{"id":30306,"date":"2025-08-02T11:44:54","date_gmt":"2025-08-02T08:44:54","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=30306"},"modified":"2025-08-02T11:44:54","modified_gmt":"2025-08-02T08:44:54","slug":"%d8%a5%d8%b9%d8%a7%d8%af%d8%a9-%d8%aa%d9%88%d8%ac%d9%8a%d9%87-%d8%a7%d9%84%d8%a3%d8%af%d9%88%d9%8a%d8%a9-drug-repurposing-%d8%a7%d8%b3%d8%aa%d8%b1%d8%a7%d8%aa%d9%8a%d8%ac%d9%8a%d8%a9-%d9%85%d8%a8","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=30306","title":{"rendered":"\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 (Drug Repurposing): \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0645\u0628\u062a\u0643\u0631\u0629 \u0644\u062a\u0633\u0631\u064a\u0639 \u0639\u0645\u0644\u064a\u0629 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a – \u0628\u0642\u0644\u0645 \u0627\u0644\u0635\u064a\u062f\u0644\u064a \u063a\u0633\u0627\u0646 \u0639\u0644\u064a \u0628\u0648\u062e\u0645\u0633\u064a\u0646"},"content":{"rendered":"

\u062a\u0639\u062a\u0628\u0631 \u0639\u0645\u0644\u064a\u0629 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0631\u062d\u0644\u0629 \u0637\u0648\u064a\u0644\u0629 \u0648\u0645\u0643\u0644\u0641\u0629 \u0648\u0645\u062d\u0641\u0648\u0641\u0629 \u0628\u0627\u0644\u0645\u062e\u0627\u0637\u0631\u060c \u0642\u062f \u062a\u0645\u062a\u062f \u0644\u0639\u0642\u062f \u0645\u0646 \u0627\u0644\u0632\u0645\u0646 \u0648\u062a\u0643\u0644\u0641 \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 \u0645\u0644\u064a\u0627\u0631 \u0627\u0644\u062f\u0648\u0644\u0627\u0631\u0627\u062a \u0644\u0643\u0644 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u064a\u0637\u0631\u062d \u0641\u064a \u0627\u0644\u0633\u0648\u0642. \u0644\u0647\u0630\u0627 \u0648\u0641\u064a \u0638\u0644 \u0627\u0644\u062d\u0627\u062c\u0629 \u0627\u0644\u0645\u0644\u062d\u0629 \u0644\u0639\u0644\u0627\u062c\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0633\u062a\u0639\u0635\u064a\u0629 \u0648\u0627\u0644\u0646\u0627\u0634\u0626\u0629\u060c \u0628\u0631\u0632 \u0645\u0641\u0647\u0648\u0645 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 (Drug Repurposing) \u2013 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u064a\u0636\u064b\u0627 \u0628\u0627\u0633\u0645 \u0625\u0639\u0627\u062f\u0629 \u062a\u0645\u0648\u0636\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0623\u0648 \u0625\u0639\u0627\u062f\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u2013 \u0643\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0648\u0627\u0639\u062f\u0629 \u0648\u0641\u0639\u0627\u0644\u0629 \u0644\u062a\u0633\u0631\u064a\u0639 \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a.<\/span><\/strong><\/span><\/p>\n

\"\"<\/p>\n

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\n\u062a\u064f\u0642\u062f\u0645 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0639\u062f\u062f\u064b\u0627 \u0645\u0646 \u0627\u0644\u0645\u0632\u0627\u064a\u0627 \u0627\u0644\u062c\u0648\u0647\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062c\u0639\u0644\u0647\u0627 \u0628\u062f\u064a\u0644\u064b\u0627 \u062c\u0630\u0627\u0628\u064b\u0627 \u0648\u0645\u0643\u0645\u0644\u064b\u0627 \u0644\u0645\u0633\u0627\u0631 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a:<\/span>
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\n2- \u062a\u0633\u0631\u064a\u0639 \u0627\u0644\u062c\u062f\u0648\u0644 \u0627\u0644\u0632\u0645\u0646\u064a:<\/strong> \u062a\u0637\u0648\u064a\u0631 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0635\u0641\u0631 \u064a\u0633\u062a\u063a\u0631\u0642 \u0639\u0627\u062f\u0629\u064b 10-15 \u0639\u0627\u0645\u064b\u0627. \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u060c \u064a\u0645\u0643\u0646 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u0627\u062f \u062a\u0648\u062c\u064a\u0647\u0647\u0627 \u0623\u0646 \u062a\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0631\u0643\u0632 \u0628\u0634\u0643\u0644 \u0623\u0633\u0627\u0633\u064a \u0639\u0644\u0649 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u062c\u0631\u0639\u0627\u062a. \u0647\u0630\u0627 \u064a\u0642\u0644\u0644 \u0628\u0634\u0643\u0644 \u062c\u0630\u0631\u064a \u0645\u0646 \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u0644\u0627\u0632\u0645 \u0644\u0637\u0631\u062d \u0627\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0633\u0648\u0642\u060c \u0645\u0645\u0627 \u064a\u0639\u0646\u064a \u0648\u0635\u0648\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0634\u0643\u0644 \u0623\u0633\u0631\u0639 \u0628\u0643\u062b\u064a\u0631. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0637\u0648\u0627\u0631\u0626 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0645\u062b\u0644 \u0627\u0644\u0623\u0648\u0628\u0626\u0629\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0648\u0641\u0631 \u0647\u0630\u0647 \u0627\u0644\u0633\u0631\u0639\u0629 \u0641\u0631\u0642\u064b\u0627 \u0647\u0627\u0626\u0644\u0627\u064b \u0641\u064a \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629.<\/span>
