{"id":16932,"date":"2022-07-22T07:20:52","date_gmt":"2022-07-22T04:20:52","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=16932"},"modified":"2022-07-22T07:20:52","modified_gmt":"2022-07-22T04:20:52","slug":"%d8%a3%d8%af%d9%84%d8%a9-%d9%85%d9%83%d8%a7%d9%81%d8%ad%d8%a9-%d8%a7%d9%84%d8%b4%d9%8a%d8%ae%d9%88%d8%ae%d8%a9-%d8%aa%d9%83%d9%85%d9%86-%d9%81%d9%8a-%d8%a7%d9%84%d8%ac%d8%b3%d9%8a%d9%85%d8%a7%d8%aa","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=16932","title":{"rendered":"\u0623\u062f\u0644\u0629 \u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u062a\u0643\u0645\u0646 \u0641\u064a \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u06291\u060c \u0648\u0645\u0631\u0627\u0643\u0632 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u062f\u0648\u064a\u0631 \u0644\u0644\u062e\u0644\u064a\u0629 – \u062a\u0631\u062c\u0645\u0629* \u0645\u062d\u0645\u062f \u062c\u0648\u0627\u062f \u0622\u0644 \u0627\u0644\u0633\u064a\u062f \u0646\u0627\u0635\u0631 \u0627\u0644\u062e\u0636\u0631\u0627\u0648\u064a"},"content":{"rendered":"

Anti-aging clues lurk in lysosomes1<\/sup>, the recycling centers of the cell <\/strong>
\n(Molly Chiu, Baylor College of Medicine – \u0628\u0642\u0644\u0645: \u0645\u0648\u0644\u064a \u062a\u0634\u064a\u0648\u060c \u0643\u0644\u064a\u0629 \u0628\u0627\u064a\u0644\u0648\u0631 \u0644\u0644\u0637\u0628) <\/span><\/h3>\n

\u0645\u0644\u062e\u0635 \u0627\u0644\u0645\u0642\u0627\u0644\u0629:<\/span><\/strong><\/p>\n

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( \u0627\u0644\u0645\u0642\u0627\u0644\u0629 )<\/strong><\/p>\n

\u0646\u0634\u0631 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0641\u064a \u0643\u0644\u064a\u0629 \u0628\u0627\u064a\u0644\u0648\u0631 \u0644\u0644\u0637\u0628 \u0648\u0645\u0639\u0647\u062f \u0647\u0648\u0627\u0631\u062f \u0647\u064a\u0648\u0632 \u0627\u0644\u0637\u0628\u064a (HHMI) \u0648\u0627\u0644\u0645\u0624\u0633\u0633\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u0627\u0648\u0646\u0629 \u0645\u0639\u0647\u0645 \u0641\u064a \u0645\u062c\u0644\u0629 “\u0639\u0644\u0645 \u0623\u062d\u064a\u0627\u0621 \u062e\u0644\u064a\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u0629” (Nature Cell Biology) \u0623\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u062f\u064a\u062f\u0627\u0646 \u0627\u0644\u0645\u0633\u062a\u062f\u064a\u0631\u0629 \u062a\u0646\u062a\u062c \u062c\u0632\u064a\u0626\u0627\u062a \u062a\u0633\u0645\u062d \u0644\u0644\u062e\u0644\u0627\u064a\u0627 “\u0628\u0627\u0644\u062a\u062d\u062f\u062b” \u0645\u0639 \u0628\u0639\u0636\u0647\u0627 \u0627\u0644\u0628\u0639\u0636 \u062d\u0648\u0644 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629\u060c \u0648\u062a\u0646\u0633\u064a\u0642 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0639\u0628\u0631 \u0643\u0644 \u0627\u0644\u0643\u0627\u0626\u0646 \u0627\u0644\u062d\u064a.<\/p>\n

