{"id":14531,"date":"2022-02-07T12:26:34","date_gmt":"2022-02-07T09:26:34","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=14531"},"modified":"2022-02-07T12:26:34","modified_gmt":"2022-02-07T09:26:34","slug":"%d9%83%d9%8a%d9%81-%d9%8a%d9%85%d9%83%d9%86%d9%86%d8%a7-%d8%a7%d8%b3%d8%aa%d8%ae%d8%af%d8%a7%d9%85-%d8%a7%d9%84%d8%b9%d9%84%d9%85-%d9%84%d8%a5%d8%b9%d8%a7%d8%af%d8%a9-%d8%a7%d9%84%d8%a8%d8%b5%d8%b1","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=14531","title":{"rendered":"\u0643\u064a\u0641 \u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0639\u0644\u0645 \u0644\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0628\u0635\u0631\u061f – \u0628\u0642\u0644\u0645 \u0627\u0644\u0645\u0647\u0646\u062f\u0633 \u0635\u0627\u062f\u0642 \u0639\u0644\u064a \u0627\u0644\u0642\u0637\u0631\u064a"},"content":{"rendered":"

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\u0648\u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0641\u064a \u0627\u0644\u0645\u0631\u0643\u0632 \u0627\u0644\u0637\u0628\u064a \u0628\u062c\u0627\u0645\u0639\u0629 \u0643\u0648\u0644\u0648\u0645\u0628\u064a\u0627 \u0648\u062c\u0627\u0645\u0639\u0629 \u0623\u064a\u0648\u0627 \u062a\u0642\u0646\u064a\u0629 \u0643\u0631\u064a\u0633\u0628\u0631 \u0644\u0625\u0635\u0644\u0627\u062d \u0637\u0641\u0631\u0629 \u062c\u064a\u0646\u064a\u0629 \u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0645\u062d\u0641\u0632\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0642\u062f\u0631\u0627\u062a \u0648\u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646 \u0645\u0631\u064a\u0636 \u0645\u0635\u0627\u0628 \u0628\u0627\u0644\u0645\u0631\u0636. \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a \u0647\u0648 \u062d\u0627\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u0629 \u0644\u0644\u0639\u064a\u0646 \u062a\u062a\u0633\u0628\u0628 \u0641\u064a \u062a\u062f\u0647\u0648\u0631 \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0641\u0642\u062f\u0627\u0646 \u0628\u0637\u064a\u0621 \u0644\u0644\u0631\u0624\u064a\u0629 \u0648\u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0644\u0639\u0645\u0649 \u0641\u064a 1.5 \u0645\u0644\u064a\u0648\u0646 \u062d\u0627\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645. \u0644\u0627 \u064a\u0648\u062c\u062f \u0639\u0644\u0627\u062c \u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a\u060c \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u062d\u064a\u062f \u0647\u0648 \u0641\u064a\u062a\u0627\u0645\u064a\u0646 \u0623\u060c \u0648\u0627\u0644\u0630\u064a \u0642\u062f \u064a\u0633\u0627\u0639\u062f \u0641\u064a \u0625\u0628\u0637\u0627\u0621 \u062a\u0642\u062f\u0645 \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0628\u0635\u0631 \u0644\u062f\u0649 \u0628\u0639\u0636 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636.<\/p>\n

\u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0646\u064f\u0634\u0631\u062a \u0641\u064a \u0645\u062c\u0644\u0629 (Scientific Reports)\u060c \u0623\u062e\u0630 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u062c\u0644\u062f \u0645\u0646 \u0645\u0631\u064a\u0636 \u0645\u0635\u0627\u0628 \u0628\u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u0645\u0646\u0638\u0645 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a (GTPase – RPGR)\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0633\u0628\u0628 \u0646\u0648\u0639\u064b\u0627 \u0639\u062f\u0648\u0627\u0646\u064a\u064b\u0627 \u0645\u0631\u062a\u0628\u0637\u064b\u0627 \u0628\u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 X. \u062a\u0645 \u062a\u062d\u062f\u064a\u062f \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0634\u0627\u0626\u0639 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636 \u0644\u0623\u0646\u0647 \u0646\u0627\u062c\u0645 \u0639\u0646 \u062e\u0637\u0623 \u0648\u0627\u062d\u062f \u0641\u064a \u062c\u064a\u0646 (RPGR)\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647 \u0645\u0631\u0634\u062d\u064b\u0627 \u062c\u064a\u062f\u064b\u0627 \u0644\u0644\u0637\u0628 \u0627\u0644\u062f\u0642\u064a\u0642.<\/p>\n

\u062d\u064a\u062b \u0642\u0627\u0644 \u0645\u0624\u0644\u0641 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0633\u062a\u064a\u0641\u0646 \u062a\u0633\u0627\u0646\u063a \u060c \u0627\u0644\u0623\u0633\u062a\u0627\u0630 \u0627\u0644\u0645\u0634\u0627\u0631\u0643 \u0641\u064a \u0639\u0644\u0645 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062e\u0644\u064a\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u0643\u0648\u0644\u0648\u0645\u0628\u064a\u0627\u060c \u0641\u064a \u0628\u064a\u0627\u0646 \u0642\u0627\u0644 \u0641\u064a\u0647 “\u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0637\u0631\u064a\u0642\u0629 \u062b\u0627\u0628\u062a\u0629 \u0644\u062a\u0648\u0644\u064a\u062f \u062e\u0644\u0627\u064a\u0627 \u062c\u0630\u0639\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0642\u062f\u0631\u0627\u062a \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u062c\u0644\u062f \u0627\u0644\u0645\u0631\u064a\u0636 \u062d\u064a\u062b \u062a\u062a\u0645\u062a\u0639 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0634\u0628\u064a\u0647\u0629 \u0628\u0627\u0644\u062c\u0646\u064a\u0646 \u0628\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 \u0623\u0648 \u0627\u0644\u062a\u062d\u0648\u0644 \u0625\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 \u0634\u0628\u0643\u064a\u0629 \u0635\u062d\u064a\u0629 \u0648\u0625\u0639\u0627\u062f\u0629 \u0632\u0631\u0627\u0639\u062a\u0647\u0627 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0645\u0631\u064a\u0636 \u0644\u0639\u0644\u0627\u062c \u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0628\u0635\u0631”.<\/p>\n