\n3- \u062e\u0641\u0636 \u0627\u0644\u062a\u0643\u0627\u0644\u064a\u0641:<\/strong> \u062a\u0637\u0648\u064a\u0631 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u064a\u0643\u0644\u0641 \u0641\u064a \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0645\u0644\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u062f\u0648\u0644\u0627\u0631\u0627\u062a. \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u062a\u0642\u0644\u0644 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062a\u0643\u0627\u0644\u064a\u0641\u060c \u062d\u064a\u062b \u064a\u0645\u0643\u0646 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 (\u062e\u0627\u0635\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629) \u0648\u0644\u0627 \u064a\u062a\u0637\u0644\u0628 \u0627\u0644\u0623\u0645\u0631 \u0627\u0633\u062a\u062b\u0645\u0627\u0631\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u0648\u0644\u064a (discovery phase). \u0647\u0630\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u062e\u064a\u0627\u0631\u064b\u0627 \u062c\u0630\u0627\u0628\u064b\u0627 \u0644\u0644\u0634\u0631\u0643\u0627\u062a \u0627\u0644\u0635\u063a\u064a\u0631\u0629\u060c \u0627\u0644\u0645\u0624\u0633\u0633\u0627\u062a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629\u060c \u0648\u0644\u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u062a\u064a \u0644\u0627 \u062a\u062d\u0638\u0649 \u0628\u0627\u0647\u062a\u0645\u0627\u0645 \u062a\u062c\u0627\u0631\u064a \u0643\u0628\u064a\u0631.<\/span><\/p>\n

\"\"
\u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0635\u0641\u0631 (\u0627\u0644\u0623\u0639\u0644\u0649) \u060c <\/span>\u0648\u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u062b\u0627\u0646\u064a \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u062c\u064a\u0647 ( \u0627\u0644\u0623\u0633\u0641\u0644).<\/span><\/figcaption><\/figure>\n

4- \u0645\u0639\u062f\u0644 \u0646\u062c\u0627\u062d \u0623\u0639\u0644\u0649:<\/strong> \u0646\u0638\u0631\u064b\u0627 \u0644\u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0628\u0627\u0644\u0641\u0639\u0644 \u0641\u0639\u0627\u0644\u064a\u0629 \u0641\u064a \u0628\u064a\u0626\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 (\u062d\u062a\u0649 \u0644\u0648 \u0643\u0627\u0646\u062a \u0644\u0645\u0624\u0634\u0631 \u0645\u062e\u062a\u0644\u0641)\u060c \u0641\u0625\u0646 \u0641\u0631\u0635 \u0646\u062c\u0627\u062d\u0647\u0627 \u0641\u064a \u0627\u0644\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u062a\u0643\u0648\u0646 \u0623\u0639\u0644\u0649 \u0628\u0643\u062b\u064a\u0631 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u062a\u0645\u0627\u0645\u064b\u0627 \u0627\u0644\u062a\u064a \u062a\u0628\u062f\u0623 \u0645\u0646 \u0627\u0644\u0635\u0641\u0631 (\u062d\u064a\u062b \u064a\u062a\u062c\u0627\u0648\u0632 \u0645\u0639\u062f\u0644 \u0627\u0644\u0641\u0634\u0644 90%). \u0627\u0644\u062e\u0628\u0631\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0641\u064a \u0627\u0633\u062a\u0642\u0644\u0627\u0628 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a \u0641\u064a \u062c\u0633\u0645 \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u062a\u0645\u0646\u062d \u0645\u064a\u0632\u0629 \u0643\u0628\u064a\u0631\u0629.<\/span>
\n5- \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 “\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u064a\u062a\u064a\u0645\u0629” \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0647\u0645\u0644\u0629:<\/strong> \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0630\u0627\u062a \u0623\u0647\u0645\u064a\u0629 \u062e\u0627\u0635\u0629 \u0644\u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0627\u062f\u0631\u0629 (\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u064a\u062a\u064a\u0645\u0629) \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0647\u0645\u0644\u0629\u060c \u062d\u064a\u062b \u064a\u0643\u0648\u0646 \u062d\u0627\u0641\u0632 \u0627\u0644\u0627\u0633\u062a\u062b\u0645\u0627\u0631 \u0641\u064a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0645\u0646\u062e\u0641\u0636\u064b\u0627 \u0628\u0633\u0628\u0628 \u0642\u0644\u0629 \u0639\u062f\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0623\u0648 \u0636\u0639\u0641 \u0627\u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u0634\u0631\u0627\u0626\u064a\u0629. \u062a\u0648\u0641\u0631 \u0647\u0630\u0647 \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0645\u0633\u0627\u0631\u064b\u0627 \u0623\u0643\u062b\u0631 \u062c\u062f\u0648\u0649 \u0627\u0642\u062a\u0635\u0627\u062f\u064a\u064b\u0627 \u0644\u062a\u0637\u0648\u064a\u0631 \u0639\u0644\u0627\u062c\u0627\u062a \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u062a\u0627\u062c\u0629.<\/span><\/p>\n

\u0622\u0644\u064a\u0627\u062a \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629<\/span><\/strong><\/span>
\n\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062a\u0645 \u0639\u0645\u0644\u064a\u0629 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0639\u062f\u0629 \u0637\u0631\u0642\u060c \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0639\u0631\u0636\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u062d\u0633\u0627\u0628\u064a\u0629 \u0627\u0644\u0645\u062a\u0637\u0648\u0631\u0629 \u0648\u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0636\u062e\u0645\u0629:<\/span>