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\u0627\u0644\u0645\u0648\u0636\u0639\u064a \u0644\u062c\u0632\u064a\u0621 \u00a0\u0648\u0627\u062d\u062f (smFISH) \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a (RNA) \u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u0646\u0648\u0649 \u0645\u0644\u0637\u062e\u0629 \u0628\u0648\u0627\u0633\u0637\u0629 \u062f\u0627\u0628\u064a3<\/sup> (DAPI). \u062a\u0645 \u0627\u0644\u0643\u0634\u0641 \u0639\u0646 egl-21 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 (\u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0645\u0639\u0628\u0623\u0629) \u0645\u0646 “\u062f\u0628\u0644\u064a\u0648 \u062a\u064a” \u0648\u0644\u0643\u0646 \u0644\u064a\u0633 \u062f\u064a\u062f\u0627\u0646 egl-21 (lf). \u0644\u0627 \u062a\u0638\u0647\u0631 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0628\u062e\u0637\u0648\u0637 \u0645\u062a\u0642\u0637\u0639\u0629 egl-21. \u0634\u0631\u064a\u0637 \u0645\u0642\u064a\u0627\u0633\u060c 30 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 \u0648 10 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 \u0641\u064a \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u062f\u0627\u062e\u0644\u064a. \u0648(g) \u060c \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0641\u0644\u0648\u0631\u0633\u0646\u062a \u0627\u0644\u0623\u062e\u0636\u0631 \u00a0(green fluorescent protein (GFP)\u00a0 \u0645\u062f\u0641\u0648\u0639\u064b\u0627 \u00a0\u0628\u0627\u0644\u0645\u0631\u0648\u062c \u0627\u0644\u062f\u0627\u062e\u0644\u064a egl-21 \u00a0\u064a\u062a\u0645 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646\u0647 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0648\u0644\u0643\u0646 \u0644\u064a\u0633 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 (\u064a\u062a\u0645\u064a\u0632 \u0628\u062e\u0637\u0648\u0637 \u0645\u062a\u0642\u0637\u0639\u0629). \u0634\u0631\u064a\u0637 \u0645\u0642\u064a\u0627\u0633\u060c 10 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631. \u0632 (h) \u060c \u062a\u062d\u062c\u0628 \u0637\u0641\u0631\u0629 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0648\u0638\u064a\u0641\u0629 \u0644\u0640 egl-21 (lf) \u00a0\u0637\u0648\u0644 \u0639\u0645\u0631 lipl-4 Tg. \u062a\u0633\u062a\u062e\u062f\u0645 \u0636\u0631\u0628\u0629 daf-16 RNAi \u00a0\u0627\u0644\u0642\u0627\u0636\u064a\u0629 \u0644\u0644\u0642\u0636\u0627\u0621 \u0639\u0644\u0649 \u062a\u0623\u062b\u064a\u0631 \u062a\u0642\u0644\u064a\u0644 ILP \u0641\u064a egl-21 (lf). \u0641\u064a \u0623 a \u0648 \u0632 h \u060c n = 3 \u0639\u064a\u0646\u0627\u062a \u0645\u0633\u062a\u0642\u0644\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u064b\u0627 \u061b NS \u060c \u063a\u064a\u0631 \u0645\u0647\u0645 (P> 0.05) \u060c *** P <0.001 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0631\u062a\u0628\u0629 \u0627\u0644\u0633\u062c\u0644 \u060c 60-120 \u062f\u0648\u062f\u0629 \u0644\u0643\u0644 \u062a\u0643\u0631\u0627\u0631. \u0627\u0646\u0638\u0631 \u0627\u0644\u062c\u062f\u0648\u0644\u064a\u0646 \u0627\u0644\u062a\u0643\u0645\u064a\u0644\u064a\u064a\u0646 4 \u0648 5 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0627\u0641\u062a\u0631\u0627\u0636\u064a \u0627\u0644\u0643\u0627\u0645\u0644. \u0641\u064a \u062c (c) \u060c \u062a\u0645\u062b\u0644 \u0623\u0634\u0631\u0637\u0629 \u0627\u0644\u062e\u0637\u0623 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u00b1 \u062e\u0637\u0623 \u0645\u0639\u064a\u0627\u0631\u064a \u0644\u0644\u0645\u062a\u0648\u0633\u0637 \u200b\u200b((sem) \u060c n = 3 \u0639\u064a\u0646\u0627\u062a \u0645\u0633\u062a\u0642\u0644\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u064b\u0627 \u060c **** P <0.0001 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 t \u0644\u0644\u0637\u0627\u0644\u0628 \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0630\u064a\u0644 \u060c ~ 2000 \u062f\u0648\u062f\u0629 \u0644\u0643\u0644 \u062a\u0643\u0631\u0627\u0631. \u0641\u064a \u0647\u0640 (e) \u060c \u062a\u0645\u062b\u0644 \u0623\u0634\u0631\u0637\u0629 \u0627\u0644\u062e\u0637\u0623 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u00b1 sem \u060c n = 3 \u0639\u064a\u0646\u0627\u062a \u0645\u0633\u062a\u0642\u0644\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u064b\u0627 \u060c DESeq2 | \u062a\u063a\u064a\u064a\u0631 \u0623\u0636\u0639\u0627\u0641 | \u22651.5 \u061b P <0.05 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u062e\u062a\u0628\u0627\u0631 \u0648\u0627\u0644\u062f \u0639\u0644\u0649 \u0627\u0644\u0648\u062c\u0647\u064a\u0646 (lipl-4 Tg \u0645\u0642\u0627\u0628\u0644 WT) \u060c \u062d\u0648\u0627\u0644\u064a 3000 \u062f\u0648\u062f\u0629 \u0644\u0643\u0644 \u062a\u0643\u0631\u0627\u0631. \u0627\u0644\u0645\u0635\u062f\u0631: Nature Cell Biology (2022). DOI: 10.1038 \/ s41556-022-00926-8.<\/span><\/figcaption><\/figure>\n