\u0644\u0643\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u0645\u0635\u0627\u0628 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0635\u0628\u0627\u063a\u064a \u0645\u0627 \u0632\u0627\u0644\u062a \u062a\u0623\u0648\u064a \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0644\u0645\u0631\u0636 \u0644\u0630\u0644\u0643 \u0641\u064a \u0645\u062d\u0627\u0648\u0644\u0629 \u0644\u0625\u0635\u0644\u0627\u062d \u0647\u0630\u0627 \u0627\u0644\u062e\u0644\u0644\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0645\u062d\u0642\u0642\u0648\u0646 \u062a\u0642\u0646\u064a\u0629 (CRISPR) \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u062e\u0637\u0623 \u0648\u062a\u0639\u062f\u064a\u0644\u0647 \u0648\u0627\u0633\u062a\u0628\u062f\u0627\u0644\u0647 \u0641\u064a (RPGR) \u062d\u064a\u062b \u0625\u0646 \u062a\u0642\u0646\u064a\u0629 (CRISPR) \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0643\u064a\u0641 \u0628\u0633\u0647\u0648\u0644\u0629 \u0645\u0639 \u0627\u0644\u062a\u0633\u0644\u0633\u0644\u0627\u062a \u0627\u0644\u0645\u062a\u0646\u0648\u0639\u0629 \u0644\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0648\u062a\u062a\u064a\u062d \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u062a\u062d\u0631\u064a\u0631\u064b\u0627 \u0623\u0633\u0631\u0639 \u0648\u0623\u0643\u062b\u0631 \u062f\u0642\u0629 \u0645\u0646 \u0627\u0644\u0637\u0631\u0642 \u0627\u0644\u0633\u0627\u0628\u0642\u0629.<\/p>\n

\u062b\u0645 \u0627\u0646\u062a\u0638\u0631 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 10 \u0623\u064a\u0627\u0645\u060c \u0648\u062c\u0645\u0639\u0648\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0623\u062c\u0631\u0648\u0627 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0639\u062f\u0629 \u0645\u0631\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0645\u0639\u0631\u0641\u0629 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0637\u0631\u064a\u0642\u0629 \u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u062a\u0639\u0645\u0644.<\/p>\n

\u0641\u064a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629\u060c \u0623\u0628\u0644\u063a \u0627\u0644\u0641\u0631\u064a\u0642 \u0639\u0646 \u0645\u0639\u062f\u0644 \u0646\u062c\u0627\u062d \u0628\u0646\u0633\u0628\u0629 13\u066a \u0641\u064a \u062a\u062d\u0648\u064a\u0644 \u0645\u062a\u063a\u064a\u0631 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u062a\u062d\u0648\u0631 \u0625\u0644\u0649 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0637\u0628\u064a\u0639\u064a. \u0644\u0627 \u064a\u0628\u062f\u0648 \u0647\u0630\u0627 \u0627\u0644\u0645\u0639\u062f\u0644 \u0646\u062c\u0627\u062d\u0627 \u0645\u0631\u062a\u0641\u0639\u064b\u0627\u060c \u0644\u0643\u0646 \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646 \u064a\u0642\u0648\u0644\u0648\u0646 \u0625\u0646\u0647 \u0645\u0646 \u0627\u0644\u0623\u0641\u0636\u0644 \u062f\u0631\u0627\u0633\u0627\u062a \u062a\u0639\u062f\u064a\u0644 \u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0627\u0644\u062a\u064a \u0623\u0628\u0644\u063a\u062a \u0639\u0646 \u0645\u0639\u062f\u0644\u0627\u062a \u062a\u0635\u062d\u064a\u062d \u0623\u0642\u0631\u0628 \u0625\u0644\u0649 1\u066a. \u0644\u0643\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0634\u062c\u0639\u062a \u0627\u0644\u0645\u0624\u0644\u0641\u064a\u0646\u060c \u0645\u0634\u064a\u0631\u064a\u0646 \u0625\u0644\u0649 \u0623\u0646 \u062a\u0631\u0643\u064a\u0628\u0629 (RPGR) – \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u0643\u0631\u0627\u0631\u0627\u062a \u0648\u0623\u0632\u0648\u0627\u062c \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0634\u062f\u064a\u062f\u0629 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 – \u062a\u062c\u0639\u0644 \u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646 \u0635\u0639\u0628\u064b\u0627.<\/p>\n

\u0641\u064a \u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u062c\u0631\u0627\u0647\u0627 \u0628\u0627\u062d\u062b\u0648\u0646 \u0641\u064a \u0645\u0639\u0647\u062f \u0627\u0644\u0639\u064a\u0646 \u0628\u062c\u0627\u0645\u0639\u0629 \u0628\u0646\u0633\u0644\u0641\u0627\u0646\u064a\u0627. \u0646\u0634\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062d\u0627\u0644\u0629\u060c \u0648\u062a\u0641\u0627\u0635\u064a\u0644\u0647\u0627 \u0641\u064a \u0648\u0631\u0642\u0629 \u0627\u0644\u064a\u0648\u0645 \u0641\u064a \u0637\u0628 \u0627\u0644\u0637\u0628\u064a\u0639 (Cideciyan)\u060c \u0648\u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0623\u062f\u0649 \u0625\u0644\u0649 \u062a\u063a\u064a\u0631\u0627\u062a \u0645\u0644\u062d\u0648\u0638\u0629 \u0641\u064a \u0627\u0644\u0646\u0642\u0631\u0629\u060c \u0648\u0645\u0639\u0638\u0645 \u0645\u0643\u0627\u0646 \u0645\u0647\u0645 \u0627\u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u0645\u0631\u0643\u0632\u064a\u0629 \u0627\u0644\u0625\u0646\u0633\u0627\u0646.<\/p>\n

\"\"
\u0627\u0644\u0645\u0635\u062f\u0631 \u0631\u0642\u0645 (1)<\/span><\/figcaption><\/figure>\n

\u0648\u0642\u062f \u0635\u0645\u0645 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0634\u062e\u0635\u062a \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0645\u0631\u0636 \u0641\u0642\u062f \u0627\u0644\u0628\u0635\u0631 \u0627\u0644\u0648\u0631\u0627\u062b\u064a (LCA) – \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0639\u064a\u0646 \u0627\u0644\u0630\u064a \u064a\u0624\u062b\u0631 \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0645 \u0627\u0644\u0623\u0648\u0644 \u0639\u0644\u0649 \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646 \u0648\u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 (CEP290)\u060c \u0627\u0644\u062a\u064a \u062a\u0639\u062f \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0648\u0631\u0637\u0629 \u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636. \u0648\u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 (LCA) \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0636\u0639\u0641 \u0627\u0644\u0628\u0635\u0631 \u0627\u0644\u0634\u062f\u064a\u062f\u060c \u0648\u0639\u0627\u062f\u0629 \u0645\u0627 \u064a\u0628\u062f\u0623 \u0641\u064a \u0633\u0646 \u0627\u0644\u0637\u0641\u0648\u0644\u0629.<\/p>\n