\n1- \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (Clinical Observation):<\/strong> \u0647\u064a \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0623\u0642\u062f\u0645 \u0648\u0627\u0644\u0623\u0643\u062b\u0631 “\u062d\u0638\u064b\u0627” \u0641\u064a \u0627\u0643\u062a\u0634\u0627\u0641 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u062c\u064a\u0647. \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0623\u062d\u064a\u0627\u0646\u060c \u064a\u0644\u0627\u062d\u0638 \u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u0623\u0646 \u062f\u0648\u0627\u0621\u064b \u0645\u0639\u064a\u0646\u064b\u0627 \u064a\u064f\u0638\u0647\u0631 \u062a\u0623\u062b\u064a\u0631\u064b\u0627 \u063a\u064a\u0631 \u0645\u062a\u0648\u0642\u0639 \u0639\u0644\u0649 \u0645\u0631\u0636 \u0622\u062e\u0631 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0646\u0627\u0648\u0644\u0648\u0646\u0647. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u064a\u0646\u0648\u0643\u0633\u064a\u062f\u064a\u0644 (Minoxidil) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0635\u0644\u0639 (\u0627\u0644\u062b\u0639\u0644\u0628\u0629 \u0627\u0644\u0623\u0646\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0629) \u0628\u0639\u062f \u0645\u0644\u0627\u062d\u0638\u0629 \u0646\u0645\u0648 \u0627\u0644\u0634\u0639\u0631 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0646\u0627\u0648\u0644\u0648\u0646\u0647 \u0644\u0639\u0644\u0627\u062c \u0627\u0631\u062a\u0641\u0627\u0639 \u0636\u063a\u0637 \u0627\u0644\u062f\u0645. \u0647\u0630\u0627 \u0627\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0639\u0631\u0636\u064a \u0623\u062f\u0649 \u0625\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u062a\u0631\u0643\u064a\u0628\u0627\u062a \u0645\u0648\u0636\u0639\u064a\u0629 \u0644\u0644\u0645\u064a\u0646\u0648\u0643\u0633\u064a\u062f\u064a\u0644 \u0643\u0639\u0644\u0627\u062c \u0644\u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0634\u0639\u0631 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u060c \u0648\u0647\u0648 \u0627\u0644\u0622\u0646 \u0623\u062d\u062f \u0623\u0643\u062b\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0634\u064a\u0648\u0639\u064b\u0627.<\/span>
\n2- \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0646\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u0641\u062d\u0635 (Experimental Screening Approaches):<\/strong> \u062a\u062a\u0636\u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0641\u062d\u0635 \u0645\u0643\u062a\u0628\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0636\u062f \u0646\u0645\u0627\u0630\u062c \u0645\u0631\u0636\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 (\u0645\u062b\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629\u060c \u0623\u0648 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0645\u062b\u0644 \u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a\u060c \u0623\u0648 \u0646\u0645\u0627\u0630\u062c \u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0644\u0644\u0645\u0631\u0636) \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0627\u0644\u0645\u062d\u062a\u0645\u0644. \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0647\u0630\u0627 \u0627\u0644\u0641\u062d\u0635 \u0639\u0627\u0644\u064a \u0627\u0644\u0625\u0646\u062a\u0627\u062c\u064a\u0629 (High-Throughput Screening – HTS)\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0628\u0641\u062d\u0635 \u0622\u0644\u0627\u0641 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0628\u0633\u0631\u0639\u0629 \u0648\u0643\u0641\u0627\u0621\u0629. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u0641\u064a \u062c\u0647\u0648\u062f \u0645\u0643\u0627\u0641\u062d\u0629 \u0643\u0648\u0641\u064a\u062f-19 (COVID-19)\u060c \u062a\u0645 \u0641\u062d\u0635 \u0622\u0644\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0628\u0633\u0631\u0639\u0629 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0627\u062a \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u060c \u0645\u0645\u0627 \u0623\u062f\u0649 \u0625\u0644\u0649 \u062a\u062d\u062f\u064a\u062f \u0623\u062f\u0648\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u0631\u064a\u0645\u062f\u064a\u0633\u064a\u0641\u064a\u0631 (Remdesivir) \u0643\u0639\u0644\u0627\u062c \u0645\u062d\u062a\u0645\u0644.<\/span>
\n3- \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u062d\u0633\u0627\u0628\u064a\u0629\/\u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 (Computational\/Bioinformatics Approaches):<\/strong> \u062a\u064f\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0645\u062a\u0637\u0648\u0631\u0629 \u0628\u0634\u0643\u0644 \u0645\u062a\u0632\u0627\u064a\u062f \u0648\u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0642\u0648\u0629 \u0627\u0644\u062d\u0648\u0633\u0628\u0629 \u0648\u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0636\u062e\u0645\u0629. \u062a\u062a\u0636\u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0642\u0648\u0627\u0639\u062f \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0636\u062e\u0645\u0629 (\u0645\u062b\u0644 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a\u060c \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a\u0629-\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u064a\u0629\u060c \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629-\u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0626\u064a\u0629 \u0644\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629\u060c \u0648\u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629) \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647\u0627 \u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0645\u0633\u0627\u0631\u0627\u062a \u0645\u0631\u0636\u064a\u0629 \u0645\u0639\u064a\u0646\u0629. \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0634\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628:<\/span><\/span>