\u0648\u0639\u0644\u0649 \u0645\u062f\u0649 \u0639\u0642\u0648\u062f\u060c \u062a\u0639\u0644\u0645 \u0637\u0644\u0627\u0628 \u0639\u0644\u0645 \u0627\u0644\u0623\u062d\u064a\u0627\u0621 \u0623\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0640 \u0648\u0647\u064a \u0623\u0643\u064a\u0627\u0633 \u0635\u063a\u064a\u0631\u0629 \u062a\u0648\u062c\u062f \u062f\u0627\u062e\u0644 \u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0640 \u0644\u0647\u0627 \u0645\u0647\u0645\u0629 \u0648\u0627\u062d\u062f\u0629: \u0627\u0644\u062a\u0647\u0627\u0645 \u0623\u062c\u0632\u0627\u0621 \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u063a\u0631\u064a\u0628\u0629 \u0648\u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0628\u0627\u0644\u064a\u0629. \u0648\u0627\u0644\u063a\u0627\u064a\u0629 \u0647\u064a \u0644\u062a\u0641\u0643\u064a\u0643\u0647\u0627 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u062f\u0648\u064a\u0631. \u0648\u0644\u0643\u0646 \u0647\u0630\u0627 \u0627\u0644\u062f\u0631\u0633 \u0642\u062f \u064a\u062d\u062a\u0627\u062c \u0642\u0631\u064a\u0628\u0627 \u0625\u0644\u0649 \u0645\u0631\u0627\u062c\u0639\u0629.<\/p>\n

\u0648\u0642\u062f \u0623\u0645\u0636\u062a \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0629 \u0645\u0646\u063a \u0648\u0627\u0646\u063a\u060c \u0627\u0644\u0623\u0633\u062a\u0627\u0630 (\u0628\u0631\u0648\u0641\u0628\u0633\u0648\u0631) \u0648\u0631\u0626\u064a\u0633 \u0643\u0631\u0633\u064a \u0648\u0642\u0641 “\u0631\u0648\u0628\u0631\u062a \u0633\u064a. \u0641\u0627\u064a\u0641” \u0627\u0644\u0645\u062a\u062e\u0635\u0635 \u0641\u064a \u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0648\u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0648\u0627\u0644\u0628\u0627\u062d\u062b \u0641\u064a \u0645\u0639\u0647\u062f \u0647\u0648\u0627\u0631\u062f \u0647\u064a\u0648\u0632 \u0627\u0644\u0637\u0628\u064a \u0641\u064a \u0628\u0627\u064a\u0644\u0648\u0631\u060c \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0633\u0628\u0639 \u0627\u0644\u0645\u0627\u0636\u064a\u0629 \u0641\u064a \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0627\u0644\u0635\u0644\u0629 \u0628\u064a\u0646 \u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631 \u0648\u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0646\u062a\u062c\u0647\u0627 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629.<\/p>\n

