{"id":25371,"date":"2024-08-10T23:18:19","date_gmt":"2024-08-10T20:18:19","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=25371"},"modified":"2024-08-10T23:18:19","modified_gmt":"2024-08-10T20:18:19","slug":"%d8%a7%d9%84%d8%a7%d8%b3%d8%aa%d8%b9%d8%af%d8%a7%d8%af-%d9%84%d8%a5%d9%85%d9%83%d8%a7%d9%86%d9%8a%d8%a9-%d8%ad%d8%af%d9%88%d8%ab-%d8%ac%d8%a7%d8%a6%d8%ad%d8%a9-%d9%81%d9%8a-%d8%a7%d9%84%d9%85%d8%b3","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=25371","title":{"rendered":"\u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062d\u062f\u0648\u062b \u062c\u0627\u0626\u062d\u0629 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644 – \u062a\u0631\u062c\u0645\u0629 \u0639\u062f\u0646\u0627\u0646 \u0623\u062d\u0645\u062f \u0627\u0644\u062d\u0627\u062c\u064a"},"content":{"rendered":"

Anticipating the Next Pandemic
\n(\u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646: \u0647\u0640. \u0643\u0648\u062f\u064a \u0645\u064a\u0633\u0646\u0631\u060c \u062f\u0643\u062a\u0648\u0631 \u0641\u064a \u0627\u0644\u0637\u0628\u060c \u0628\u064a\u0644 \u063a. \u0643\u0627\u0628\u0648\u062c\u064a\u0627\u0646\u064a\u0633\u060c \u062f\u0643\u062a\u0648\u0631 \u0641\u064a \u0627\u0644\u0637\u0628\u060c \u0648\u062f\u0627\u0646\u064a\u0627\u0644 \u0625\u0646. \u0648\u0648\u0644\u0641\u060c \u062f\u0643\u062a\u0648\u0631\u0627\u0647. \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0648\u062a\u0648\u0627\u0628\u0639\u0647\u0627)<\/span>
\n(Authors: H. Cody Meissner, M.D., Bill G. Kapogiannis, M.D., and Daniel N. Wolfe, Ph.D.Author Info & Affiliations)<\/span><\/h3>\n

\u062c\u0627\u0626\u062d\u0629 \u0643\u0648\u0641\u064a\u062f-19 \u0627\u0644\u062a\u064a \u0623\u0648\u062f\u062a \u0628\u062d\u064a\u0627\u0629 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 \u0636\u0639\u0641 \u0639\u062f\u062f \u0645\u0646 \u0645\u0627\u062a \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0645\u0646 \u062c\u0627\u0626\u062d\u0629 \u0627\u0644\u0623\u0646\u0641\u0644\u0648\u0646\u0632\u0627 \u0627\u0644\u062a\u064a \u062d\u062f\u062b\u062a \u0639\u0627\u0645 1918 – \u0648\u0627\u0644\u062a\u064a \u0643\u0627\u0646\u062a \u0623\u0633\u0648\u0623 \u062a\u0641\u0634\u064a \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0639\u062f\u064a\u0629 \u0641\u064a \u0627\u0644\u0633\u062c\u0644 \u0627\u0644\u062a\u0627\u0631\u064a\u062e\u064a \u0644\u0644\u0628\u0644\u0627\u062f \u0642\u0628\u0644 \u062c\u0627\u0626\u062d\u0629 \u0643\u0648\u0641\u064a\u062f – 19 – \u0642\u062f\u0645\u062a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0648\u0633 \u0628\u0634\u0623\u0646 \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f\u0627\u062a \u0644\u0644\u062c\u0648\u0627\u0626\u062d \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0647\u0627(<\/sup>1<\/sup>)<\/sup>. <\/span><\/strong><\/p>\n

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\u0648\u0645\u0646 \u0639\u062c\u064a\u0628 \u0627\u0644\u0645\u0641\u0627\u0631\u0642\u0627\u062a \u0623\u0646 \u0627\u0644\u062f\u0631\u0633 \u0627\u0644\u062b\u0627\u0646\u064a<\/strong> \u0627\u0644\u0630\u064a \u0642\u062f\u0645\u062a\u0647 \u0627\u0644\u062c\u0627\u0626\u062d\u0629 \u064a\u062f\u0648\u0631 \u062d\u0648\u0644 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0647\u0634\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u064a\u0634\u0647\u0627 \u0634\u0631\u0643\u0627\u062a \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0648\u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0642\u0636\u0627\u064a\u0627 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0646\u0642\u0644 \u0648\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u0644\u0642\u0627\u062d(<\/sup>3<\/sup>)<\/sup> \u0648\u0642\u0628\u0648\u0644\u0647 [\u0642\u0628\u0648\u0644 \u0627\u0644\u0644\u0642\u0627\u062d \u064a\u0634\u0645\u0644 \u0642\u0628\u0648\u0644 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0644\u0642\u062d\u064a\u0646 \u0623\u0648 \u0644\u062f\u064a\u0647\u0645 \u0631\u063a\u0628\u0629 \u0641\u064a \u062a\u0644\u0642\u064a \u0627\u0644\u0644\u0642\u0627\u062d \u0623\u0648 \u064a\u0646\u062a\u0638\u0631\u0648\u0646 \u062a\u0644\u0642\u064a \u0627\u0644\u0644\u0642\u0627\u062d(4)<\/sup>].<\/span><\/p>\n

\u0627\u0644\u062f\u0631\u0633 \u0627\u0644\u062b\u0627\u0644\u062b<\/strong> \u0647\u0648 \u0623\u0646 \u0627\u0644\u0634\u0631\u0627\u0643\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0636\u0645 \u0645\u0624\u0633\u0633\u0627\u062a \u062e\u0627\u0635\u0629 \u0648\u062d\u0643\u0648\u0645\u064a\u0629 \u0648\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0643\u0627\u0646\u062a \u0644\u0647\u0627 \u0623\u0647\u0645\u064a\u0629 \u0634\u062f\u064a\u062f\u0629 \u0641\u064a \u062a\u0633\u0647\u064a\u0644 \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0633\u0631\u064a\u0639 \u0644\u0644\u062c\u064a\u0644 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0644\u0642\u0627\u062d\u0627\u062a \u0643\u0648\u0641\u064a\u062f-19. <\/span><\/p>\n

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\"\"
\u0627\u0644\u0645\u0635\u062f\u0631: Welcom.org<\/span><\/figcaption><\/figure>\n

