{"id":14072,"date":"2021-12-28T04:50:09","date_gmt":"2021-12-28T01:50:09","guid":{"rendered":"https:\/\/www.qatifscience.com\/?p=14072"},"modified":"2021-12-28T04:50:09","modified_gmt":"2021-12-28T01:50:09","slug":"%d9%82%d8%b6%d8%a7%d9%8a%d8%a7-%d8%af%d9%88%d8%a7%d8%a6%d9%8a%d8%a9-%d8%b1%d8%ad%d9%84%d8%a9-%d8%a7%d9%84%d8%af%d9%88%d8%a7%d8%a1-%d9%85%d9%86-%d8%a7%d9%84%d9%85%d8%ae%d8%aa%d8%a8%d8%b1","status":"publish","type":"post","link":"https:\/\/www.qatifscience.com\/?p=14072","title":{"rendered":"\u0642\u0636\u0627\u064a\u0627 \u062f\u0648\u0627\u0626\u064a\u0629 \u2026 \u0631\u062d\u0644\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0625\u0644\u0649 \u0631\u0641 \u0627\u0644\u0635\u064a\u062f\u0644\u064a\u0629 – \u0627\u0644\u0635\u064a\u062f\u0644\u064a \u063a\u0633\u0627\u0646 \u0639\u0644\u064a \u0628\u0648\u062e\u0645\u0633\u064a\u0646*"},"content":{"rendered":"

\u064a\u0645\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0639\u0628\u0631 \u0631\u062d\u0644\u0629 \u0637\u0648\u064a\u0644\u0629 \u0648\u0645\u0643\u0644\u0641\u0629 \u062c\u062f\u0627\u064b \u062d\u062a\u0649 \u064a\u0635\u0644 \u0625\u0644\u064a\u0646\u0627\u060c \u0648\u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0648\u0636\u0639\u0647\u0627 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0648\u062e\u0628\u0631\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0639\u062f \u062f\u0631\u0627\u0633\u0627\u062a \u0648\u062a\u062c\u0627\u0631\u0628 \u0639\u062f\u064a\u062f\u0629 \u0639\u0628\u0631 \u0639\u0642\u0648\u062f \u0637\u0648\u064a\u0644\u0629\u061b \u0644\u0636\u0645\u0627\u0646 \u0623\u0642\u0635\u0649 \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0623\u0645\u0627\u0646 \u0648\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621.<\/strong><\/span><\/p>\n

\u062a\u0639\u0627\u0644\u0648\u0627 \u0644\u0646\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0628\u0639\u0636\u064d \u0645\u0646 \u062c\u0648\u0627\u0646\u0628 \u0647\u0630\u0647 \u0627\u0644\u0631\u062d\u0644\u0629 \u0627\u0644\u0637\u0648\u064a\u0644\u0629 \u0648\u0627\u0644\u0645\u0636\u0646\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u064a\u0646\u062a\u0642\u0644 \u0641\u064a\u0647\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0645\u0631\u062d\u0644\u0629 \u0625\u0644\u0649 \u0623\u062e\u0631\u0649\u060c\u00a0 \u0642\u062f \u062a\u0633\u062a\u063a\u0631\u0642 \u0647\u0630\u0647 \u0627\u0644\u0631\u062d\u0644\u0629 \u062d\u0648\u0627\u0644\u064a 10 \u0633\u0646\u0648\u0627\u062a \u0648\u062a\u0643\u0644\u0641 \u0645\u0626\u0627\u062a \u0645\u0644\u0627\u064a\u064a\u0646 \u0627\u0644\u062f\u0648\u0644\u0627\u0631\u0627\u062a. \u0648\u0627\u0644\u0639\u062c\u064a\u0628 \u0623\u0646 \u0645\u0627 \u064a\u0635\u0644 \u0627\u0644\u0649 \u0631\u0641 \u0627\u0644\u0635\u064a\u062f\u0644\u064a\u0629 \u0641\u0639\u0644\u064a\u0627\u064b\u060c\u00a0 \u0647\u0648 \u0623\u0642\u0644 \u0628\u0643\u062b\u064a\u0631 \u0645\u0646 1\u066a \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u062a\u064a \u062c\u0631\u0649 \u062a\u0637\u0648\u064a\u0631\u0647\u0627 \u0641\u064a \u0627\u0644\u0645\u0635\u0627\u0646\u0639 \u0648\u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0627\u062a.<\/p>\n

