{"id":2656,"date":"2019-05-22T22:16:30","date_gmt":"2019-05-22T19:16:30","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=2656"},"modified":"2019-05-22T22:16:30","modified_gmt":"2019-05-22T19:16:30","slug":"%d8%af%d8%b1%d8%a7%d8%b3%d8%aa%d8%a7%d9%86-%d8%aa%d8%b3%d8%aa%d9%83%d8%b4%d9%81%d8%a7%d9%86-%d9%85%d8%a7-%d8%a5%d8%b0%d8%a7-%d8%a7%d9%84%d9%88%d9%82%d8%aa-%d9%85%d9%86-%d8%a7%d9%84%d9%8a%d9%88%d9%85","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=2656","title":{"rendered":"\u062f\u0631\u0627\u0633\u062a\u0627\u0646 \u062a\u0633\u062a\u0643\u0634\u0641\u0627\u0646 \u0645\u0627 \u0625\u0630\u0627 \u0627\u0644\u0648\u0642\u062a \u0645\u0646 \u0627\u0644\u064a\u0648\u0645 \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0625\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u062c\u0633\u0645 \u0644\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 – \u062a\u0631\u062c\u0645\u0629 \u0639\u062f\u0646\u0627\u0646 \u0623\u062d\u0645\u062f \u0627\u0644\u062d\u0627\u062c\u064a"},"content":{"rendered":"

\u062a\u0624\u0643\u062f \u0648\u0631\u0642\u062a\u0627\u0646 \u0646\u0634\u0631\u062a\u0627 \u0641\u064a \u0661\u0668 \u0623\u0628\u0631\u064a\u0644 \u0662\u0660\u0661\u0669 \u0641\u064a \u0645\u062c\u0644\u0629 \u0633\u064a\u0644 \u0645\u064a\u062a\u0627\u0628\u0644\u0648\u0632\u064a\u0645 Cell Metabolism \u0623\u0646 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0628\u0627\u064a\u0644\u0648\u062c\u064a\u0629 \u0647\u064a \u0639\u0627\u0645\u0644 \u0645\u0647\u0645 \u0641\u064a \u0643\u064a\u0641 \u064a\u0633\u062a\u062c\u064a\u0628 \u0627\u0644\u062c\u0633\u0645 \u0644\u0644\u0645\u062c\u0647\u0648\u062f \u0627\u0644\u0628\u062f\u0646\u064a. \u00a0\u0631\u0643\u0632\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0649 \u0639\u0646\u0627\u0635\u0631 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u062a\u0645\u0631\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062a\u0645\u0645 \u0628\u0639\u0636\u0647\u0627 \u0628\u0639\u0636\u0627\u064b. \u00a0\u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u0628\u062d\u062b\u064a \u0628\u0645\u0641\u0631\u062f\u0647 \u060c \u0645\u0646 \u0627\u0644\u0633\u0627\u0628\u0642 \u0644\u0623\u0648\u0627\u0646\u0647 \u062a\u062d\u062f\u064a\u062f \u0645\u062a\u0649 \u064a\u0643\u0648\u0646 \u0623\u0641\u0636\u0644 \u0648\u0642\u062a \u0644\u0643 \u0644\u0644\u0642\u064a\u0627\u0645 \u0628\u062a\u0645\u0631\u064a\u0646 \u0627\u0644\u0631\u0643\u0636. \u00a0\u0648\u0644\u0643\u0646 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u060c \u064a\u0628\u062f\u0648 \u0623\u0646 \u0627\u0644\u062a\u0645\u0631\u064a\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0621 \u0647\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u0625\u0646\u062a\u0627\u062c\u064a\u0629 \u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0623\u0643\u062b\u0631 \u062a\u0639\u0642\u064a\u062f\u064b\u0627 \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0641\u0625\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u062c\u0627\u0644 \u0645\u0646 \u0627\u0644\u0628\u062d\u062b \u0642\u062f \u0628\u062f\u0623 \u0644\u0644\u062a\u0648.<\/p>\n