\u0645\u0634\u0631\u0648\u0639 \u0627\u0644\u0640\u062c\u064a\u0644 \u0627\u0644\u062b\u0627\u0646\u064a (NextGen) \u0647\u0648 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u0628\u0627\u062f\u0631\u0629 \u0628\u0645\u064a\u0632\u0627\u0646\u064a\u0629 \u062a\u0628\u0644\u063a 5 \u0645\u0644\u064a\u0627\u0631\u0627\u062a \u062f\u0648\u0644\u0627\u0631 \u062a\u0631\u0639\u0627\u0647\u0627 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0635\u062d\u0629 \u0648\u0627\u0644\u062e\u062f\u0645\u0627\u062a \u0627\u0644\u0625\u0646\u0633\u0627\u0646\u064a\u0629 \u062a\u0647\u062f\u0641 \u0625\u0644\u0649 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u0642\u0627\u062f\u0645 \u0644\u0645\u0643\u0627\u0641\u062d\u0629 \u0643\u0648\u0641\u064a\u062f -19.1. \u0648\u0633\u062a\u062f\u0639\u0645 \u0647\u0630\u0647 \u0627\u0644\u0645\u0628\u0627\u062f\u0631\u0629 \u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 2B \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629(<\/sup>5<\/sup>)<\/sup>\u00a0\u0648\u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645 \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0627\u0644\u0646\u0634\u0637\u0629 \u0648\u0627\u0644\u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u0631\u0642\u0627\u0628\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0633\u0644\u0627\u0645\u0629 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0627\u0633\u062a\u0645\u0646\u0627\u0639 (\u062a\u0648\u0644\u064a\u062f \u0627\u0644\u0645\u0646\u0627\u0639\u0629)(<\/sup>6<\/sup>)<\/sup>\u00a0\u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062a\u0646\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0646\u0627\u062d\u064a\u0629 \u0627\u0644\u0639\u0631\u0642\u064a\u0629 \u0648\u0627\u0644\u0627\u062b\u0646\u064a\u0629 [\u0627\u0644\u062b\u0642\u0627\u0641\u064a\u0629](<\/sup>7<\/sup>)<\/sup> \u060c \u0648\u0646\u062a\u0648\u0642\u0639 \u0623\u0646 \u064a\u062a\u0645 \u0645\u0644\u0627\u0621\u0645\u0629 \u0645\u0646\u0635\u0627\u062a \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a [\u0627\u0644\u0645\u062a\u0635\u0629 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u0629 (<\/sup>8<\/sup>)<\/sup>] \u0644\u062a\u0643\u0648\u0646 \u0644\u0642\u0627\u062d\u0627\u062a \u0644\u0623\u0645\u0631\u0627\u0636 \u0645\u0639\u062f\u064a\u0629 \u0623\u062e\u0631\u0649\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0627\u0644\u0625\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0644\u062c\u0648\u0627\u0626\u062d \u0623\u062e\u0631\u0649 \u062a\u0647\u062f\u062f \u0627\u0644\u0623\u0645\u0646 \u0627\u0644\u0635\u062d\u064a \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644.<\/span><\/p>\n

\u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0623\u0648\u0644\u064a \u0644\u0644\u0645\u0631\u062d\u0644\u0629 2B \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 \u0647\u064a \u062a\u062d\u0633\u064a\u0646 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0644\u0642\u0627\u062d \u0628\u0646\u0633\u0628\u0629 \u062a\u0632\u064a\u062f \u0639\u0646 30% \u0648\u062a\u0633\u062a\u0645\u0631 \u0641\u062a\u0631\u0629 12 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u062d\u0627\u0644\u064a\u064b\u0627. \u0648\u0633\u062a\u0639\u062a\u0645\u062f \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0623\u0639\u0631\u0627\u0636 \u0643\u0648\u0641\u064a\u062f-19\u061b \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0633\u064a\u062c\u0631\u064a \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0641\u062d\u0635\u064b\u0627 \u0630\u0627\u062a\u064a\u064b\u0627 (\u064a\u0642\u0648\u0645\u0648\u0646 \u0628\u0647 \u0628\u0623\u0646\u0641\u0633\u0647\u0645) \u0648\u0628\u0634\u0643\u0644 \u0623\u0633\u0628\u0648\u0639\u064a \u0645\u0633\u062a\u062e\u062f\u0645\u064a\u0646 \u0645\u0633\u062d\u0627\u062a \u0623\u0646\u0641\u064a\u0629 \u0644\u0623\u062e\u0630 \u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0623\u0646\u0641 \u0644\u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0639\u0646\u00a0 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u062f\u0648\u0649 \u063a\u064a\u0631 \u0627\u0644\u0645\u0635\u062d\u0648\u0628\u0629 \u0628\u0623\u0639\u0631\u0627\u0636 \u0643\u0647\u062f\u0641 \u062b\u0627\u0646\u0648\u064a. <\/span><\/p>\n

\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0645\u062a\u0648\u0641\u0631\u0629 \u062d\u0627\u0644\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0636\u062f \u0627\u0644\u0634\u0648\u0643\u064a (spike antigen) \u0648\u0627\u0644\u062a\u064a \u062a\u0624\u062e\u0630 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062d\u0642\u0646 \u0627\u0644\u0639\u0636\u0644\u064a(<\/sup>9<\/sup>)<\/sup>\u060c \u0641\u0625\u0646 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0645\u0631\u0634\u062d\u0629 \u0644\u0644\u062c\u064a\u0644 \u0627\u0644\u0642\u0627\u062f\u0645 \u0633\u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0645\u0646\u0635\u0627\u062a \u062a\u0637\u0648\u064a\u0631 \u0644\u0642\u0627\u062d\u0627\u062a \u0623\u0643\u062b\u0631 \u062a\u0646\u0648\u0639\u064b\u0627 \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u062c\u064a\u0646\u0627\u062a \u0634\u0648\u0643\u064a\u0629 (spike genes) \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0627\u0644\u0623\u0643\u062b\u0631 \u062d\u0641\u0638\u064b\u0627\u060c \u0645\u062b\u0644 \u0627\u0644\u0642\u0641\u064a\u0635\u0629 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 (nucleocapsid) \u0627\u0644\u0645\u0634\u0641\u0631\u0629 \u0644\u0644\u062c\u064a\u0646\u0627\u062a \u0623\u0648 \u0627\u0644\u063a\u0634\u0627\u0621 \u0623\u0648 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649.\u00a0<\/span><\/p>\n

\u0642\u062f \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0645\u0646\u0635\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0644\u0642\u0627\u062d\u0627\u062a \u0646\u0648\u0627\u0642\u0644 \u0641\u064a\u0631\u0648\u0633\u064a\u0629 (vectors) \u0645\u0624\u0634\u0628\u0629 (recombinant) \u062a\u0633\u062a\u062e\u062f\u0645 \u0646\u0648\u0627\u0642\u0644 (vectors)\u00a0 \u063a\u064a\u0631 \u0643\u0641\u0624\u0629 \u0623\u0648 \u0643\u0641\u0624\u0629 \u0644\u0644\u062a\u0643\u0627\u062b\u0631 \u0648\u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u062c\u064a\u0646\u0627\u062a \u062a\u0634\u0641\u0631 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0648\u063a\u064a\u0631 \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u0629 \u0644\u0640 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0641\u064a\u062f-2.\u00a0 \u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0631\u0633\u0627\u0644 \u0627\u0644\u062a\u064a \u062a\u062a\u0632\u0627\u064a\u062f \u0643\u0645\u064a\u062a\u0647\u0627 \u0630\u0627\u062a\u064a\u064b\u0627 \u0628\u0645\u062c\u0631\u062f \u062f\u062e\u0648\u0644\u0647\u0627 \u0627\u0644\u062e\u0644\u064a\u0629(<\/sup>10<\/sup>)<\/sup> [\u064a\u0637\u0644\u0642 \u0639\u0644\u064a\u0647\u0627 samRNA] \u062a\u0639\u062f \u0623\u062d\u062f \u0623\u0634\u0643\u0627\u0644 \u062a\u0643\u0646\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0646\u0627\u0634\u0626\u0629 \u0628\u0633\u0631\u0639\u0629 \u0648\u0627\u0644\u062a\u064a \u0633\u062a\u064f\u0642\u064a\u0651\u064e\u0645 \u0643\u062e\u064a\u0627\u0631 \u0622\u062e\u0631.<\/span><\/p>\n