\u062a\u0646\u0642\u0633\u0645 \u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0623\u0633\u0627\u0633\u0627\u064b \u0625\u0644\u0649 \u0642\u0633\u0645\u064a\u0646:<\/strong><\/span><\/p>\n

\u0623\u0648\u0644\u0627 :\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (preclinical)<\/span><\/strong><\/p>\n

\u062a\u0647\u062f\u0641 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (\u0627\u0644\u0625\u0643\u0644\u064a\u0646\u064a\u0643\u064a\u0629) \u0625\u0644\u0649 \u062a\u062d\u062f\u064a\u062f \u0645\u062f\u0649 \u0623\u0642\u0635\u0649 \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0623\u0645\u0627\u0646 \u0644\u0644\u0639\u0642\u0627\u0631, \u0648\u0647\u064a \u0645\u0631\u062d\u0644\u0629 \u062a\u062a\u0636\u0645\u0646 \u0643\u0644 \u0645\u0646 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0645\u0631\u0627\u062f \u0645\u0639\u0627\u0644\u062c\u062a\u0647\u060c \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u0627\u0644\u062a\u062c\u0631\u0628\u0629.<\/p>\n

\"\"
\u0631\u062d\u0644\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0627\u0644\u0649 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0645\u0631\u0634\u062d \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0625\u0643\u0644\u064a\u0646\u064a\u0643\u064a\u0629<\/span><\/figcaption><\/figure>\n

\u0627\u0644\u062a\u062d\u0631\u064a \u0648\u0627\u0644\u062a\u0635\u0645\u064a\u0645 <\/strong><\/p>\n

\u062a\u062a\u0636\u0645\u0646 \u0639\u0645\u0644\u064a\u0629 \u0625\u064a\u062c\u0627\u062f \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u062a\u062c\u0627\u0647 \u0647\u062f\u0641 \u0645\u062e\u062a\u0627\u0631 \u0644\u0645\u0631\u0636 \u0645\u062d\u062f\u062f \u0645\u0627\u060c \u064a\u062f\u0639\u0649 \u0628\u0627\u0644\u062a\u062d\u0631\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u0625\u0646\u062a\u0627\u062c\u064a\u0629<\/p>\n

“high-throughput screening (HTS)”\u060c \u0648\u0627\u0644\u0630\u064a \u062a\u062e\u062a\u0628\u0631 \u0641\u064a\u0647 \u0645\u0643\u062a\u0628\u0627\u062a \u0636\u062e\u0645\u0629 \u062a\u0636\u0645 \u0645\u0644\u0627\u064a\u064a\u0646 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0644\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0641\u064a \u0642\u062f\u0631\u062a\u0647\u0627 \u0628\u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u0647\u062f\u0641.<\/p>\n