\"\"<\/p>\n

\u064a\u0642\u0648\u0644 \u062c\u0627\u062f \u0622\u0634\u0631 Gad Asher \u0645\u0646 \u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0645\u0639\u0647\u062f \u0648\u0627\u064a\u0632\u0645\u0627\u0646 \u0644\u0644\u0639\u0644\u0648\u0645 \u060c \u0648\u0647\u0648 \u0643\u0628\u064a\u0631 \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 \u0641\u064a \u0625\u062d\u062f\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a: “\u0645\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u062a\u0645\u0627\u0645\u064b\u0627 \u0623\u0646 \u0643\u0644 \u062c\u0627\u0646\u0628 \u0645\u0646 \u062c\u0648\u0627\u0646\u0628 \u0627\u0644\u0641\u0633\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0648\u0627\u0644\u0623\u064a\u0636 (\u0627\u0644\u0625\u0633\u062a\u0642\u0644\u0627\u0628) \u0644\u062f\u064a\u0646\u0627 \u062a\u0645\u0644\u064a\u0647 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629”. \u00a0“\u0647\u0630\u0627 \u0635\u062d\u064a\u062d \u0644\u064a\u0633 \u0641\u0642\u0637 \u0641\u064a \u0627\u0644\u0628\u0634\u0631 \u0648\u0644\u0643\u0646 \u0641\u064a \u0643\u0644 \u0643\u0627\u0626\u0646 \u062d\u064a \u062d\u0633\u0627\u0633 \u0644\u0644\u0636\u0648\u0621. \u0642\u0631\u0631\u0646\u0627 \u0623\u0646 \u0646\u0633\u0623\u0644 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u0635\u0644\u0629 \u0628\u064a\u0646 \u0627\u0644\u0648\u0642\u062a \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0648\u0623\u062f\u0627\u0621 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629.”<\/p>\n

\u064a\u0636\u064a\u0641 \u0628\u0627\u0648\u0644\u0648 \u0633\u0627\u0633\u0648\u0646\u064a-\u0643\u0648\u0631\u0633\u064a Paolo Sassone-Corsi \u0645\u0646 \u0645\u0631\u0643\u0632 \u0639\u0644\u0648\u0645 \u0625\u0628\u064a\u062c\u064a\u0646\u062a\u0643\u0633 (\u0661) \u0648\u0627\u0644\u0623\u064a\u0636 \u0628\u062c\u0627\u0645\u0639\u0629 \u0643\u0627\u0644\u064a\u0641\u0648\u0631\u0646\u064a\u0627 \u060c \u0641\u064a \u0625\u064a\u0631\u0641\u064a\u0646 \u060c \u0648\u0647\u0648 \u0643\u0628\u064a\u0631 \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 \u0644\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0623\u062e\u0631\u0649: “\u062a\u0647\u064a\u0645\u0646 \u0627\u0644\u0625\u064a\u0642\u0627\u0639\u0627\u062a \u0627\u0644\u064a\u0648\u0645\u064a\u0629 \u0639\u0644\u0649 \u0643\u0644 \u0645\u0627 \u0646\u0642\u0648\u0645 \u0628\u0647”. \u00a0“\u0644\u0642\u062f \u0623\u0648\u0636\u062d\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u0627\u0647\u0627 \u0645\u062e\u062a\u0628\u0631\u0646\u0627 \u0623\u0646 \u0665\u0660\u066a \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0645\u0646 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0623\u064a\u0636 \u0639\u0646\u062f\u0646\u0627 \u0647\u064a \u0625\u064a\u0642\u0627\u0639\u064a\u0629 \u060c \u0648\u0623\u0646 \u0665\u0660\u066a \u0645\u0646 \u0646\u0648\u0627\u062a\u062c \u0627\u0644\u0623\u064a\u0636 \u0641\u064a \u0623\u062c\u0633\u0627\u0645\u0646\u0627 \u062a\u062a\u0623\u0631\u062c\u062d \u0625\u0639\u062a\u0645\u0627\u062f\u0627\u064b \u00a0\u0639\u0644\u0649 \u00a0\u062f\u0648\u0631\u0629 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0628\u0627\u064a\u0644\u0648\u062c\u064a\u0629. \u0648\u0645\u0646 \u0627\u0644\u0645\u0646\u0637\u0642\u064a \u0623\u0646 \u0627\u0644\u062a\u0645\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a \u0633\u064a\u0643\u0648\u0646 \u0623\u062d\u062f \u0627\u0644\u0623\u0634\u064a\u0627\u0621 \u0627\u0644\u062a\u064a \u062a\u062a\u0623\u062b\u0631 \u0628\u0630\u0644\u0643 “.<\/p>\n

