)<\/sup>.<\/span><\/p>\n

\u0645\u0646 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644\u060c \u0627\u0644\u0630\u064a \u064a\u0633\u062a\u0647\u062f\u0641 \u0646\u0648\u0627\u062a\u062c \u062c\u064a\u0646 (NOTCH4) \u0648\u064a\u0646\u062a\u0645\u064a \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0625\u0644\u0649 \u0639\u0627\u0626\u0644\u0629 (NOTCH) \u0648\u0647\u0648 \u0645\u0639\u0631\u0648\u0641 \u0628\u062f\u0648\u0631\u0647 \u0641\u064a \u062a\u0646\u0638\u064a\u0645 \u0648\u0638\u064a\u0641\u0629 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0648\u0644\u0647 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631\u0647 \u0641\u064a \u062a\u0643\u0648\u0651\u0650\u0646 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0648\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u062f\u0645\u060c \u0648\u0643\u0644 \u0630\u0644\u0643 \u0642\u062f \u064a\u064f\u0633\u0647\u0645 \u0641\u064a \u062a\u062e\u0641\u064a\u0641 \u0634\u062f\u0629 \u0627\u0644\u0645\u0631\u0636(60\u060c 61)<\/sup>. \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646\u060c \u062a\u0639\u0631\u0641\u0646\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u062a\u063a\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0631\u0642\u0645 (rs3132946). \u0648\u062a\u0634\u064a\u0631 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0644\u0649 \u062a\u0639\u062f\u062f \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0645\u0641\u0631\u062f\u0629 \u0627\u0644\u0645\u0642\u062a\u0631\u0646\u0629 \u0628\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0641\u064a \u062c\u064a\u0646 (NOTCH4). \u0627\u0644\u0645\u062a\u063a\u064a\u0631 (rs3132946) \u0633\u0628\u0642 \u0627\u0643\u062a\u0634\u0627\u0641\u0647 \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u0639\u0644\u0627\u0645\u0629 \u062d\u064a\u0648\u064a\u0629 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0631\u0626\u0629 \u0627\u0644\u062e\u0644\u0627\u0644\u064a\u0629 (ILD ) (\u0623\u0645\u0631\u0627\u0636 \u062a\u0635\u064a\u0628 \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u062e\u0644\u0627\u0644\u064a \u0627\u0644\u0631\u0626\u0648\u064a)(62)<\/sup>.<\/span><\/p>\n

\u062a\u064f\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0629 \u0634\u0627\u0626\u0639\u0629 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u062d\u064a\u062b \u0638\u0647\u0631 \u0639\u0644\u0649 74\u066a\u061c \u0645\u0646 \u0627\u0644\u0631\u0627\u0634\u062f\u064a\u0646 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u062d\u0634\u062f\u064a\u0629 (\u0648\u064a\u0637\u0644\u0642 \u0639\u0644\u064a\u0647\u0627 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0639\u0631\u0636\u060c \u0648\u062a\u062a\u0645\u064a\u0632 \u0628\u0623\u0646\u0647\u0627 \u062a\u062d\u062a\u0627\u062c \u0639\u064a\u0646\u0629 \u0643\u0628\u064a\u0631\u0629 \u0648\u0623\u0646\u0647\u0627 \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0648\u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0623\u0645\u062f) \u0644\u0645\u0631\u0636\u0649 \u0630\u0648\u064a \u0646\u0645\u0637 \u062a\u0642\u064a\u064a\u062f\u064a \u0641\u064a \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0631\u0626\u0629 (\u062d\u064a\u062b \u0644\u0627 \u062a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0631\u0626\u062a\u0627\u0646 \u0627\u0644\u0627\u0645\u062a\u0644\u0627\u0621 \u0628\u0627\u0644\u0647\u0648\u0627\u0621 \u0646\u0638\u0631\u064b\u0627 \u0644\u062d\u062c\u0645\u0647\u0645\u0627 \u0627\u0644\u0635\u063a\u064a\u0631)(63)<\/sup>. \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0634\u062a\u0631\u0643\u0629 \u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0631\u0626\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a (\u0623\u064a \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u0647\u064a \u0645\u0646 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a) \u0644\u0627 \u062a\u0638\u0647\u0631 \u0639\u0644\u0649 \u0643\u0644 \u0627\u0644\u0631\u0627\u0634\u062f\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0625\u0644\u0627 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062a\u0642\u064a\u064a\u062f\u064a \u064a\u0628\u0642\u0649 \u0645\u0633\u062a\u0645\u0631\u064b\u0627 \u0641\u064a \u0627\u0644\u0638\u0647\u0648\u0631 \u0633\u0631\u064a\u0631\u064a\u064b\u0627 \u0628\u0646\u0641\u0633 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0648\u0639\u0644\u0649 \u0646\u0641\u0633 \u0627\u0644\u0645\u0646\u0648\u0627\u0644\u060c \u0645\u0645\u0627 \u064a\u0624\u0643\u062f \u062a\u0623\u062b\u064a\u0631\u0647 \u0627\u0644\u0645\u0639\u062a\u0628\u0631 \u0625\u062d\u0635\u0627\u0626\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a.<\/span><\/p>\n

\u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644\u060c \u0648\u0647\u0648 \u0645\u062b\u0628\u0637 \u0625\u0646\u0632\u064a\u0645 \u0623\u0648\u0643\u0633\u064a\u062f\u064a\u0632 \u0627\u0644\u0632\u0627\u0646\u062b\u064a\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 (\u0623\u064a \u064a\u062e\u0641\u0636 \u0646\u0634\u0627\u0637\u0647)\u060c \u0648\u0627\u0644\u0630\u064a \u0627\u0633\u062a\u064f\u062e\u062f\u0645 \u0644\u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629 \u0644\u0639\u0644\u0627\u062c \u0641\u0631\u0637 \u062d\u0645\u0636 \u064a\u0648\u0631\u064a\u0643 \u0627\u0644\u062f\u0645 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0646\u0642\u0631\u0633 \u0623\u0648 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0646\u062d\u0644\u0627\u0644 \u0627\u0644\u0648\u0631\u0645 (\u062a\u062d\u062f\u062b \u0639\u0646\u062f \u062a\u062f\u0645\u064a\u0631 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0628\u0633\u0631\u0639\u0629 \u0648\u0627\u0646\u062a\u0634\u0627\u0631 \u0645\u062d\u062a\u0648\u064a\u0627\u062a\u0647\u0627 \u0641\u064a \u0627\u0644\u062f\u0645)(64)<\/sup>\u060c \u0623\u0638\u0647\u0631 \u0641\u0648\u0627\u0626\u062f \u0648\u0639\u0627\u0626\u064a\u0629 \u0623\u0648\u0633\u0639. \u0625\u0630 \u064a\u0645\u0643\u0646\u0647 \u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0645\u0646 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a \u0648\u0625\u0635\u0627\u0628\u0627\u062a \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0631\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0643\u0631\u0631\u0629 (\u064a\u062d\u062f\u062b \u0639\u0646\u062f\u0645\u0627 \u064a\u062a\u062f\u0641\u0642 \u0627\u0644\u062f\u0645 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0628\u0639\u062f \u0646\u0642\u0635 \u0627\u0644\u062a\u0631\u0648\u064a\u0629 \u0623\u0648 \u0646\u0642\u0635 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646)\u060c \u0648\u0643\u0644\u0627\u0647\u0645\u0627 \u0639\u0646\u0635\u0631\u0627\u0646 \u0623\u0633\u0627\u0633\u064a\u0627\u0646 \u0641\u064a \u0623\u0645\u0631\u0627\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(65)<\/sup>. \u0648\u0628\u062a\u062b\u0628\u064a\u0637 \u0625\u0646\u062a\u0627\u062c \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a (ROS) \u064a\u062d\u0627\u0641\u0638 \u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0641\u0631 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0644\u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643\u060c \u0645\u0645\u0627 \u064a\u062f\u0639\u0645 \u0627\u0633\u062a\u0631\u062e\u0627\u0621 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0648\u0648\u0638\u064a\u0641\u062a\u0647\u0627(66)<\/sup>. <\/span><\/p>\n

\u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0644\u0649 \u0646\u0645\u0627\u0630\u062c \u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0645\u0635\u0627\u0628\u0629 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0646\u062a\u0627\u0626\u062c \u0645\u062a\u0628\u0627\u064a\u0646\u0629\u061b \u0641\u0628\u064a\u0646\u0645\u0627 \u0644\u0645 \u062a\u064f\u0634\u0631 \u0625\u062d\u062f\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0623\u064a \u062a\u0623\u062b\u064a\u0631 \u064a\u064f\u0630\u0643\u0631 \u0639\u0644\u0649 \u0627\u0644\u062a\u0635\u0627\u0642 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 (\u0625\u0645\u0627 \u0628\u0628\u0639\u0636\u0647\u0627\u060c \u0623\u0648 \u0628\u0633\u0637\u062d\u060c \u0623\u0648 \u063a\u0634\u0627\u0621)\u060c \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u062a\u062d\u0633\u0646\u064b\u0627 \u0641\u064a \u062a\u062f\u0641\u0642 \u0627\u0644\u062f\u0645 \u0648\u0627\u0646\u062e\u0641\u0627\u0636\u064b\u0627 \u0641\u064a \u062a\u062d\u0634\u064a\u062f \u0643\u0631\u064a\u0627\u062a \u0627\u0644\u062f\u0645 \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0639\u0646\u062f \u0627\u0644\u062a\u0639\u0631\u0636 \u0625\u0644\u0649 (\u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0640) \u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644(67\u061b 68)<\/sup>. \u0646\u0638\u0631\u064b\u0627 \u0644\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a \u0648\u062e\u0644\u0644 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0641\u0625\u0646 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u062d\u0648\u0644 \u0627\u0644\u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644\u060c \u0648\u062e\u0627\u0635\u0629\u064b \u0639\u0646\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0645\u0639 \u0623\u062f\u0648\u064a\u0629 \u0623\u062e\u0631\u0649\u060c \u0623\u0645\u0631\u064c \u0636\u0631\u0648\u0631\u064a. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0622\u062b\u0627\u0631\u0647 (\u0623\u0639\u0631\u0627\u0636\u0647) \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0648\u0631\u062f\u0648\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0634\u062f\u064a\u062f\u0629 \u0627\u0644\u0646\u0627\u062f\u0631\u0629\u060c \u0623\u0645\u0631\u064c \u0628\u0627\u0644\u063a \u0627\u0644\u0623\u0647\u0645\u064a\u0629. \u062d\u062a\u0649 \u0641\u064a \u0627\u0644\u0645\u062c\u062a\u0645\u0639\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0627 \u064a\u0646\u062a\u0634\u0631 \u0641\u064a\u0647\u0627 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0637\u0641\u0631\u0629 (HLA-B*5801)\u060c \u0648\u0647\u0648 \u0645\u0636\u0627\u062f \u0645\u0646 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0643\u0631\u064a\u0627\u062a \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 (HLA) \u0627\u0644\u0645\u0647\u0645\u0629 \u0641\u064a \u0639\u0644\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u060c \u062a\u0631\u062a\u0628\u0637 \u0647\u0630\u0647 \u0627\u0644\u0637\u0641\u0631\u0629 \u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0628\u0632\u064a\u0627\u062f\u0629 \u0627\u062d\u062a\u0645\u0627\u0644 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0644\u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 \u0627\u0644\u0634\u062f\u064a\u062f\u0629(69)<\/sup>. \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0643\u0648\u0646 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 (HLA-B*5801) \u0642\u062f \u064a\u0633\u0627\u0639\u062f \u0641\u064a \u0627\u0644\u062a\u062e\u0641\u064a\u0641 \u0645\u0646 \u062e\u0637\u0631 \u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0628\u0633\u0628\u0628 \u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 \u0639\u0646\u062f \u0648\u0635\u0641\u0647 \u0644\u0644\u0645\u0631\u064a\u0636(70)<\/sup>.<\/span><\/p>\n