\n1- \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062a\u0648\u0642\u064a\u0639 \u0627\u0644\u062c\u064a\u0646\u064a (Gene Signature Analysis):<\/strong> \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0641\u0643\u0631\u0629 \u0623\u0646 \u0643\u0644 \u062f\u0648\u0627\u0621 \u0648\u0645\u0631\u0636 \u0644\u0647 “\u062a\u0648\u0642\u064a\u0639” \u0641\u0631\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a. \u062a\u0628\u062d\u062b \u0647\u0630\u0647 \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0639\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u0643\u0633 \u0623\u0648 \u062a\u062d\u0627\u0643\u064a \u0627\u0644\u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0645\u0639\u064a\u0646. \u0641\u0645\u062b\u0644\u0627\u064b\u060c \u0625\u0630\u0627 \u0643\u0627\u0646 \u0645\u0631\u0636 \u0645\u0639\u064a\u0646 \u064a\u062a\u0645\u064a\u0632 \u0628\u0641\u0631\u0637 \u0646\u0634\u0627\u0637 \u062c\u064a\u0646\u0627\u062a \u0645\u0639\u064a\u0646\u0629 \u0648\u0642\u0645\u0639 \u062c\u064a\u0646\u0627\u062a \u0623\u062e\u0631\u0649\u060c \u0641\u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u064a\u0628\u062d\u062b\u0648\u0646 \u0639\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0646\u062a\u062c \u062a\u0623\u062b\u064a\u0631\u064b\u0627 \u0645\u0639\u0627\u0643\u0633\u064b\u0627 \u0639\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a\u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 “\u062a\u0635\u062d\u064a\u062d” \u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u0645\u0631\u0636\u064a.<\/span>
\n2- \u0627\u0644\u0631\u0628\u0637 \u0627\u0644\u062c\u0632\u064a\u0626\u064a (Molecular Docking):<\/strong> \u064a\u062a\u0646\u0628\u0623 \u0628\u0643\u064a\u0641\u064a\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0623\u0647\u062f\u0627\u0641 \u0628\u0631\u0648\u062a\u064a\u0646\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 (\u0645\u062b\u0644 \u0627\u0644\u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a) \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0645\u062e\u062a\u0644\u0641 \u0639\u0646 \u0627\u0644\u0645\u0624\u0634\u0631 \u0627\u0644\u0623\u0635\u0644\u064a \u0644\u0644\u062f\u0648\u0627\u0621. \u062a\u064f\u0633\u062a\u062e\u062f\u0645 \u0647\u0630\u0647 \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0641\u064a \u062a\u0635\u0645\u064a\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0631\u0634\u062d\u064a\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u064a\u0646 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u062c\u064a\u0647 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0642\u064a\u064a\u0645 \u0645\u062f\u0649 \u0645\u0644\u0627\u0621\u0645\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0644\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0633\u062a\u0647\u062f\u0641 \u0641\u064a \u0645\u0631\u0636 \u0645\u062e\u062a\u0644\u0641.<\/span>
\n3- \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0634\u0628\u0643\u0627\u062a (Network Analysis):<\/strong> \u064a\u062d\u062f\u062f \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0634\u0628\u0643\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0645\u0639\u0642\u062f\u0629 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0645\u0631\u0636. \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062d\u0644\u064a\u0644 \u0634\u0628\u0643\u0627\u062a \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u064a\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0645\u0639\u064a\u0646\u060c \u064a\u0645\u0643\u0646 \u0644\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u062f “\u062a\u0639\u064a\u062f \u0636\u0628\u0637” \u0627\u0644\u0634\u0628\u0643\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0629 \u0625\u0644\u0649 \u062d\u0627\u0644\u0629 \u0635\u062d\u064a\u0629 \u0637\u0628\u064a\u0639\u064a\u0629 \u0623\u0648 \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0646\u0642\u0627\u0637 \u0645\u062d\u0648\u0631\u064a\u0629 \u0641\u064a \u0634\u0628\u0643\u0629 \u0627\u0644\u0645\u0631\u0636.<\/span>