\u0646\u0638\u0631 \u0643\u0644 \u0645\u0646 \u0641\u0631\u064a\u0642\u064a \u0627\u0644\u0628\u062d\u062b \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0645 \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0648\u0642\u062a \u0645\u0646 \u0627\u0644\u064a\u0648\u0645 \u0648\u0623\u062f\u0627\u0621 \u0627\u0644\u062a\u0645\u0631\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646. \u00a0\u0644\u0623\u0646 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0644\u064a\u0644\u064a\u0629 \u0627\u0644\u0646\u0634\u0627\u0637 \u060c \u0627\u0644\u0634\u064a\u0621 \u0627\u0644\u0648\u062d\u064a\u062f \u0627\u0644\u0630\u064a \u0643\u0627\u0646 \u064a\u062a\u0639\u064a\u0646 \u0639\u0644\u064a\u0647\u0645 \u0627\u0644\u0642\u064a\u0627\u0645 \u0628\u0647 \u0647\u0648 \u062a\u0631\u062c\u0645\u0629 \u062a\u0648\u0642\u064a\u062a \u0627\u0644\u0641\u0623\u0631 \u0625\u0644\u0649 \u062a\u0648\u0642\u064a\u062a \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u060c \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062a\u0645\u064a\u064a\u0632 \u0628\u064a\u0646 \u0637\u0648\u0631 \u0627\u0644\u0646\u0634\u0627\u0637 \u0648\u0637\u0648\u0631 \u0627\u0644\u0631\u0627\u062d\u0629 \u0644\u0644\u0641\u0626\u0631\u0627\u0646 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0625\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u0631\u0642\u0627\u0645 \u0627\u0644\u062a\u064a \u0639\u0644\u0649 \u0627\u0644\u0633\u0627\u0639\u0629.<\/p>\n

\u0628\u062f\u0623\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0622\u0634\u0631 \u0628\u0648\u0636\u0639 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u064a\u062f\u0645\u064a\u0644 (\u0633\u064a\u0631 \u0644\u0644\u0645\u0634\u064a \u0643\u0647\u0631\u0628\u0627\u0626\u064a) \u0641\u064a \u0623\u0648\u0642\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u064a\u0648\u0645 \u0636\u0645\u0646 \u0637\u0648\u0631\u0647\u0627 \u0627\u0644\u0646\u0634\u0637. \u00a0\u0642\u0627\u0645\u0648\u0627 \u0628\u0641\u062d\u0635 \u0642\u062f\u0631\u0629 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0639\u0644\u0649 \u0627\u0644\u062a\u0645\u0631\u064a\u0646 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0643\u062b\u0627\u0641\u0629 \u062a\u0645\u0631\u064a\u0646 \u0648\u0623\u0646\u0638\u0645\u0629 \u062a\u063a\u0630\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629 \u0644\u0644\u062a\u0645\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a \u0648\u0648\u062c\u062f\u0648\u0627 \u0623\u0646 \u0623\u062f\u0627\u0621 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0623\u0641\u0636\u0644 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 (\u062d\u0648\u0627\u0644\u064a \u0665\u0660 \u066a \u0641\u064a \u0627\u0644\u0645\u062a\u0648\u0633\u0637 \u0648\u0623\u0643\u062b\u0631 \u0645\u0646 \u0630\u0644\u0643 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644\u0627\u062a) \u0641\u064a “\u0645\u0633\u0627\u0621 \u0627\u0644\u0641\u0623\u0631” (\u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0648\u0642\u062a \u0646\u0634\u0627\u0637\u0647) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0633\u0627\u0639\u0627\u062a \u0627\u0644\u0635\u0628\u0627\u062d. \u0647\u0630\u0647 \u0627\u0644\u0625\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0627\u0644\u064a\u0648\u0645\u064a\u0629 \u062a\u0636\u0627\u0621\u0644\u062a \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u062a\u064a \u0643\u0627\u0646\u062a \u0633\u0627\u0639\u0627\u062a\u0647\u0627 \u0627\u0644\u0628\u064a\u0644\u0648\u062c\u064a\u0629 \u0637\u0627\u0641\u0631\u0629 mutant – \u0645\u0645\u0627 \u064a\u062f\u0639\u0645 \u0627\u0644\u062f\u0648\u0631 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0644\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0628\u064a\u0644\u0648\u062c\u064a\u0629 \u0641\u064a \u0627\u0644\u062a\u0628\u0627\u064a\u0646 \u0627\u0644\u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0623\u062f\u0627\u0621 \u0627\u0644\u062a\u0645\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a.<\/p>\n