\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u0642\u0629 (\u0645\u062b\u0644 \u0623\u062f\u0648\u064a\u0629 \u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628\u060c \u0648\u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628\u060c \u0648\u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a) \u062a\u062a\u0637\u0644\u0628 \u062d\u064f\u0642\u0646\u064b\u0627 \u0645\u0646\u062a\u0638\u0645\u0629 \u0648\u062a\u0643\u0644\u0641\u062a\u0647\u0627 \u0627\u0644\u0645\u0627\u0644\u064a\u0629 \u0639\u0627\u0644\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u0623\u062b\u0628\u062a\u062a \u0633\u0644\u0627\u0645\u062a\u0647\u0627 \u0648\u0641\u0639\u0627\u0644\u064a\u062a\u0647\u0627 \u0641\u064a \u062e\u0641\u0636 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0648\u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u062d\u0627\u062f\u0629 \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0623\u0645\u0627 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629\u060c \u0645\u062b\u0644 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0627\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u062f\u0648\u0649\u060c \u0641\u0647\u0630\u0647 \u0627\u0644\u0623\u062b\u0627\u0631 \u064a\u0645\u0643\u0646 \u0625\u062f\u0627\u0631\u062a\u0647\u0627 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645\u060c \u0648\u0646\u0641\u0639 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0641\u064a \u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062d\u0627\u062f\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0645\u0639\u064a\u0646\u0629 \u062a\u0639\u062a\u0628\u0631 \u0623\u0639\u0644\u0649 \u0645\u0646 \u0636\u0631\u0631\u0647\u0627 \u0628\u0643\u062b\u064a\u0631(71)<\/sup>. <\/span><\/p>\n

\u0648\u0642\u062f \u062a\u0628\u064a\u0646 \u0628\u0639\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0623\u0646 \u0633\u0644\u0627\u0645\u062a\u0647\u0627 \u0645\u0642\u0628\u0648\u0644\u0629 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u0643\u0632 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0627\u0644\u062a\u064a \u064a\u0642\u062f\u0645 \u0641\u064a\u0647\u0627 \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0645\u062b\u0644 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u064a\u0627\u062a \u0648\u0627\u0644\u0639\u064a\u0627\u062f\u0627\u062a\u060c \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u062d\u0627\u0644\u0627\u062a \u0641\u0631\u0637 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0623\u062e\u0631\u0649\u060c \u062f\u0648\u0646 \u0645\u0644\u0627\u062d\u0638\u0629 \u0623\u064a \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u062e\u0637\u064a\u0631\u0629(72)<\/sup>. \u0648\u0642\u062f \u0627\u0639\u062a\u0645\u062f\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u062f\u0648\u0627\u0621 \u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u0641\u064a \u0627\u0644\u0628\u062f\u0627\u064a\u0629 \u0639\u0627\u0645 2003 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0631\u0628\u0648 \u0627\u0644\u0645\u0632\u0645\u0646 \u0627\u0644\u0630\u064a \u064a\u062a\u0631\u0627\u0648\u062d \u0641\u064a \u0627\u0644\u0634\u062f\u0629 \u0645\u0646 \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0625\u0644\u0649 \u0627\u0644\u062d\u0627\u062f\u060c \u062b\u0645 \u0628\u0639\u062f \u0630\u0644\u0643 \u0648\u0633\u0639\u062a \u0646\u0637\u0627\u0642 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0644\u0627\u062d\u0642\u0629(73)<\/sup>. \u0648\u0642\u062f \u0628\u0631\u0632 \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0627\u0644\u0630\u064a \u064a\u0633\u062a\u0647\u062f\u0641 \u0646\u0648\u0627\u062a\u062c \u062c\u064a\u0646 (FCER1A)\u060c \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647 \u0623\u062d\u062f \u0623\u0628\u0631\u0632 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645. \u0647\u0630\u0627 \u0627\u0644\u063a\u0644\u0648\u0628\u064a\u0648\u0644\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0645\u064f\u0624\u062a\u0644\u0641 G (IgG) \u0647\u0648 \u062c\u0633\u0645 \u0645\u0636\u0627\u062f \u0648\u062d\u064a\u062f \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u064a\u0631\u062a\u0628\u0637 \u0627\u0646\u062a\u0642\u0627\u0626\u064a\u064b\u0627 \u0628\u0640 \u0627\u0644\u063a\u0644\u0648\u0628\u064a\u0648\u0644\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a (IgE) \u0627\u0644\u062d\u0631 (\u063a\u064a\u0631 \u0627\u0644\u0645\u0624\u062a\u0644\u0641)\u060c \u0645\u0627 \u0645\u0646 \u0634\u0623\u0646\u0647 \u0623\u0646 \u064a\u064f\u062e\u0641\u0641 \u0645\u0646 \u062d\u062f\u0629 \u0627\u0644\u0631\u0628\u0648 \u0627\u0644\u062a\u062d\u0633\u0633\u064a.<\/span><\/p>\n

\u0648\u0630\u0644\u0643 \u0628\u0645\u0646\u0639 (IgE) \u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0645\u0639 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a (Fc\u03b5) \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u0644\u0641\u0629 (\u0627\u0644\u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u062a\u0648\u0633\u0637 \u0641\u064a \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062a\u062d\u0633\u0633\u064a\u0629 \u0648\u0630\u0644\u0643 \u0628\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0640 (Fc) \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u063a\u0644\u0648\u0628\u064a\u0648\u0644\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a E (IgE) \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0633\u062a\u0641\u062d\u0644\u0629 (\u0627\u0644\u062a\u064a \u062a\u0633\u062a\u062c\u064a\u0628 \u0625\u0644\u0649 \u0645\u062b\u064a\u0631 \u0645\u0627)\u060c \u0645\u062b\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u062f\u064a\u0646\u0629 (\u062e\u0644\u0627\u064a\u0627 \u0645\u0646\u0627\u0639\u064a\u0629 \u062a\u0648\u062c\u062f \u0641\u064a \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u0636\u0627\u0645). \u064a\u064f\u0639\u062f\u0644 \u062f\u0648\u0627\u0621 \u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u064f\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0644\u062a\u0647\u0627\u0628 \u0642\u0635\u0628\u0629 \u0627\u0644\u0647\u0648\u0627\u0621\u060c \u0648\u0642\u062f \u064a\u064f\u062d\u062f \u0623\u064a\u0636\u064b\u0627 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u062a\u062e\u062b\u0631 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0646\u0634\u0627\u0637 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(74)<\/sup>.<\/span><\/p>\n

\u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646\u060c \u062a\u0645 \u0627\u0644\u0643\u0634\u0641 \u0639\u0646 \u0645\u062a\u063a\u064a\u0631 (rs2494250) \u0641\u064a \u062c\u064a\u0646 (FCER1A)\u060c \u0648\u0642\u062f \u0630\u0643\u0631 \u0633\u0627\u0628\u0642\u064b\u0627 \u0627\u0642\u062a\u0631\u0627\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u062a\u063a\u064a\u0631 \u0628\u0634\u0643\u0644 \u0645\u0639\u062a\u0628\u0631 \u0627\u062d\u0635\u0627\u0626\u064a\u064b\u0627 \u0628\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 (CCL2\/MCP-1) (\u0631\u0628\u064a\u0637\u0629 \u0627\u0644\u0643\u064a\u0645\u0648\u0643\u064a\u0646 2 \/ \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062c\u0630\u0628 \u0627\u0644\u0643\u064a\u0645\u0627\u0626\u064a \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u062d\u064a\u062f\u0629-1\u060c \u0648\u064a\u0639\u062a\u0628\u0631 \u0639\u0627\u0645\u0644\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0641\u064a \u062a\u062d\u0634\u064a\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u060c \u0644\u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628)(75)<\/sup>. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u0641\u0627\u062f\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0628\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0639\u062f\u0644 \u0627\u0646\u062a\u0634\u0627\u0631 (IgE) \u0628\u064a\u0646 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0632\u064a\u062f \u0645\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0635\u062f\u0631 \u0627\u0644\u062d\u0627\u062f\u0629 (ACS) \u0648\u0627\u0644\u062a\u064a \u0645\u0646\u0647\u0627 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u062d\u0627\u062f\u0629 \u0648\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u062e\u0631\u062c \u0627\u0644\u0635\u062f\u0631 \u0648\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0645\u0633\u0643\u0629 \u0627\u0644\u0628\u0631\u0643\u064a\u0629). \u062a\u062c\u062f\u0631 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u0625\u0644\u0649 \u0623\u0646 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0635\u062f\u0631 \u0627\u0644\u062d\u0627\u062f\u0629 \u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 25% \u0645\u0646 \u062d\u0627\u0644\u0627\u062a \u062f\u062e\u0648\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u062d\u062f\u0627\u062a \u0627\u0644\u0639\u0646\u0627\u064a\u0629 \u0627\u0644\u0645\u0631\u0643\u0632\u0629 \u064828.5% \u0645\u0646 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0628\u064a\u0646 \u0645\u0631\u0636\u0649 \u062f\u0627\u0621 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0628\u062a\u0633\u062c\u064a\u0644 \u0645\u0639\u062f\u0644\u0627\u062a \u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0635\u0627\u0628\u0629 \u0628\u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0628\u0634\u0643\u0644 \u062e\u0627\u0635 \u0644\u062f\u0649 \u0623\u0641\u0631\u0627\u062f \u0645\u0646 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0623\u062d\u0633\u0627\u0621(76 – 78)<\/sup>. \u064a\u0644\u0632\u0645 \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0644\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0641\u0648\u0627\u0626\u062f \u062f\u0648\u0627\u0621 \u0623\u0648\u0645\u0627\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u0641\u064a \u0627\u0644\u062d\u062f \u0645\u0646 \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636.<\/span><\/p>\n