\u062a\u0642\u0648\u0645 \u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0640 (SamRNA) \u0628\u062a\u0634\u0641\u064a\u0631 \u0625\u0646\u0632\u064a\u0645 \u0645\u062a\u0646\u0633\u062e (replicase) \u0628\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0645\u0633\u062a\u0645\u0646\u0639(<\/sup>6<\/sup>)<\/sup> \u0627\u0644\u0645\u0639\u064a\u0646 \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u062d\u0642\u0646\u0647 \u0641\u064a \u062c\u0633\u064a\u0645\u0627\u062a \u062f\u0647\u0646\u064a\u0629 \u0646\u0627\u0646\u0648\u064a\u0629 \u0644\u0627\u0633\u062a\u062b\u0627\u0631\u0629 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u0643\u062a\u0633\u0628\u0629(<\/sup>11<\/sup>)<\/sup>\u00a0\u062f\u0642\u064a\u0642\u0629. \u0627\u0644\u0645\u0632\u0627\u064a\u0627 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u0646\u0635\u0629 \u062a\u0646\u0637\u0648\u064a \u0639\u0644\u0649 \u0625\u0639\u0637\u0627\u0621 \u062c\u0631\u0639\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u0644\u0639\u062f\u062f \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u0646\u0627\u0633(<\/sup>12<\/sup>)\u00a0<\/sup>(\u0645\u0645\u0627 \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631 \u0639\u0643\u0633\u064a \u0623\u0642\u0644 \u0644\u0644\u0642\u0627\u062d(<\/sup>13<\/sup>)<\/sup> – \u0645\u0646 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0643\u0633\u064a (reactogenicity) \u0627\u062d\u0645\u0631\u0627\u0631 \u0648\u0627\u0646\u062a\u0641\u0627\u062e \u0645\u0648\u0636\u0639 \u0627\u0644\u062d\u0642\u0646 \u0648\u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0648\u0627\u0644\u0623\u0644\u0645)\u060c \u0648\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0645\u0646\u0627\u0639\u064a\u0629 \u0623\u0643\u062b\u0631 \u0627\u0633\u062a\u062f\u0627\u0645\u0629(<\/sup>14<\/sup>)<\/sup>\u060c \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0648\u062b\u0628\u0627\u062a \u0627\u0644\u0644\u0642\u0627\u062d \u0641\u064a \u062f\u0631\u062c\u0627\u062a \u062d\u0631\u0627\u0631\u0629 \u0627\u0644\u062b\u0644\u0627\u062c\u0629.\u00a0<\/span><\/p>\n

\u0646\u0638\u064a\u0631 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 (CoP) \u0647\u0648 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062e\u0644\u0637\u064a\u0629(<\/sup>15<\/sup>)<\/sup> \u0648\u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0627\u0644\u0645\u0643\u062a\u0633\u0628\u0629 \u0627\u0644\u0645\u0639\u064a\u0646\u0629 \u0627\u0644\u062a\u064a \u062a\u0636\u0641\u064a \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0636\u062f \u0627\u0644\u0639\u062f\u0648\u0649 \u0623\u0648 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0639\u062f\u0648\u0649 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0645\u0646 \u062c\u0631\u0627\u0621 \u0627\u0644\u0627\u0635\u0627\u0628\u0629 \u0628\u0641\u064a\u0631\u0648\u0633 \u0645\u0639\u064a\u0646\u060c. \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 2B\u00a0 \u0633\u062a\u0642\u0648\u0645 \u0628\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0640 (CoPs) \u0627\u0644\u0642\u0627\u062f\u0645 \u0644\u0640 \u0644\u0642\u0627\u062d\u0627\u062a \u0643\u0648\u0641\u064a\u062f-19. \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629\u060c \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0640 (CoP) \u064a\u064f\u0639\u062f \u0639\u0645\u0644\u064a\u0629 \u0635\u0639\u0628\u0629 \u0644\u0623\u0646 \u0639\u0646\u0627\u0635\u0631 \u0645\u062a\u0639\u062f\u062f\u0629 \u0645\u0646 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u062a\u0639\u0645\u0644 \u0628\u0634\u0643\u0644 \u062a\u0622\u0632\u0631\u064a \u0644\u062a\u0639\u0637\u064a\u0644 \u0646\u0634\u0627\u0637 \u0627\u0644\u0641\u064a\u0631\u0648\u0633(<\/sup>15<\/sup>)<\/sup>\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0639\u062f\u0644(<\/sup>16<\/sup>)\u00a0<\/sup>\u0648\u063a\u064a\u0631 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 (\u0645\u062b\u0644 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0644\u062a\u0635\u0642\u0629 \u0623\u0648 \u0627\u0644\u0645\u062a\u0631\u0633\u0628\u0629 \u0623\u0648 \u0627\u0644\u0645\u062b\u0628\u062a\u0629 \u0627\u0644\u0645\u062a\u0645\u0645\u0629).\u00a0 <\/span><\/p>\n

\u062f\u0648\u0631 \u0647\u0630\u0647 \u0627\u0644\u0639\u062a\u0627\u0635\u0631 \u0641\u064a \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 \u0643\u0648\u0641\u064a\u062f-19 (SARS-CoV-2) \u0631\u0628\u0645\u0627 \u064a\u062e\u062a\u0644\u0641 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0636\u0639 \u0627\u0644\u062a\u0634\u0631\u064a\u062d\u064a (\u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0623\u0648 \u0627\u0644\u0623\u0646\u0633\u062c\u0629\u060c \u0623\u0648 \u0633\u0637\u062d \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u062e\u0627\u0637\u064a \u0627\u0644\u062a\u0646\u0641\u0633\u064a).\u00a0 \u0648\u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0646\u0647\u0627\u0626\u064a \u0642\u064a\u062f \u0627\u0644\u0646\u0638\u0631 (\u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u0627\u0644\u0639\u062f\u0648\u0649 \u063a\u064a\u0631 \u0627\u0644\u0645\u0635\u062d\u0648\u0628\u0629 \u0628\u0623\u0639\u0631\u0627\u0636\u060c \u0623\u0648 \u0627\u0644\u0639\u062f\u0648\u0649 \u0627\u0644\u0645\u0635\u062d\u0648\u0628\u0629 \u0628\u0623\u0639\u0631\u0627\u0636\u060c \u0623\u0648 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u062d\u0627\u062f).<\/span><\/p>\n