\u0644\u062a\u062d\u062f\u064a\u062f \u0623\u062d\u062f \u0627\u0644\u0645\u062d\u062f\u062f\u0627\u062a \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0644\u062a\u0628\u0627\u064a\u0646 \u0627\u0644\u064a\u0648\u0645\u064a \u0641\u064a \u0623\u062f\u0627\u0621 \u0627\u0644\u062a\u0645\u0631\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u060c \u0642\u0627\u0645\u0648\u0627 \u0628\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u062a\u0631\u0646\u0633\u0643\u0631\u064a\u0628\u062a\u0648\u0645 \u00a0transcriptomics (\u0662) \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0625\u0646\u062a\u0627\u062c\u064a\u0629 high-throughput \u0648\u0646\u0648\u0627\u062a\u062c \u0627\u0644\u0623\u064a\u0636 metabolomics \u0639\u0644\u0649 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0639\u0636\u0644\u064a\u0629. \u00a0\u0648\u062c\u062f \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u0646\u0647 \u0625\u0633\u062a\u062c\u0627\u0628\u0629\u064b \u0644\u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u062a\u0645\u0631\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u0641\u064a “\u0645\u0633\u0627\u0621 \u00a0\u0627\u0644\u0641\u0623\u0631” \u060c \u0643\u0627\u0646\u062a \u0647\u0646\u0627\u0643 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0623\u0639\u0644\u0649 \u0645\u0646 \u0646\u0627\u062a\u062c \u0627\u0644\u0623\u064a\u0636 \u0627\u0644\u0645\u0633\u0645\u0649 \u0628 ZMP \u0648\u0647\u0648 \u0627\u062e\u062a\u0635\u0627\u0631 \u0644 5-aminoimidazole-4-carboxamide ribonucleotide. \u00a0\u0648\u0645\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u0646 ZMP \u064a\u0642\u0648\u0645 \u0628\u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0623\u064a\u0636\u064a\u0629 metabolic \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u062a\u062d\u0644\u0644 \u0627\u0644\u0633\u0643\u0631 \u0648\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0646\u0634\u064a\u0637 \u0627\u0644 AMPK \u060c \u0648\u0647\u0648 \u0645\u0646\u0638\u0645 \u0623\u064a\u0636\u064a \u062e\u0644\u064a\u0648\u064a \u0631\u0626\u064a\u0633\u064a master cellular metabolic. \u00a0\u0644\u0630\u0644\u0643 \u060c \u0645\u0646 \u0627\u0644\u0645\u0631\u062c\u062d \u0623\u0646 \u064a\u0633\u0628\u0628 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u00a0\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u0631\u064a\u0627\u0636\u0629 \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0621. \u00a0\u064a\u0642\u0648\u0644 \u0622\u0634\u0631: “\u0645\u0646 \u0627\u0644\u0645\u062b\u064a\u0631 \u0644\u0644\u0625\u0647\u062a\u0645\u0627\u0645 \u0623\u0646 ZMP \u0647\u0648 \u0645\u062a\u0646\u0627\u0638\u0631 \u062f\u0627\u062e\u0644\u064a endogenous analog \u0644\u0640 AICAR \u0648\u0647\u0648 \u0625\u062e\u062a\u0635\u0627\u0631 \u0644 \u00a0aminoimidazole carboxamide riboside\u060c \u0648\u0647\u0648 \u0645\u0631\u0643\u0628 \u064a\u0633\u062a\u062e\u062f\u0645\u0647 \u0628\u0639\u0636 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0643\u0645\u0646\u0634\u0637”.<\/p>\n