\u0648\u064a\u062a\u063a\u0644\u063a\u0644 \u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631\u060c \u0639\u0644\u0649 \u0645\u0627 \u064a\u0628\u062f\u0648\u060c \u0628\u0639\u0645\u0642 \u0641\u064a \u062f\u0645 \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0648\u0627\u0646\u063a – \u0639\u0627\u0634\u062a \u062c\u062f\u0627\u062a\u0647\u0627 \u0645\u0646 \u0627\u0644\u0623\u0628 \u0648\u0627\u0644\u0623\u0645 \u062d\u062a\u0649 \u0633\u0646 100 \u0648 95 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0648\u0642\u0627\u0644\u062a: “\u0644\u0645 \u064a\u0643\u0646 \u0623\u064a \u0645\u0646\u0647\u0645\u0627 \u0645\u0631\u064a\u0636\u0627\u060c \u0648\u0644\u0645\u0627\u0630\u0627 \u0645\u0627\u062a\u0627 \u0644\u0627 \u064a\u0632\u0627\u0644 \u0644\u063a\u0632\u0627”. \u0648\u062a\u0627\u0628\u0639\u062a: “\u0647\u0630\u0627 \u064a\u062c\u0639\u0644\u0646\u064a \u0623\u0634\u0639\u0631 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0633\u0631\u064b\u0627 \u0644\u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631\u060c \u0648\u0625\u0630\u0627 \u062a\u0645\u0643\u0646\u0627 \u0645\u0646 \u062f\u0631\u0627\u0633\u0629 \u0647\u0630\u0627\u060c \u0641\u0631\u0628\u0645\u0627 \u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0639\u0631\u0641\u0629 \u0648\u062a\u0637\u0628\u064a\u0642\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062c\u0645\u064a\u0639”.<\/p>\n

“\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u062d\u0648\u0644 \u0627\u0644\u062c\u0633\u0645 \u062a\u0631\u0633\u0644 \u0625\u0634\u0627\u0631\u0627\u062a \u0644\u0628\u0639\u0636\u0647\u0627 \u0627\u0644\u0628\u0639\u0636 \u0628\u0627\u0633\u062a\u0645\u0631\u0627\u0631”\u060c \u0642\u0627\u0644\u062a \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0648\u0627\u0646\u063a\u060c \u0648\u0647\u064a \u0639\u0636\u0648 \u0641\u064a \u0645\u0631\u0643\u0632 \u062f\u0627\u0646 \u0625\u0644 \u062f\u0646\u0643\u0627\u0646 \u0627\u0644\u0634\u0627\u0645\u0644 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0641\u064a \u0628\u0627\u064a\u0644\u0648\u0631. \u0648\u0623\u0636\u0627\u0641\u062a: “\u0639\u0646\u062f\u0645\u0627 \u0646\u0643\u0648\u0646 \u0635\u063a\u0627\u0631\u064b\u0627\u060c \u0643\u0644 \u0634\u064a\u0621 \u0645\u062a\u0635\u0644 \u0648\u064a\u062a\u0648\u0627\u0635\u0644\u060c \u0648\u0644\u0643\u0646 \u0645\u0639 \u062a\u0642\u062f\u0645\u0646\u0627 \u200b\u200b\u0641\u064a \u0627\u0644\u0639\u0645\u0631\u060c \u062a\u0641\u0642\u062f \u0628\u0639\u0636 \u0647\u0630\u0647 \u0627\u0644\u0631\u0648\u0627\u0628\u0637 \u0648\u062a\u062a\u062f\u0647\u0648\u0631 \u0627\u0644\u0648\u0638\u064a\u0641\u0629”.<\/p>\n

\u0625\u0637\u0627\u0644\u0629 \u0627\u0644\u0639\u0645\u0631<\/strong><\/p>\n

\u0628\u062d\u0644\u0648\u0644 \u0639\u0627\u0645 2050\u060c \u064a\u062a\u0648\u0642\u0639 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0623\u0646 \u064a\u062a\u0636\u0627\u0639\u0641 \u0639\u062f\u062f \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u062a\u0628\u0644\u063a \u0623\u0639\u0645\u0627\u0631\u0647\u0645 65 \u0639\u0627\u0645\u064b\u0627 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645 \u0625\u0644\u0649 1.5 \u0645\u0644\u064a\u0627\u0631\u060c \u0648\u0641\u0642\u064b\u0627 \u0644\u062a\u0642\u0631\u064a\u0631 \u0635\u0627\u062f\u0631 \u0639\u0646 \u0627\u0644\u0623\u0645\u0645 \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0639\u0627\u0645 2019. \u0648\u064a\u0639\u0644\u0645 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0623\u0646 \u0627\u0644\u062a\u0642\u062f\u0645 \u0641\u064a \u0627\u0644\u0633\u0646 \u064a\u0623\u062a\u064a \u0645\u0639 \u0632\u064a\u0627\u062f\u0629 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0627\u0644\u0645\u0634\u0627\u0643\u0644 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649.<\/p>\n