\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0639\u062a\u0645\u0627\u062f \u0627\u0644 (CoP) \u0644\u0627 \u064a\u0632\u0627\u0644 \u064a\u0645\u062b\u0644 \u062a\u062d\u062f\u064a\u064b\u0627\u060c \u0625\u0644\u0627 \u0623\u0646 \u0646\u062a\u0627\u0626\u062c \u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u062e\u064a\u0635 \u0633\u0627\u0639\u062f\u062a \u0641\u064a \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0644\u0642\u0627\u062d(<\/sup>16<\/sup>)<\/sup>. \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0640 (CoP) \u0645\u0646 \u0634\u0623\u0646\u0647 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u0647 \u0641\u0648\u0627\u0626\u062f \u0639\u062f\u064a\u062f\u0629. \u0627\u0644\u0640 (CoP) \u0627\u0644\u062b\u0627\u0628\u062a \u0642\u062f \u064a\u0633\u0627\u0639\u062f \u0641\u064a \u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u062c\u0633\u064a\u0631 \u0627\u0644\u0645\u0646\u0627\u0639\u064a [\u0648\u0647\u0648 \u0645\u0627 \u064a\u0639\u062f \u0643\u0628\u062f\u064a\u0644 \u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0642\u0627\u0631\u0646 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0623\u0648 \u0627\u0644\u0646\u0638\u064a\u0631 \u0627\u0644\u0648\u0642\u0627\u0626\u064a \u0644\u0640 \u0627\u0644\u0644\u0642\u0627\u062c \u0627\u0644\u0645\u0631\u0634\u062d \u0628\u0641\u0627\u0639\u0644\u064a\u0629 \u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u0645\u0631\u062e\u0635 (\u0627\u0644\u0645\u0639\u062a\u0645\u062f). <\/span><\/p>\n

\u0648\u0647\u064a \u062a\u062c\u0631\u0628\u0629 \u0644\u0625\u062b\u0628\u0627\u062a \u0623\u0646 \u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u0645\u0631\u0634\u062d \u0648\u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u064a\u0646\u062a\u062c\u0627\u0646 \u0646\u0641\u0633 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 (18)<\/sup> \u0645\u0646 \u0645\u0646\u0635\u0627\u062a \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u064a \u0647\u064a \u0623\u0633\u0631\u0639 \u0648\u0623\u0642\u0644 \u062a\u0643\u0644\u0641\u0629 \u0641\u064a \u0627\u0644\u062a\u0646\u0641\u064a\u0630 \u0645\u0646 \u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0643\u0628\u064a\u0631\u0629 \u0627\u0644\u062a\u064a \u062a\u062c\u0631\u0649 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a \u0639\u0644\u0649 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629(<\/sup>19<\/sup>)<\/sup>\u060c \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0647\u0644 \u0639\u0645\u0644\u064a\u0629 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u0644\u0642\u0627\u062d \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0645 \u062a\u064f\u062f\u0631\u062c \u0641\u064a \u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629\u060c \u0645\u062b\u0644 \u0627\u0644\u0623\u0637\u0641\u0627\u0644.\u00a0 \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0640 (CoP)\u00a0 \u0633\u064a\u0633\u0645\u062d \u0623\u064a\u0636\u064b\u0627 \u0628\u062a\u0642\u064a\u064a\u0645 \u0645\u062f\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0628\u0639\u062f \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0633\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u0646\u0627\u0634\u0626\u0629 \u0623\u0648 \u0627\u0644\u062a\u0637\u0639\u064a\u0645 \u0636\u062f\u0647\u0627 \u0648\u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0645\u0639\u0631\u0641\u0629 \u0645\u062a\u0649 \u062a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0645\u0639\u0632\u0632\u0627\u062a \u0627\u0644\u0644\u0642\u0627\u062d.<\/span><\/p>\n

\u0623\u0648\u0644 \u0645\u062a\u062d\u0648\u0631 \u0623\u0648\u0645\u064a\u0643\u0631\u0648\u0646(<\/sup>20<\/sup>)\u00a0<\/sup>\u0638\u0647\u0631 \u0641\u064a \u0646\u0648\u0641\u0645\u0628\u0631 2021\u060c \u0648\u0635\u064f\u0646\u0641 \u0639\u0644\u0649 \u0623\u0646\u0647 \u0645\u062a\u062d\u0648\u0631 \u0645\u062b\u064a\u0631 \u0644\u0644\u0645\u062e\u0627\u0648\u0641 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 30 \u0627\u0633\u0628\u0630\u0627\u0644\u064b\u0627 \u0644\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 (amino-acid substitutions) [\u0627\u0633\u062a\u0628\u062f\u0627\u0644 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u064a\u0639\u0646\u064a \u0627\u0633\u062a\u0628\u062f\u0627\u0644 \u0648\u0627\u062d\u062f \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629 \u0644 \u0628\u0623\u062d\u0645\u0627\u0636 \u0623\u0645\u064a\u0646\u064a\u0629 \u062f(<\/sup>21<\/sup>)\u00a0<\/sup>] (\u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 15 \u0641\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0634\u0648\u0643\u064a\u0651 (<\/sup>22<\/sup>)<\/sup>) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0633\u0644\u0627\u0644\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0623\u0635\u0644\u064a\u0629. <\/span><\/p>\n

\u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0627\u0644\u0639\u062f\u0648\u0649 \u0623\u062b\u0646\u0627\u0621 \u0645\u0648\u062c\u0627\u062a \u0645\u062a\u062d\u0648\u0631\u0627\u062a \u0623\u0644\u0641\u0627 \u0648\u0628\u064a\u062a\u0627 \u0648\u063a\u0627\u0645\u0627 \u0648\u062f\u0644\u062a\u0627 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0623\u0648 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062a\u0637\u0639\u064a\u0645 \u0623\u0638\u0647\u0631\u062a \u0627\u0646\u062e\u0641\u0627\u0636\u064b\u0627 \u0641\u064a \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0639\u062f\u0644(<\/sup>16<\/sup>) <\/sup>\u0636\u062f \u0645\u062a\u062d\u0648\u0631 \u0623\u0648\u0645\u064a\u0643\u0631\u0648\u0646\u060c \u0645\u0645\u0627 \u0645\u0643\u0646 \u0623\u0648\u0645\u064a\u0643\u0631\u0648\u0646 \u0645\u0646 \u0627\u0644\u062a\u063a\u0644\u0628 \u0639\u0644\u0649 \u0645\u062a\u062d\u0648\u0631 \u062f\u0644\u062a\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0639\u0627\u0644\u0645\u064a \u0641\u064a \u063a\u0636\u0648\u0646 \u0623\u0633\u0627\u0628\u064a\u0639. \u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0633\u0628\u064a\u0644 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0627\u0644\u0633\u0641\u0644\u064a(<\/sup>23<\/sup>)\u00a0<\/sup>\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0633\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0633\u0627\u0628\u0642\u0629\u060c \u062a\u0633\u0628\u0628 \u0645\u062a\u062d\u0648\u0631 \u0623\u0648\u0645\u064a\u0643\u0631\u0648\u0646 \u0641\u064a \u0627\u0644\u0628\u062f\u0627\u064a\u0629 \u0641\u064a \u0632\u064a\u0627\u062f\u0629 \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0625\u0635\u0627\u0628\u0629.\u00a0<\/span><\/p>\n