\u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u062e\u0636\u0639 \u062f\u0648\u0627\u0621 \u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628 (canakinumab) \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 49 \u0637\u0641\u0644\u0627\u064b \u0648\u0634\u0627\u0628\u0627\u064b \u0645\u0635\u0627\u0628\u0627\u064b \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u062d\u062f\u064a\u062b\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0648\u0645\u0639\u0634\u0627\u0629(12\u060c 72)<\/sup>. \u0648\u0642\u062f \u0623\u062b\u0628\u062a \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0633\u062a\u0648\u0649 \u0623\u0645\u0627\u0646 \u0645\u0642\u0628\u0648\u0644\u0627\u064b\u060c \u0628\u0639\u0643\u0633 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u062a\u064a \u063a\u0627\u0644\u0628\u0627\u064b \u0645\u0627 \u062a\u0642\u062a\u0631\u0646 \u0628\u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u062f\u0648\u0649(80\u060c 81)<\/sup>. \u0648\u0631\u063a\u0645 \u0623\u0646 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u0639\u0634\u0627\u0629 \u0648\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u062f\u0648\u0627\u0621 \u0648\u0647\u0645\u064a (\u0628\u0644\u0627\u0633\u064a\u0628\u0648) \u0644\u062f\u0648\u0627\u0621 \u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628 \u0639\u0644\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0627\u0644\u0634\u0628\u0627\u0628 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0644\u0645 \u062a\u062d\u0642\u0642 \u0647\u062f\u0641\u0647\u0627 \u0627\u0644\u0631\u0626\u064a\u0633 \u0627\u0644\u0645\u062a\u0645\u062b\u0644 \u0641\u064a \u062e\u0641\u0636 \u062d\u062f\u0629 \u0627\u0644\u0623\u0644\u0645 \u0627\u0644\u064a\u0648\u0645\u064a \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u062d\u0627\u0644\u0629 \u0628\u062f\u0648\u0646 \u0639\u0644\u0627\u062c\u060c \u0641\u0642\u062f \u0623\u062b\u0628\u062a\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0641\u0648\u0627\u0626\u062f \u0645\u0645\u0643\u0646\u0629. \u0648\u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062a\u062d\u062f\u064a\u062f\u060c \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629\u060c \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0639\u062f\u0644\u0627\u062a \u062f\u062e\u0648\u0644 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649\u060c \u0648\u062a\u062d\u0633\u0646 \u0641\u064a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u064a \u0623\u0628\u0644\u063a \u0639\u0646\u0647\u0627 \u0627\u0644\u0645\u0631\u0636\u0649 \u0630\u0627\u062a\u064a\u064b\u0627\u060c \u0645\u062b\u0644 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062a\u0639\u0628 \u0648\u0627\u0644\u0625\u0631\u0647\u0627\u0642 \u0648\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0648 \u0627\u0644\u0639\u0645\u0644 (\u0639\u062f\u0645 \u0627\u0644\u062a\u063a\u064a\u0628 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644 \u0623\u0648 \u0627\u0644\u062f\u0631\u0627\u0633\u0629).<\/span><\/p>\n

\u062a\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646\u0647 \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0639\u062f\u0645 \u062a\u062d\u0642\u064a\u0642 \u0647\u062f\u0641 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u062a\u0645\u062b\u0644 \u0641\u064a \u062e\u0641\u0636 \u062d\u062f\u0629 \u0644\u0644\u0623\u0644\u0645\u060c \u0625\u0644\u0627 \u0623\u0646 \u062f\u0648\u0627\u0621 \u0643\u0627\u0646\u0627\u0643\u064a\u0646\u0648\u0645\u0627\u0628 \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647 \u0641\u0648\u0627\u0626\u062f \u0623\u062e\u0631\u0649 \u0641\u064a \u0625\u062f\u0627\u0631\u0629 \u062c\u0648\u0627\u0646\u0628 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0644\u0643\u0646 \u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0644\u062a\u0623\u0643\u064a\u062f \u062c\u062f\u0648\u0627\u0647 \u0645\u0646 \u0627\u0644\u0646\u0627\u062d\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (\u0645\u062f\u0649 \u0641\u0627\u0626\u062f\u0629 \u0627\u0644\u0641\u062d\u0635 \u0623\u0648 \u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0641\u064a \u062a\u062d\u0633\u064a\u0646 \u0635\u062d\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u0648\u0627\u0644\u0627\u0633\u062a\u0631\u0634\u0627\u062f \u0628\u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0644\u0627\u062a\u062e\u0627\u0630 \u0627\u0644\u0642\u0631\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u060c \u0648\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629\u060c \u0623\u0648 \u0625\u062f\u0627\u0631\u0629 \u0623\u0641\u0636\u0644 \u0644\u0644\u0645\u0631\u0636). \u0645\u0646 \u062c\u0647\u0629 \u0623\u062e\u0631\u0649\u060c \u062f\u0648\u0627\u0621 \u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a (etanercept)\u060c \u0648\u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u064f\u062b\u0628\u0650\u0651\u0637 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0646\u062e\u0631 \u0627\u0644\u0648\u0631\u0645 \u0623\u0644\u0641\u0627 (TNF-\u03b1) \u0642\u062f \u064a\u064f\u0648\u0642\u0641 \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 (\u0627\u0644\u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a) \u0627\u0644\u062a\u064a \u064a\u0628\u062f\u0623\u0647\u0627 \u0639\u0627\u0645\u0644 \u0646\u062e\u0631 \u0627\u0644\u0648\u0631\u0645 \u0623\u0644\u0641\u0627 \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628(78)<\/sup>. \u0648\u064a\u0645\u0643\u0646 \u062a\u0642\u0644\u064a\u0644 \u0646\u0648\u0628\u0627\u062a \u0625\u0635\u0627\u0628\u0629 \u0646\u0642\u0635 \u0627\u0644\u062a\u0631\u0648\u064a\u0629 \u0648\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0631\u0648\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0624\u062f\u064a \u0639\u0627\u062f\u0629\u064b \u0625\u0644\u0649 \u062e\u0644\u0644 \u0641\u064a \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0648\u0645\u0627 \u064a\u062a\u0628\u0639\u0647 \u0645\u0646 \u0627\u0646\u0633\u062f\u0627\u062f \u0648\u0639\u0627\u0626\u064a \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062f\u0648\u0627\u0621 \u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a(28)<\/sup>. <\/span><\/p>\n

\u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0644\u062f\u0648\u0627\u0621 \u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a \u0644\u0639\u0644\u0627\u062c \u0641\u0626\u0631\u0627\u0646 \u0645\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u062d\u0627\u062f\u0629\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u060c \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0644\u0645\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0623\u0644\u0645\u060c \u0648\u0639\u062f\u062f \u0627\u0644\u0643\u0631\u064a\u0627\u062a \u0627\u0644\u0628\u064a\u0636\u0627\u0621\u060c \u0648\u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629(82)<\/sup>. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u0645 \u0639\u0644\u0627\u062c \u062d\u0627\u0644\u062a\u064a\u0646 \u0633\u0631\u064a\u0631\u064a\u062a\u064a\u0646 \u0644\u0645\u0631\u0636\u0649 \u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u0648\u0645\u0627\u062a\u0648\u064a\u062f\u064a \u0648\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0628\u0646\u062c\u0627\u062d \u0648\u0623\u0645\u0627\u0646 \u0628\u062f\u0648\u0627\u0621 \u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a(83)<\/sup>. \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0644\u0629 \u062a\u062f\u0639\u0645 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0625\u062c\u0631\u0627\u0621 \u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0646\u062a\u0627\u0626\u062c \u062f\u0648\u0627\u0621 \u0625\u064a\u062a\u0627\u0646\u064a\u0631\u0633\u064a\u0628\u062a \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a.<\/span><\/p>\n

\u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0648\u0627\u0639\u062f\u0629 \u0641\u064a \u0625\u062f\u0627\u0631\u0629 \u062d\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u062a\u062a\u0645\u064a\u0632 \u0628\u062e\u0635\u0627\u0626\u0635 \u0645\u062a\u0646\u0648\u0639\u0629\u060c \u062d\u064a\u062b \u062a\u0639\u0645\u0644 \u0628\u0637\u0631\u0642 \u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u064a\u0645\u0643\u0646 \u062a\u0646\u0627\u0648\u0644\u0647\u0627 \u0628\u0623\u0634\u0643\u0627\u0644 \u0645\u062e\u062a\u0644\u0641\u0629 (\u062d\u0628\u0648\u0628 \u0623\u0648 \u062d\u0642\u0646). \u0643\u0645\u0627 \u0623\u0646 \u0628\u0639\u0636\u0647\u0627 \u064a\u062a\u0645\u064a\u0632 \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u062a\u0643\u0644\u0641\u062a\u0647\u0627\u060c \u0645\u0627 \u0645\u0646 \u0634\u0623\u0646\u0647 \u0623\u0646 \u064a\u0633\u0647\u0644 \u0627\u0639\u062a\u0645\u0627\u062f\u0647\u0627 \u0633\u0631\u064a\u0631\u064a\u064b\u0627 \u0648\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0643\u0627\u062f\u0631 \u0627\u0644\u0635\u062d\u064a. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u062f\u0648\u0627\u0621 \u0633\u064a\u0645\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 (simvastatin) \u0648\u062f\u0648\u0627\u0621 \u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 (allopurinol) \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639\u060c \u0648\u0647\u0645\u0627 \u0645\u062a\u0648\u0641\u0631\u0627\u0646 \u0641\u064a \u062a\u0631\u0643\u064a\u0628\u0627\u062a \u0641\u0645\u0648\u064a\u0629 (\u0633\u0627\u0626\u0644 \u0623\u0648 \u062d\u0628\u0648\u0628)\u060c \u0648\u064a\u0645\u0643\u0646 \u0648\u0635\u0641 \u062c\u0646\u064a\u0633 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 (\u062c\u0646\u064a\u0633 \u0627\u0644\u062f\u0648\u0627\u0621 \u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u0643\u0627\u0641\u0626 \u0648\u0645\u0637\u0627\u0628\u0642 \u0644\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0635\u0644\u064a) \u0648\u062a\u0628\u0627\u0639 \u0628\u0623\u0633\u0639\u0627\u0631 \u0645\u0639\u0642\u0648\u0644\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0647\u0644 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u064a\u0647\u0645\u0627 \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f(76\u060c 83\u060c 84)<\/sup>. <\/span><\/p>\n

\u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u060c \u062a\u0624\u062b\u0631 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u0623\u064a\u0636\u064b\u0627 \u0641\u064a \u0645\u0633\u0627\u0631\u0627\u062a \u062d\u062f\u0629 \u0627\u0644\u0645\u0631\u0636 (\u062a\u0642\u0644\u0644 \u0645\u062f\u0649 \u062d\u062f\u062a\u0647)\u061b \u0628\u064a\u062f \u0623\u0646\u0647\u0627 \u062a\u062a\u0637\u0644\u0628 \u062d\u0642\u0646\u064b\u0627 \u062a\u062d\u062a \u0627\u0644\u062c\u0644\u062f\u060c \u062a\u064f\u0639\u0637\u0649 \u063a\u0627\u0644\u0628\u064b\u0627 \u0623\u062b\u0646\u0627\u0621 \u0632\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649 \u0628\u064a\u0646 \u0643\u0644 4-8 \u0623\u0633\u0627\u0628\u064a\u0639\u060c \u0645\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u063a\u064a\u0631 \u0645\u0631\u064a\u062d\u0629 \u0623\u0648 \u0645\u0644\u0627\u0626\u0645\u0629 \u0644\u0644\u0645\u0631\u064a\u0636. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0642\u062f \u062a\u064f\u062d\u062f\u0651 \u062a\u0643\u0627\u0644\u064a\u0641\u0647\u0627 \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0645\u0646 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u064a\u0647\u0627(78\u060c 85\u060c 86)<\/sup>. \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u062a\u0639\u062a\u0628\u0631 \u0623\u0643\u062b\u0631 \u0645\u0644\u0627\u0621\u0645\u0629 \u062d\u064a\u062b \u064a\u064f\u0645\u0643\u0646 \u062a\u0646\u0627\u0648\u0644\u0647\u0627 \u064a\u0648\u0645\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u0628\u064a\u062a\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u062d\u0633\u0651\u0646 \u0645\u0646 \u0627\u0644\u062a\u0632\u0627\u0645 \u0627\u0644\u0645\u0631\u064a\u0636 \u0628\u0627\u0644\u0639\u0644\u0627\u062c\u060c \u062e\u0627\u0635\u0629\u064b \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0632\u0645\u0646\u0629\u060c \u0645\u062b\u0644 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a.<\/span><\/p>\n