\u0643\u0645\u0627 \u062f\u0631\u0633 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0661\u0662 \u0634\u062e\u0635\u064b\u0627 \u0648\u0648\u062c\u062f\u0648\u0627 \u0622\u062b\u0627\u0631\u064b\u0627 \u0645\u0645\u0627\u062b\u0644\u0629. \u00a0\u0639\u0645\u0648\u0645\u0627\u064b \u060c \u0643\u0627\u0646 \u0644\u062f\u0649 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u0634\u0645\u0644\u062a\u0647\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0633\u062a\u0647\u0644\u0627\u0643 \u0623\u0648\u0643\u0633\u062c\u064a\u0646 \u0623\u0642\u0644 \u00a0\u0623\u062b\u0646\u0627\u0621 \u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0621 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u0635\u0628\u0627\u062d. \u00a0\u0647\u0630\u0627 \u064a\u064f\u062a\u0631\u062c\u0645 \u0625\u0644\u0649 \u0643\u0641\u0627\u0621\u0629 \u062a\u0645\u0631\u064a\u0646 \u0631\u064a\u0627\u0636\u064a \u0623\u0641\u0636\u0644 .<\/p>\n

\u0648\u0636\u0639 \u0641\u0631\u064a\u0642 \u0633\u0627\u0633\u0648\u0646\u064a-\u0643\u0648\u0631\u0633\u064a Paolo Sassone-Corsi \u0623\u064a\u0636\u064b\u0627 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u064a\u062f\u0645\u064a\u0644 (\u0633\u064a\u0631 \u0627\u0644\u0645\u0634\u064a) \u00a0\u060c \u0648\u0644\u0643\u0646 \u0643\u0627\u0646 \u0644\u062f\u064a\u0647\u0645 \u0645\u0642\u0627\u0631\u0628\u0629 \u0645\u062e\u062a\u0644\u0641\u0629. \u00a0\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u0631\u0646\u0633\u0643\u0631\u064a\u0628\u062a\u0648\u0645 \u00a0transcriptomics \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0625\u0646\u062a\u0627\u062c\u064a\u0629 \u0648\u0627\u0644\u0646\u0648\u0627\u062a\u062c \u0627\u0644\u0623\u064a\u0636\u064a\u0629 (\u0627\u0644\u0645\u062a\u0627\u0628\u0648\u0644\u0648\u0645\u064a\u0627\u062a) \u0644\u0641\u062d\u0635 \u0645\u062c\u0645\u0648\u0639\u0629 \u0648\u0627\u0633\u0639\u0629 \u0645\u0646 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u060c \u0648\u0642\u0627\u0645\u0648\u0627 \u0628\u062a\u062d\u062f\u064a\u062f \u0645\u0639\u0627\u0644\u0645 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0623\u0646\u0633\u062c\u0629 \u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u062a\u064a \u062a\u062d\u062f\u062b \u0625\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629. \u00a0\u0623\u062a\u0627\u062d \u0644\u0647\u0645 \u0630\u0644\u0643 \u0627\u0644\u0646\u0638\u0631 \u0641\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0645\u062b\u0644 \u062a\u062d\u0644\u0644 \u0627\u0644\u0633\u0643\u0631 (\u0627\u0644\u0630\u064a \u064a\u0633\u0628\u0628 \u0625\u0633\u062a\u0642\u0644\u0627\u0628 -\u0623\u064a\u0636- \u0627\u0644\u0633\u0643\u0631 \u0648\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0637\u0627\u0642\u0629) \u0648\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u062f\u0647\u0648\u0646 (\u062d\u0631\u0642 \u0627\u0644\u062f\u0647\u0648\u0646).<\/p>\n