\u062a\u0637\u0648\u0631\u062a \u0645\u062a\u062d\u0648\u0631\u0627\u062a \u0623\u0648\u0645\u064a\u0643\u0631\u0648\u0646 \u0627\u0644\u0644\u0627\u062d\u0642\u0629 \u0645\u0639 \u0627\u0632\u062f\u064a\u0627\u062f \u062a\u062f\u0631\u064a\u062c\u064a \u0641\u064a \u0642\u062f\u0631\u062a\u0647 \u0639\u0644\u0649 \u062a\u0641\u0627\u062f\u064a \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0648\u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0642\u0648\u0629 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629 \u0644\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0646\u0632\u064a\u0645 2 \u0627\u0644\u0645\u062d\u0648\u0644 \u0644\u0644\u0623\u0646\u062c\u064a\u0648\u062a\u0646\u0633\u064a\u0646 [\u0648\u0647\u0648 \u0647\u0631\u0645\u0648\u0646 \u0628\u064a\u0628\u062a\u064a\u062f \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u062a\u0636\u064a\u0642 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629(<\/sup>24<\/sup>)<\/sup>] (ACE2)\u060c \u0645\u0645\u0627 \u0623\u062f\u0649 \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0639\u062f\u0648\u0649. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0627\u0631\u062a\u0628\u0637\u062a \u0647\u0630\u0647 \u0627\u0644\u0633\u0644\u0627\u0644\u0627\u062a [\u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u062a\u062d\u0648\u0631 (JN.1)\u060c \u0633\u0644\u064a\u0644 \u0627\u0644\u0645\u062a\u062d\u0648\u0631 (BA.2.86) \u0627\u0644\u0641\u0631\u0639\u064a \u0644\u0640 \u0645\u062a\u062d\u0648\u0631 \u0623\u0645\u064a\u0643\u0631\u0648\u0646] \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u0639\u0628\u0621 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u062d\u0627\u062f [\u0639\u0628\u0621 \u0627\u0644\u0645\u0631\u0636 \u0647\u0648 \u0645\u062c\u0645\u0648\u0639 \u0627\u0644\u0645\u0631\u0627\u0636\u0629 \u0648\u0627\u0644\u0648\u0641\u064a\u0627\u062a\u060c \u0628\u062d\u0633\u0628 \u0627\u0644\u062a\u0639\u0631\u064a\u0641(<\/sup>25<\/sup>)<\/sup>]. <\/span><\/p>\n

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\u0642\u062f \u064a\u0641\u0633\u0631 \u0647\u0630\u0627 \u0627\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0633\u0628\u0628 \u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u0633\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u0648\u0631\u0629 \u0636\u0639\u064a\u0641\u0629 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0639\u062f\u0644\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0645\u0633\u0628\u0642\u064b\u0627 \u0628\u0645\u0631\u0636 \u0623\u0642\u0644 \u062d\u062f\u0629\u060c \u0648\u064a\u0624\u0643\u062f \u0639\u0644\u0649 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0641\u062d\u0648\u0635\u0627\u062a \u0645\u062d\u0633\u0646\u0629 \u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0627\u0633\u0637\u0629 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629.<\/span><\/p>\n

\u0633\u0628\u064a\u0644 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0627\u0644\u0639\u0644\u0648\u064a \u0647\u0648 \u0623\u0648\u0644 \u0645\u0648\u0636\u0639 \u062a\u0645\u0627\u0633 \u0648\u0628\u0648\u0627\u0628\u0629 \u062f\u062e\u0648\u0644 \u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0627\u0644\u0645\u0633\u062a\u0646\u0634\u0642\u0629\u060c \u0643\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 (\u0638\u0647\u0627\u0631\u0629 \u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0623\u0646\u0641 \u063a\u0646\u064a\u0629 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0640 ACE2)\u060c \u062d\u064a\u062b \u062a\u0633\u062a\u062b\u0627\u0631 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0641\u0637\u0631\u064a\u0629(<\/sup>31<\/sup>)\u00a0<\/sup>\u0648\u0627\u0644\u0645\u0643\u062a\u0633\u0628\u0629. \u062a\u062a\u0645\u062a\u0639 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u062a\u0649 \u062a\u0624\u062e\u0630 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062d\u0642\u0646 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u062a\u0648\u0641\u0631 \u062d\u0627\u0644\u064a\u064b\u0627 \u0628\u0642\u062f\u0631\u0629 \u0645\u062d\u062f\u0648\u062f\u0629 \u0639\u0644\u0649 \u0625\u062b\u0627\u0631\u0629 \u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u062e\u0627\u0637\u064a\u0629 \u0642\u0648\u064a\u0629(<\/sup>32<\/sup>)<\/sup>.\u00a0<\/span><\/p>\n

\u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u0643\u062a\u0645\u0644\u0629 \u062c\u0631\u0627\u0639\u0627\u062a \u0627\u0644\u062a\u0637\u0639\u064a\u0645\u060c \u0627\u0644\u0639\u062f\u0648\u0649 \u0628\u0627\u0644\u0645\u062a\u062d\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0645\u0631 \u0641\u064a \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u064a\u0645\u0643\u0646\u0647\u0627 \u0623\u0646 \u062a\u0648\u0644\u062f \u0636\u063a\u0637\u064b\u0627 \u0627\u0646\u062a\u0642\u0627\u0626\u064a\u064b\u0627 \u0644\u0644\u0633\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u0648\u0631\u0629 \u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0627\u062d\u062a\u0645\u0627\u0644 \u062a\u0641\u0627\u062f\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a. \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062d\u062f \u0645\u0646 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0645\u0631\u0636 \u0641\u064a \u0627\u0644\u0645\u062c\u062a\u0645\u0639 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0642\u0627\u062d \u0645\u062e\u0627\u0637\u064a \u064a\u062d\u0641\u0632 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0645\u0648\u0636\u0639\u064a\u0629 \u0644\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u062e\u0627\u0637\u064a \u0627\u0644\u062a\u0646\u0641\u0633\u064a \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0623\u0645\u0631 \u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647 \u062c\u062f\u064b\u0627.<\/span><\/p>\n