\u0631\u063a\u0645 \u0623\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062d\u0642\u0646\u0647\u0627 \u0642\u062f \u062a\u0643\u0648\u0646 \u0623\u0643\u062b\u0631 \u0641\u0639\u0627\u0644\u064a\u0629\u060c \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u0644\u0627 \u062a\u062e\u0644\u0648 \u0645\u0646 \u062a\u062d\u062f\u064a\u0627\u062a \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0636\u0637\u0631\u0627\u0631 \u0627\u0644\u0645\u0631\u064a\u0636 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062f\u062f \u0639\u0644\u0649 \u0645\u0642\u062f\u0645\u064a \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0641\u064a \u0627\u0644\u0639\u064a\u0627\u062f\u0627\u062a \u0648\u0627\u0644\u0645\u0633\u062a\u0634\u0641\u064a\u0627\u062a \u0644\u062a\u0644\u0642\u064a \u062d\u0642\u0646 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u062a\u0643\u0627\u0644\u064a\u0641. \u0623\u0645\u0627 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0641\u0642\u062f \u064a\u0643\u0648\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u062e\u064a\u0627\u0631\u064b\u0627 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u064b\u0627 \u0642\u064a\u0651\u0645\u0627 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0648\u0625\u062f\u0627\u0631\u0629 \u0645\u0636\u0627\u0639\u0641\u0627\u062a\u0647 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0623\u0641\u0636\u0644\u064a\u0629 \u0627\u0644\u062a\u0632\u0627\u0645 \u0627\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629 \u0648\u0627\u0639\u062a\u0628\u0627\u0631\u0627\u062a \u0645\u0643\u0627\u0646 \u062a\u0644\u0642\u064a \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629.<\/span><\/p>\n

\u0625\u062d\u062f\u0649 \u0627\u0644\u0637\u0631\u0642 \u0627\u0644\u0645\u0647\u0645\u0629 \u0644\u0625\u062d\u062f\u0627\u062b \u062a\u0623\u062b\u064a\u0631 \u0625\u064a\u062c\u0627\u0628\u064a \u0641\u064a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u062a\u0642\u0644\u064a\u0644 \u062a\u0641\u0627\u0639\u0644\u0627\u062a\u0647 \u0641\u064a \u062c\u0633\u0645 \u0627\u0644\u0645\u0635\u0627\u0628 \u0647\u064a \u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u0645\u0643\u0646\u0629. \u0644\u0630\u0627\u060c \u0641\u0625\u0646 \u0627\u0642\u062a\u0631\u0627\u062d \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u062f\u0648\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0630\u0627\u062a \u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a\u0629 \u0639\u0645\u0644 \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0645\u0631\u0636 \u0645\u062b\u0644 \u062a\u0639\u062f\u064a\u0644 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0647\u064a\u0645\u0648\u063a\u0644\u0648\u0628\u064a\u0646 \u0627\u0644\u062c\u0646\u064a\u0646\u064a\u060c \u0648\u0645\u0646\u0639 \u0623\u0648 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u062a\u0635\u0627\u0642 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0628\u0628\u0639\u0636\u0647\u0627 \u0648\u062a\u0645\u0646\u062c\u0644\u0647\u0627\u060c \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u0646\u0642\u0635 \u0627\u0644\u062a\u0631\u0648\u064a\u0629 \u0648\u0645\u062e\u0627\u0637\u0631 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0631\u0648\u064a\u0629\u060c \u0648\u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u060c \u0648\u062a\u062e\u062b\u0631 \u0623\u0648 \u062a\u062c\u0644\u0637 \u0627\u0644\u062f\u0645\u060c \u0648\u0633\u0645\u064a\u0629 \u0627\u0644\u0647\u064a\u0645 \u0627\u0644\u062d\u0631 (\u0627\u0644\u0630\u064a \u064a\u0633\u0645\u0645 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0648\u064a\u0624\u062b\u0631 \u0633\u0644\u0628\u064b\u0627 \u0641\u064a \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0643\u0644\u0649\u060c \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629\u060c \u0648\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0644\u0628\u060c \u0648\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0628\u062f\u060c \u0648\u0643\u0631\u064a\u0627\u062a \u0627\u0644\u062f\u0645 \u0627\u0644\u0628\u064a\u0636\u0627\u0621 \u0627\u0644\u0645\u062d\u064a\u0637\u064a\u0629). \u0648\u0644\u062a\u062d\u0642\u064a\u0642 \u0630\u0644\u0643\u060c \u064a\u064f\u0648\u0635\u0649 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0632\u064a\u062c \u0645\u0646 \u0639\u0644\u0627\u062c\u0627\u062a \u062f\u0648\u0627\u0626\u064a\u0629 \u0644\u0647\u0627 \u0622\u0644\u064a\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629(28)<\/sup>.<\/span><\/p>\n

\u0641\u064a \u0633\u064a\u0627\u0642 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0623\u0647\u062f\u0627\u0641 \u062f\u0648\u0627\u0626\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0648\u0627\u0639\u062f\u0629\u060c \u0646\u062c\u062d\u0646\u0627 \u0641\u064a \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0645\u0648\u0627\u0636\u0639 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 (\u0623\u064a \u0627\u0644\u0645\u0648\u0627\u0636\u0639 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0628\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u064a\u063a\u064a\u0631 \u0648\u0638\u064a\u0641\u062a\u0647\u0627) \u0641\u064a \u0627\u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u0643\u0646 \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0633\u0627\u0628\u0642\u064b\u0627 \u0636\u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0646\u0648\u0635\u064a \u0628\u0634\u062f\u0629 \u0628\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0645\u062c\u0645\u0648\u0639\u0629 \u062c\u064a\u0646\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0634\u0645\u064a\u0629 (\u0641\u064a \u0627\u0644\u0623\u0646\u0641) \u0628\u0627\u0639\u062a\u0628\u0627\u0631\u0647\u0627 \u0623\u0647\u062f\u0627\u0641\u064b\u0627 \u062c\u062f\u064a\u062f\u0629\u060c \u0648\u0644\u0627 \u0633\u064a\u0645\u0627 \u062c\u064a\u0646\u0627\u062a [OR51V1 \u0648OR52A1 \u0648OR51B5]. \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u0647\u0645\u0629 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a – \u0645\u062b\u0644 (rs7933549) (\u0637\u0641\u0631\u0629 \u0645\u063a\u0644\u0637\u0629\u060c \u0648\u0647\u064a \u0637\u0641\u0631\u0629 \u0646\u0642\u0637\u064a\u0629 \u0641\u064a \u0646\u064a\u0643\u0648\u0644\u062a\u064a\u062f\u0629 \u0648\u0627\u062d\u062f\u0629)\u060c \u0648 (rs112098990) (\u0637\u0641\u0631\u0629 \u0625\u0632\u0627\u062d\u0629 \u0627\u0644\u0625\u0637\u0627\u0631)\u060c \u0648 (rs147062602) (\u0637\u0641\u0631\u0629 \u0625\u0632\u0627\u062d\u0629 \u0627\u0644\u0625\u0637\u0627\u0631)\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a – \u0647\u064a \u062c\u064a\u0646\u0627\u062a \u0634\u0627\u0626\u0639\u0629 \u0644\u062f\u0649 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u062a\u0631\u062a\u0628\u0637 \u0628\u0639\u064a\u0648\u0628 \u0641\u064a \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0648\u0637\u0631\u064a\u0642\u0629 \u062a\u062d\u0644\u0644\u0647 \u0644\u0627\u062d\u0642\u0627.<\/span><\/p>\n

\u0623\u0641\u0627\u062f \u062e\u0637\u0646\u0627 \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0623\u064a\u0636\u064b\u0627 \u0628\u0623\u0646 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a [TRIM 6 \u0648SIDT2 \u0648CADM3] \u062d\u064a\u062b \u062a\u064f\u0639\u062f \u0623\u0647\u062f\u0627\u0641\u064b\u0627 \u0639\u0644\u0627\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0648\u0648\u0627\u0639\u062f\u0629. \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0639\u0627\u0626\u0644\u0629 [TRIM\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 TRIM6 \u0648TRIM22 \u0648TRIM34]\u060c \u0645\u0639\u0646\u064a\u0629 \u0628\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 (\u0644\u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0645\u0633\u0628\u0628\u0627\u062a \u0627\u0644\u0623\u0645\u0631\u0627\u0636\u060c \u0648\u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0645\u0631\u0627\u0636\u060c \u0623\u0648 \u0645\u0646\u0639 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647\u0627)\u060c \u0648\u062a\u0642\u062f\u0645 \u062f\u0648\u0631\u0629 \u0627\u0644\u062e\u0644\u064a\u0629 (\u0645\u0646 \u062a\u0637\u0648\u0631 \u0648\u0627\u0646\u0642\u0633\u0627\u0645)\u060c \u0648\u062a\u0646\u0638\u064a\u0645 \u0627\u0644\u0646\u0633\u062e \u0627\u0644\u062c\u064a\u0646\u064a (\u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u062e\u062f\u0645\u0647\u0627 \u0627\u0644\u062e\u0644\u064a\u0629 \u0641\u064a \u062a\u0646\u0638\u064a\u0645 \u062a\u062d\u0648\u0644 \u0627\u0644\u062f\u0646\u0627 \u0625\u0644\u0649 \u0631\u0646\u0627\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0646\u0633\u064a\u0642 \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a)\u060c \u0645\u0645\u0627 \u064a\u0648\u062d\u064a \u0628\u0623\u0646\u0647\u0627 \u0642\u062f \u062a\u0624\u062b\u0631 \u0641\u064a \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u060c \u0648\u062a\u0645\u0627\u064a\u0632 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0644\u062f\u0645\u060c \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629(88)<\/sup>. \u0648\u062a\u064f\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0628\u0627\u0644\u063a\u0629 \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0641\u064a\u0633\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u0645\u0636\u0627\u0639\u0641\u0627\u062a\u0647.<\/span><\/p>\n