“\u0648\u0628\u064a\u0646\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0639\u0627\u064a\u064a\u0631 \u062c\u062f\u064a\u062f\u0629 \u0645\u0646 \u0627\u0644\u062a\u062d\u0633\u064a\u0646\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0645\u0643\u0646\u0629 \u0645\u0639 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u0628\u0639\u0644\u0627\u062c \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0641\u064a LCA \u0627\u0644\u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a CEP290″\u060c \u0648\u0642\u0627\u0644 \u0627\u0644\u0645\u0634\u0627\u0631\u0643 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0627\u0644\u0645\u0624\u0644\u0641 \u0627\u0631\u062a\u0648\u0631 (V. Cideciyan)\u060c \u062f\u0643\u062a\u0648\u0631\u0627\u0647\u060c \u0623\u0633\u062a\u0627\u0630 \u0628\u0627\u062d\u062b \u0641\u064a \u0637\u0628 \u0627\u0644\u0639\u064a\u0648\u0646. “\u0627\u0644\u0623\u0647\u0645 \u0645\u0646 \u0630\u0644\u0643\u060c \u0623\u0646\u0634\u0623\u0646\u0627 \u0645\u0642\u0627\u0631\u0646\u0629 \u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u062c\u0627\u0631\u064a\u0629 \u062d\u0627\u0644\u064a\u0627 \u0644\u0646\u0641\u0633 \u0627\u0644\u0645\u0631\u0636\u060c \u0648\u0627\u0644\u062a\u064a \u0633\u0648\u0641 \u062a\u0633\u0645\u062d \u0644\u0644\u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0632\u0627\u064a\u0627 \u0627\u0644\u0646\u0633\u0628\u064a\u0629 \u0644\u0625\u062b\u0646\u064a\u0646 \u0645\u0646 \u0627\u0644\u062a\u062f\u062e\u0644\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629”.<\/p>\n

\u0648\u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062f\u0648\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0642\u0648\u062f\u0647\u0627 \u0641\u064a \u0627\u0644\u0637\u0628 \u0628\u0646\u0633\u0644\u0641\u0627\u0646\u064a\u0627 \u0627\u0644\u062a\u064a \u0643\u062a\u0628\u062a\u0647\u0627 \u0648\u0646\u0634\u0631\u062a \u0641\u064a (Cideciyan) \u0628\u0648\u0627\u0633\u0637\u0629 \u0635\u0645\u0648\u0626\u064a\u0644 \u062c\u0627\u0643\u0648\u0628\u0633\u0648\u0646\u060c \u0623\u0633\u062a\u0627\u0630 \u0637\u0628 \u0648\u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u0639\u064a\u0648\u0646\u060c \u062a\u0644\u0642\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u062d\u0642\u0646 \u062f\u0627\u062e\u0644 \u0627\u0644\u0639\u064a\u0646 \u0644\u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631 \u062a\u0633\u0645\u0649 (sepofarsen) \u062d\u064a\u062b \u0627\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u0632\u064a\u0621 RNA \u0642\u0635\u064a\u0631 \u0648\u064a\u0639\u0645\u0644 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 (CEP290) \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0629 \u0644\u0644\u0636\u0648\u0621 \u0641\u064a \u0627\u0644\u0639\u064a\u0646\u060c \u0648\u062a\u062d\u0633\u064a\u0646 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0641\u064a \u0638\u0644 \u0638\u0631\u0648\u0641 \u0627\u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u064a\u0648\u0645\u064a\u0629.<\/p>\n

\u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u0623\u062c\u0631\u064a\u062a \u0641\u064a \u0639\u0627\u0645 2019 \u0648\u0627\u0644\u062a\u064a \u0646\u0634\u0631\u062a \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0645\u062c\u0644\u0629 \u0637\u0628 \u0627\u0644\u0637\u0628\u064a\u0639\u0629 (Cideciyan)\u060c \u062c\u0627\u0643\u0648\u0628\u0633\u0648\u0646\u060c \u0648\u0627\u0644\u0645\u062a\u0639\u0627\u0648\u0646\u064a\u0646 \u0648\u062c\u062f\u0648\u0627 \u0623\u0646 \u062d\u0642\u0646 (sepofarsen) \u062a\u062a\u0643\u0631\u0631 \u0643\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631 \u062d\u064a\u062b \u0623\u0633\u0641\u0631\u062a \u0639\u0646 \u0627\u0633\u062a\u0645\u0631\u0627\u0631 \u0645\u0643\u0627\u0633\u0628 \u0627\u0644\u0631\u0624\u064a\u0629 \u0641\u064a 10 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0648\u0627\u0644\u0645\u0631\u064a\u0636 \u0627\u0644\u062d\u0627\u062f\u064a \u0639\u0634\u0631 \u0643\u0627\u0646 \u0627\u0644\u0645\u0641\u0635\u0644 \u0644\u0644\u0639\u0644\u0627\u062c\u060c \u062d\u064a\u062b \u062a\u0644\u0642\u0649 \u062d\u0642\u0646\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u0642\u0637 \u0648\u0644\u0648\u062d\u0638\u062a \u0639\u0644\u0649 \u0645\u062f\u0649 \u0641\u062a\u0631\u0629 15 \u0634\u0647\u0631\u0627. \u0642\u0628\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u0643\u0627\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u064a\u0639\u0627\u0646\u064a \u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u062d\u062f\u0629 \u0627\u0644\u0628\u0635\u0631\u060c \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0645\u062f\u0649 \u0627\u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u0644\u064a\u0644\u064a\u0629. \u0628\u0639\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0642\u0631\u0631 \u0627\u0644\u0645\u0631\u064a\u0636 \u0644\u0644\u062a\u062e\u0644\u064a \u0639\u0646 \u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0635\u064a\u0627\u0646\u0629 \u0627\u0644\u0641\u0635\u0644\u064a\u0629\u060c \u0648\u0630\u0644\u0643 \u0644\u0623\u0646 \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0639\u0627\u062f\u064a\u0629 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0625\u0639\u062a\u0627\u0645 \u0639\u062f\u0633\u0629 \u0627\u0644\u0639\u064a\u0646.<\/p>\n

\u0641\u0628\u0639\u062f \u062d\u0642\u0646\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 (sepofarsen)\u060c \u0623\u0638\u0647\u0631\u062a \u0623\u0643\u062b\u0631 \u0645\u0646 \u0639\u0634\u0631\u0629 \u0642\u064a\u0627\u0633\u0627\u062a \u0648\u0638\u064a\u0641\u0629 \u0628\u0635\u0631\u064a\u0629 \u0648\u0628\u0646\u064a\u0629 \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646 \u062a\u062d\u0633\u064a\u0646\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u062a\u062f\u0639\u0645 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c. \u0643\u0627\u0646 \u0645\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0643\u0627\u0646 \u0628\u0637\u064a\u0626\u0627 \u0646\u0633\u0628\u064a\u0627 \u0641\u064a \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635. \u0648\u0631\u0623\u0649 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u062a\u062d\u0633\u0646 \u0627\u0644\u0631\u0624\u064a\u0629 \u0628\u0639\u062f \u0634\u0647\u0631 \u0648\u0627\u062d\u062f\u060c \u0648\u0644\u0643\u0646 \u0648\u0635\u0644 \u062a\u062d\u0633\u0646 \u0631\u0624\u064a\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0648\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062d\u0642\u0646\u0629 \u0630\u0631\u0648\u062a\u0647\u0627 \u0628\u0639\u062f \u0634\u0647\u0631\u064a\u0646 \u0648\u0627\u0644\u0623\u0643\u062b\u0631 \u0644\u0641\u062a\u0627\u060c \u0639\u0646\u062f \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u0631\u064a\u0636 \u0638\u0644\u062a \u0627\u0644\u062a\u062d\u0633\u064a\u0646\u0627\u062a \u0639\u0644\u0649 \u0645\u062f\u0649 15 \u0634\u0647\u0631\u0627 \u0628\u0639\u062f \u0627\u0644\u062d\u0642\u0646 \u0627\u0644\u0623\u0648\u0644 \u0648\u0627\u0644\u0648\u062d\u064a\u062f.<\/p>\n