\u0627\u0644\u0637\u0631\u0642 \u0627\u0644\u0628\u062f\u064a\u0644\u0629 \u0644\u0625\u062f\u062e\u0627\u0644 \u0627\u0644\u062f\u0648\u0627\u0621 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0628\u0634\u0631\u0629 (\u0631\u0642\u064a\u0642\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062f\u0642\u064a\u0642\u0629(<\/sup>33<\/sup>)<\/sup>\u060c \u0623\u0648 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 (\u0623\u0642\u0631\u0627\u0635)\u060c \u0623\u0648 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0623\u0646\u0641 (\u0631\u0630\u0627\u0630 \u0623\u0648 \u0642\u0637\u0631\u0627\u062a)\u060c \u0623\u0648 \u0637\u0631\u064a\u0642 \u0627\u0644\u0627\u0633\u062a\u0646\u0634\u0627\u0642 (\u0647\u0628\u0627\u0621). \u062a\u0648\u0641\u0631 \u0644\u0642\u0627\u062d \u0628\u062f\u0648\u0646 \u0627\u0644\u062d\u0642\u0646 \u0628\u0627\u0644\u0625\u0628\u0631 \u0642\u062f \u064a\u062d\u062f \u0645\u0646 \u0627\u0644\u062a\u0631\u062f\u062f \u0641\u064a \u0623\u062e\u0630 \u0627\u0644\u0644\u0642\u0627\u062d \u0648\u064a\u0632\u064a\u062f \u0645\u0646 \u0642\u0628\u0648\u0644\u0647. <\/span><\/p>\n

\u0648\u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u0639\u0646 \u0627\u0644\u0623\u0633\u0644\u0648\u0628\u060c \u0641\u0625\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u0645\u0628\u0633\u0637\u0629 \u0645\u0646 \u0634\u0623\u0646\u0647\u0627 \u0623\u0646 \u062a\u0642\u0644\u0644 \u0627\u0644\u0623\u0639\u0628\u0627\u0621 \u0627\u0644\u0645\u0641\u0631\u0648\u0636\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0627\u0645\u0644\u064a\u0646 \u0641\u064a \u0645\u062c\u0627\u0644 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u0627\u0644\u0644\u0642\u0627\u062d \u0648\u0645\u0646 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0636\u062f \u062c\u0627\u0626\u062d\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629\u060c \u0648\u062e\u0627\u0635\u0629 \u0625\u0630\u0627 \u0623\u0635\u0628\u062d\u062a \u0628\u0631\u0627\u0645\u062c \u0627\u0644\u062a\u0637\u0639\u064a\u0645 \u0627\u0644\u0634\u0627\u0645\u0644 \u0636\u0631\u0648\u0631\u064a\u0629. \u0633\u064a\u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u062c\u0631\u0639\u0629 \u0641\u0631\u064a\u062f\u0629 \u0645\u0639\u0632\u0632\u0629 \u0628\u0623\u0642\u0631\u0627\u0635 \u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u0645\u063a\u0644\u0641\u0629 \u0645\u0639\u0648\u064a\u064b\u0627 (\u0644\u062d\u0645\u0627\u064a\u062a\u0647\u0627 \u0645\u0646 \u062d\u0645\u0648\u0636\u0629 \u0627\u0644\u0645\u0639\u062f\u0629) \u0627\u0644\u0641\u0645\u0648\u064a\u0629 \u0648\u0627\u0644\u062b\u0627\u0628\u062a\u0629 \u0641\u064a \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0648\u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0627\u0644\u0623\u0646\u0641\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0642\u064a\u064a\u0645 \u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u063a\u0644\u0648\u0628\u0648\u0644\u064a\u0646 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0647\u0640(<\/sup>34<\/sup>)\u00a0<\/sup> (IgA) \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0645\u0633\u062a\u0636\u062f \u0645\u0639\u064a\u0646 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a \u0648\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u062a\u0646\u0641\u0633\u064a.<\/span><\/p>\n

\u0628\u0646\u0641\u0633 \u0627\u0644\u0642\u062f\u0631 \u0645\u0646 \u0627\u0644\u0623\u0647\u0645\u064a\u0629\u060c \u0643\u0625\u062b\u0628\u0627\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u062d\u0633\u0646\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u062d\u0644\u0629 (2B)\u060c \u0641\u0625\u0646 \u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646. \u0633\u064a\u062a\u0645 \u062c\u0645\u0639 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u062a\u062d\u0644\u064a\u0644\u0647\u0627 \u0628\u0634\u0643\u0644 \u0645\u0645\u0646\u0647\u062c. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u062e\u0627\u0635\u064a\u0629 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u062b\u0628\u062a\u0629 \u0644\u0640 \u0644\u0642\u0627\u062d\u0627\u062a \u0643\u0648\u0641\u064a\u062f-19 \u0627\u0644\u062d\u0627\u0644\u064a\u0629\u060c \u0642\u062f \u062a\u062d\u062f\u062b \u0631\u062f\u0648\u062f \u0641\u0639\u0644 (\u0623\u0639\u0631\u0627\u0636) \u0633\u0644\u0628\u064a\u0629 \u0628\u0639\u062f \u0623\u064a \u062a\u0637\u0639\u064a\u0645\u060c \u0648\u0647\u0646\u0627\u0643 \u0628\u0631\u0627\u0645\u062c \u0642\u0627\u0626\u0645\u0629 \u0644\u062a\u0633\u062c\u064a\u0644 \u0631\u062f\u0648\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0633\u0644\u0628\u064a\u0629 \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0645\u0631\u062e\u0635\u0629(<\/sup>35<\/sup>)<\/sup>.<\/span><\/p>\n

\u0648\u0641\u064a \u062a\u062c\u0627\u0631\u0628 (NextGen) \u060c \u0633\u064a\u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u0627\u062d\u062a\u0645\u0627\u0644 \u0648\u0642\u0648\u0639 \u0631\u062f\u0648\u062f \u0641\u0639\u0644 \u0633\u0644\u0628\u064a\u0629 \u0636\u0627\u0631\u0629 \u0639\u0644\u0649 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 10 \u0622\u0644\u0627\u0641 \u0645\u0634\u0627\u0631\u0643 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a \u0628\u0646\u0633\u0628\u0629 1:1 \u0645\u0646 \u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0623\u0648 \u0627\u0644\u0644\u0642\u0627\u062d \u0627\u0644\u0645\u0631\u062e\u0635. \u0627\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062a\u0641\u0635\u064a\u0644\u064a \u0644\u0631\u062f\u0648\u062f \u0627\u0644\u0641\u0639\u0644 \u0627\u0644\u0633\u0644\u0628\u0629 \u0627\u0644\u0645\u062d\u0644\u064a\u0629 \u0648\u0627\u0644\u0645\u0645\u0646\u0647\u062c\u0629 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0645\u0647\u0645\u0629\u060c \u0628\u0645\u0627 \u0641\u064a\u0647\u0627 \u062d\u062f\u0648\u062b \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0645\u062b\u0644 \u0627\u0644\u062a\u0647\u0627\u0628 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628(<\/sup>36<\/sup>)\u00a0<\/sup>\u00a0\u0623\u0648 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062a\u0627\u0645\u0648\u0631 (\u0643\u064a\u0633 \u0644\u064a\u0641\u064a \u0645\u062d\u064a\u0637 \u0628\u0627\u0644\u0642\u0644\u0628)(<\/sup>37<\/sup>)<\/sup>.<\/span><\/p>\n

