{"id":15737,"date":"2022-04-14T03:23:58","date_gmt":"2022-04-14T00:23:58","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=15737"},"modified":"2022-04-14T03:23:58","modified_gmt":"2022-04-14T00:23:58","slug":"%d8%a3%d8%ac%d8%b3%d8%a7%d9%85-%d8%a7%d9%84%d8%a3%d9%84%d8%a8%d9%83%d8%a9-%d8%a7%d9%84%d9%86%d8%a7%d9%86%d9%88%d9%8a%d8%a9-%d8%a7%d9%84%d9%82%d9%88%d9%8a%d8%a9-%d8%aa%d8%ad%d9%8a%d8%af-%d9%85%d8%aa","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=15737","title":{"rendered":"\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0623\u0644\u0628\u0643\u0629 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0642\u0648\u064a\u0629 \u062a\u062d\u064a\u062f \u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633 (\u0643\u0648\u0631\u0648\u0646\u0627-2) – \u062a\u0631\u062c\u0645\u0629* \u0645\u062d\u0645\u062f \u062c\u0648\u0627\u062f \u0622\u0644 \u0627\u0644\u0633\u064a\u062f \u0646\u0627\u0635\u0631 \u0627\u0644\u062e\u0636\u0631\u0627\u0648\u064a"},"content":{"rendered":"

Potent alpaca nanobodies neutralize SARS-CoV-2 variants<\/strong>
\n(Karolinska Institutet – \u062a\u0642\u062f\u064a\u0645: \u0645\u0639\u0647\u062f \u0643\u0627\u0631\u0648\u0644\u064a\u0646\u0633\u0643\u0627)\u00a0<\/span><\/h3>\n

\u0645\u0644\u062e\u0635 \u0627\u0644\u0645\u0642\u0627\u0644\u0629:<\/strong><\/span><\/p>\n

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\u0648\u064a\u0635\u0641 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u0645\u062c\u0644\u0629 “\u0627\u062a\u0635\u0627\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0639\u0629” (Nature Communications) \u062c\u0633\u0645\u0627 \u0646\u0627\u0646\u0648\u064a\u0627 \u0648\u0627\u062d\u062f\u0627\u060c “\u0627\u0641 \u064a\u06482” (Fu2) (\u0633\u0645\u064a \u0639\u0644\u0649 \u0627\u0633\u0645 \u062d\u064a\u0648\u0627\u0646 \u0627\u0644\u0623\u0644\u0628\u0643\u0629 \u0641\u0648\u0646\u064a)\u060c \u0627\u0644\u0630\u064a \u0642\u0644\u0644 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0645\u0646 \u0627\u0644\u062d\u0645\u0644 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a \u0644\u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-2 \u00a0\u0641\u064a \u0645\u0632\u0627\u0631\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0641\u0626\u0631\u0627\u0646. \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0645\u0628\u0631\u062f[\u0662]<\/sup><\/strong>\u060c \u0648\u062c\u062f \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u0646 “\u0627\u0641 \u064a\u06482” \u064a\u0631\u062a\u0628\u0637 \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a \u0628\u0645\u0648\u0642\u0639\u064a\u0646 \u0645\u0646\u0641\u0635\u0644\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0634\u0648\u0643 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a\u060c \u0645\u0645\u0627 \u064a\u0645\u0646\u0639 \u0642\u062f\u0631\u0629 \u0627\u0644\u0641\u064a\u0631\u0648\u0633 \u0639\u0644\u0649 \u062f\u062e\u0648\u0644 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0645\u0636\u064a\u0641\u0629.<\/p>\n

\u0648\u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u0647\u0630\u0627 \u0627\u0644\u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0627\u0644\u062a\u0639\u0627\u0648\u0646 \u0645\u0639 \u0647\u0631\u064a\u0634\u064a\u0643\u064a\u0634 \u062f\u0627\u0633 \u0648\u0645\u0627\u0631\u062a\u0646 \u0647\u0627\u0644\u0628\u0631\u063a \u0641\u064a \u0642\u0633\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0639\u0644\u0645 \u0627\u0644\u0623\u062d\u064a\u0627\u0621 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0641\u064a \u0645\u0639\u0647\u062f \u0643\u0627\u0631\u0648\u0644\u064a\u0646\u0633\u0643\u0627.<\/p>\n