\u0648\u0648\u0641\u0642\u0627 \u0644\u0644\u0628\u0627\u062d\u062b\u064a\u0646\u060c \u0641\u0625\u0646 \u0645\u062a\u0627\u0646\u0629 \u0637\u0648\u064a\u0644\u0629 \u0645\u0646 \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0631\u0624\u064a\u0629 \u063a\u064a\u0631 \u0645\u062a\u0648\u0642\u0639\u0629\u060c \u0648\u062a\u0648\u0641\u0631 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u0645\u062a\u0631\u062a\u0628\u0629 \u0639\u0644\u0649 \u0639\u0644\u0627\u062c (ciliopathies) \u0623\u062e\u0631\u0649 – \u0627\u0633\u0645 \u0641\u0626\u0629 \u0643\u0628\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u062a\u0631\u0645\u064a\u0632 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u0641\u0629\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0648\u0638\u064a\u0641\u0629 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a\u0629 \u0645\u0646 \u0627\u0644\u0623\u0647\u062f\u0627\u0628\u060c \u0648\u0639\u0636\u064a\u0647 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062d\u0633\u064a\u0629 \u0648\u062c\u062d\u0648\u0638.<\/p>\n

“\u0647\u0630\u0627 \u0627\u0644\u0639\u0645\u0644 \u064a\u0645\u062b\u0644 \u0627\u062a\u062c\u0627\u0647\u0627 \u0645\u062b\u064a\u0631\u0627 \u062d\u0642\u0627 \u0644\u0644 (RNA) \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631. \u0645\u0646\u0630 30 \u0639\u0627\u0645\u0627 \u0643\u0627\u0646\u062a \u0647\u0646\u0627\u0643 \u0623\u062f\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 (RNA) \u0623\u0644\u064a\u063a\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0627\u0644\u0639\u0642\u0627\u0642\u064a\u0631\u060c \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u062c\u0645\u064a\u0639 \u064a\u062f\u0631\u0643 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0648\u0639\u0648\u062f\u0627 \u0643\u0628\u064a\u0631\u0629 \u0644\u0647\u0630\u0647 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a”\u060c \u0648\u0642\u0627\u0644 \u062c\u0627\u0643\u0648\u0628\u0633\u0648\u0646. “\u0625\u0646 \u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u063a\u064a\u0631 \u0645\u062a\u0648\u0642\u0639 \u0645\u0646 \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644\u064a\u0629 \u0627\u0644\u0647\u062f\u0628\u064a\u0629 \u062d\u064a\u062b \u0644\u0648\u062d\u0638 \u0641\u064a \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0646\u0638\u0631 \u0644\u0645\u0637\u0627\u0644\u0628\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636 \u0645\u0646 \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0648\u0627\u0644\u062c\u062f\u0627\u0648\u0644 \u0627\u0644\u0632\u0645\u0646\u064a\u0629 \u0644 (sepofarsen)\u060c \u0641\u0636\u0644\u0627 \u0639\u0646 \u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a”.<\/p>\n

\u0623\u062d\u062f \u0627\u0644\u0623\u0633\u0628\u0627\u0628 \u0627\u0644\u0642\u0644\u064a\u0644\u0629 \u0627\u0644\u062a\u064a \u0623\u062b\u0628\u062a\u062a \u0646\u062c\u0627\u062d \u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0641\u064a \u0639\u0644\u0627\u062c \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0646\u0627\u062f\u0631 \u0648\u0648\u0641\u0642\u0627 \u0644\u0644\u0628\u0627\u062d\u062b\u064a\u0646\u060c \u0647\u0648 \u0623\u0646 \u062c\u0632\u064a\u0626\u0627\u062a \u0647\u0630\u0627 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0647\u064a \u0635\u063a\u064a\u0631\u0629 \u0628\u0645\u0627 \u064a\u0643\u0641\u064a \u0644\u0644\u0648\u0635\u0648\u0644 \u0627\u0644\u0649 \u0646\u0648\u0627\u0629 \u0627\u0644\u062e\u0644\u064a\u0629\u060c \u0648\u0644\u0643\u0646 \u0644\u0627 \u064a\u062a\u0645 \u0645\u0633\u062d\u0647\u0627 \u0628\u0633\u0631\u0639\u0629 \u0643\u0628\u064a\u0631\u0629\u060c \u062d\u062a\u0649 \u0623\u0646\u0647\u0627 \u062a\u0628\u0642\u0649 \u0637\u0648\u064a\u0644\u0627 \u0628\u0645\u0627 \u064a\u0643\u0641\u064a \u0644\u0644\u0642\u064a\u0627\u0645 \u0628\u0645\u0647\u0645\u062a\u0647\u0627.<\/p>\n

\u0634\u0631\u0643\u0629 (BioTech Company Editas Editas Medicine)\u060c \u0647\u064a \u0623\u0648\u0644 \u0645\u0646 \u062d\u0642\u0646 \u0628\u0622\u0644\u064a\u0629 \u0627\u0644\u0643\u0631\u064a\u0633\u0641 \u0645\u0628\u0627\u0634\u0631\u0629 \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0644\u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u062d\u064a\u062b \u062a\u0645 \u062a\u0639\u062f\u064a\u0644 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0631\u064a\u0636 \u0641\u064a \u0637\u0628\u0642 \u0648\u062a\u0645 \u0625\u0639\u0627\u062f\u0629 \u062a\u0646\u0634\u064a\u0637\u0647\u0627 \u0644\u0627\u062d\u0642\u0627. \u0648\u0642\u0627\u0644 \u062c\u0627\u0643 \u062f\u0646\u0643\u0627\u0646\u060c \u0628\u0627\u062d\u062b \u0644\u0637\u0628 \u0648\u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u0639\u064a\u0648\u0646 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u0643\u0627\u0644\u064a\u0641\u0648\u0631\u0646\u064a\u0627\u060c \u0627\u0644\u0630\u064a \u062a\u0631\u0623\u0633 \u0627\u0644\u062c\u0644\u0633\u0629 \u062d\u064a\u062b \u062a\u0645 \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u062f\u0648\u0631\u0629 \u0641\u064a\u0647\u0627.<\/p>\n