\u064a\u0646\u0628\u063a\u064a \u0625\u064a\u062c\u0627\u062f \u0645\u0631\u0643\u0628 \u064a\u062a\u062f\u062e\u0651\u0644 \u0641\u0642\u0637 \u0645\u0639 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0645\u062e\u062a\u0627\u0631\u060c \u0644\u0643\u0646 \u0644\u064a\u0633 \u0645\u0639 \u063a\u064a\u0631\u0647 \u0645\u0646 \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629. \u0648\u0644\u0644\u0648\u0635\u0648\u0644 \u0644\u0630\u0644\u0643 \u0641\u0625\u0646\u0647 \u062a\u062c\u0631\u0649 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u062d\u0631\u0651\u064a \u0644\u0645\u0639\u0631\u0641\u0629 \u0625\u0630\u0627 \u0645\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0646\u0627\u062c\u062d\u0629 “HTS” \u062a\u062c\u0627\u0647 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0645\u062e\u062a\u0627\u0631 \u0633\u062a\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u0623\u062e\u0631\u0649 \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629\u060c \u0648\u0647\u0630\u0627 \u0645\u0627 \u064a\u062f\u0639\u0649 \u0628\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u062d\u0631\u0651\u064a \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644. \u0627\u0644\u062a\u062d\u0631\u0651\u064a \u0627\u0644\u0645\u062a\u062f\u0627\u062e\u0644 (cross-screening) \u0647\u0627\u0645\u061b \u0644\u0623\u0646\u0647 \u0643\u0644\u0645\u0627 \u0637\u0627\u0628\u0642 \u0627\u0644\u0645\u0631\u0643\u0628 \u0623\u0647\u062f\u0627\u0641 \u0644\u064a\u0633\u062a \u0630\u0627\u062a \u0639\u0644\u0627\u0642\u0629\u060c \u0643\u0644\u0645\u0627 \u0632\u0627\u062f \u0627\u062d\u062a\u0645\u0627\u0644 \u062d\u062f\u0648\u062b \u0633\u0645\u064a\u0629 \u0627\u0644\u0628\u0639\u062f \u0639\u0646 \u0627\u0644\u0647\u062f\u0641 (off-target toxicity) \u0648\u0647\u0630\u0627 \u064a\u0636\u0639\u0641 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0629 \u0646\u062c\u0627\u062d \u0627\u0644\u062f\u0648\u0627\u0621.<\/p>\n

\"\"
\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u062a\u062d\u0631\u064a \u0648\u0627\u0644\u062a\u0635\u0645\u064a\u0645<\/span><\/figcaption><\/figure>\n

\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 (HTS) \u0637\u0631\u064a\u0642\u0629 \u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u064a \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629\u060c \u0644\u0643\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0648\u062d\u064a\u062f\u0629. \u0625\u0630 \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u0623\u0646 \u064a\u062c\u0631\u064a \u0627\u0644\u0628\u062f\u0621 \u0645\u0646 \u0645\u0631\u0643\u0628 \u0648\u0627\u0644\u0630\u064a \u064a\u0645\u0644\u0643 \u0628\u0627\u0644\u0623\u0635\u0644 \u0628\u0639\u0636 \u0645\u0646 \u0627\u0644\u062e\u0648\u0627\u0635 \u0627\u0644\u0645\u0631\u063a\u0648\u0628\u0629. \u0648\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0643\u0628 \u064a\u0643\u0648\u0646 \u0645\u0646\u062a\u062c \u0637\u0628\u064a\u0639\u064a\u0627\u064b \u0623\u0648 \u062d\u062a\u0649 \u0623\u0646 \u064a\u0643\u0648\u0646 \u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0633\u0648\u0642 \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629.<\/p>\n

\u0639\u0646\u062f\u0645\u0627 \u064a\u062a\u0645 \u062a\u0639\u064a\u064a\u0646 \u0633\u0644\u0627\u0633\u0644 \u0645\u0631\u0643\u0628\u0627\u062a \u0631\u0626\u064a\u0633\u064a\u0629 \u0645\u0639 \u0641\u0627\u0639\u0644\u064a\u0629 \u0647\u062f\u0641 \u0643\u0627\u0641\u064a\u0629 \u0648\u0627\u0646\u062a\u0642\u0627\u0626\u064a\u0629 \u0648\u062e\u0648\u0627\u0635 \u0645\u0634\u0627\u0628\u0647\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 \u0645\u0631\u063a\u0648\u0628\u0629\u060c \u0639\u0646\u062f\u0647\u0627 \u064a\u064f\u0642\u062f\u0645 \u0645\u0631\u0643\u0628 \u0623\u0648 \u0645\u0631\u0643\u0628\u064a\u0646 \u0644\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a<\/a>. \u0625\u0646 \u0623\u0641\u0636\u0644\u0647\u0627 \u064a\u0633\u0645\u0649 \u0639\u0645\u0648\u0645\u0627\u064b \u0628\u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0631\u0626\u064a\u0633\u064a<\/a> (lead compound)\u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u0623\u062e\u0631\u0649 \u0633\u062a\u0644\u0642\u0651\u0628 \u0643\u0640”\u062f\u0639\u0645”.<\/p>\n