\u0648\u0642\u0627\u0644\u062a \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0629 \u0634\u064a\u0627\u0648\u0634\u064a\u0646 \u0648\u0627\u0646\u063a\u060c \u0639\u0627\u0644\u0645\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0627\u0621 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0627\u0644\u0635\u064a\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 (CAS) \u0641\u064a \u0628\u0643\u064a\u0646 \u0648\u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629: “\u0647\u0630\u0627 \u064a\u0641\u0633\u0631 \u0633\u0628\u0628 \u0627\u0646\u0637\u0644\u0627\u0642 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u062d\u0648\u0644 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0648\u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631 \u0641\u064a \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0623\u062e\u064a\u0631\u0629”. \u0648\u0623\u0636\u0627\u0641\u062a: “\u0644\u0642\u062f \u0639\u0631\u0641 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0645\u0646\u0630 \u0623\u0643\u062b\u0631 \u0645\u0646 50 \u0639\u0627\u0645\u064b\u0627 \u0623\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u062f\u0647\u0648\u0646 \u0648\u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u062a\u0645\u064a\u0644 \u0625\u0644\u0649 \u0627\u0644\u062a\u0631\u0627\u0643\u0645 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u062f\u064a\u0645\u0629\u060c \u0648\u0644\u0643\u0646 \u0627\u0644\u0622\u0646 \u0641\u0642\u0637 \u064a\u0648\u0644\u064a \u0627\u0644\u0646\u0627\u0633 \u0645\u0632\u064a\u062f\u064b\u0627 \u0645\u0646 \u0627\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u062c\u0632\u0627\u0621 \u0645\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a”.<\/p>\n

\u0648\u0646\u0638\u0631\u064b\u0627 \u0644\u0623\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0647\u064a \u0645\u0648\u0642\u0639 \u0631\u0645\u064a \u0627\u0644\u0642\u0645\u0627\u0645\u0629 \u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0646\u0641\u0627\u064a\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629\u060c \u064a\u0642\u0648\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u062f\u0631\u0627\u0633\u062a\u0647\u0627 \u0628\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0641\u0635\u064a\u0644\u060c \u0648\u064a\u0634\u062a\u0628\u0647\u0648\u0646 \u0641\u064a \u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0627 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629. \u0648\u062e\u0644\u0627\u0644 \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0645\u0627\u0636\u064a\u060c \u0623\u0638\u0647\u0631 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0623\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u062a\u0639\u0645\u0644 \u0643\u0645\u0646\u0635\u0629 \u062a\u0633\u062a\u062e\u062f\u0645\u0647\u0627 \u0627\u0644\u062e\u0644\u064a\u0629 \u0644\u0625\u0631\u0633\u0627\u0644 \u0631\u0633\u0627\u0626\u0644 \u062d\u0648\u0644 \u062d\u0627\u0644\u062a\u0647\u0627 \u0627\u0644\u0639\u0627\u0645\u0629\u060c \u0645\u062b\u0644 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062c\u0644\u0648\u0643\u0648\u0632 \u0648\u0627\u0644\u062a\u0648\u062a\u0631. \u0648\u0641\u064a \u0639\u0627\u0645 2015\u060c \u0643\u0627\u0646\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0645\u064a\u0646\u063a \u0648\u0627\u0646\u063a \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0623\u0648\u0627\u0626\u0644 \u0645\u0646 \u0627\u0643\u062a\u0634\u0641\u0648\u0627 \u0625\u0634\u0627\u0631\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0644\u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u062a\u0646\u062a\u062c\u0647\u0627 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u062f\u0648\u062f\u0629 \u0627\u0644\u0645\u0633\u062a\u062f\u064a\u0631\u0629 “\u0633\u064a. \u0627\u0644\u064a\u063a\u0627\u0646\u0632” (C. elegans).<\/p>\n

\"\"
\u0645\u0635\u062f\u0631 \u0627\u0644\u0635\u0648\u0631\u0629: \u0627\u0644\u062f\u0648\u062f\u0629 \u0627\u0644\u0645\u0633\u062a\u062f\u064a\u0631\u0629 “\u0633\u064a. \u0627\u0644\u064a\u063a\u0627\u0646\u0632”(C. Elegans) . \u0627\u0644\u0645\u0635\u062f\u0631: https:\/\/www.bing.com\/images<\/span><\/figcaption><\/figure>\n

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\u0645\u0646 \u062e\u0644\u064a\u0629 \u0625\u0644\u0649 \u0623\u062e\u0631\u0649<\/strong><\/p>\n