\u0645\u0631\u0636 \u0641\u0642\u062f \u0627\u0644\u0628\u0635\u0631 \u0627\u0644\u0648\u0631\u0627\u062b\u064a (LCA – Leber’s Congenital Amaurosis) \u062a\u0638\u0647\u0631 \u0641\u064a\u0647 \u0627\u0644\u0639\u064a\u0648\u0628 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0636\u0648\u0626\u064a\u0629 \u0641\u064a \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646 \u0623\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0642\u0631\u064a\u0628\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0641\u064a \u0623\u0646 \u064a\u0628\u062f\u0623 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0641\u0642\u062f\u0627\u0646 \u0631\u0624\u064a\u062a\u0647\u0645 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0648\u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0628\u0644\u0648\u063a\u060c \u0642\u062f \u064a\u0631\u0648\u0646 \u0641\u0642\u0637 \u0635\u0648\u0631 \u062e\u0627\u0641\u062a\u0629\u060c \u0636\u0628\u0627\u0628\u064a\u0629 \u0623\u0645\u0627\u0645\u0647\u0645 \u0645\u0628\u0627\u0634\u0631\u0629\u060c \u0645\u0645\u0627 \u064a\u0634\u0628\u0647 \u0627\u0644\u0646\u0638\u0631 \u0625\u0644\u0649 \u0642\u0634\u0629 \u0627\u0644\u0634\u0631\u0628 \u0648\u0641\u064a \u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0623\u062d\u064a\u0627\u0646 \u062a\u0645\u0627\u064a\u0644 \u0639\u064a\u0648\u0646\u0647\u0645 \u0645\u0646 \u062c\u0627\u0646\u0628 \u0625\u0644\u0649 \u0622\u062e\u0631.<\/p>\n

\u064a\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0630\u064a \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647 \u0641\u064a \u0639\u0627\u0645 2017 \u0644 (LCA) \u0641\u064a\u0631\u0648\u0633\u0627 \u0645\u0631\u062a\u0628\u0637\u0627 \u0628\u0627\u0644\u0623\u064a\u0646\u064a\u0648 \u063a\u064a\u0631 \u0636\u0627\u0631 (AAV)\u060c \u0644\u062a\u0642\u062f\u064a\u0645 \u0646\u0633\u062e\u0629 \u0639\u0645\u0644 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646 \u064a\u0633\u0645\u0649 (RPE65) \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0634\u0628\u0643\u064a\u0629. \u0648\u0644\u0643\u0646 \u0625\u062f\u0631\u0627\u062c \u062c\u064a\u0646 \u0645\u0639 (AAV) \u0644\u0646 \u064a\u0639\u0645\u0644 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u0627 \u0644\u0644\u0645\u0631\u0636\u060c (LCA) \u0646\u0648\u0639 10 (LCA10). \u0633\u0628\u0628 \u0647\u0630\u0627 \u0627\u0644\u0634\u0631\u0637 \u0639\u064a\u0648\u0628 \u0628\u0633\u0628\u0628 \u0641\u064a \u062c\u064a\u0646 \u0622\u062e\u0631\u060c (CEP290)\u060c \u0627\u0644\u0630\u064a \u064a\u0631\u0645\u0632 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0630\u064a \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u0646\u0642\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u062d\u0648\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0636\u0648\u0626\u064a\u0629. \u0644\u0633\u0648\u0621 \u0627\u0644\u062d\u0638\u060c (CEP290) \u0643\u0628\u064a\u0631 \u062c\u062f\u0627 \u0648\u0644\u0627 \u062a\u0646\u0627\u0633\u0628 \u0641\u064a\u0631\u0648\u0633 (AAV).<\/p>\n

\u0644\u0630\u0644\u0643 \u064a\u0633\u062a\u062e\u062f\u0645 (Editas AAV) \u0644\u0646\u0642\u0644 \u0627\u0644\u0645\u0642\u0635 \u0627\u0644\u0648\u0631\u0627\u062b\u064a \u0641\u064a \u200b\u200b\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0634\u0628\u0643\u064a\u0629\u060c \u0628\u062f\u0644\u0627 \u0645\u0646 \u0630\u0644\u0643. \u0628\u0645\u062c\u0631\u062f \u0623\u0646 \u064a\u0642\u0648\u0645 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0628\u0623\u0646\u0632\u064a\u0645 [CAS9 CAS9 CAS9 \u0648 RNAS] \u062f\u0644\u064a\u0644\u064a\u0646 \u0641\u064a \u0627\u0644\u062f\u0627\u062e\u0644\u060c \u0641\u0625\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u062a\u0646\u062a\u062c (CAS9)\u060c \u0627\u0644\u062a\u064a \u062a\u062e\u0641\u0641 \u0637\u0641\u0631\u0629 \u0645\u0634\u062a\u0631\u0643\u0629 \u0641\u064a (CEP290)\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0644\u0647\u0627 \u0628\u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0639\u0645\u0644.<\/span><\/p>\n

\u0641\u064a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u062a\u064a \u0635\u062f\u0631\u062a (\u0627\u0644\u064a\u0648\u0645)<\/em>\u060c \u062d\u0635\u0644 \u0633\u062a\u0629 \u0623\u0634\u062e\u0627\u0635 \u0628\u0627\u0644\u063a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0631\u0624\u064a\u0629 \u0634\u062f\u064a\u062f\u0629 \u0628\u0634\u062f\u0629 \u0627\u0644\u062d\u0642\u0646 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u060c (Edit-101)\u060c \u0641\u064a \u0639\u064a\u0646 \u0648\u0627\u062d\u062f\u0629\u060c \u0641\u064a \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u062b\u0644\u0627\u062b \u062c\u0631\u0639\u0627\u062a \u0645\u0645\u0643\u0646\u0629. \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629\u060c \u0643\u0627\u0646\u0648\u0627 \u062e\u0641\u064a\u0641\u064a\u0646\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0622\u0644\u0627\u0645 \u0627\u0644\u0639\u064a\u0646 \u0623\u0648 \u0627\u0644\u062a\u0647\u0627\u0628.<\/p>\n