\u0644\u0642\u062f \u0648\u062c\u062f\u0648\u0627 \u0623\u0646 \u0628\u0631\u0648\u062a\u064a\u0646\u064b\u0627 \u064a\u064f\u0633\u0645\u0651\u0649 \u0627\u0644\u0639\u0627\u0645\u0644 \u0627\u0644\u0630\u064a \u064a\u062d\u0641\u0632 \u0646\u0642\u0635 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u0648\u0627\u0635\u0644 \u0627\u0644\u0649 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 hypoxia-inducible factor 1-alpha (HIF-1\u03b1) \u064a\u0644\u0639\u0628 \u062f\u0648\u0631\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0648\u0623\u0646\u0647 \u064a\u062a\u0645 \u062a\u0646\u0634\u064a\u0637\u0647 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u0628\u0637\u0631\u0642 \u0645\u062e\u062a\u0644\u0641\u0629 \u0625\u0639\u062a\u0645\u0627\u062f\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0648\u0642\u062a \u0645\u0646 \u0627\u0644\u064a\u0648\u0645. \u00a0HIF-1\u03b1 \u0647\u0648 \u0639\u0627\u0645\u0644 \u0625\u0633\u062a\u0646\u0633\u0627\u062e \u00a0transcription \u0648\u0645\u0639\u0631\u0648\u0641 \u0623\u0646\u0647 \u064a\u062b\u064a\u0631 \u062c\u064a\u0646\u0627\u062a \u0645\u0639\u064a\u0646\u0629 \u0639\u0644\u0649 \u0623\u0633\u0627\u0633 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629. \u00a0\u064a\u0642\u0648\u0644 \u0633\u0627\u0633\u0648\u0646\u064a \u0643\u0648\u0631\u0633\u064a: “\u0645\u0646 \u0627\u0644\u0645\u0646\u0637\u0642\u064a \u0623\u0646 \u064a\u0643\u0648\u0646 HIF-1\u03b1 \u0645\u0647\u0645\u064b\u0627 \u0647\u0646\u0627 \u060c \u0644\u0643\u0646 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u0644\u0645 \u0646\u0643\u0646 \u0646\u0639\u0631\u0641 \u0623\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a\u0647 \u062a\u062a\u0642\u0644\u0628 \u0648\u0641\u0642\u064b\u0627 \u0644\u0644\u0648\u0642\u062a \u0645\u0646 \u0627\u0644\u064a\u0648\u0645”. \u00a0“\u0647\u0630\u0627 \u0625\u0643\u062a\u0634\u0627\u0641 \u062c\u062f\u064a\u062f.”<\/p>\n

\u0625\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u0630\u064a \u0642\u0627\u0645 \u0628\u0647 \u0641\u0631\u064a\u0642 \u062c\u0627\u0645\u0639\u0629 \u0643\u0627\u0644\u0641\u0648\u0631\u0646\u064a\u0627 \u0641\u064a \u0625\u064a\u06a4\u0631\u064a\u0646 UC Irvine \u060c \u0628\u062f\u0627 \u0623\u0646 \u0627\u0644\u062a\u0645\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a \u0644\u0647 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0623\u0643\u062b\u0631 \u0641\u0627\u0626\u062f\u0629 \u0639\u0644\u0649 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0623\u064a\u0636 (\u0627\u0644\u0625\u0633\u062a\u0642\u0644\u0627\u0628) \u0641\u064a \u0628\u062f\u0627\u064a\u0629 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0637\u0648\u0631 \u0627\u0644\u0646\u0634\u0637 (\u0623\u064a \u0645\u0627 \u064a\u0639\u0627\u062f\u0644 \u0648\u0642\u062a\u0627\u064b \u0645\u062a\u0623\u062e\u0631\u0627\u064b \u0645\u0646 \u0627\u0644\u0635\u0628\u0627\u062d \u0639\u0646\u062f \u0627\u0644\u0628\u0634\u0631) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0631\u0627\u062d\u0629 (\u0641\u064a \u0627\u0644\u0645\u0633\u0627\u0621).<\/p>\n