\u062a\u0623\u062e\u0630 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0628\u062d\u062b \u062e\u0637\u0648\u0629 \u0623\u062e\u0631\u0649 \u0625\u0644\u0649 \u0627\u0644\u0623\u0645\u0627\u0645. \u0648\u0641\u064a \u0627\u0644\u0639\u0645\u0644 \u0627\u0644\u0630\u064a \u0642\u0627\u062f\u062a\u0647 \u0645\u0627\u0631\u0632\u064a\u0627 \u0633\u0627\u0641\u064a\u0646\u064a\u060c \u0637\u0627\u0644\u0628\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 (\u062a\u062d\u062a \u0627\u0634\u0631\u0627\u0641 \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0645\u0646\u063a \u0648\u0627\u0646\u063a)\u060c \u0627\u0643\u062a\u0634\u0641 \u0641\u0631\u064a\u0642 \u0628\u0627\u064a\u0644\u0648\u0631 \u0623\u0646\u0647 \u0639\u0646\u062f\u0645\u0627 \u062a\u0646\u062a\u062c \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u062d\u0645\u0636 \u062f\u0647\u0646\u064a \u064a\u0633\u0645\u0649 \u062d\u0645\u0636 \u062f\u064a\u0647\u0648\u0645\u0648-\u062c\u0627\u0645\u0627-\u0644\u064a\u0646\u0648\u0644\u064a\u0643 (dihomo-gamma-linoleic acid)\u060c \u064a\u0628\u062f\u0623 \u062a\u0641\u0627\u0639\u0644 \u0645\u062a\u0633\u0644\u0633\u0644 \u0644\u0644\u0631\u0633\u0627\u0626\u0644 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0648\u064a\u0637\u064a\u0644 \u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u0637\u0627\u0641 \u062d\u064a\u0627\u0629 \u0627\u0644\u062f\u064a\u062f\u0627\u0646. \u0648\u0639\u0646\u062f\u0645\u0627 \u0623\u062f\u0627\u0631 (\u0646\u0634\u0637) \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0647\u0630\u0647\u060c \u0639\u0627\u0634\u062a \u0627\u0644\u062f\u064a\u062f\u0627\u0646 \u0645\u0646 20 \u0625\u0644\u0649 25 \u064a\u0648\u0645\u064b\u0627\u060c \u0648\u0647\u064a \u0632\u064a\u0627\u062f\u0629 \u0639\u0646 \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0627\u0644\u0628\u0627\u0644\u063a 17 \u064a\u0648\u0645\u064b\u0627. \u0648\u0628\u0634\u0643\u0644 \u062d\u0627\u0633\u0645\u060c \u062a\u0645 \u0625\u0646\u0634\u0627\u0621 \u062c\u0632\u064a\u0621 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629\u060c \u0648\u0645\u0639 \u0630\u0644\u0643 \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641\u0647 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u0623\u0645\u0627\u0643\u0646 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062f\u064a\u062f\u0627\u0646. \u0648\u0647\u0630\u0627 \u064a\u0639\u0646\u064a \u0623\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u062a\u0646\u062a\u062c \u0625\u0634\u0627\u0631\u0627\u062a \u062a\u0633\u062a\u062e\u062f\u0645\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u062a\u0646\u0633\u064a\u0642 \u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631 \u0639\u0628\u0631 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629.<\/p>\n

\u0648\u0642\u0627\u0644\u062a \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0645\u0646\u063a \u0648\u0627\u0646\u063a: “\u0625\u0646\u0647\u0627 \u062a\u0633\u0627\u0639\u062f\u0646\u0627 \u062d\u0642\u064b\u0627 \u0641\u064a \u0641\u0647\u0645 \u0643\u064a\u0641\u064a\u0629 \u062a\u0646\u0638\u064a\u0645 \u0637\u0648\u0644 \u0627\u0644\u0639\u0645\u0631 \u0639\u0644\u0649 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0643\u0627\u0626\u0646 \u0627\u0644\u062d\u064a \u0628\u0623\u0643\u0645\u0644\u0647”.<\/p>\n