\u0648\u062a\u0639\u0645\u0642 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u0639\u062f \u0630\u0644\u0643 \u0641\u064a \u0630\u062e\u064a\u0631\u0629 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0644\u0628\u0643\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062c\u0645\u0639 \u0628\u064a\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a\u0629 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629 \u0648\u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u062d\u0633\u0627\u0628\u064a\u0629\u060c \u0645\u0645\u0627 \u0623\u062f\u0649 \u0625\u0644\u0649 \u0645\u0643\u062a\u0628\u0629 \u0645\u0646 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0645\u0648\u0635\u0648\u0641\u0629 \u0628\u0627\u0644\u062a\u0641\u0635\u064a\u0644.<\/p>\n

\u0648\u0643\u0634\u0641\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c\u060c \u0627\u0644\u0645\u0642\u062f\u0645\u0629 \u0641\u064a \u0645\u062c\u0644\u0629 “\u062a\u0642\u062f\u0645 \u0627\u0644\u0639\u0644\u0648\u0645” (Science Advances)\u060c \u0639\u0646 \u0623\u062c\u0633\u0627\u0645 \u0646\u0627\u0646\u0648\u064a\u0629 \u0625\u0636\u0627\u0641\u064a\u0629 \u0641\u064a \u0645\u0632\u0627\u0631\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u062d\u064a\u062f\u062a \u0628\u0634\u0643\u0644 \u0641\u0639\u0627\u0644 \u0643\u0644 \u0645\u0646 \u0627\u0644\u0645\u062a\u062d\u0648\u0631 \u0627\u0644\u0645\u0624\u0633\u0633 \u0648\u0645\u062a\u062d\u0648\u0631 \u0627\u0644\u0628\u064a\u062a\u0627 \u0645\u0646 \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-2 \u0648\u062d\u062a\u0649 \u062a\u062d\u064a\u064a\u062f \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-1 \u0627\u0644\u0623\u0643\u062b\u0631 \u0635\u0644\u0629.<\/p>\n

\u0648\u064a\u0642\u0648\u0644 \u0627\u0644\u0645\u0624\u0644\u0641 \u0627\u0644\u0623\u0648\u0644 \u0644\u0644\u0648\u0631\u0642\u0629 \u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0644\u064a\u0648 \u0647\u0627\u0646\u0643\u064a\u060c \u0628\u0627\u062d\u062b \u0645\u0627 \u0628\u0639\u062f \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u0627\u0644\u0630\u064a \u0623\u0646\u0634\u0623 \u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0627\u0643\u064a\u0646\u064a\u0631\u0646\u064a: “\u062a\u0645\u062b\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0645\u0631\u0634\u062d\u0627 \u0639\u0644\u0627\u062c\u064a\u0627 \u0648\u0627\u0639\u062f\u0627 \u0636\u062f \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0645\u062a\u062d\u0648\u0631\u0627\u062a \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-2”.<\/p>\n

\u0648\u064a\u0637\u0628\u0642 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u062d\u0627\u0644\u064a\u0627 \u0646\u0641\u0633 \u0627\u0644\u062a\u0642\u0646\u064a\u0627\u062a \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0643\u062b\u0631 \u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u062d\u064a\u064a\u062f \u0627\u0648\u0645\u064a\u0643\u0631\u0648\u0646\u060c \u0648\u0647\u0648 \u0645\u062a\u062d\u0648\u0631 \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-2 \u0627\u0644\u0645\u0647\u064a\u0645\u0646 \u0627\u0644\u0622\u0646. \u0648\u064a\u0642\u0648\u0644 \u0627\u0644\u0623\u0633\u062a\u0627\u0630 \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0628\u0646 \u0645\u0648\u0631\u064a\u0644\u060c \u0648\u0647\u0648 \u0623\u064a\u0636\u0627 \u0645\u0624\u0644\u0641 \u0623\u0648\u0644 \u0645\u0634\u062a\u0631\u0643 \u0644\u0643\u0644\u062a\u0627 \u0627\u0644\u062f\u0631\u0627\u0633\u062a\u064a\u0646: “\u0628\u0645\u062c\u0631\u062f \u0625\u0646\u0634\u0627\u0626\u0647\u0627\u060c \u064a\u0645\u0643\u0646 \u062a\u0648\u0633\u064a\u0639 \u0647\u0630\u0647 \u0627\u0644\u0645\u0643\u062a\u0628\u0627\u062a \u0648\u062a\u0646\u062c\u064a\u0645\u0647\u0627 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u064a\u062f \u0627\u0644\u0645\u062a\u062d\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u0634\u0626\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629”.<\/p>\n

*\u062a\u0645\u062a \u0627\u0644\u062a\u0631\u062c\u0645\u0629 \u0628\u062a\u0635\u0631\u0641<\/span><\/p>\n