\u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0642\u062f \u064a\u064f\u0633\u0627\u0647\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u062c\u064a\u0646 (SIDT2) \u0641\u064a \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0625\u0630 \u064a\u0631\u062a\u0628\u0637 \u0628\u0627\u062e\u062a\u0644\u0627\u0644 \u062a\u0646\u0638\u064a\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u062c\u064a\u0646 (SIDT2) \u0628\u0627\u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0623\u064a\u0636\u064a\u0629 (\u062a\u062d\u0648\u064a\u0644 \u0627\u0644\u063a\u0630\u0627\u0621 \u0625\u0644\u0649 \u0637\u0627\u0642\u0629) \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0643\u0628\u062f\u060c \u0648\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0643\u0644\u0649 \u0627\u0644\u0645\u0635\u0627\u062d\u0628 \u0644\u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(89\u060c 90)<\/sup>. \u064a\u0644\u0639\u0628 \u062c\u064a\u0646 (SIDT2) \u062f\u0648\u0631\u064b\u0627 \u0641\u064a \u0648\u0638\u064a\u0641\u0629 \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u0644\u0627\u064a\u0633\u0648\u0633\u0648\u0645 (lysosomes) \u060c \u0648\u0642\u062f \u064a\u0624\u062f\u064a \u062a\u0639\u0637\u064a\u0644\u0647\u0627 \u0625\u0644\u0649 \u062d\u062f\u0648\u062b \u062e\u0644\u0644 \u0641\u064a \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0646\u0641\u0627\u064a\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0648\u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0641\u064a \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0623\u064a\u0636\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u064f\u0641\u0627\u0642\u0645 \u0627\u062e\u062a\u0644\u0627\u0644 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0648\u062d\u0635\u0648\u0644 \u0628\u0639\u0636 \u0627\u0644\u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0646\u0641\u0633\u0647\u060c \u0642\u062f \u064a\u064f\u0624\u062f\u064a \u0627\u062e\u062a\u0644\u0627\u0644 \u062a\u0646\u0638\u064a\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u062c\u064a\u0646 (CADM3)\u060c \u0627\u0644\u0645\u0639\u0646\u064a \u0628\u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0638\u0647\u0627\u0631\u064a\u0629 (\u0632\u064a\u0627\u062f\u062a\u0647\u0627 \u0641\u064a \u0627\u0644\u0628\u0648\u0644 \u0642\u062f \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0648\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0643\u0644\u0649) \u0648\u0627\u0644\u062a\u0635\u0627\u0642 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0628\u0639\u0636\u0647\u0627 \u0641\u064a \u062f\u0648\u0631\u0629 \u0627\u0644\u062e\u0644\u064a\u0629(91)<\/sup>\u060c \u0625\u0644\u0649 \u0625\u0636\u0639\u0627\u0641 \u0627\u0644\u062a\u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0644\u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0645 \u0648\u062a\u0639\u0637\u064a\u0644 \u0639\u0645\u0644\u064a\u0629 \u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0624\u062b\u0631 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645 \u0648\u0646\u0636\u0648\u062c\u0647\u0627. <\/span><\/p>\n

\u0642\u062f \u062a\u0624\u062f\u064a \u0647\u0630\u0647 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u062a\u0641\u0627\u0642\u0645 \u0627\u0644\u0623\u0646\u064a\u0645\u064a\u0627\u060c \u0623\u0648 \u0632\u064a\u0627\u062f\u0629 \u0639\u062f\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u063a\u064a\u0631 \u0627\u0644\u0646\u0627\u0636\u062c\u0629 \u0641\u064a \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0623\u0648 \u062a\u062b\u0628\u064a\u0637 \u0623\u0648 \u062a\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629\u060c \u0648\u0643\u0644\u0647\u0627 \u0639\u0648\u0627\u0645\u0644 \u062d\u0627\u0633\u0645\u0629 \u0641\u064a \u062a\u0628\u0627\u064a\u0646 \u0648\u062d\u062f\u0651\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a(92)<\/sup>. \u064a\u062a\u0645\u062a\u0639 \u0643\u0644 \u0647\u062f\u0641 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0628\u062f\u0631\u062c\u0629 \u0639\u0627\u0644\u064a\u0629 \u0645\u0646 \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u062f\u0648\u0627\u0626\u064a (\u0645\u0624\u0634\u0631 \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0647\u0648 \u0645\u0642\u064a\u0627\u0633 \u062d\u0648\u0633\u0628\u064a \u064a\u062a\u0631\u0627\u0648\u062d \u0639\u0627\u062f\u0629\u064b \u0645\u0627 \u0628\u064a\u0646 0 \u06481\u060c \u0648\u064a\u062a\u0646\u0628\u0623 \u0628\u0645\u062f\u0649 \u0633\u0647\u0648\u0644\u0629 \u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0645\u0648\u0636\u0639 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646)\u060c \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 0.7 \u06480.86\u060c \u0645\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u0645\u0631\u0634\u062d\u0629 \u0628\u0642\u0648\u0629 \u0644\u062a\u0637\u0648\u064a\u0631 \u0623\u062f\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644.<\/span><\/p>\n

4.1 \u0642\u064a\u0648\u062f \u0627\u0644\u0646\u062a\u0627\u0626\u062c<\/span><\/strong>
\n\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0642\u062f\u0645\u062a \u0625\u0637\u0627\u0631\u064b\u0627 \u0648\u0627\u0639\u062f\u064b\u0627 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629\u060c \u0643\u0645\u0627 \u062a\u0639\u0631\u0641\u0646\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644\u0647\u0627 \u0639\u0644\u0649 \u0623\u0647\u062f\u0627\u0641 \u062f\u0648\u0627\u0626\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u0625\u062f\u0627\u0631\u0629 \u062d\u062f\u0629 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u0644\u0627 \u062a\u062e\u0644\u0648 \u0645\u0646 \u0628\u0639\u0636 \u0627\u0644\u0642\u064a\u0648\u062f (\u0645\u062d\u062f\u0648\u062f\u064a\u0627\u062a) \u0627\u0644\u062a\u064a \u062a\u062d\u062f \u0645\u0646 \u0628\u0639\u0636 \u0635\u0644\u0627\u062d\u064a\u0629 \u0646\u062a\u0627\u0626\u062c\u0647\u0627. \u0645\u0646 \u062a\u0644\u0643 \u0627\u0644\u0642\u064a\u0648\u062f \u0647\u064a \u0623\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0639\u062a\u0645\u062f\u062a \u0641\u064a \u0645\u0646\u0647\u062c\u064a\u062a\u0647\u0627 \u062c\u0632\u0626\u064a\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062d\u0648\u0633\u0628\u064a\u0629 \u0648\u0639\u0644\u0645 \u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 (\u0639\u0644\u0645 \u0627\u0644\u0623\u062d\u064a\u0627\u0621 \u0627\u0644\u062d\u0648\u0633\u0628\u064a). \u0648\u0645\u0639 \u0623\u0646 \u0647\u0630\u064a\u0646 \u0627\u0644\u0646\u0647\u062c\u064a\u0646 \u064a\u0645\u0644\u0643\u0627\u0646 \u0642\u0648\u0629 \u062a\u0646\u0628\u0624\u064a\u0629 \u0625\u0644\u0651\u0627 \u0623\u0646\u0647\u0645\u0627 \u063a\u064a\u0631 \u0642\u0627\u062f\u0631\u064a\u0646 \u0639\u0644\u0649 \u0627\u0633\u062a\u064a\u0639\u0627\u0628 \u0643\u0644 \u0627\u0644\u062a\u0639\u0642\u064a\u062f\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0646\u0637\u0648\u064a \u0639\u0644\u064a\u0647\u0627 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0641\u064a \u062a\u062c\u0627\u0631\u0628 \u062e\u0627\u0631\u062c \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a. \u0625\u0644\u0627 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0623\u0645\u0631 \u062a\u0645\u062a \u0645\u0639\u0627\u0644\u062c\u062a\u0647 \u062c\u0632\u0626\u064a\u064b\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u062c\u0631\u0627\u0621 \u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0633\u0627\u0628\u0642\u0629 \u0639\u0644\u0649 \u062d\u064a\u0648\u0627\u0646\u0627\u062a\u060c \u0648\u0644\u0643\u0646 \u0639\u064a\u0646\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0643\u0627\u0646\u062a \u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u062d\u062c\u0645\u060c \u0648\u0627\u0644\u062a\u064a\u060c \u0648\u0644\u0644\u0647 \u0627\u0644\u062d\u0645\u062f\u060c \u0627\u062a\u0633\u0642\u062a \u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u062a\u0646\u0627\u060c \u0625\u0644\u064b\u0627 \u0623\u0646\u0646\u0627 \u0644\u0627 \u0646\u0632\u0627\u0644 \u0628\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u062f\u0631\u0627\u0633\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0637\u0648\u0644\u064a\u0629 \u0648\u0623\u0643\u0628\u0631 \u062d\u062c\u0645\u064b\u0627.<\/span><\/p>\n

\u0644\u0644\u0627\u0637\u0644\u0627\u0639 \u0627\u0644\u0643\u0627\u0645\u0644 \u0639\u0644\u0649 \u0627\u0644\u0642\u064a\u0648\u062f \u0627\u0644\u0623\u062e\u0631\u0649 \u0631\u0627\u062c\u0639 \u0627\u0644\u0641\u0642\u0631\u0629 4.1 \u0641\u064a \u0627\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0623\u0635\u0644\u064a\u0629.<\/span><\/p>\n

4.2 \u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a<\/span><\/strong>
\n\u062a\u0634\u064a\u0631 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0625\u0644\u0649 \u0623\u0646 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u062d\u0635\u0648\u0644 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u062c\u064a\u0646\u0627\u062a \u0645\u062f\u0639\u0648\u0645\u0629 \u0628\u0623\u062f\u0644\u0629 \u062c\u064a\u0646\u064a\u0629 \u0628\u0634\u0631\u064a\u0629 \u0642\u0648\u064a\u0629\u060c \u0645\u062b\u0644 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0643\u0627\u0645\u0644 (GWAS)\u060c \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u062a\u0639\u062a\u0628\u0631 \u0623\u0641\u0636\u0644 \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u0641\u062a\u0642\u0631 \u0625\u0644\u0649 \u0645\u062b\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0644\u0629. \u0628\u064a\u062f \u0623\u0646 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644 \u0623\u062e\u0631\u0649\u060c \u0644\u0627 \u0639\u0644\u0649 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u062d\u062f\u0647\u0627. \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0646\u0647\u062c\u064a\u0629 \u0631\u0627\u0633\u062e\u0629 \u062a\u0645\u0643\u0646\u0627 \u0645\u0646 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0648\u0627\u0644\u0648\u0627\u0639\u062f\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0639\u0644\u0627\u062c \u062d\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u060c \u0648\u0644\u0627 \u0633\u064a\u0645\u0627 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a\u060c \u0648\u0623\u062f\u0648\u064a\u0629 \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u0629\u060c \u0648\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0644\u0644\u0648\u0628\u064a\u0648\u0631\u064a\u0646\u0648\u0644 (allopurinol). <\/span><\/p>\n

\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u0639\u0631\u0641\u0646\u0627 \u0639\u0644\u0649 \u0623\u0647\u062f\u0627\u0641 \u062c\u062f\u064a\u062f\u0629 – \u0648\u062a\u062d\u062f\u064a\u062f\u064b\u0627 \u0639\u0644\u0649 \u0639\u0627\u0626\u0644\u062a\u064a \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0634\u0645\u064a\u0629 (OR) \u0648\u062c\u064a\u0646\u0627\u062a [(tripartite motif (TRIM] – \u0644\u062a\u0637\u0648\u064a\u0631 \u0623\u062f\u0648\u064a\u0629 \u0645\u0645\u0643\u0646\u0629 \u0644\u0644\u062a\u062e\u0641\u064a\u0641 \u0645\u0646 \u062d\u062f\u0629 \u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0648\u0645\u0636\u0627\u0639\u0641\u0627\u062a\u0647\u060c \u0645\u0639 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u0649 \u0627\u0644\u0633\u0643\u0627\u0646 \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646. \u0648\u0642\u062f \u0627\u0633\u062a\u0646\u062f \u0627\u062e\u062a\u064a\u0627\u0631 \u0647\u0630\u0647 \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0625\u0644\u0649 \u062d\u0635\u0648\u0644\u0647\u0627 \u0639\u0644\u0649 \u062f\u0631\u062c\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0644\u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u062f\u0648\u0627\u0626\u064a\u064b\u0627 \u0648\u0627\u0646\u062e\u0631\u0627\u0637\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0646\u0629 \u0648\u0631\u0627\u0621 \u0627\u0644\u0645\u0631\u0636. \u0644\u0627 \u062a\u064f\u0639\u0632\u0632 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0641\u0647\u0645\u0646\u0627 \u0644\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0645\u0631\u0636 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0641\u062d\u0633\u0628\u060c \u0628\u0644 \u062a\u064f\u0645\u0647\u062f \u0627\u0644\u0637\u0631\u064a\u0642 \u0623\u064a\u0636\u064b\u0627 \u0625\u0644\u0649 \u0645\u0642\u0627\u0631\u0628\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0623\u0643\u062b\u0631 \u0627\u0633\u062a\u0647\u062f\u0627\u0641\u064b\u0627 \u0648\u0645\u0641\u0639\u0648\u0644\u064a\u0629. <\/span><\/p>\n