\u062a\u0646\u0642\u0633\u0645 \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0625\u0644\u0649 \u0639\u062f\u0629 \u0645\u0631\u0627\u062d\u0644:<\/strong><\/p>\n

1. \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a (biological target):<\/strong><\/p>\n

\u064a\u062c\u0628 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0630\u064a \u0633\u0648\u0641 \u064a\u0624\u062b\u0631 \u0639\u0644\u064a\u0647 \u0627\u0644\u062f\u0648\u0627\u0621 \u0623\u0648 \u0627\u0644\u0639\u0642\u0627\u0631, \u0648\u064a\u0633\u0645\u0649 \u0628\u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0648\u064a\u0642\u0635\u062f \u0628\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a (\u0645\u062b\u0644: \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a) \u0623\u0648 \u0642\u0646\u0648\u0627\u062a \u0623\u064a\u0648\u0646\u064a\u0629 \u0623\u0648 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0644\u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u062a\u062d\u0648\u064a\u0631 \u0646\u0634\u0627\u0637\u0647\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u0624\u062b\u0631 \u062f\u0648\u0627\u0626\u064a.\u00a0 \u064a\u0633\u062a\u062e\u062f\u0645 \u0645\u0635\u0637\u0644\u062d \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0641\u064a \u0645\u062c\u0627\u0644 \u0627\u0644\u0628\u062d\u0648\u062b \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629, \u0644\u0648\u0635\u0641 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0630\u064a \u064a\u064f\u062d\u0648\u0631 \u0646\u0634\u0627\u0637\u0647 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0639\u0642\u0627\u0631 \u0648\u0628\u0630\u0644\u0643 \u064a\u0646\u062a\u062c \u0639\u0646\u0647 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0627\u0644\u0645\u0637\u0644\u0648\u0628, \u0648\u0623\u064a\u0636\u0627\u064b \u064a\u0633\u0645\u0649 (\u0628\u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u062f\u0648\u0627\u0626\u064a) (drug target).<\/p>\n

2. \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u062f\u0648\u0627\u0621\u00a0<\/strong><\/p>\n

\u0648\u0647\u064a \u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062a\u064a \u064a\u0643\u062a\u0634\u0641 \u0628\u0647\u0627 \u062a\u0631\u0643\u064a\u0628\u0629 \u0627\u0644\u062f\u0648\u0627\u0621. \u00a0\u0641\u064a \u0627\u0644\u0645\u0627\u0636\u064a, \u0643\u0627\u0646 \u064a\u0643\u062a\u0634\u0641 \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0639\u0627\u0644\u0629 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0634\u0639\u0628\u064a\u0629 \u0623\u0648 \u0628\u0627\u0644\u0645\u0635\u0627\u062f\u0641\u0629. \u062d\u062f\u064a\u062b\u0627, \u062a\u062a\u0636\u0645\u0646 \u0637\u0631\u064a\u0642\u0629 \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0628\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0631\u0634\u062d \u0627\u0644\u0645\u0646\u0627\u0633\u0628 \u0648\u0637\u0631\u064a\u0642\u0629 \u062a\u0635\u0646\u064a\u0639\u0647 \u0648\u062e\u0635\u0627\u0626\u0635\u0647 \u0648\u062a\u062d\u0644\u064a\u0644\u0647 \u0644\u0636\u0645\u0627\u0646 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u060c \u0648\u062d\u0627\u0644\u0645\u0627 \u064a\u062b\u0628\u062a \u0645\u0631\u0643\u0628 \u0645\u0627 \u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a, \u062a\u0628\u062f\u0623 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0644\u0647 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0642 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0625\u0643\u0644\u064a\u0646\u064a\u0643\u064a\u0629.<\/p>\n