\u0627\u0644\u0645\u0635\u062f\u0631:<\/strong><\/p>\n

https:\/\/phys.org\/news\/2022-03-potent-alpaca-nanobodies-neutralize-sars-cov-.html<\/a><\/p>\n

\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a:<\/strong><\/span><\/p>\n

\u0644\u064a\u0648 \u0647\u0627\u0646\u0643\u064a \u0648\u0622\u062e\u0631\u0648\u0646\u060c A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo, Nature Communications (2022). DOI: 10.1038\/s41467-021-27610-z<\/span><\/p>\n

\u0644\u064a\u0648 \u0647\u0627\u0646\u0643\u064a \u0648\u0622\u062e\u0631\u0648\u0646\u060c Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralising SARS-CoV-2 nanobodies, Science Advances (2022). DOI: 10.1126\/sciadv.abm0220. www.science.org\/doi\/10.1126\/sciadv.abm0220<\/a><\/span><\/p>\n

\u0627\u0644\u0647\u0648\u0627\u0645\u0634:<\/strong><\/p>\n

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[\u0662] \u0627\u0644\u0645\u062c\u0647\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0627\u0644\u0645\u0628\u0631\u062f (cryo-EM) \u0647\u064a \u062a\u0642\u0646\u064a\u0629 \u0645\u062c\u0647\u0631\u064a\u0629 \u064a\u062a\u0645 \u062a\u0637\u0628\u064a\u0642\u0647\u0627 \u0639\u0644\u0649 \u0639\u064a\u0646\u0627\u062a \u0645\u0628\u0631\u062f\u0629 \u0625\u0644\u0649 \u062f\u0631\u062c\u0627\u062a \u062d\u0631\u0627\u0631\u0629 \u0645\u0628\u0631\u062f\u0629 (\u0645\u0646\u062e\u0641\u0636\u0629 \u062c\u062f\u0627) \u0648\u0645\u062f\u0645\u062c\u0629 \u0641\u064a \u0628\u064a\u0626\u0629 \u0645\u0646 \u0627\u0644\u0645\u0627\u0621 \u0627\u0644\u0632\u062c\u0627\u062c\u064a.<\/span><\/p>\n

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Potent alpaca nanobodies neutralize SARS-CoV-2 variants (Karolinska Institutet – \u062a\u0642\u062f\u064a\u0645: \u0645\u0639\u0647\u062f \u0643\u0627\u0631\u0648\u0644\u064a\u0646\u0633\u0643\u0627)\u00a0 \u0645\u0644\u062e\u0635 \u0627\u0644\u0645\u0642\u0627\u0644\u0629: \u0637\u0648\u0631 \u0628\u0627\u062d\u062b\u0648 \u0645\u0639\u0647\u062f \u0643\u0627\u0631\u0648\u0644\u064a\u0646\u0633\u0643\u0627 \u0627\u0644\u0633\u0648\u064a\u062f\u064a \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u062d\u062f\u064a\u062f \u0623\u062c\u0633\u0627\u0645 \u0645\u0636\u0627\u062f\u0629 \u0645\u0635\u063a\u0631\u0629 \u0642\u0648\u064a\u0629 (\u062a\u0633\u0645\u0649 \u0623\u062c\u0633\u0627\u0645 \u0646\u0627\u0646\u0648\u064a\u0629) \u0636\u062f \u0645\u062a\u062d\u0648\u0631\u0627\u062a \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-2 \u0627\u0644\u0646\u0627\u0634\u0626\u0629\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0645\u0633\u062a\u0645\u062f\u0629 \u0645\u0646 \u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u0623\u0644\u0628\u0643\u0629 \u0627\u0644\u062a\u064a \u062a\u0645 \u062a\u062d\u0635\u064a\u0646\u0647\u0627 \u0628\u0645\u0633\u062a\u0635\u062f\u0627\u062a \u0641\u064a\u0631\u0648\u0633 \u0633\u0627\u0631\u0633-\u0643\u0648\u0631\u0648\u0646\u0627-2. \u0648\u0623\u062f\u0649 \u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u0625\u0644\u0649 \u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u062c\u0633\u0627\u0645 \u0646\u0627\u0646\u0648\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 …<\/p>\n","protected":false},"author":4,"featured_media":15740,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-15737","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-19"],"_links":{"self":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/15737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15737"}],"version-history":[{"count":1,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/15737\/revisions"}],"predecessor-version":[{"id":15741,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/posts\/15737\/revisions\/15741"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=\/wp\/v2\/media\/15740"}],"wp:attachment":[{"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.qatifscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}