\u062a\u0628\u062f\u0623 \u062e\u0627\u0631\u0637\u0629 \u0627\u0644\u0637\u0631\u064a\u0642 \u0627\u0644\u0645\u0646\u0637\u0642\u064a\u0629 \u0644\u062a\u0631\u062c\u0645\u0629 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0628\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u062e\u0628\u0631\u064a\u0629 \u0645\u064f\u0648\u062c\u064e\u0651\u0647\u0629 \u0644\u062a\u0623\u0643\u064a\u062f \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0648\u0638\u064a\u0641\u064a \u0644\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u064f\u062d\u062f\u064e\u0651\u062f\u0629 \u0648\u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u062c\u062f\u064a\u062f\u0629\u060c \u062a\u0644\u064a\u0647\u0627 \u062f\u0631\u0627\u0633\u0627\u062a \u062d\u064a\u0648\u064a\u0629 (\u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a) \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0648\u0627\u0644\u0633\u0644\u0627\u0645\u0629 (\u0627\u0644\u0623\u0645\u0627\u0646) \u0639\u0646\u062f \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0646\u064a\u0645\u064a\u0627 \u0627\u0644\u0645\u0646\u062c\u0644\u064a\u0629 \u062a\u062d\u062f\u064a\u062f\u064b\u0627. \u0628\u0639\u062f \u0630\u0644\u0643\u060c \u064a\u0645\u0643\u0646 \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644 \u0628\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0648\u0627\u0644\u0648\u0627\u0639\u062f\u0629 \u0625\u0644\u0649 \u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0641\u064a \u0645\u0631\u0627\u062d\u0644\u0647\u0627 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062c\u062f\u0648\u0649 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0648\u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0645\u062b\u0644\u0649\u060c \u0648\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0645\u0645\u0627 \u064a\u0645\u0647\u062f \u0627\u0644\u0637\u0631\u064a\u0642 \u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0645\u064f\u0648\u062c\u064e\u0651\u0647\u0629 \u062c\u064a\u0646\u064a\u064b\u0627 \u0648\u0645\u064f\u062e\u0635\u064e\u0651\u0635\u0629 \u0644\u0641\u0626\u0627\u062a \u0645\u064f\u062d\u062f\u064e\u0651\u062f\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a. \u062a\u064f\u0639\u062f\u0651 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0648\u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0623\u0645\u062f \u0636\u0631\u0648\u0631\u064a\u0629 \u0644\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0635\u062d\u0629 \u0647\u0630\u0647 \u0627\u0644\u062a\u0646\u0628\u0624\u0627\u062a \u0627\u0644\u062d\u0648\u0633\u0628\u064a\u0629 \u0648\u062a\u0631\u062c\u0645\u062a\u0647\u0627 \u0625\u0644\u0649 \u0639\u0644\u0627\u062c\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0645\u0646 \u0634\u0623\u0646\u0647\u0627 \u0623\u0646 \u062a\u064f\u062d\u0633\u0650\u0651\u0646 \u0645\u0646 \u0645\u062e\u0631\u062c\u0627\u062a \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a.<\/span><\/p>\n

\u0627\u0644\u0647\u0648\u0627\u0645\u0634:<\/strong>
\n1- Inusa, B. P. D., Hsu, L. L., Kohli, N., Patel, A., Ominu-Evbota, K., Anie, K., et al. (2019). Sickle cell disease-genetics, pathophysiology, clinical presentation and treatment. Int. J. Neonatal Screen. 5 (2), 20. doi:10.3390\/ijns5020020
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

2- Belis\u00e1rio, A. R., Silva, C. M., Velloso-Rodrigues, C., and Viana, M. B. (2018). Genetic, laboratory and clinical risk factors in the development of overt ischemic stroke in children with sickle cell disease. Hematol. Transfus. Cell Ther. 40 (2), 166\u2013181. doi:10.1016\/j.bjhh.2017.08.008<\/p>\n

3- Nnodu, O. E., Oron, A. P., Sopekan, A., Akaba, G. O., Piel, F. B., and Chao, D. L. (2021). Child mortality from sickle cell disease in Nigeria: a model-estimated, population-level analysis of data from the 2018 demographic and health survey. Lancet Haematol. 8 (10), e723\u2013e731. doi:10.1016\/S2352-3026(21)00216-7
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

4- GBD 2021<\/p>\n

5- Sickle Cell Disease Collaborators McHugh, T. A., Oron, A. P., Teply, C., Lonberg, N., Vilchis Tella, V., Kassebaum, N. J., et al. (2023). Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the global burden of disease study 2021. Lancet Haematol. 10 (8), e585\u2013e599. doi:10.1016\/S2352-3026(23)00118-7
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

6- Kumar, A., and Bhattacharya, S. (2024). Sickle cell disease: a comparative perspective on global and national initiatives. Front. Hematol. 3, 1457158. doi:10.3389\/frhem.2024.1457158
\nCrossRef Full Text | Google Scholar<\/p>\n

7- Ware, R. E., de Montalembert, M., Tshilolo, L., and Abboud, M. R. (2017). Sickle cell disease. Lancet 390 (10091), 311\u2013323. doi:10.1016\/S0140-6736(17)30193-9
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

8- Jastaniah, W. (2011). Epidemiology of sickle cell disease in Saudi Arabia. Ann. Saudi Med. 31 (3), 289\u2013293. doi:10.4103\/0256-4947.81540
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

9- Bin Zuair, A., Aldossari, S., Alhumaidi, R., Alrabiah, M., and Alshabanat, A. (2023). The burden of sickle cell disease in Saudi Arabia: a single-institution large retrospective study. Int. J. Gen. Med. 16, 161\u2013171. doi:10.2147\/IJGM.S393233
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

10- el-Hazmi, M. A., al-Swailem, A. R., Warsy, A. S., al-Swailem, A. M., Sulaimani, R., and al-Meshari, A. A. (1995). Consanguinity among the Saudi Arabian population. J. Med. Genet. 32 (8), 623\u2013626. doi:10.1136\/jmg.32.8.623
\nPubMed Abstract | CrossRef Full Text | Google Scholar
\n11- Kavanagh, P. L., Fasipe, T. A., and Wun, T. (2022). Sickle cell disease: a review. JAMA 328 (1), 57\u201368. doi:10.1001\/jama.2022.10233
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

12- Salinas, C. G., and Thein, S. L. (2020). Recent advances in the treatment of sickle cell disease. Front. Physiol. 11, 435. doi:10.3389\/fphys.2020.00435
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

13- pfizer. (2024). Pfizer voluntarily withdraws all lots of sickle cell disease treatment OXBRYTA\u00ae (voxelotor) from worldwide markets. Available online at: https:\/\/www.pfizer.com\/news\/press-release\/press-release-detail\/pfizer-voluntarily-withdraws-all-lots-sickle-cell-disease (Accessed September 27, 2024).
\nGoogle Scholar<\/p>\n

14- European Medicines Agency. (2023). Revocation of authorisation for sickle cell disease medicine adakveo. Amsterdam, The Netherlands: European Medicines Agency. Available online at: https:\/\/www.ema.europa.eu\/en\/news\/revocation-authorisation-sickle-cell-disease-medicine-adakveo (Accessed August 30, 2024).
\nGoogle Scholar<\/p>\n

15- Leonard, A., and Tisdale, J. F. (2024). A new frontier: FDA approvals for gene therapy in sickle cell disease. Mol. Ther. 32, 264\u2013267. doi:10.1016\/j.ymthe.2024.01.015
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

16- Rueda, J., de Miguel Beriain, \u00cd., and Montoliu, L. (2024). Affordable pricing of CRISPR treatments is a pressing ethical imperative. CRISPR J. 7 (5), 220\u2013226. doi:10.1089\/crispr.2024.0042
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

17- Burt, T., and Dhillon, S. (2013). Pharmacogenomics in early-phase clinical development. Pharmacogenomics 14 (9), 1085\u20131097. doi:10.2217\/pgs.13.81
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

18- Alghubayshi, A., Wijesinghe, D., Alwadaani, D., Algahtani, F. H., Abohelaika, S., Alzahrani, M., et al. (2025). Unraveling the complex genomic interplay of sickle cell disease among the Saudi population: a case-control GWAS analysis. Int. J. Mol. Sci. 26 (6), 2817. doi:10.3390\/ijms26062817
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

19- Alshabeeb, M. A., Alwadaani, D., Al Qahtani, F. H., Abohelaika, S., Alzahrani, M., Al Zayed, A., et al. (2023). Impact of genetic variations on thromboembolic risk in Saudis with sickle cell disease. Genes (Basel) 14 (10), 1919. doi:10.3390\/genes14101919
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

20- Tragante, V., Hemerich, D., Alshabeeb, M., Br\u00e6nne, I., Lempi\u00e4inen, H., Patel, R. S., et al. (2018). Druggability of coronary artery disease risk loci. Circ. Genom Precis. Med. 11 (8), e001977. doi:10.1161\/CIRCGEN.117.001977
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

21- Pushpakom, S. (2024). Introduction and historical overview of drug repurposing opportunities. Available online at: https:\/\/books.rsc.org\/books\/edited-volume\/1885\/chapter\/2472263\/Introduction-and-Historical-Overview-of-Drug (Accessed September 4, 2024).
\nGoogle Scholar<\/p>\n

22- Kirkham, J. K., Estepp, J. H., Weiss, M. J., and Rashkin, S. R. (2023). Genetic variation and sickle cell disease severity: a systematic review and meta-analysis. JAMA Netw. Open 6 (10), e2337484. doi:10.1001\/jamanetworkopen.2023.37484
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

23- Pincez, T., Ashley-Koch, A. E., Lettre, G., and Telen, M. J. (2022). Genetic modifiers of sickle cell disease. Hematol. Oncol. Clin. North Am. 36 (6), 1097\u20131124. doi:10.1016\/j.hoc.2022.06.006
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

24- Page, G. P., Kanias, T., Guo, Y. J., Lanteri, M. C., Zhang, X., Mast, A. E., et al. (2021). Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage. J. Clin. Invest 131 (13), 146077. doi:10.1172\/JCI146077
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