\u062a\u0639\u0631\u064a\u0641 \u0648\u0645\u0635\u062f\u0631 \u0645\u0646 \u062e\u0627\u0631\u062c \u0648\u062f\u0627\u062e\u0644 \u0627\u0644\u0646\u0635:<\/strong><\/h5>\n
\u0661-\u062a\u0639\u0631\u064a\u0641 \u0625\u0628\u064a\u062c\u064a\u0646\u062a\u0643\u0633 epigenetics \u0641\u064a \u0645\u0639\u0646\u0627\u0647 \u0627\u0644\u062d\u062f\u064a\u062b\u060c \u00a0\u0647\u0648 \u0645\u0635\u0637\u0644\u062d \u064a\u0633\u062a\u062e\u062f\u0645 \u0644\u0648\u0635\u0641 \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0622\u0644\u064a\u0627\u062a \u0623\u062e\u0631\u0649 \u063a\u064a\u0631 \u062a\u0633\u0644\u0633\u0644 \u00a0\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a DNA \u0644\u0644\u062c\u064a\u0646\u0627\u062a . \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0646\u0637\u0628\u0642 \u0639\u0644\u0649 \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062a\u064a \u0646\u064f\u0642\u0644\u062a \u0645\u0646 \u062e\u0644\u064a\u0629 \u0625\u0644\u0649 \u0628\u0646\u0627\u062a\u0647\u0627 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0641\u064a \u0625\u0646\u0642\u0633\u0627\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0625\u0644\u0649 \u0633\u0645\u0627\u062a \u0643\u0627\u0626\u0646 \u062d\u064a \u0643\u0627\u0645\u0644. \u00a0\u0648\u062a\u0639\u0645\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0639\u0644\u0627\u0645\u0627\u062a tags \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0645\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0641\u064a \u0627\u0644\u0648\u0627\u0642\u0639 \u00a0\u0639\u0644\u0649 \u062a\u0634\u063a\u064a\u0644 \u0623\u0648 \u0625\u064a\u0642\u0627\u0641 \u062a\u0634\u063a\u064a\u0644 \u0627\u0644\u062c\u064a\u0646\u0627\u062a. \u062a\u0631\u062c\u0645\u0646\u0627 \u0647\u0630\u0627 \u0627\u0644\u062a\u0639\u0631\u064a\u0641 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u0635\u062f\u0631 https:\/\/bscb.org\/learning-resources\/softcell-e-learning\/epigenetics-its-not-just-genes-that-make-us\/<\/h5>\n
\u0648\u0644\u062a\u0641\u0627\u0635\u064a\u0644 \u0623\u0643\u062b\u0631 \u064a\u0631\u062c\u0649 \u0645\u0631\u0627\u062c\u0639\u0629 https:\/\/ar.m.wikipedia.org\/wiki\/\u0639\u0644\u0645_\u0627\u0644\u062a\u062e\u0644\u0642<\/h5>\n
\u0662-https:\/\/ar.m.wikipedia.org\/wiki\/\u062a\u0631\u0646\u0633\u0643\u0631\u0628\u064a\u062a\u0648\u0645<\/h5>\n

\u0627\u0644\u0646\u0635 \u0627\u0644\u0631\u0626\u064a\u0633\u064a:<\/strong><\/p>\n

Two studies explore whether time of day can affect the body’s response to exercise
\nApril 18, 2019 ,
\nCell Press
\nhttps:\/\/m.medicalxpress.com\/news\/2019-04-explore-day-affect-body-response.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter<\/h5>\n","protected":false},"excerpt":{"rendered":"

\u062a\u0624\u0643\u062f \u0648\u0631\u0642\u062a\u0627\u0646 \u0646\u0634\u0631\u062a\u0627 \u0641\u064a \u0661\u0668 \u0623\u0628\u0631\u064a\u0644 \u0662\u0660\u0661\u0669 \u0641\u064a \u0645\u062c\u0644\u0629 \u0633\u064a\u0644 \u0645\u064a\u062a\u0627\u0628\u0644\u0648\u0632\u064a\u0645 Cell Metabolism \u0623\u0646 \u0627\u0644\u0633\u0627\u0639\u0629 \u0627\u0644\u0628\u0627\u064a\u0644\u0648\u062c\u064a\u0629 \u0647\u064a \u0639\u0627\u0645\u0644 \u0645\u0647\u0645 \u0641\u064a \u0643\u064a\u0641 \u064a\u0633\u062a\u062c\u064a\u0628 \u0627\u0644\u062c\u0633\u0645 \u0644\u0644\u0645\u062c\u0647\u0648\u062f \u0627\u0644\u0628\u062f\u0646\u064a. \u00a0\u0631\u0643\u0632\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0649 \u0639\u0646\u0627\u0635\u0631 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u062a\u0645\u0631\u064a\u0646\u0627\u062a \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062a\u0645\u0645 \u0628\u0639\u0636\u0647\u0627 \u0628\u0639\u0636\u0627\u064b. \u00a0\u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u0628\u062d\u062b\u064a \u0628\u0645\u0641\u0631\u062f\u0647 \u060c \u0645\u0646 \u0627\u0644\u0633\u0627\u0628\u0642 \u0644\u0623\u0648\u0627\u0646\u0647 \u062a\u062d\u062f\u064a\u062f \u0645\u062a\u0649 \u064a\u0643\u0648\u0646 \u0623\u0641\u0636\u0644 \u0648\u0642\u062a \u0644\u0643 \u0644\u0644\u0642\u064a\u0627\u0645 …<\/p>\n","protected":false},"author":4,"featured_media":2624,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-2656","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-19"],"_links":{"self":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/2656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2656"}],"version-history":[{"count":2,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/2656\/revisions"}],"predecessor-version":[{"id":2659,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/2656\/revisions\/2659"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/media\/2624"}],"wp:attachment":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}