\u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u062e\u0645\u0633\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u062a\u062a\u0648\u0641\u0631 \u0646\u062a\u0627\u0626\u062c \u0627\u062e\u062a\u0628\u0627\u0631 \u0631\u0624\u064a\u062a\u0647\u0645\u060c \u062b\u0644\u0627\u062b\u0629 \u0644\u0645 \u062a\u0635\u062f\u0631 \u0645\u0643\u0627\u0633\u0628 \u0648\u0627\u0636\u062d\u0629. \u0644\u0643\u0646 \u0627\u062b\u0646\u064a\u0646\u060c \u0643\u0644 \u0645\u0646\u0647\u0645 \u062a\u0644\u0642\u0649 \u062c\u0631\u0639\u0629 (MIDRANGE)\u060c \u062a\u0645\u0643\u0646\u0627 \u0623\u0646 \u064a\u0634\u0639\u0631\u0627 \u0628\u0636\u0648\u0621 \u0623\u0643\u062b\u0631 \u0645\u0645\u0627 \u0643\u0627\u0646\u0627 \u0639\u0644\u064a\u0647 \u0642\u0628\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0643<\/span>\u0645\u0627 \u062a\u0642\u0627\u0633 \u0631\u062f\u0648\u062f\u0647\u0645 \u0639\u0644\u0649 \u0636\u0648\u0621 \u0648\u0627\u0645\u0636. \u0648\u0642\u062f\u0645 \u0627\u0644\u0645\u062d\u0642\u0642 \u0645\u0627\u0631\u0643 \u0628\u064a\u0646\u064a\u0632\u064a\u060c \u0628\u0627\u062d\u062b \u0639\u0644\u0648\u0645 \u0631\u0624\u064a\u0629 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u0623\u0648\u0631\u064a\u063a\u0648\u0646 \u0644\u0644\u0635\u062d\u0629 \u0648\u0627\u0644\u0639\u0644\u0648\u0645\u060c \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u064a\u0648\u0645 \u0641\u064a \u0627\u0644\u0646\u062f\u0648\u0629 \u0627\u0644\u062f\u0648\u0644\u064a\u0629 \u0639\u0646 \u062a\u0646\u0643\u0633 \u0627\u0644\u0634\u0628\u0643\u064a\u0629 \u0641\u064a \u0646\u0627\u0634\u0641\u064a\u0644\u060c \u062a\u064a\u0646\u064a\u0633\u064a.<\/p>\n

\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u0629\u060c \u0642\u0627\u0644 \u0623\u062d\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0645\u0643\u0646\u0647\u0645 \u0623\u0646 \u064a\u0634\u0639\u0631\u0648\u0646 \u0628\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0636\u0648\u0621 – \u0627\u0645\u0631\u0623\u0629 \u062a\u0628\u0644\u063a \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 54 \u0639\u0627\u0645\u0627 – \u062a\u062d\u0633\u0646\u062a \u0623\u064a\u0636\u0627 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0639\u0644\u0649 \u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u062d\u062f\u0629 \u0627\u0644\u0628\u0635\u0631 6 \u0623\u0634\u0647\u0631 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c. \u0641\u064a \u0627\u0644\u0648\u0627\u0642\u0639\u060c \u0630\u0647\u0628\u062a \u0645\u0646 \u0639\u062f\u0645 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0641\u064a \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0639\u0644\u0648\u064a \u0645\u0646 \u0645\u062e\u0637\u0637 \u0627\u0644\u0639\u064a\u0646 \u0644\u0631\u0624\u064a\u062a\u0647\u060c \u0643\u0645\u0627 \u064a\u0642\u0648\u0644 (Pennesi). \u0643\u0645\u0627 \u0623\u062a\u0642\u0646\u062a \u062f\u0648\u0631\u0629 \u0639\u0642\u0628\u0629 \u0641\u064a \u0636\u0648\u0621 \u062e\u0627\u0641\u062a \u062d\u064a\u062b \u0623\u0646\u0647\u0627 \u0641\u0634\u0644\u062a \u0633\u0627\u0628\u0642\u0627 \u0641\u064a \u0636\u0648\u0621 \u0645\u0634\u0631\u0642. \u0648\u0635\u0631\u062d\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u0629\u060c \u0643\u0627\u0631\u0644\u064a\u0646 \u0641\u0627\u0631\u0633 \u0628\u0648\u0631\u062a\u0644\u0627\u0646\u062f\u060c \u0623\u0648\u0631\u064a\u063a\u0648\u0646\u060c \u0644 (NPR) \u0644\u0645 \u062a\u0639\u062f \u062a\u0639\u0648\u062f \u0625\u0644\u0649 \u0645\u0642\u0635\u0648\u0631\u0627\u062a \u0632\u0645\u0644\u0627\u0626\u0647\u0627 \u0641\u064a \u0627\u0644\u0639\u0645\u0644. “\u0625\u0646\u0647 \u0644\u0637\u064a\u0641\u060c \u0623\u0646\u0627 \u0644\u0627 \u0627\u062e\u064a\u0641 \u0627\u0644\u0646\u0627\u0633 \u0648\u0644\u064a\u0633 \u0644\u062f\u064a \u0627\u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0643\u062f\u0645\u0627\u062a \u0639\u0644\u0649 \u062c\u0633\u062f\u064a”\u060c \u0645\u0627\u0632\u062d\u0629.<\/p>\n

\u064a\u0642\u0648\u0644 \u0628\u064a\u0646\u064a\u0632\u064a \u0625\u0646 \u0627\u0644\u0641\u0627\u0631\u0633 \u0642\u062f \u0641\u0639\u0644\u062a \u0630\u0644\u0643 \u062c\u064a\u062f\u0627 \u0644\u0623\u0646\u0647\u0627 \u0643\u0627\u0646\u062a \u0644\u062f\u064a\u0647\u0627 \u0637\u0641\u0631\u0629 \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0645\u0646 (CAS9) \u0641\u064a \u0643\u0644\u0627 \u0646\u0633\u062e\u0647\u0627 \u0645\u0646 \u062c\u064a\u0646\u0647\u0627 (CEP290)\u060c \u0639\u0644\u0649 \u0639\u0643\u0633 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0622\u062e\u0631\u064a\u0646. \u0648\u0644\u0643\u0646\u060c “\u0627\u0644\u062c\u0648\u0627\u0628 \u0627\u0644\u0635\u0627\u062f\u0642 \u0647\u0648 \u0623\u0646\u0646\u0627 \u0644\u0627 \u0646\u0639\u0631\u0641” \u0644\u0645\u0627\u0630\u0627 \u0643\u0627\u0646\u062a \u0646\u062a\u0627\u0626\u062c\u0647\u0627 \u0623\u0641\u0636\u0644.<\/p>\n

\"\"
\u062a\u0637\u0648\u0639 \u0643\u0627\u0631\u0644\u064a\u0646 \u0641\u0627\u0631\u0633\u060c \u0627\u0644\u062a\u064a \u0644\u062f\u064a\u0647\u0627 \u0627\u0636\u0637\u0631\u0627\u0628 \u0627\u0644\u0639\u064a\u0646 \u0627\u0644\u062e\u0644\u0642\u064a\u060c \u0644\u0644\u0633\u0645\u0627\u062d \u0644\u0644\u0623\u0637\u0628\u0627\u0621 \u0628\u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0641\u064a \u0634\u0628\u0643\u064a\u0629 \u0627\u0644\u0639\u064a\u0646 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0642\u0631\u0635. \u0627\u0644\u0635\u0648\u0631\u0629 \u0628\u0648\u0627\u0633\u0637\u0629 OHSU\/JOSH ANDERSEN<\/span><\/figcaption><\/figure>\n