\u0648\u062a\u0648\u0627\u0635\u0644 \u0627\u0644\u0628\u0631\u0648\u0641\u064a\u0633\u0648\u0631 \u0645\u0646\u063a \u0648\u0627\u0646\u063a \u0648\u0641\u0631\u064a\u0642\u0647\u0627 \u2013 \u0627\u0644\u064a\u0648\u0645 – \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u062c\u0632\u064a\u0626\u0627\u062a \u0623\u062e\u0631\u0649 \u062a\u0646\u062a\u062c\u0647\u0627 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0643\u0648\u0646 \u0628\u0645\u062b\u0627\u0628\u0629 \u0625\u0634\u0627\u0631\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0634\u064a\u062e\u0648\u062e\u0629. \u0648\u0642\u0627\u0644\u062a: “\u0644\u0627 \u064a\u0632\u0627\u0644 \u0647\u0646\u0627\u0643 \u0627\u0644\u0643\u062b\u064a\u0631 \u0644\u0644\u0643\u0634\u0641 \u0639\u0646\u0647\u060c \u0645\u062b\u0644 \u0645\u0639\u0631\u0641\u0629 \u0645\u062a\u0649 \u062a\u0628\u062f\u0623 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u0641\u064a \u0627\u0644\u0639\u0645\u0644 \u0643\u0625\u0634\u0627\u0631\u0627\u062a\u060c \u0648\u0643\u064a\u0641 \u062a\u0646\u0638\u0645 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0648\u0643\u064a\u0641 \u062a\u062a\u0644\u0627\u0634\u0649 \u0647\u0630\u0647 \u0627\u0644\u0648\u0638\u064a\u0641\u0629 \u0645\u0639 \u062a\u0642\u062f\u0645 \u0627\u0644\u0639\u0645\u0631”.<\/p>\n

\u0648\u0623\u0636\u0627\u0641\u062a: “\u0627\u0644\u0647\u062f\u0641 \u0644\u064a\u0633 \u0623\u0646 \u064a\u0639\u064a\u0634 \u0627\u0644\u062c\u0645\u064a\u0639 \u0644\u0642\u0631\u0648\u0646\u060c \u0648\u0644\u0643\u0646 \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0630\u0644\u0643 \u064a\u0642\u0636\u064a \u0627\u0644\u0646\u0627\u0633 \u0633\u0646\u0648\u0627\u062a\u0647\u0645 \u0627\u0644\u0623\u062e\u064a\u0631\u0629 \u0628\u0635\u062d\u0629 \u062c\u064a\u062f\u0629 \u0648\u0646\u0634\u0637\u0629 \u0648\u0645\u0633\u062a\u0642\u0644\u0629 – \u062a\u0645\u0627\u0645\u064b\u0627 \u0645\u062b\u0644 \u062c\u062f\u0627\u062a\u064a. \u0623\u0646\u0627 \u0645\u062a\u062d\u0645\u0633\u0629 \u0644\u0645\u0639\u0631\u0641\u0629 \u0643\u064a\u0641 \u064a\u062d\u0627\u0641\u0638 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0648\u0627\u0644\u0645\u0646\u0638\u0645\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0635\u062d\u0629 \u0645\u0639 \u0627\u0644\u0648\u0642\u062a”.<\/p>\n

*\u062a\u0645\u062a \u0627\u0644\u062a\u0631\u062c\u0645\u0629 \u0628\u062a\u0635\u0631\u0641<\/span><\/p>\n

\u0627\u0644\u0645\u0635\u062f\u0631:<\/strong><\/p>\n

https:\/\/phys.org\/news\/2022-06-anti-aging-clues-lurk-lysosomes-recycling.html<\/a><\/p>\n

\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a<\/strong>: \u0645\u0627\u0631\u0632\u064a\u0627 \u0633\u0627\u0641\u064a\u0646\u064a \u0648\u0622\u062e\u0631\u0648\u0646\u060c Lysosome lipid signalling from the periphery to neurons regulates longevity, Nature Cell Biology (2022). DOI: 10.1038\/s41556-022-00926-8<\/span><\/p>\n