\u0628\u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0646\u0634\u0648\u0621 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u062a\u062c\u0645\u064a\u0639\u064a\u0629 \u0643\u062c\u0632\u0621 \u0644\u0627 \u064a\u062a\u062c\u0632\u0651\u0623 \u0639\u0646 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629\u060c \u0641\u0625\u0646 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0644\u0627 \u062a\u0632\u0627\u0644 \u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0631\u0626\u064a\u0633\u064a\u0627\u064b \u0643\u0645\u0627\u062f\u0629 \u0627\u0646\u0637\u0644\u0627\u0642 \u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629. \u0646\u064f\u0634\u0631 \u062a\u0642\u0631\u064a\u0631 \u0641\u064a \u0639\u0627\u0645 2007 \u064a\u063a\u0637\u0651\u064a \u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0628\u064a\u0646 1981 \u0648 2006 \u0641\u064a \u0645\u0633\u0627\u0647\u0645\u0629 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u062a\u0634\u0643\u0644\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629. \u062a\u0628\u0639\u0627\u064b \u0644\u0647\u0630\u0627 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0648\u062c\u062f \u0623\u0646\u0647 \u0645\u0646 \u0628\u064a\u0646 974 \u0643\u064a\u0627\u0646 \u0643\u064a\u0645\u064a\u0627\u0626\u064a \u062c\u062f\u064a\u062f \u0630\u0648 \u062c\u0632\u064a\u0626\u0629 \u0635\u063a\u064a\u0631\u0629\u060c \u0643\u0627\u0646 63% \u0645\u0646\u0647\u0627 \u0645\u0634\u062a\u0642 \u0637\u0628\u064a\u0639\u064a\u0627\u064b \u0623\u0648 \u0645\u0634\u062a\u0642\u0627\u062a \u0646\u0635\u0641 \u0635\u0646\u0627\u0639\u064a\u0629 \u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0637\u0628\u064a\u0639\u064a\u0629.<\/p>\n

3. \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621:\u00a0<\/strong><\/p>\n

\u064a\u0639\u0631\u0641 \u0645\u0635\u0637\u0644\u062d \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0623\u0648 \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u0625\u0643\u0644\u064a\u0646\u064a\u0643\u064a \u0641\u064a \u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0634\u0631\u0643\u0627\u062a \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0623\u0646\u0647 \u0639\u0645\u0644\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0623\u0633\u0627\u0633\u064a (active pharmaceutical ingredient API) (\u0627\u0644\u0645\u0627\u062f\u0629 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629) \u0648\u0645\u0631\u0648\u0631\u0647\u0627 \u0641\u064a \u0645\u0631\u0627\u062d\u0644 \u0636\u0631\u0648\u0631\u064a\u0629 \u0644\u062c\u0639\u0644\u0647\u0627 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062c\u0631\u0628\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0634\u0631. \u0648\u0623\u0647\u0645 \u0645\u0631\u0627\u062d\u0644 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062f\u0648\u0627\u0621 \u0647\u0648 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u0627\u0631\u0628.<\/p>\n

\"\"
\u0623\u0645\u062b\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0627\u0644\u0623\u0633\u0627\u0633 API<\/span><\/figcaption><\/figure>\n

\u062b\u0645\u0629 \u0646\u0648\u0639\u0627\u0646 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0639\u0644\u0649 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a:\u00a0<\/strong><\/p>\n

1. (In vitro) (\u0643\u0644\u0645\u0629 \u0644\u0627\u062a\u064a\u0646\u064a\u0629 \u062a\u0639\u0646\u064a \u062f\u0627\u062e\u0644 \u0627\u0644\u0632\u062c\u0627\u062c)<\/span> \u0648\u0647\u064a \u062a\u0642\u0646\u064a\u0629 \u062a\u0633\u062a\u062e\u062f\u0645 \u0644\u0644\u0642\u064a\u0627\u0645 \u0628\u0639\u0645\u0644\u064a\u0629 \u0645\u0639\u064a\u0646\u0629\u060c \u0641\u064a \u0645\u062d\u064a\u0637 \u0645\u062d\u062f\u062f \u062e\u0627\u0631\u062c \u062c\u0633\u0645 \u0627\u0644\u0643\u0627\u0626\u0646 \u0627\u0644\u062d\u064a.<\/p>\n