25- Pritchard, J. L. E., O\u2019Mara, T. A., and Glubb, D. M. (2017). Enhancing the promise of drug repositioning through genetics. Front. Pharmacol. 8, 896. doi:10.3389\/fphar.2017.00896
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

26- Metaferia, B., Cellmer, T., Dunkelberger, E. B., Li, Q., Henry, E. R., Hofrichter, J., et al. (2022). Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease. Proc. Natl. Acad. Sci. U. S. A. 119 (40), e2210779119. doi:10.1073\/pnas.2210779119
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

27- Agu, P. C., Afiukwa, C. A., Orji, O. U., Ezeh, E. M., Ofoke, I. H., Ogbu, C. O., et al. (2023). Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management. Sci. Rep. 13 (1), 13398. doi:10.1038\/s41598-023-40160-2
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

28- Telen, M. J., Malik, P., and Vercellotti, G. M. (2019). Therapeutic strategies for sickle cell disease: towards a multi-agent approach. Nat. Rev. Drug Discov.18 (2), 139\u2013158. doi:10.1038\/s41573-018-0003-2
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

29- Driss, A., Asare, K. O., Hibbert, J. M., Gee, B. E., Adamkiewicz, T. V., and Stiles, J. K. (2009). Sickle cell disease in the post genomic era: a monogenic disease with a polygenic phenotype. Genomics Insights 2009 (2), GEI.S2626\u201348. doi:10.4137\/gei.s2626
\nCrossRef Full Text | Google Scholar<\/p>\n

30- Tragante, V., Hemerich, D., Alshabeeb, M., Br\u00e6nne, I., Lempi\u00e4inen, H., Patel, R. S., et al. (2018). Druggability of coronary artery disease risk loci. Circ. Genom Precis. Med. 11 (8), e001977. doi:10.1161\/CIRCGEN.117.001977
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

31- Cannon, M., Stevenson, J., Stahl, K., Basu, R., Coffman, A., Kiwala, S., et al. (2024). DGIdb 5.0: rebuilding the drug-gene interaction database for precision medicine and drug discovery platforms. Nucleic Acids Res. 52 (D1), D1227\u2013D1235. doi:10.1093\/nar\/gkad1040
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

32- WHO. (2024). VigiAccess. Available online at: https:\/\/www.vigiaccess.org\/(Accessed September 4, 2024). Google Scholar<\/p>\n

33- http:\/\/sideeffects.embl.de<\/p>\n

34- Kuhn, M., Letunic, I., Jensen, L. J., and Bork, P. (2016). The SIDER database of drugs and side effects. Nucleic Acids Res. 44 (D1), D1075\u2013D1079. doi:10.1093\/nar\/gkv1075
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

35- Van Bever, E., Wirtz, V. J., Azermai, M., De Loof, G., Christiaens, T., Nicolas, L., et al. (2014). Operational rules for the implementation of INN prescribing. Int. J. Med. Inf. 83 (1), 47\u201356. doi:10.1016\/j.ijmedinf.2013.09.004
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

36- Kang, H., Pan, S., Lin, S., Wang, Y. Y., Yuan, N., and Jia, P. (2024). PharmGWAS: a GWAS-based knowledgebase for drug repurposing. Nucleic Acids Res. 52 (D1), D972\u2013D979. doi:10.1093\/nar\/gkad832
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

37- Ochoa, D., Karim, M., Ghoussaini, M., Hulcoop, D. G., McDonagh, E. M., and Dunham, I. (2022). Human genetics evidence supports two-thirds of the 2021 FDA-Approved drugs. Nat. Rev. Drug Discov. 21 (8), 551. doi:10.1038\/d41573-022-00120-3
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

38- Nelson, M. R., Tipney, H., Painter, J. L., Shen, J., Nicoletti, P., Shen, Y., et al. (2015). The support of human genetic evidence for approved drug indications. Nat. Genet. 47 (8), 856\u2013860. doi:10.1038\/ng.3314
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

39- Ochoa, D., Karim, M., Ghoussaini, M., Hulcoop, D. G., McDonagh, E. M., and Dunham, I. (2022). Human genetics evidence supports two-thirds of the 2021 FDA-Approved drugs. Nat. Rev. Drug Discov. 21 (8), 551. doi:10.1038\/d41573-022-00120-3
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

40- Ullah, A. (2025). Perspective chapter: technological advances in population genetics. London, United Kingdom: IntechOpen. doi:10.5772\/intechopen.1009271
\nCrossRef Full Text | Google Scholar<\/p>\n

41- Ku, C. S., Loy, E. Y., Pawitan, Y., and Chia, K. S. (2010). The pursuit of genome-wide association studies: where are we now? J. Hum. Genet. 55 (4), 195\u2013206. doi:10.1038\/jhg.2010.19
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

42- Reay, W. R., and Cairns, M. J. (2021). Advancing the use of genome-wide association studies for drug repurposing. Nat. Rev. Genet. 22 (10), 658\u2013671. doi:10.1038\/s41576-021-00387-z
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

43- Drug Repurposing (DR) (2024). An emerging approach in drug discovery | IntechOpen. Available online at: https:\/\/www.intechopen.com\/chapters\/72744 (Accessed September 4, 2024).
\nGoogle Scholar<\/p>\n

44- Nanda, H., Ponnusamy, N., Odumpatta, R., Jeyakanthan, J., and Mohanapriya, A. (2020). Exploring genetic targets of psoriasis using genome wide association studies (GWAS) for drug repurposing. 3 Biotech. 10 (2), 43. doi:10.1007\/s13205-019-2038-4
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

45- Xu, J., Mao, C., Hou, Y., Luo, Y., Binder, J. L., Zhou, Y., et al. (2022). Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer\u2019s disease. Cell Rep.41 (9), 111717. doi:10.1016\/j.celrep.2022.111717
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

46- Blood. (2024). ASCENT1: a phase 2 trial to evaluate the efficacy and safety of oral decitabine-tetrahydrouridine (NDec) in patients with sickle cell disease. American Society of Hematology. Available online at: https:\/\/ashpublications.org\/blood\/article\/140\/Supplement%201\/5420\/487531\/ASCENT1-A-Phase-2-Trial-to-Evaluate-the-Efficacy(Accessed September 2, 2025).
\nGoogle Scholar<\/p>\n

47- Chowdhury, F. A., Colussi, N., Sharma, M., Wood, K. C., Xu, J. Z., Freeman, B. A., et al. (2023). Fatty acid nitroalkenes – multi-target agents for the treatment of sickle cell disease. Redox Biol. 68, 102941. doi:10.1016\/j.redox.2023.102941
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

48- Adam, S. S., and Hoppe, C. (2013). Potential role for statins in sickle cell disease. Pediatr. Blood Cancer 60 (4), 550\u2013557. doi:10.1002\/pbc.24443
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

49- Bereal-Williams, C., Machado, R. F., McGowan, V., Chi, A., Hunter, C. J., and Kato, G. J. (2012). Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia. Haematologica 97 (11), 1768\u20131770. doi:10.3324\/haematol.2011.054957
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

50- Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J., et al. (2008). Rosuvastatin to prevent vascular events in men and women with elevated C-Reactive protein. N. Engl. J. Med. 359 (21), 2195\u20132207. doi:10.1056\/NEJMoa0807646
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

51- Wong, K., Lai, W. K., and Jackson, D. E. (2022). HLA classII regulation of immune response in sickle cell disease patients: susceptibility to red blood cell alloimmunization (systematic review and meta-analysis). Vox Sang. 117 (11), 1251\u20131261. doi:10.1111\/vox.13351
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

52- Tamouza, R., Neonato, M. G., Busson, M., Marzais, F., Girot, R., Labie, D., et al. (2002). Infectious complications in sickle cell disease are influenced by HLA class II alleles. Hum. Immunol. 63 (3), 194\u2013199. doi:10.1016\/s0198-8859(01)00378-0
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

53- Martins, J. O., Pagani, F., Dezan, M. R., Oliveira, V. B., Conrado, M., Ziza, K. C., et al. (2022). Impact of HLA-G +3142C>G on the development of antibodies to blood group systems other than the Rh and Kell among sensitized patients with sickle cell disease. Transfus. Apher. Sci. 61 (5), 103447. doi:10.1016\/j.transci.2022.103447
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

54- Akaba, K., Nwogoh, B., Oshatuyi, O., and Angchaisuksiri, P. (2020). Determination of von Willebrand factor level in patient with sickle cell diseasein vaso-occlusive crisis. Res. Pract. Thromb. Haemost. 4 (5), 902\u2013905. doi:10.1002\/rth2.12378
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

55- Sahebkar, A., Serban, C., Ursoniu, S., Mikhailidis, D. P., Undas, A., Lip, G. Y. H., et al. (2016). The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials. Thromb. Haemost. 115 (3), 520\u2013532. doi:10.1160\/TH15-08-0620
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

56- Hoppe, C., Jacob, E., Styles, L., Kuypers, F., Larkin, S., and Vichinsky, E. (2017). Simvastatin reduces vaso-occlusive pain in sickle cell anaemia: a pilot efficacy trial. Br. J. Haematol. 177 (4), 620\u2013629. doi:10.1111\/bjh.14580
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

57- Xi, C., Palani, C., Takezaki, M., Shi, H., Horuzsko, A., Pace, B. S., et al. (2024). Simvastatin-mediated Nrf2 activation induces fetal hemoglobin and antioxidant enzyme expression to ameliorate the phenotype of sickle cell disease. Antioxidants (Basel) 13 (3), 337. doi:10.3390\/antiox13030337
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

58- Ademi, B., Folker, J., and Rothwell, W. B. (2025). Statin-induced debilitating weakness and myopathy. Drug Ther. Bull. 63 (6), 94\u201397. doi:10.1136\/dtb.2024.256956rep
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

59- Choi, S. A., Kim, J. S., Park, Y. A., Lee, D. H., Park, M., Yee, J., et al. (2025). Transporter genes and statin-induced hepatotoxicity. Cardiovasc Drugs Ther. 39 (4), 801\u2013810. doi:10.1007\/s10557-024-07580-2
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

60- L\u00f3pez-L\u00f3pez, S., Romero de \u00c1vila, M. J., Hern\u00e1ndez de Le\u00f3n, N. C., Ruiz-Marcos, F., Baladr\u00f3n, V., Nueda, M. L., et al. (2021). NOTCH4 exhibits anti-inflammatory activity in activated macrophages by interfering with Interferon-\u03b3 and TLR4 signaling. Front. Immunol. 12, 734966. doi:10.3389\/fimmu.2021.734966
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

61- Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., et al. (2022). Notch signaling pathway: architecture, disease, and therapeutics. Signal Transduct. Target Ther. 7 (1), 95. doi:10.1038\/s41392-022-00934-y
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

62- Fingerlin, T. E., Murphy, E., Zhang, W., Peljto, A. L., Brown, K. K., Steele, M. P., et al. (2013). Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat. Genet. 45 (6), 613\u2013620. doi:10.1038\/ng.2609
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

63- Field, J. J., Burdick, M. D., DeBaun, M. R., Strieter, B. A., Liu, L., Mehrad, B., et al. (2012). The role of fibrocytes in sickle cell lung disease. PLoS One 7 (3), e33702. doi:10.1371\/journal.pone.0033702
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

64- Adeyinka, A., and Bashir, K. (2024). \u201cTumor lysis syndrome,\u201d in StatPearls(Treasure Island, FL: StatPearls Publishing). Available online at: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK518985\/<\/p>\n