\u0627\u0644\u0647\u0648\u0627\u0645\u0634:<\/strong><\/p>\n

    \n
  1. \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 (\u0627\u0644\u0644\u064a\u0633\u0648\u0633\u0648\u0645\u0627\u062a Lysosomes) -\u0627\u0646\u0638\u0631 \u0627\u0644\u0634\u0643\u0644- \u0647\u0648 \u0639\u0636\u064a\u0629 \u062e\u0644\u0648\u064a\u0629 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u063a\u0634\u0627\u0621 \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0647\u0636\u0645\u064a\u0629. \u062a\u0634\u0627\u0631\u0643 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0641\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629. \u062a\u0642\u0648\u0645 \u0628\u0643\u0633\u0631 (\u062a\u0641\u062a\u064a\u062a) \u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0632\u0627\u0626\u062f\u0629 \u0623\u0648 \u0627\u0644\u0628\u0627\u0644\u064a\u0629. \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647\u0627 \u0644\u062a\u062f\u0645\u064a\u0631 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0648\u0627\u0644\u0628\u0643\u062a\u064a\u0631\u064a\u0627 \u0627\u0644\u063a\u0627\u0632\u064a\u0629. \u0641\u064a \u062d\u0627\u0644\u0629 \u062a\u0644\u0641 \u0627\u0644\u062e\u0644\u064a\u0629 \u0628\u0634\u0643\u0644 \u0644\u0627 \u064a\u0645\u0643\u0646 \u0625\u0635\u0644\u0627\u062d\u0647\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u062a\u062f\u0645\u064a\u0631 \u0627\u0644\u0630\u0627\u062a\u064a \u0641\u064a \u0639\u0645\u0644\u064a\u0629 \u062a\u0633\u0645\u0649 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0645\u0628\u0631\u0645\u062c \u0623\u0648 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c. \u0627\u0644\u0645\u0635\u062f\u0631: https:\/\/www.genome.gov\/genetics-glossary\/Lysosome<\/a><\/li>\n<\/ol>\n

    \"\"<\/p>\n

      \n
    • \u0627\u0644\u0643\u0648\u0627\u0633\u0627\u0631 670 \u0627\u0644\u0623\u062d\u0645\u0631 (Red Quasar 670) \u0644\u0644\u062a\u0647\u062c\u064a\u0646 \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u0644\u062c\u0632\u064a\u0621 \u0648\u0627\u062d\u062f (smFISH) \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a (RNA) \u0647\u0648 \u0625\u0646\u062f\u0648\u0643\u0627\u0631\u0628\u0648\u0633\u064a\u0627\u0646\u064a\u0646 (indocarbocyanine) \u064a\u062a\u0623\u0644\u0642 \u0641\u064a \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0645\u0646 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0645\u0631\u0626\u064a. \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0643\u0628 \u0647\u0648 \u0628\u062f\u064a\u0644 \u0645\u0628\u0627\u0634\u0631 \u0644\u0640 “\u0633\u064a\u0627\u0646\u064a\u0646-5 Cyanine-5 (Cy5) \u060c \u0648\u0647\u0648 \u0645\u0631\u0643\u0628 \u0641\u0644\u0648\u0631\u064a \u0630\u0648 \u0630\u0631\u0648\u0629 \u0625\u062b\u0627\u0631\u0629 \u0639\u0646\u062f 651 \u0646\u0627\u0646\u0648\u0645\u062a\u0631 \u0648\u0630\u0631\u0648\u0629 \u0627\u0646\u0628\u0639\u0627\u062b \u0639\u0646\u062f 670 \u0646\u0627\u0646\u0648\u0645\u062a\u0631. \u0627\u0644\u0645\u0635\u062f\u0631: https:\/\/www.biosearchtech.com\/quasar-670-amidite<\/li>\n
    • \u062f\u0627\u0628\u064a (DAPI) \u060c \u0623\u0648 4\u2032 \u060c6-\u062f\u064a\u0627\u0645\u064a\u062f\u064a\u0646\u0648-2-\u0641\u064a\u0646\u064a\u0644\u064a\u0646\u062f\u0648\u0644 (4\u2032 \u060c 6-Diamidino-2-phenylindole) \u060c \u0647\u064a \u0628\u0642\u0639\u0629 \u0641\u0644\u0648\u0631\u064a\u0629 \u062a\u0631\u062a\u0628\u0637 \u0628\u0642\u0648\u0629 \u0628\u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u0623\u062f\u064a\u0646\u064a\u0646 \u0648\u0627\u0644\u062b\u064a\u0645\u064a\u0646 \u0641\u064a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639 \u0641\u064a \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0645\u062c\u0647\u0631\u064a \u0627\u0644\u0641\u0644\u0648\u0631\u064a. \u0648\u064a\u0643\u064a\u0628\u064a\u062f\u064a\u0627.<\/li>\n<\/ul>\n
      \"\"
      \u0627\u0644\u0645\u0647\u0646\u062f\u0633 \u0645\u062d\u0645\u062f \u062c\u0648\u0627\u062f \u0622\u0644 \u0627\u0644\u0633\u064a\u062f \u0646\u0627\u0635\u0631 \u0627\u0644\u062e\u0636\u0631\u0627\u0648\u064a<\/span><\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

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