\u0627\u0644\u062a\u062d\u062f\u064a \u0627\u0644\u062f\u064a \u064a\u0641\u0648\u0642 \u0627\u0644\u062a\u062d\u0645\u0644 \u0627\u0644\u0630\u064a \u064a\u0648\u0627\u062c\u0647\u0647 \u0645\u0635\u0646\u0639\u0648 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0641\u064a \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0627\u0635\u0627\u0628\u0629 \u0623\u0648 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u0648\u0641\u064a\u0631 \u0627\u0644\u0645\u062a\u0637\u0644\u0628\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0639\u0627\u062f\u064a\u0629 \u0623\u0648 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 \u062c\u062f\u064b\u0627 \u0644\u0644\u0645\u0631\u0636\u0649\u061b \u064a\u062c\u0628 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0635\u0646\u0639\u0648\u0646 \u0642\u0627\u062f\u0631\u064a\u0646 \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0645\u0626\u0627\u062a \u0627\u0644\u0645\u0644\u0627\u064a\u064a\u0646 \u0645\u0646 \u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0644\u0642\u0627\u062d \u0636\u0645\u0646 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0632\u0645\u0646\u064a \u0627\u0644\u0641\u064a\u062f\u0631\u0627\u0644\u064a \u0627\u0644\u0645\u0642\u062a\u0631\u062d \u0648\u0647\u0648 100 \u064a\u0648\u0645 \u0628\u0639\u062f \u0638\u0647\u0648\u0631 \u0627\u0644\u062c\u0627\u0626\u062d\u0629. <\/span><\/p>\n

\u0648\u0645\u0639 \u0627\u0646\u062d\u0633\u0627\u0631 \u0627\u0644\u062c\u0627\u0626\u062d\u0629 \u0648\u062e\u0644\u0627\u0644 \u0641\u062a\u0631\u0627\u062a \u0645\u0627 \u0628\u064a\u0646 \u0627\u0644\u062c\u0648\u0627\u0626\u062d\u060c \u0633\u064a\u0646\u062e\u0641\u0636 \u0627\u0644\u0637\u0644\u0628 \u0639\u0644\u0649 \u0627\u0644\u0644\u0642\u0627\u062d\u0627\u062a \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0648\u0633\u064a\u0648\u0627\u062c\u0647 \u0627\u0644\u0645\u0635\u0646\u0639\u0648\u0646 \u062a\u062d\u062f\u064a\u0627\u062a \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0633\u0644\u0627\u0633\u0644 \u0627\u0644\u062a\u0648\u0631\u064a\u062f \u0648\u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 (\u0627\u0644\u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0648\u0627\u0644\u062f\u0647\u0648\u0646 \u0648\u0627\u0644\u0645\u062e\u0627\u0632\u0646 \u0627\u0644\u0645\u0624\u0642\u062a\u0629 \u0648\u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a) \u0648\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u062c\u0647\u064a\u0632 \u0627\u0644\u062d\u0642\u0646 \u0628\u0627\u0644\u0643\u0627\u0645\u0644. \u0627\u0644\u0637\u0644\u0628 \u0627\u0644\u062d\u0627\u0644\u064a \u0639\u0644\u0649 \u0644\u0642\u0627\u062d\u0627\u062a \u0643\u0648\u0641\u064a\u062f-19 \u0623\u0642\u0644 \u0645\u0645\u0627 \u0643\u0627\u0646 \u0639\u0644\u064a\u0647 \u0641\u064a 2021\u060c \u0644\u0643\u0646 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u0635\u0646\u064a\u0639 \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0623\u0642\u0644 \u0645\u0645\u0627 \u0643\u0627\u0646 \u0641\u064a \u0641\u062a\u0631\u0629 “\u0627\u0644\u062c\u0627\u0626\u062d\u0629” \u0644\u0627 \u062a\u0632\u0627\u0644 \u062a\u062a\u0637\u0644\u0628 \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0635\u0646\u064a\u0639 \u0645\u0646 \u0642\u0628\u0644 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0641\u062f\u0631\u0627\u0644\u064a\u0629. <\/span><\/p>\n

\u0648\u0633\u062a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0623\u064a\u0636\u064b\u0627 \u0625\u0644\u0649 \u0627\u0644\u062a\u062d\u0642\u0642 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a \u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0651 \u0644\u0644\u0642\u0627\u062d\u060c \u0648\u0627\u0644\u0630\u064a \u0642\u062f \u064a\u0634\u0645\u0644 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u062a\u0633\u0627\u0642 \u0627\u0644\u0623\u062f\u0627\u0621 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u064a \u0648\u0645\u062a\u0627\u0628\u0639\u0629 \u0628\u0631\u0627\u0645\u062c \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629. \u0625\u0646 \u0646\u062a\u0627\u0626\u062c \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 (2B) \u0627\u0644\u0645\u062e\u0637\u0637 \u0644\u0647\u0627\u060c \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0648\u0627\u0639\u062f\u0629\u060c \u064a\u062c\u0628 \u0623\u0646 \u062a\u062d\u062f \u0628\u0634\u0643\u0644 \u0645\u0639\u062a\u0628\u0631 \u0645\u0646 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0648\u062a\u0628\u0639\u062b \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u062b\u0645\u0627\u0631 \u0627\u0644\u062e\u0627\u0635 \u0641\u064a \u0645\u062b\u0644 \u0647\u0630\u0647 \u0627\u0644\u062a\u062c\u0627\u0631\u0628\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0644\u062a\u0646\u0645\u064a\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u064a\u0629.<\/span><\/p>\n