\u0628\u062f\u0623 \u0645\u062d\u0642\u0642\u0648 (LCA10) \u0627\u0644\u0622\u0646 \u0641\u064a \u0639\u0644\u0627\u062c \u0623\u0631\u0628\u0639\u0629 \u0623\u0634\u062e\u0627\u0635 \u0628\u0627\u0644\u063a\u064a\u0646 \u0628\u0623\u0639\u0644\u0649 \u062c\u0631\u0639\u0629 \u0645\u062a\u0648\u0641\u0631\u0629 \u0641\u064a \u0627\u0644\u0645\u062d\u0627\u0643\u0645\u0629. \u0627\u0639\u062a\u0645\u0627\u062f\u0627 \u0639\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0648\u0627\u0644\u0642\u0631\u0648\u062f\u060c “\u0646\u062d\u0646 \u0646\u0623\u0645\u0644 \u0623\u0646 … \u062c\u0631\u0639\u0627\u062a \u0623\u0639\u0644\u0649 \u0633\u062a\u062a\u0631\u062c\u0645 \u0625\u0644\u0649 \u062a\u0623\u062b\u064a\u0631 \u0633\u0631\u064a\u0631\u064a \u0623\u0642\u0648\u0649”.<\/p>\n

\u062a\u062a\u0648\u0642\u0639 \u0627\u0644\u0634\u0631\u0643\u0629 \u0623\u064a\u0636\u0627 \u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0642\u0631\u064a\u0628\u0627 \u0643\u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u0645\u062d\u0627\u0643\u0645\u0629. \u0644\u0623\u0646 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 (LCA) \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0636\u064a\u0648\u0641 \u0627\u0644\u0641\u0627\u062e\u0631\u0629 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0645\u0639 \u0627\u0644\u062d\u0627\u0644\u0629\u060c \u0641\u0642\u062f \u064a\u0638\u0647\u0631\u0648\u0646 \u0645\u0643\u0627\u0633\u0628 \u0623\u0643\u0628\u0631\u060c \u0643\u0645\u0627 \u064a\u0642\u0648\u0644 (Pennesi). \u0643\u0645\u0627 \u064a\u0636\u064a\u0641 \u0630\u0644\u0643 \u0623\u064a\u0636\u0627 \u0623\u0646 \u0623\u062f\u0645\u063a\u062a\u0647\u0645 \u0627\u0644\u0628\u0644\u0627\u0633\u062a\u064a\u0643\u064a\u0629 \u0633\u062a\u062a\u0643\u064a\u0641 \u0628\u0634\u0643\u0644 \u0623\u0641\u0636\u0644 \u0645\u0639 \u0645\u0639\u0627\u0644\u062c\u0629 \u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u0645\u062d\u0633\u0646\u0629.<\/p>\n

\u0641\u064a \u0627\u0644\u0639\u0627\u0645 \u0627\u0644\u0645\u0627\u0636\u064a\u060c \u0633\u062c\u0644 \u0627\u0644\u0623\u064a\u0633\u0631 \u0623\u0648\u0644 \u0646\u062c\u0627\u062d \u0633\u0631\u064a\u0631\u064a \u0644\u0647 \u0644\u0623\u0645\u0631\u0627\u0636 \u0645\u0648\u0631\u0648\u062b\u0629 \u0646\u0627\u062f\u0631\u0629\u060c \u0648\u062a\u062e\u0641\u064a\u0641 \u0641\u0642\u0631 \u0627\u0644\u062f\u0645 \u0648\u0627\u0644\u0623\u0644\u0645 \u0648\u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0623\u062e\u0631\u0649 \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u062f\u0645 \u062e\u0637\u064a\u0631\u0629. \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0642\u0627\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u062f\u0645\u0648\u064a\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0637\u0628\u0642\u060c \u062b\u0645 \u063a\u0631\u0633 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0641\u064a \u0623\u062c\u0633\u0627\u062f\u0647\u0645.<\/p>\n

\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 (Editas) \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0645\u062d\u0627\u0643\u0645\u062a\u0647\u0627 \u0627\u0644\u0645\u062d\u0627\u0643\u0645\u0629 \u0643\u0623\u0648\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 (Crispr) \u0644\u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645\u060c \u0641\u0625\u0646 \u0645\u062d\u0627\u0643\u0645\u0629 “\u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a” \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u062a\u064a \u0623\u0637\u0644\u0642\u062a \u0641\u064a \u0648\u0642\u062a \u0644\u0627\u062d\u0642 (Gasalready) \u0623\u0633\u0641\u0631\u062a \u0639\u0646 \u0646\u062a\u0627\u0626\u062c \u0641\u0641\u064a \u064a\u0648\u0646\u064a\u0648 \/ \u062d\u0632\u064a\u0631\u0627\u0646\u060c \u0630\u0643\u0631 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u0646 \u062a\u0631\u0633\u064a\u0628\u0631\u0641\u0631 \u0642\u062f \u062a\u062f\u0641\u0642 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0627\u0645 \u0627\u0644\u0630\u064a \u0623\u062f\u0649 \u0628\u0647 \u0627\u0644\u0649 \u0627\u0644\u0643\u0628\u062f \u0627\u0644\u0630\u064a \u064a\u0633\u0628\u0628 \u0645\u0631\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0639\u0635\u0628. \u0628\u062f\u0644\u0627 \u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u064a\u0631\u0648\u0633 \u0644\u062a\u062e\u0637\u064a\u0637 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0641\u064a \u0627\u0644\u062c\u0633\u0645\u060c \u062d\u0642\u0646 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0627\u0644\u062c\u0633\u064a\u0645\u0627\u062a \u0627\u0644\u0646\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0631\u0633\u0648\u0644 \u062a\u0631\u0645\u064a\u0632 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a \u0641\u064a \u062f\u0645\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649. \u0642\u062f \u064a\u0643\u0648\u0646 \u0644\u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0623\u0643\u062b\u0631 \u0639\u0627\u0628\u0631\u0629 \u0644\u062a\u062d\u0631\u064a\u0631 \u062c\u064a\u0646\u0627\u062a – \u0648\u0625\u062b\u0628\u0627\u062a \u0623\u0643\u062b\u0631 \u0623\u0645\u0627\u0646\u0627 – \u0648\u0644\u0643\u0646 \u0642\u062f \u064a\u0643\u0648\u0646 \u0645\u0646 \u0627\u0644\u0635\u0639\u0628 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u062e\u0627\u0631\u062c \u0627\u0644\u0643\u0628\u062f.<\/p>\n