\u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0628\u062d\u0648\u062b \u0625\u0644\u0649 \u0648\u0635\u0641 \u0622\u062b\u0627\u0631 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0644\u0644\u062a\u062c\u0627\u0631\u0628 \u0639\u0644\u0649 \u0623\u062c\u0632\u0627\u0621 \u0645\u0646 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u0627\u062a \u0628\u062f\u064a\u0644\u0629 \u0639\u0646 \u0627\u0644\u062c\u0633\u0645 \u0643\u0627\u0645\u0644\u0627\u064b\u060c \u062a\u0645\u064a\u0644 \u0644\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u0649 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0623\u062c\u0632\u0627\u0621 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a, \u0648\u0647\u064a \u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u062a\u062a\u0628\u0639 \u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a\u0629 \u0639\u0645\u0644 \u0627\u0644\u062f\u0648\u0627\u0621.<\/p>\n

2. (In vivo) (\u0643\u0644\u0645\u0629 \u0644\u0627\u062a\u064a\u0646\u064a\u0629 \u062a\u0639\u0646\u064a \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645)<\/span> \u0648\u062a\u0631\u0645\u0632 \u0625\u0644\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062d\u064a\u0648\u0627\u0646 \u0627\u0644\u062d\u064a \u0643\u0627\u0645\u0644\u0627\u064b \u0639\u0644\u0649 \u0639\u0643\u0633 \u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062d\u064a\u0648\u0627\u0646 \u0645\u064a\u062a \u0623\u0648 \u062c\u0632\u0621 \u0645\u0646\u0647.<\/p>\n

\u062b\u0627\u0646\u064a\u0627: \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (\u0627\u0644\u0627\u0643\u0644\u064a\u0646\u064a\u0643\u064a\u0629):<\/strong><\/span><\/p>\n

\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629:\u00a0<\/strong>\u062a\u062c\u0631\u0649 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0636\u0645\u0646 3<\/strong> \u0645\u0631\u0627\u062d\u0644:<\/p>\n

\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649: <\/strong><\/p>\n

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\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629:<\/strong><\/p>\n

\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0647\u064a \u062a\u062c\u0627\u0631\u0628 \u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u062d\u062c\u0645 \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0648\u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629<\/a> \u0641\u064a 100 \u0625\u0644\u0649 250 \u0645\u0631\u064a\u0636. \u0643\u0645\u0627 \u064a\u0646\u062f\u0631\u062c \u062a\u062d\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629.<\/p>\n

\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629:<\/strong><\/p>\n

\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0647\u064a \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062f\u0631\u0627\u0633\u0627\u062a \u0648\u0627\u0633\u0639\u0629 \u0627\u0644\u0646\u0637\u0627\u0642 \u0644\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 \u0623\u0639\u062f\u0627\u062f \u0643\u0628\u064a\u0631\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649. \u0648\u0641\u064a \u0623\u062b\u0646\u0627\u0621 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u064a\u062a\u0645 \u0627\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u062a\u0642\u062f\u064a\u0645 \u0637\u0644\u0628 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f (NDA) (\u0648\u0627\u0644\u0630\u064a \u064a\u062a\u0645 \u062a\u0642\u064a\u064a\u0645\u0647 \u0645\u0646 \u0642\u0628\u0644 \u0645\u0631\u0643\u0632 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u0648\u062b (CDER)\u060c \u0623\u0648 \u0637\u0644\u0628 \u062a\u0631\u062e\u064a\u0635 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 (BLA) (\u0648\u0627\u0644\u0630\u064a \u064a\u064f\u0642\u064a\u0651\u0645 \u0645\u0646 \u0642\u0628\u0644 \u0645\u0631\u0643\u0632 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u0648\u062b (CBER) \u0627\u0644\u062a\u0627\u0628\u0639 \u0644\u0645\u0624\u0633\u0633\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621.<\/p>\n

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