\n4- \u0627\u0644\u062a\u0639\u0644\u0645 \u0627\u0644\u0622\u0644\u064a \u0648\u0627\u0644\u0630\u0643\u0627\u0621 \u0627\u0644\u0627\u0635\u0637\u0646\u0627\u0639\u064a (Machine Learning and AI):<\/strong> \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062e\u0648\u0627\u0631\u0632\u0645\u064a\u0627\u062a \u0645\u062a\u0642\u062f\u0645\u0629 \u0644\u062a\u062d\u0644\u064a\u0644 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u0636\u062e\u0645\u0629 \u0648\u0645\u0639\u0642\u062f\u0629 (Big Data) \u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0646\u0645\u0627\u0637 \u0648\u0639\u0644\u0627\u0642\u0627\u062a \u063a\u064a\u0631 \u0638\u0627\u0647\u0631\u0629 \u0642\u062f \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u062f\u0648\u0627\u0621 \u0645\u0639\u064a\u0646. \u062f\u0631\u0627\u0633\u0629 \u062d\u062f\u064a\u062b\u0629 \u0627\u0633\u062a\u062e\u062f\u0645\u062a \u0627\u0644\u062a\u0639\u0644\u0645 \u0627\u0644\u0639\u0645\u064a\u0642 \u0644\u062a\u062d\u062f\u064a\u062f \u0623\u062f\u0648\u064a\u0629 \u0645\u0648\u062c\u0648\u062f\u0629 \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0641\u0639\u0627\u0644\u0629 \u0636\u062f \u0627\u0644\u062a\u0644\u064a\u0641 \u0627\u0644\u0643\u064a\u0633\u064a (Cystic Fibrosis) \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062d\u0644\u064a\u0644 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0644\u0645\u0631\u0636\u0649. \u064a\u0645\u0643\u0646 \u0644\u0644\u0630\u0643\u0627\u0621 \u0627\u0644\u0627\u0635\u0637\u0646\u0627\u0639\u064a \u062a\u0633\u0631\u064a\u0639 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0641\u062d\u0635 \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0628\u0634\u0643\u0644 \u063a\u064a\u0631 \u0645\u0633\u0628\u0648\u0642.<\/span><\/p>\n

\"\"
\u0645\u0646\u0627\u0647\u062c \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u0648\u0636\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0635\u062d\u062a\u0647\u0627.<\/span><\/figcaption><\/figure>\n

\u0623\u0645\u062b\u0644\u0629 \u0646\u0627\u062c\u062d\u0629 \u0648\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0645\u064a\u0629 \u0645\u0641\u0635\u0644\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629<\/span><\/strong><\/span>
\n\u0647\u0646\u0627\u0643 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u062b\u0644\u0629 \u0627\u0644\u0628\u0627\u0631\u0632\u0629 \u0639\u0644\u0649 \u0627\u0644\u0646\u062c\u0627\u062d\u0627\u062a \u0641\u064a \u0645\u062c\u0627\u0644 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062f\u0639\u0645\u0647\u0627 \u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0645\u064a\u0629 \u0642\u0648\u064a\u0629:<\/span>
\n1- \u0627\u0644\u0623\u0633\u0628\u0631\u064a\u0646 (Aspirin):<\/strong> \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641\u0647 \u0641\u064a \u0627\u0644\u0623\u0635\u0644 \u0643\u0645\u0633\u0643\u0646 \u0644\u0644\u0623\u0644\u0645 \u0648\u0645\u0636\u0627\u062f \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0648\u0645\u062e\u0641\u0636 \u0644\u0644\u062d\u0631\u0627\u0631\u0629 \u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0642\u0631\u0646 \u0627\u0644\u062a\u0627\u0633\u0639 \u0639\u0634\u0631. \u0628\u0639\u062f \u0639\u0642\u0648\u062f\u060c \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0648\u0627\u0633\u0639\u0629 \u0627\u0644\u0646\u0637\u0627\u0642 \u0641\u064a \u0627\u0644\u062b\u0645\u0627\u0646\u064a\u0646\u064a\u0627\u062a (\u0645\u062b\u0644 \u062f\u0631\u0627\u0633\u0629 Physicians’ Health Study) \u0623\u0646 \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0645\u0646 \u0627\u0644\u0623\u0633\u0628\u0631\u064a\u0646 (75-325 \u0645\u0644\u062c\u0645 \u064a\u0648\u0645\u064a\u064b\u0627) \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0642\u0644\u0644 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0645\u0646 \u062e\u0637\u0631 \u0627\u0644\u0646\u0648\u0628\u0627\u062a \u0627\u0644\u0642\u0644\u0628\u064a\u0629 \u0648\u0627\u0644\u0633\u0643\u062a\u0627\u062a \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062b\u0628\u064a\u0637 \u062a\u062c\u0645\u0639 \u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u062f\u0645\u0648\u064a\u0629. \u0647\u0630\u0627 \u0623\u062f\u0649 \u0625\u0644\u0649 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647\u0647 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0643\u0639\u0627\u0645\u0644 \u0645\u0636\u0627\u062f \u0644\u062a\u062e\u062b\u0631 \u0627\u0644\u062f\u0645 \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0648\u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629.<\/span>
\n2- \u0627\u0644\u0633\u064a\u0644\u062f\u064a\u0646\u0627\u0641\u064a\u0644 (Sildenafil):<\/strong> \u062a\u0645 \u062a\u0637\u0648\u064a\u0631\u0647 \u0641\u064a \u0627\u0644\u0628\u062f\u0627\u064a\u0629 \u0628\u0648\u0627\u0633\u0637\u0629 \u0641\u0627\u064a\u0632\u0631 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0630\u0628\u062d\u0629 \u0627\u0644\u0635\u062f\u0631\u064a\u0629 (\u0623\u0644\u0645 \u0627\u0644\u0635\u062f\u0631 \u0627\u0644\u0646\u0627\u062a\u062c \u0639\u0646 \u0646\u0642\u0635 \u062a\u062f\u0641\u0642 \u0627\u0644\u062f\u0645 \u0625\u0644\u0649 \u0627\u0644\u0642\u0644\u0628) \u0641\u064a \u0623\u0648\u0627\u0626\u0644 \u0627\u0644\u062a\u0633\u0639\u064a\u0646\u064a\u0627\u062a. \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629\u060c \u0623\u0628\u0644\u063a \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0639\u0646 \u062a\u0623\u062b\u064a\u0631 \u062c\u0627\u0646\u0628\u064a \u063a\u064a\u0631 \u0645\u062a\u0648\u0642\u0639 \u062a\u0645\u062b\u0644 \u0641\u064a \u062a\u062d\u0633\u064a\u0646 \u0636\u0639\u0641 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0628. \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0629\u060c \u0623\u0639\u0627\u062f\u062a \u0641\u0627\u064a\u0632\u0631 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0623\u062c\u0631\u062a \u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0625\u0636\u0627\u0641\u064a\u0629 \u0623\u062f\u062a \u0625\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 (FDA) \u0639\u0644\u064a\u0647 \u0643\u0639\u0644\u0627\u062c \u0644\u0636\u0639\u0641 \u0627\u0644\u0627\u0646\u062a\u0635\u0627\u0628 \u0641\u064a \u0639\u0627\u0645 1998 \u062a\u062d\u062a \u0627\u0644\u0627\u0633\u0645 \u0627\u0644\u062a\u062c\u0627\u0631\u064a “\u0641\u064a\u0627\u063a\u0631\u0627”. \u0644\u0627\u062d\u0642\u064b\u0627\u060c \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u064a\u0644\u062f\u064a\u0646\u0627\u0641\u064a\u0644 \u0623\u064a\u0636\u064b\u0627 \u0644\u0639\u0644\u0627\u062c \u0627\u0631\u062a\u0641\u0627\u0639 \u0636\u063a\u0637 \u0627\u0644\u062f\u0645 \u0627\u0644\u0634\u0631\u064a\u0627\u0646\u064a \u0627\u0644\u0631\u0626\u0648\u064a (Pulmonary Arterial Hypertension – PAH)\u060c \u0648\u0647\u0648 \u0645\u062b\u0627\u0644 \u0622\u062e\u0631 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u062c\u064a\u0647.<\/span>
\n3- \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 (Metformin):<\/strong> \u062f\u0648\u0627\u0621 \u0634\u0627\u0626\u0639 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0643\u0631\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0644\u0623\u0643\u062b\u0631 \u0645\u0646 60 \u0639\u0627\u0645\u064b\u0627. \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0648\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0648\u0628\u0627\u0626\u064a\u0629 (\u0645\u062b\u0644 \u062f\u0631\u0627\u0633\u0629 UKPDS – UK Prospective Diabetes Study) \u0623\u0638\u0647\u0631\u062a \u0623\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0646\u0627\u0648\u0644\u0648\u0646 \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0644\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u064a\u0645\u064a\u0644\u0648\u0646 \u0625\u0644\u0649 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u062f\u064a\u0647\u0645 \u0645\u0639\u062f\u0644\u0627\u062a \u0625\u0635\u0627\u0628\u0629 \u0623\u0642\u0644 \u0628\u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0645\u062b\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627\u060c \u0648\u062a\u062d\u0633\u064a\u0646 \u0641\u064a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0639\u0644\u0627\u062c. \u0623\u062f\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u0644\u0627\u062d\u0638\u0627\u062a \u0625\u0644\u0649 \u0639\u062f\u062f \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062c\u0627\u0631\u064a\u0629 \u0645\u062b\u0644 [Metformin in Lung Cancer (NCT01807358) \u0648 Metformin in Breast Cancer (NCT01807345)] \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0643\u0634\u0641 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0643\u0639\u0644\u0627\u062c \u0645\u0633\u0627\u0639\u062f \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0623\u0648 \u0643\u0639\u0627\u0645\u0644 \u0648\u0642\u0627\u0626\u064a. \u0643\u0645\u0627 \u062a\u0634\u064a\u0631 \u062f\u0631\u0627\u0633\u0627\u062a \u0623\u062e\u0631\u0649 (\u0645\u062b\u0644 \u062f\u0631\u0627\u0633\u0629 TAME – Targeting Aging with Metformin) \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u0645\u064a\u062a\u0641\u0648\u0631\u0645\u064a\u0646 \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0648\u0625\u0637\u0627\u0644\u0629 \u0627\u0644\u0639\u0645\u0631 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0623\u062b\u064a\u0631\u0647 \u0639\u0644\u0649 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0623\u064a\u0636 \u0627\u0644\u062e\u0644\u0648\u064a \u0645\u062b\u0644 (mTOR) \u0648 (AMPK)\u060c \u0645\u0645\u0627 \u064a\u0648\u0633\u0639 \u0646\u0637\u0627\u0642 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647\u0647 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631.<\/span>
\n4- \u0627\u0644\u062b\u0627\u0644\u064a\u062f\u0648\u0645\u064a\u062f (Thalidomide):<\/strong> \u0627\u0643\u062a\u0633\u0628 \u0633\u0645\u0639\u0629 \u0633\u064a\u0626\u0629 \u0641\u064a \u0627\u0644\u0633\u062a\u064a\u0646\u064a\u0627\u062a \u0628\u0633\u0628\u0628 \u0622\u062b\u0627\u0631\u0647 \u0627\u0644\u062a\u064a\u0631\u0627\u062a\u062c\u064a\u0646\u064a\u0629 (\u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u062a\u0634\u0648\u0647\u0627\u062a \u062e\u0644\u0642\u064a\u0629 \u0634\u062f\u064a\u062f\u0629 \u0645\u062b\u0644 \u0627\u0644\u0641\u0648\u0643\u0648\u0645\u064a\u0627) \u0639\u0646\u062f \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0643\u0645\u0647\u062f\u0626 \u0648\u0645\u0636\u0627\u062f \u0644\u0644\u063a\u062b\u064a\u0627\u0646 \u0644\u062f\u0649 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u062d\u0648\u0627\u0645\u0644. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u064a \u0627\u0644\u062b\u0645\u0627\u0646\u064a\u0646\u064a\u0627\u062a \u0648\u0627\u0644\u062a\u0633\u0639\u064a\u0646\u064a\u0627\u062a\u060c \u0623\u0639\u064a\u062f \u0627\u0643\u062a\u0634\u0627\u0641\u0647 \u0643\u0639\u0644\u0627\u062c \u0641\u0639\u0627\u0644 \u0644\u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 (\u062e\u0627\u0635\u0629 \u0627\u0644\u0645\u0627\u064a\u0644\u0648\u0645\u0627 \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629) \u0648\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u062c\u0630\u0627\u0645 \u0628\u0633\u0628\u0628 \u062e\u0635\u0627\u0626\u0635\u0647 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0644\u0644\u0645\u0646\u0627\u0639\u0629 \u0648\u0645\u0636\u0627\u062f\u0627\u062a \u062a\u0643\u0648\u0651\u0646 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629. \u0647\u0630\u0627 \u0627\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u062f\u0649 \u0625\u0644\u0649 \u0648\u0636\u0639 \u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644\u0627\u062a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0635\u0627\u0631\u0645\u0629 \u0644\u0644\u063a\u0627\u064a\u0629 \u0644\u0636\u0645\u0627\u0646 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u0631\u0636\u0649\u060c \u0645\u0645\u0627 \u064a\u0628\u0631\u0632 \u0623\u0647\u0645\u064a\u0629 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0648\u062c\u064a\u0647.<\/span><\/p>\n

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\u0627\u0644\u0645\u0646\u0647\u062c\u064a\u0627\u062a \u0648\u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u0645\u062a\u0628\u0639\u0629 \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u0648\u0636\u0639 \u0627\u0644\u062f\u0648\u0627\u0621.<\/span><\/figcaption><\/figure>\n

\u0627\u0644\u062a\u062d\u062f\u064a\u0627\u062a \u0648\u0627\u0644\u0622\u0641\u0627\u0642 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0644\u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629<\/span><\/strong><\/span>
\n\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0625\u0645\u0643\u0627\u0646\u064a\u0627\u062a \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0648\u0627\u0639\u062f\u0629\u060c \u0625\u0644\u0627 \u0623\u0646\u0647\u0627 \u0644\u0627 \u062a\u062e\u0644\u0648 \u0645\u0646 \u0627\u0644\u062a\u062d\u062f\u064a\u0627\u062a \u0627\u0644\u062c\u0648\u0647\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u062c\u0628 \u0645\u0639\u0627\u0644\u062c\u062a\u0647\u0627 \u0644\u062a\u062d\u0642\u064a\u0642 \u0623\u0642\u0635\u0649 \u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629:<\/span>
\n1- \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629:<\/strong> \u0642\u062f \u0644\u0627 \u062a\u0643\u0648\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u062b\u0644\u0649 \u0623\u0648 \u0646\u0638\u0627\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u062f\u0648\u0627\u0621 \u0645\u064f\u0639\u0627\u062f \u062a\u0648\u062c\u064a\u0647\u0647 \u0647\u0648 \u0646\u0641\u0633\u0647 \u0641\u064a \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u062c\u062f\u064a\u062f. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0645\u0646 \u0627\u0644\u0623\u0633\u0628\u0631\u064a\u0646 \u062a\u062e\u062a\u0644\u0641 \u062a\u0645\u0627\u0645\u064b\u0627 \u0639\u0646 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u062f\u0645\u0648\u064a\u0629. \u0647\u0630\u0627 \u064a\u062a\u0637\u0644\u0628 \u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0625\u0636\u0627\u0641\u064a\u0629 \u0645\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u064b\u0627 \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u0627\u0644\u062a\u0631\u0643\u064a\u0628\u0629 \u0627\u0644\u0645\u062b\u0644\u0649 \u0644\u0644\u0645\u0624\u0634\u0631 \u0627\u0644\u062c\u062f\u064a\u062f\u060c \u0648\u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0639\u0645\u0644\u064a\u0629 \u0645\u0639\u0642\u062f\u0629.<\/span>
\n2- \u0627\u0644\u0645\u0644\u0643\u064a\u0629 \u0627\u0644\u0641\u0643\u0631\u064a\u0629 \u0648\u0628\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0631\u0627\u0639:<\/strong> \u0628\u0645\u062c\u0631\u062f \u0627\u0646\u062a\u0647\u0627\u0621 \u0635\u0644\u0627\u062d\u064a\u0629 \u0628\u0631\u0627\u0621\u0629 \u0627\u062e\u062a\u0631\u0627\u0639 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0635\u0644\u064a\u060c \u0642\u062f \u064a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u062d\u0627\u0641\u0632 \u062a\u062c\u0627\u0631\u064a \u0623\u0642\u0644 \u0644\u0644\u0634\u0631\u0643\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0643\u0628\u064a\u0631\u0629 \u0644\u0644\u0627\u0633\u062a\u062b\u0645\u0627\u0631 \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647\u0647\u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062d\u0645\u0627\u064a\u0629 \u062d\u0635\u0631\u064a\u0629 \u0644\u0644\u0645\u0646\u062a\u062c. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u064a\u0645\u0643\u0646 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0628\u0631\u0627\u0621\u0627\u062a \u0627\u062e\u062a\u0631\u0627\u0639 \u062c\u062f\u064a\u062f\u0629 \u0644\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 (patent for new use) \u0623\u0648 \u0644\u062a\u0631\u0643\u064a\u0628\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0623\u0648 \u0637\u0631\u0642 \u0627\u0644\u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0645\u0628\u062a\u0643\u0631\u0629. \u0647\u0630\u0627 \u0627\u0644\u0645\u062c\u0627\u0644 \u064a\u0645\u062b\u0644 \u062a\u062d\u062f\u064a\u064b\u0627 \u0642\u0627\u0646\u0648\u0646\u064a\u064b\u0627 \u0648\u062a\u062c\u0627\u0631\u064a\u064b\u0627 \u064a\u062a\u0637\u0644\u0628 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0645\u0628\u062a\u0643\u0631\u0629.<\/span>