\u0645\u0635\u0627\u062f\u0631 \u0645\u0646 \u062f\u0627\u062e\u0644 \u0648\u062e\u0627\u0631\u062c \u0627\u0644\u0646\u0635:<\/strong>
\n1- https:\/\/ar.wikipedia.org\/wiki\/\u062a\u0646\u0628\u0624\u0627\u062a_\u0627\u0644\u062c\u0627\u0626\u062d\u0629_\u0648\u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f\u0627\u062a_\u0642\u0628\u0644_\u062c\u0627\u0626\u062d\u0629_\u0643\u0648\u0641\u064a\u062f-19<\/a>
\n2- https:\/\/pubmed.ncbi.nlm.nih.gov\/9627935\/<\/a>
\n3- https:\/\/teltonika-gps.com\/use-cases\/logistics\/vaccine-distribution<\/a>
\n4- https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vaccine-acceptance<\/a>
\n5- https:\/\/sciencescafe.com\/?p=8671<\/a>
\n6- https:\/\/ar.wikipedia.org\/wiki\/\u062a\u0648\u0644\u064a\u062f_\u0627\u0644\u0645\u0646\u0627\u0639\u0629<\/a>
\n7- https:\/\/www.verywellmind.com\/difference-between-race-and-ethnicity-5074205<\/a>
\n8- https:\/\/ncirs.org.au\/vaccine-platforms<\/a>
\n9- https:\/\/ar.wikipedia.org\/wiki\/\u062d\u0642\u0646_\u0639\u0636\u0644\u064a<\/a>
\n10- https:\/\/www.science.org\/content\/blog-post\/first-self-amplifying-mrna-vaccine<\/a>
\n11- https:\/\/altibbi.com\/\u0645\u0642\u0627\u0644\u0627\u062a-\u0637\u0628\u064a\u0629\/\u0639\u0644\u0645-\u0627\u0644\u0645\u0646\u0627\u0639\u0629\/\u0627\u0644\u0641\u0631\u0642-\u0628\u064a\u0646-\u0627\u0644\u0645\u0646\u0627\u0639\u0629-\u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629-\u0648\u0627\u0644\u0645\u0643\u062a\u0633\u0628\u0629-9408<\/a>
\n12- https:\/\/www.kansascity.com\/news\/local\/article264459351.html<\/a>
\n13- https:\/\/en.wikipedia.org\/wiki\/Reactogenicity
\n14- https:\/\/ar.wikipedia.org\/wiki\/\u0627\u0633\u062a\u062c\u0627\u0628\u0629_\u0645\u0646\u0627\u0639\u0629<\/a>
\n15- https:\/\/ar.wikipedia.org\/wiki\/\u0645\u0646\u0627\u0639\u0629_\u062e\u0644\u0637\u064a\u0629<\/a>
\n16- https:\/\/ar.wikipedia.org\/wiki\/\u062c\u0633\u0645_\u0645\u0636\u0627\u062f_\u0645\u0639\u062f\u0644<\/a>
\n17- https:\/\/www.nejm.org\/doi\/10.1056\/NEJMp2211314<\/a>
\n18- https:\/\/www.news-medical.net\/health\/What-is-Immunobridging.aspx<\/a>
\n19- https:\/\/ar.wikipedia.org\/wiki\/\u062f\u0631\u0627\u0633\u0627\u062a_\u0627\u0644\u0639\u0644\u0627\u062c_\u0627\u0644\u0648\u0647\u0645\u064a<\/a>
\n20- https:\/\/ar.wikipedia.org\/wiki\/\u0645\u062a\u062d\u0648\u0631_\u0623\u0648\u0645\u064a\u0643\u0631\u0648\u0646<\/a>
\n21- https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/amino-acid-substitution<\/a>
\n22- https:\/\/ar.wikipedia.org\/wiki\/\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646_\u0627\u0644\u0634\u0648\u0643\u064a_\u0644\u0641\u064a\u0631\u0648\u0633_\u0643\u0648\u0631\u0648\u0646\u0627<\/a>
\n23- https:\/\/ar.wikipedia.org\/wiki\/\u0639\u062f\u0648\u0649_\u0627\u0644\u062c\u0647\u0627\u0632_\u0627\u0644\u062a\u0646\u0641\u0633\u064a_\u0627\u0644\u0633\u0641\u0644\u064a<\/a>
\n24- https:\/\/ar.wikipedia.org\/wiki\/\u0623\u0646\u062c\u064a\u0648\u062a\u0646\u0633\u064a\u0646<\/a>
\n25- https:\/\/www.moh.gov.om\/documents\/274609\/275070\/CH9Y05.pdf\/bc0eed2f-df01-47fc-891a-cdf7c0aa8951<\/a>
\n26- https:\/\/ar.wikipedia.org\/wiki\/\u0645\u0646\u0627\u0639\u0629_\u062e\u0644\u0648\u064a\u0629<\/a>
\n27- https:\/\/ar.wikipedia.org\/wiki\/\u0630\u0627\u0643\u0631\u0629_\u0645\u0646\u0627\u0639\u064a\u0629<\/a>
\n28- https:\/\/ar.wikipedia.org\/wiki\/\u062d\u0627\u062a\u0645\u0629<\/a>
\n29- https:\/\/www.news-medical.net\/health\/What-is-a-Receptor-Binding-Domain-(RBD).aspx<\/a>
\n30- https:\/\/ar.wikipedia.org\/wiki\/\u0628\u0631\u0648\u062a\u064a\u0646_\u0641\u064a\u0631\u0648\u0633\u064a_\u0644\u0627\u0628\u0646\u064a\u0648\u064a<\/a>
\n31- https:\/\/www.moh.gov.sa\/HealthAwareness\/EducationalContent\/PublicHealth\/Pages\/Immunity.aspx<\/a>
\n32- https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mucosal-immunity<\/a>
\n33- https:\/\/www.bibalex.org\/sciplanet\/ar\/article\/details.aspx?id=10298<\/a>
\n34- https:\/\/altibbi.com\/\u0645\u0635\u0637\u0644\u062d\u0627\u062a-\u0637\u0628\u064a\u0629\/\u0639\u0644\u0645-\u0627\u0644\u0645\u0646\u0627\u0639\u0629\/\u0645\u062e\u062a\u0635\u0631-\u0627\u0644\u0627\u064a\u062c-\u0627\u0644\u063a\u0644\u0648\u0628\u0648\u0644\u064a\u0646-\u0627\u0644\u0645\u0646\u0627\u0639\u064a-e#:~<\/a>
\n35- https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra2200583<\/a>
\n36- https:\/\/ar.wikipedia.org\/wiki\/\u0627\u0644\u062a\u0647\u0627\u0628_\u0627\u0644\u0639\u0636\u0644\u0629_\u0627\u0644\u0642\u0644\u0628\u064a\u0629<\/a>
\n37- https:\/\/ar.wikipedia.org\/wiki\/\u0627\u0644\u062a\u0647\u0627\u0628_\u0627\u0644\u062a\u0627\u0645\u0648\u0631<\/a><\/h5>\n

\u0627\u0644\u0645\u0635\u062f\u0631 \u0627\u0644\u0631\u0626\u064a\u0633:<\/strong>
\nhttps:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMp2403598<\/a><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Anticipating the Next Pandemic (\u0627\u0644\u0645\u0624\u0644\u0641\u0648\u0646: \u0647\u0640. \u0643\u0648\u062f\u064a \u0645\u064a\u0633\u0646\u0631\u060c \u062f\u0643\u062a\u0648\u0631 \u0641\u064a \u0627\u0644\u0637\u0628\u060c \u0628\u064a\u0644 \u063a. \u0643\u0627\u0628\u0648\u062c\u064a\u0627\u0646\u064a\u0633\u060c \u062f\u0643\u062a\u0648\u0631 \u0641\u064a \u0627\u0644\u0637\u0628\u060c \u0648\u062f\u0627\u0646\u064a\u0627\u0644 \u0625\u0646. \u0648\u0648\u0644\u0641\u060c \u062f\u0643\u062a\u0648\u0631\u0627\u0647. \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0648\u062a\u0648\u0627\u0628\u0639\u0647\u0627) (Authors: H. Cody Meissner, M.D., Bill G. Kapogiannis, M.D., and Daniel N. Wolfe, Ph.D.Author Info & Affiliations) \u062c\u0627\u0626\u062d\u0629 \u0643\u0648\u0641\u064a\u062f-19 \u0627\u0644\u062a\u064a \u0623\u0648\u062f\u062a \u0628\u062d\u064a\u0627\u0629 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 \u0636\u0639\u0641 \u0639\u062f\u062f \u0645\u0646 \u0645\u0627\u062a \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 …<\/p>\n","protected":false},"author":4,"featured_media":15540,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-25371","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-19"],"_links":{"self":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/25371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25371"}],"version-history":[{"count":3,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/25371\/revisions"}],"predecessor-version":[{"id":25375,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/25371\/revisions\/25375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/media\/15540"}],"wp:attachment":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}