65- Pritchard, K. A. Jr, Besch, T. L., Wang, J., Xu, H., Jones, D. W., Foster, T. D., et al. (2005). Differential effects of lovastatin and allopurinol therapy in a murine model of sickle cell disease. Blood 106 (11), 2325. doi:10.1182\/blood.V106.11.2325.2325
\nCrossRef Full Text | Google Scholar<\/p>\n

66- Kelkar, A., Kuo, A., and Frishman, W. H. (2011). Allopurinol as a cardiovascular drug. Cardiol. Rev. 19 (6), 265\u2013271. doi:10.1097\/CRD.0b013e318229a908
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

67- Wood, K. C., Hebbel, R. P., and Granger, D. N. (2005). Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice. FASEB J. 19 (8), 989\u2013991. doi:10.1096\/fj.04-3218fje
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

68- Kaul, D. K., Liu, X. D., Choong, S., Belcher, J. D., Vercellotti, G. M., and Hebbel, R. P. (2004). Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice. Am. J. Physiol. Heart Circ. Physiol. 287 (1), H293\u2013H301. doi:10.1152\/ajpheart.01150.2003
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

69- Dashti, M., Al-Matrouk, A., Channanath, A., Hebbar, P., Al-Mulla, F., and Thanaraj, T. A. (2022). Distribution of HLA-B alleles and haplotypes in Qatari: recommendation for establishing pharmacogenomic markers screening for drug hypersensitivity. Front. Pharmacol. 13, 891838. doi:10.3389\/fphar.2022.891838
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

70- Dean, L., and Kane, M. (2012). \u201cAllopurinol therapy and HLA-B*58:01 genotype,\u201d in Medical genetics summaries. Editors V. M. Pratt, S. A. Scott, M. Pirmohamed, B. Esquivel, B. L. Kattman, and A. J. Malheiro (Bethesda, MA: National Center for Biotechnology Information US). Available online at: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK127547\/<\/p>\n

71- Yessayan, L. T., Neyra, J. A., Westover, A. J., Szamosfalvi, B., and Humes, H. D. (2022). Extracorporeal immunomodulation treatment and clinical outcomes in ICU COVID-19 patients. Crit. Care Explor 4 (5), e0694. doi:10.1097\/CCE.0000000000000694
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

72- Rees, D. C., Kilinc, Y., Unal, S., Dampier, C., Pace, B. S., Kaya, B., et al. (2022). A randomized, placebo-controlled, double-blind trial of canakinumab in children and young adults with sickle cell anemia. Blood 139 (17), 2642\u20132652. doi:10.1182\/blood.2021013674
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

73- Drugs.com (2024). Xolair (omalizumab) FDA Approval History. Available online at: https:\/\/www.drugs.com\/history\/xolair.html<\/p>\n

74- Kaplan, A. P., Gim\u00e9nez-Arnau, A. M., and Saini, S. S. (2017). Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria. Allergy 72 (4), 519\u2013533. doi:10.1111\/all.13083
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

75- Benjamin, E. J., Dupuis, J., Larson, M. G., Lunetta, K. L., Booth, S. L., Govindaraju, D. R., et al. (2007). Genome-wide association with select biomarker traits in the framingham heart study. BMC Med. Genet. 8 (Suppl. 1), S11. doi:10.1186\/1471-2350-8-S1-S11
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

76- Al-Suliman, A., Elsarraf, N. A., Baqishi, M., Homrany, H., Bousbiah, J., and Farouk, E. (2006). Patterns of mortality in adult sickle cell disease in Al-Hasa region of Saudi Arabia. Ann. Saudi Med. 26 (6), 487\u2013488. doi:10.5144\/0256-4947.2006.487
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

77- Alhaj, Z. M., Mohamed, N. E., Mady, A. F., Alamri, M. M., Alshammari, S., Alshebaily, A. K., et al. (2023). Predictors of mortality in adults with sickle cell disease admitted to the intensive care unit in king saud medical city, Saudi Arabia. Cureus 15 (5), e38817. doi:10.7759\/cureus.38817
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

78- An, P., Barron-Casella, E. A., Strunk, R. C., Hamilton, R. G., Casella, J. F., and DeBaun, M. R. (2011). Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. J. Allergy Clin. Immunol. 127 (6), 1440\u20131446. doi:10.1016\/j.jaci.2010.12.1114
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

79- Awojoodu, A. O., Keegan, P. M., Lane, A. R., Zhang, Y., Lynch, K. R., Platt, M. O., et al. (2014). Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood 124 (12), 1941\u20131950. doi:10.1182\/blood-2014-01-543652
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

80- Fern\u00e1ndez-Ruiz, M., and Aguado, J. M. (2018). Risk of infection associated with anti-TNF-\u03b1 therapy. Expert Rev. Anti Infect. Ther. 16 (12), 939\u2013956. doi:10.1080\/14787210.2018.1544490
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

81- Contejean, A., Janssen, C., Orsini-Piocelle, F., Zecchini, C., Charlier, C., and Chouchana, L. (2023). Increased risk of infection reporting with anti-BCMA bispecific monoclonal antibodies in multiple myeloma: a worldwide pharmacovigilance study. Am. J. Hematol. 98 (12), E349\u2013E353. doi:10.1002\/ajh.27071
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

82- Solovey, A., Somani, A., Belcher, J. D., Milbauer, L., Vincent, L., Pawlinski, R., et al. (2017). A monocyte-TNF-endothelial activation axis in sickle transgenic mice: therapeutic benefit from TNF blockade. Am. J. Hematol. 92 (11), 1119\u20131130. doi:10.1002\/ajh.24856
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

83- Adelowo, O., and Edunjobi, A. S. (2011). Juvenile idiopathic arthritis coexisting with sickle cell disease: two case reports. BMJ Case Rep. 2011, bcr1020114889. doi:10.1136\/bcr.10.2011.4889
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

84- Drugs.com(2024a). Simvastatin Prices, Coupons & Patient Assistance Programs. Available online at: https:\/\/www.drugs.com\/price-guide\/simvastatin(Accessed September 4, 2024).
\nGoogle Scholar<\/p>\n

85- Drugs.com(2024b). Allopurinol Prices, Coupons & Patient Assistance Programs. Available online at: https:\/\/www.drugs.com\/price-guide\/allopurinol(Accessed September 4, 2024).
\nGoogle Scholar<\/p>\n

86- Drugs.com(2024c). Ilaris Prices, Coupons & Patient Assistance Programs. Available online at: https:\/\/www.drugs.com\/price-guide\/ilaris(Accessed September 4, 2024).
\nGoogle Scholar<\/p>\n

87- Drugs.com (2024d). Xolair Prices, Coupons & Patient Assistance Programs. Available online at: https:\/\/www.drugs.com\/price-guide\/xolair (Accessed September 4, 2024).
\nGoogle Scholar<\/p>\n

88- Uchil, P. D., Hinz, A., Siegel, S., Coenen-Stass, A., Pertel, T., Luban, J., et al. (2013). TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J. Virol. 87 (1), 257\u2013272. doi:10.1128\/JVI.01804-12
\nPubMed Abstract | CrossRef Full Text<\/p>\n

89- Qian, D., Cong, Y., Wang, R., Chen, Q., Yan, C., and Gong, D. (2023). Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity. Nat. Commun. 14 (1), 3568. doi:10.1038\/s41467-023-39335-2
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

90- Geng, M. Y., Wang, L., Song, Y. Y., Gu, J., Hu, X., Yuan, C., et al. (2021). Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function. Cell Death Dis. 13 (1), 7. doi:10.1038\/s41419-021-04453-6
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

91- Estelius, J., Lengqvist, J., Ossipova, E., Idborg, H., Le Ma\u00eetre, E., Andersson, M. L. A., et al. (2019). Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients\u2014Immune-related candidate proteins affected by TNF blocking treatment. Arthritis Res. Ther. 21, 60. doi:10.1186\/s13075-019-1846-6
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

92- Jarczak, J., Thetchinamoorthy, K., Wierzbicka, D., Bujko, K., Ratajczak, M. Z., and Kucia, M. (2025). Expression of innate immunity genes in human hematopoietic stem\/progenitor cells – single cell RNA-Seq analysis. Front. Immunol. 16, 1515856. doi:10.3389\/fimmu.2025.1515856
\nPubMed Abstract | CrossRef Full Text | Google Scholar<\/p>\n

\u0627\u0644\u0645\u0635\u062f\u0631 \u0627\u0644\u0631\u0626\u064a\u0633:<\/strong>
\nhttps:\/\/www.frontiersin.org\/journals\/bioinformatics\/articles\/10.3389\/fbinf.2025.1671626\/full<\/a><\/p>\n

\"\"
\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0645\u062d\u0645\u062f \u0622\u0644 \u0634\u0628\u064a\u0628<\/span><\/figcaption><\/figure>\n
\"\"
\u0627\u0644\u0623\u0633\u062a\u0627\u0630 \u0639\u062f\u0646\u0627\u0646 \u0623\u062d\u0645\u062f \u0627\u0644\u062d\u0627\u062c\u064a<\/span><\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Genomics-driven drug repurposing and novel targets identification for sickle cell disease in Saudi patients (\u062f\u0631\u0627\u0633\u0629 \u0631\u0627\u0626\u062f\u0629 \u0645\u0633\u062a\u0646\u062f\u0629 \u0625\u0644\u0649 \u0639\u0644\u0645 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u0638\u064a\u0641 \u0623\u062f\u0648\u064a\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0623\u062e\u0631\u0649\u060c \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0627\u0644\u0645\u0646\u062c\u0644\u064a \u0627\u0644\u0633\u0639\u0648\u062f\u064a\u064a\u0646) [\u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646\u061b \u0639\u0644\u0649 \u0627\u0644\u063a\u0628\u064a\u0634\u064a\u060c \u0645\u062d\u0645\u062f \u0627\u0644\u0634\u0628\u064a\u0628\u060c \u0648\u064a\u062c\u064a\u0633\u064a\u0646\u062c\u0647\u0627 \u062f\u064a\u0627\u0646\u062c\u0627\u0646\u060c \u0645\u062d\u0645\u062f \u0627\u0644\u0639\u0648\u0636\u060c \u0633\u0639\u0627\u062f \u0627\u0644\u0634\u0645\u0631\u064a\u060c \u062e\u0644\u064a\u0641\u0629 \u0627\u0644\u0631\u0627\u062c\u062d\u060c \u0645\u0646\u0649 \u0627\u0644\u062e\u064a\u0631\u064a\u060c \u0639\u0645\u0627\u062f \u0627\u0644\u0625\u0633\u0644\u0627\u0645\u060c \u0648\u0623\u062d\u0645\u062f \u0627\u0644\u0639\u0633\u0643\u0631] (\u0627\u0644\u0646\u0627\u0634\u0631\u061b \u0645\u062c\u0644\u0629 \u0641\u0631\u0648\u0646\u062a\u064a\u0631\u0632 …<\/p>\n","protected":false},"author":4,"featured_media":32784,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-32777","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-14"],"_links":{"self":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/32777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=32777"}],"version-history":[{"count":10,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/32777\/revisions"}],"predecessor-version":[{"id":32791,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/32777\/revisions\/32791"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/media\/32784"}],"wp:attachment":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=32777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=32777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=32777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}