\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a (<\/strong>CEP290)<\/strong><\/p>\n

\u064a\u0631\u0643\u0632 \u0647\u0630\u0627 \u0627\u0644\u0645\u0634\u0631\u0648\u0639 \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a \u0639\u0644\u0649 \u062a\u0635\u0645\u064a\u0645 \u0646\u0647\u062c \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0646\u0641\u0633 \u0627\u0644\u062c\u064a\u0646 (CEP290). \u0639\u0644\u0649 \u0639\u0643\u0633 \u0646\u0647\u062c (CRISPR)\u060c \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0633\u062a\u0647\u062f\u0641 \u0637\u0641\u0631\u0629 \u0645\u0639\u064a\u0646\u0629 \u0641\u0642\u0637 \u0641\u064a \u0648\u0642\u062a \u0648\u0627\u062d\u062f\u060c \u064a\u0642\u0648\u0645 \u0641\u0631\u064a\u0642\u064a \u0628\u062a\u0637\u0648\u064a\u0631 \u0646\u0647\u062c \u0645\u0646 \u0634\u0623\u0646\u0647 \u0623\u0646 \u064a\u0639\u0645\u0644 \u0645\u0639 \u062c\u0645\u064a\u0639 \u0637\u0641\u0631\u0627\u062a (CEP290) \u0641\u064a \u0645\u0631\u0636 \u0644\u064a\u0628\u0631 \u0627\u0644\u062e\u0644\u0642\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 10.<\/p>\n

\u064a\u062a\u0636\u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0634\u0643\u0627\u0644 \u0623\u0642\u0635\u0631 \u0644\u0643\u0646\u0647\u0627 \u0648\u0638\u064a\u0641\u064a\u0629 \u0645\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 (CEP290) \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u062a\u0648\u0635\u064a\u0644\u0647 \u0625\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0636\u0648\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0633\u0631\u064a\u0631\u064a.<\/p>\n

\u064a\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0630\u064a \u064a\u062a\u0636\u0645\u0646 \u062a\u0642\u0646\u064a\u0629 \u0643\u0631\u064a\u0633\u0628\u0631 \u0628\u0625\u0635\u0644\u0627\u062d \u062f\u0627\u0626\u0645 \u0648\u0641\u062a\u0631\u0629 \u062a\u0639\u0627\u0641\u064a \u0645\u0646\u062e\u0641\u0636\u0629 \u0648\u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631. \u064a\u062a\u0645\u062b\u0644 \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0633\u0644\u0628\u064a \u0644\u0646\u0647\u062c \u0643\u0631\u064a\u0633\u0628\u0631 \u0641\u064a \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u062d\u062f\u0648\u062b \u062a\u0623\u062b\u064a\u0631 \u062e\u0627\u0631\u062c \u0627\u0644\u0647\u062f\u0641 \u062d\u064a\u062b \u064a\u062a\u0645 \u062a\u062d\u0631\u064a\u0631 \u0645\u0646\u0637\u0642\u0629 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u0644\u062e\u0644\u064a\u0629\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u062a\u0633\u0628\u0628 \u0641\u064a \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u063a\u064a\u0631 \u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647\u0627\u060c \u0645\u062b\u0644 \u0627\u0644\u0633\u0631\u0637\u0627\u0646. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u062c\u0639\u0644\u062a \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0648\u0627\u0644\u0645\u062d\u0633\u0651\u0646\u0629 \u0645\u062b\u0644 \u0647\u0630\u0627 \u0627\u0644\u0627\u062d\u062a\u0645\u0627\u0644 \u0645\u0646\u062e\u0641\u0636\u064b\u0627 \u0644\u0644\u063a\u0627\u064a\u0629.<\/p>\n

\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u062f\u0631\u0627\u0633\u0629 (CRISPR) \u0645\u062e\u0635\u0635\u0629 \u0644\u0637\u0641\u0631\u0629 \u0645\u0639\u064a\u0646\u0629 \u0641\u064a (CEP290)\u060c \u0625\u0644\u0627 \u0623\u0646\u0646\u064a \u0623\u0639\u062a\u0642\u062f \u0623\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0642\u0646\u064a\u0629 (CRISPR) \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0633\u064a\u0643\u0648\u0646 \u0645\u062b\u064a\u0631\u064b\u0627 \u0648\u0642\u0641\u0632\u0629 \u0639\u0645\u0644\u0627\u0642\u0629. \u0623\u0639\u0644\u0645 \u0623\u0646 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0645\u0628\u0643\u0631\u0629\u060c \u0644\u0643\u0646\u0647 \u064a\u0638\u0647\u0631 \u0648\u0627\u0639\u062f\u0627 \u0628\u0634\u0643\u0644 \u0648\u0627\u0636\u062d. \u0641\u064a \u0631\u0623\u064a\u064a\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0623\u0630\u0647\u0627\u0646 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0627\u0644\u0622\u062e\u0631\u064a\u0646\u060c \u064a\u062d\u0645\u0644 \u0627\u0644\u0627\u0628\u062a\u0643\u0627\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0628\u0648\u0633\u0627\u0637\u0629 \u0643\u0631\u064a\u0633\u0628\u0631 \u0648\u0639\u0648\u062f\u064b\u0627 \u0647\u0627\u0626\u0644\u0629.<\/p>\n

\u0634\u0627\u0647\u062f \u0627\u0644\u0643\u0644\u064a\u0628\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629:
\nhttps:\/\/www.youtube.com\/watch?v=rbVvu_104Pg<\/a>
\nhttps:\/\/www.youtube.com\/watch?v=o8ymjSE_W0E<\/a>
\nhttps:\/\/www.youtube.com\/watch?v=2tHPdi5vX1s<\/a>
\nhttps:\/\/www.youtube.com\/watch?v=v8NLQEX3ViM<\/a><\/h5>\n

\u0627\u0644\u0645\u0635\u0627\u062f\u0631:<\/strong><\/p>\n

    \n
  1. https:\/\/www.scientificamerican.com\/article\/how-can-science-help-reverse-blindness\/<\/a><\/li>\n
  2. https:\/\/www.forbes.com\/sites\/emilymullin\/2016\/01\/29\/crispr-used-to-repair-blindness-causing-gene-defect\/?sh=56ff50d3f46a<\/a><\/li>\n
  3. https:\/\/www.sciencedaily.com\/releases\/2021\/04\/210401112532.htm<\/a><\/li>\n
  4. https:\/\/www.science.org\/content\/article\/crispr-helps-blind-woman-see-doesn-t-help-all-patients<\/a><\/li>\n
  5. https:\/\/geneticliteracyproject.org\/2021\/01\/27\/inherited-blindness-can-now-be-cured-thanks-to-crispr\/<\/a><\/li>\n<\/ol>\n
    \"\"
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