\n3- \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0627\u0644\u0633\u0644\u0627\u0645\u0629:<\/strong> \u064a\u062c\u0628 \u0623\u0646 \u062a\u062e\u0636\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u0627\u062f \u062a\u0648\u062c\u064a\u0647\u0647\u0627 \u0644\u062a\u062c\u0627\u0631\u0628 \u0633\u0631\u064a\u0631\u064a\u0629 \u0635\u0627\u0631\u0645\u0629 \u0644\u0625\u062b\u0628\u0627\u062a \u0641\u0639\u0627\u0644\u064a\u062a\u0647\u0627 \u0648\u0633\u0644\u0627\u0645\u062a\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0624\u0634\u0631 \u0627\u0644\u062c\u062f\u064a\u062f\u060c \u062a\u0645\u0627\u0645\u064b\u0627 \u0645\u062b\u0644 \u0623\u064a \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f\u060c \u0644\u0636\u0645\u0627\u0646 \u0623\u0646\u0647\u0627 \u062a\u0644\u0628\u064a \u0627\u0644\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0627\u0644\u0635\u0627\u0631\u0645\u0629 [\u0645\u062b\u0644 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u062f\u0647\u0627 (FDA) \u0623\u0648 (EMA)]. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u062a\u0643\u0648\u0646 \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u062e\u062a\u0635\u0631\u0629\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0627 \u062a\u0632\u0627\u0644 \u0636\u0631\u0648\u0631\u064a\u0629 \u0648\u0645\u0643\u0644\u0641\u0629.<\/span>
\n4- \u0627\u0644\u0641\u0634\u0644 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629:<\/strong> \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0645\u0639\u062f\u0644 \u0627\u0644\u0646\u062c\u0627\u062d \u0623\u0639\u0644\u0649\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u0627\u062f \u062a\u0648\u062c\u064a\u0647\u0647\u0627 \u0644\u0627 \u062a\u0632\u0627\u0644 \u062a\u0648\u0627\u062c\u0647 \u062e\u0637\u0631 \u0627\u0644\u0641\u0634\u0644 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0625\u0630\u0627 \u0644\u0645 \u062a\u0643\u0646 \u0641\u0639\u0627\u0644\u0629 \u0623\u0648 \u0622\u0645\u0646\u0629 \u0628\u0645\u0627 \u0641\u064a\u0647 \u0627\u0644\u0643\u0641\u0627\u064a\u0629 \u0644\u0644\u0645\u0624\u0634\u0631 \u0627\u0644\u062c\u062f\u064a\u062f\u060c \u0623\u0648 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u062a\u0641\u0648\u0642 \u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0641\u064a \u0627\u0644\u0633\u064a\u0627\u0642 \u0627\u0644\u062c\u062f\u064a\u062f.<\/span>
\n5- \u0627\u0644\u062a\u0639\u0642\u064a\u062f \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a:<\/strong> \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0645\u0639\u0642\u062f\u0629 \u0648\u062a\u062a\u0623\u062b\u0631 \u0628\u0645\u0633\u0627\u0631\u0627\u062a \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629. \u0642\u062f \u0644\u0627 \u064a\u0643\u0648\u0646 \u0644\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u0639\u0627\u062f \u062a\u0648\u062c\u064a\u0647\u0647 \u062a\u0623\u062b\u064a\u0631 \u0643\u0627\u0641\u064d \u0639\u0644\u0649 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0636\u0631\u0648\u0631\u064a\u0629 \u0644\u062a\u062d\u0642\u064a\u0642 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629.<\/span><\/p>\n

\u0641\u064a \u0627\u0644\u062e\u062a\u0627\u0645\u060c<\/strong> \u064a\u064f\u0639\u062f \u0645\u0628\u062f\u0623 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0631\u0643\u064a\u0632\u0629 \u0623\u0633\u0627\u0633\u064a\u0629 \u0648\u0648\u0627\u0639\u062f\u0629 \u0641\u064a \u0645\u0634\u0647\u062f \u0627\u0643\u062a\u0634\u0627\u0641 \u0648\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u0627\u0635\u0631. \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0648\u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u062d\u0648\u0644 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0642\u0627\u0626\u0645\u0629\u060c \u064a\u0645\u0643\u0646 \u0644\u0647\u0630\u0647 \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0623\u0646 \u062a\u0642\u0644\u0644 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0645\u0646 \u0627\u0644\u0648\u0642\u062a \u0648\u0627\u0644\u062a\u0643\u0627\u0644\u064a\u0641 \u0648\u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u062c\u0644\u0628 \u0639\u0644\u0627\u062c\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649. \u0645\u0639 \u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0645\u0633\u062a\u0645\u0631 \u0641\u064a \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u062a\u0639\u0644\u0645 \u0627\u0644\u0622\u0644\u064a\u060c \u0645\u0646 \u0627\u0644\u0645\u0631\u062c\u062d \u0623\u0646 \u062a\u0632\u062f\u0627\u062f \u0643\u0641\u0627\u0621\u0629 \u0648\u062f\u0642\u0629 \u0639\u0645\u0644\u064a\u0629 \u0625\u0639\u0627\u062f\u0629 \u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0641\u062a\u062d \u0622\u0641\u0627\u0642\u064b\u0627 \u062c\u062f\u064a\u062f\u0629 \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0633\u062a\u0639\u0635\u064a\u0629 \u0637\u0628\u064a\u064b\u0627 \u0648\u064a\u0642\u062f\u0645 \u0628\u0635\u064a\u0635 \u0623\u0645\u0644 \u0644\u0645\u0644\u0627\u064a\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645.<\/span><\/p>\n

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